Synthetic approach to borrelidin fragments: focus on key intermediates

• Yudhi Dwi Kurniawan,
• Zetryana Puteri Tachrim,
• Teni Ernawati,
• Faris Hermawan,
• Ima Nurasiyah and
• Muhammad Alfin Sulmantara

Beilstein J. Org. Chem. 2025, 21, 1135–1160, doi:10.3762/bjoc.21.91

• hurdles, this work advocates for a fragment-focused approach as a crucial step toward advancing borrelidin research and expanding its potential applications. Keywords: borrelidin analogs; borrelidin derivatives; borrelidin fragments; borrelidin synthesis; fragment-based synthesis; Introduction

• synthesis of Theodorakis’ C3–C11 fragment 82 developed by Herber and Breit [33]. Retrosynthesis of the C3–C17 fragment of borrelidin by Iqbal and co-workers [35]. Synthesis of key intermediates 137 and 147 for the synthesis of the C3–C17 fragment of borrelidin. Synthesis of the C3–C17 fragment 150a,b of

• borrelidin. Synthesis of the C11–C15 fragment 155a of borrelidin. Macrocyclization of borrelidin model compounds 155a and 155b using ring-closing metathesis. Summary of the borrelidin family: structures, sources, and related literature. Funding The authors express their gratitude to the Research