Identification and removal of a cryptic impurity in pomalidomide-PEG based PROTAC

• Bingnan Wang,
• Yong Lu and
• Chuo Chen

Beilstein J. Org. Chem. 2025, 21, 407–411, doi:10.3762/bjoc.21.28

• length (including 6 for n = 5), the decontamination process is slow and the costs are high. Additionally, it could not remove the trace amount of the residual impurity, potentially due to inefficient diffusion of the substrate into the resin at low concentrations. We next sought to use soluble amines to

• sulfonate to the byproduct by reacting it with taurine allows for easy decontamination. This method may facilitate the purification of other similar reactions and improve the quality of related pomalidomide derivatives. The structures of veliparib and iVeliparib-AP6. Identification of the cryptic impurity

Structure–efficiency relationships of cyclodextrin scavengers in the hydrolytic degradation of organophosphorus compounds

• Sophie Letort,
• Michaël Bosco,
• Benedetta Cornelio,
• Frédérique Brégier,
• Sébastien Daulon,
• Géraldine Gouhier and
• François Estour

Beilstein J. Org. Chem. 2017, 13, 417–427, doi:10.3762/bjoc.13.45

• of the agents. The degradation efficiency was found to be dependent on the relative position of the heterocycle towards the reactive group as well as on the nature of the organophosphorus derivative. Keywords: cyclodextrin; decontamination; enzyme mimic; nerve agents; organophosphorus pesticides

• current geopolitical situation and the increasing number of terrorist attacks worldwide, more efficient means against nerve agents are required [12]. Four steps have to be considered to reach this objective: detection, individual and collective protection, decontamination, and medical countermeasures

• pesticides and soman was evaluated. Some structural features of the scavengers could be identified as the key elements in charge to accelerate the decontamination of organophosphorus compounds: (1) the degradation kinetics of organophosphorus constituents is dependent on their affinity for the cyclodextrin

Cross-linked cyclodextrin-based material for treatment of metals and organic substances present in industrial discharge waters

• Élise Euvrard,
• Nadia Morin-Crini,
• Coline Druart,
• Justine Bugnet,
• Bernard Martel,
• Cesare Cosentino,
• Virginie Moutarlier and
• Grégorio Crini

Beilstein J. Org. Chem. 2016, 12, 1826–1838, doi:10.3762/bjoc.12.172

• their own treatment plants, generally physicochemical decontamination steps, the DWs still contain non-negligible amounts of pollutants. Among them, metals (in particular chromium, nickel and zinc) are commonly found at concentrations in the range of milligrams per liter, and organic molecules, such as

Interactions of cyclodextrins and their derivatives with toxic organophosphorus compounds

• Sophie Letort,
• Sébastien Balieu,
• William Erb,
• Géraldine Gouhier and
• François Estour

Beilstein J. Org. Chem. 2016, 12, 204–228, doi:10.3762/bjoc.12.23

• organophosphorus compounds, CDs have gained a significant attention for a variety of applications such as sensors for detection [31][32] or materials for nerve agents decontamination [33]. Various analytical methods exist to monitor the NOPs exposure [34][35][36]. However, these are long, expensive, required

Bis(β-lactosyl)-[60]fullerene as novel class of glycolipids useful for the detection and the decontamination of biological toxins of the Ricinus communis family

• Hirofumi Dohi,
• Takeru Kanazawa,
• Akihiro Saito,
• Keita Sato,
• Hirotaka Uzawa,
• Yasuo Seto and
• Yoshihiro Nishida

Beilstein J. Org. Chem. 2014, 10, 1504–1512, doi:10.3762/bjoc.10.155

• quantified by means of sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), and the results were discussed in terms of detection and decontamination of the deadly biological toxin in the Ricinus communis family. Keywords: fullerene; multivalent glycosystems; oligosaccharides; proteotoxins

• attempts of applying these glycomaterials for both the detection and the decontamination of biological toxins in an assumed polluted scene [19][20][21]. In the present study, we attempted to apply our N-glycosyl-[60]fullerenes [22][23][24][25], which were designed as a novel class of glycolipids with

• detection of the biological toxin. Glyco-nanotechnology for locking the deadly toxin at the bottom In an assumed situation of bioterrorism, the total time required for the identification and the decontamination is one of the key factors for minimizing possible damages from contaminated biological toxins

Influence of intramolecular hydrogen bonds on the binding potential of methylated β-cyclodextrin derivatives

• Gerhard Wenz

Beilstein J. Org. Chem. 2012, 8, 1890–1895, doi:10.3762/bjoc.8.218

• already applied industrially on a large scale, e.g., for switching the viscosity of polymeric thickeners [22], for decontamination of soil [23][24], or for cosmetic formulations [25]. High binding potentials of the methylated CDs are essential for their specific functions in these applications. Therefore

Evaluation of a commercial packed bed flow hydrogenator for reaction screening, optimization, and synthesis

• Marian C. Bryan,
• David Wernick,
• Christopher D. Hein,
• James V. Petersen,
• John W. Eschelbach and
• Elizabeth M. Doherty

Beilstein J. Org. Chem. 2011, 7, 1141–1149, doi:10.3762/bjoc.7.132

• ]. In addition, the contamination appears to accumulate through continued use of the reactor, presenting a signficant challenge with regard to performance stability. It should be noted that after thorough decontamination of the reactor we were able to reproduce the high chemoselectivity observed in the