Recent advances in allylation of chiral secondary alkylcopper species

• Minjae Kim,
• Gwanggyun Kim,
• Doyoon Kim,
• Jun Hee Lee and
• Seung Hwan Cho

Beilstein J. Org. Chem. 2025, 21, 639–658, doi:10.3762/bjoc.21.51

• advancement requires establishing catalytic systems that effectively utilize chiral secondary organocopper species, making the understanding of their nature and behavior crucial for expanding the synthetic utility of this transformation. The purpose of this review is to present recent procedures for

• transmetalation sequence. ZnCl2-promoted stereospecific SN2' allylic substitution of secondary alkylcopper species via sequential iodide–lithium–copper transmetalation. Temperature and time-dependent configurational stability of chiral secondary organocopper species. DFT analysis of B–C bond lengths in various

• secondary organocopper; copper-mediated reaction; stereoselectivity; Introduction The transition-metal-catalyzed regio- and enantioselective allylic substitution represents a pivotal methodology in organic synthesis, providing remarkable versatility for complex molecule construction [1][2][3][4]. The