Recent advances in controllable/divergent synthesis

• Jilei Cao,
• Leiyang Bai and
• Xuefeng Jiang

Beilstein J. Org. Chem. 2025, 21, 890–914, doi:10.3762/bjoc.21.73

• discipline and pursue novel advancements in the realm of chemical synthesis. Keywords: controllable; divergent; diverse products; switchable synthesis; Introduction In the era of synthetic organic chemistry, divergence can produce stereodivergence (including diastereodivergence and enantiodivergence) [1][2

Stereoselective mechanochemical synthesis of thiomalonate Michael adducts via iminium catalysis by chiral primary amines

• Michał Błauciak,
• Dominika Andrzejczyk,
• Błażej Dziuk and
• Rafał Kowalczyk

Beilstein J. Org. Chem. 2024, 20, 2313–2322, doi:10.3762/bjoc.20.198

• ][5]. The transient impact of kinetic energy, channeled into the reaction, facilitates overcoming the constraints inherent in equilibrium models. Thus, employing limited substrates could potentially yield diverse products through a simple alteration of conditions, compared to solvent-based methods [6

Pyridine C(sp²)–H bond functionalization under transition-metal and rare earth metal catalysis

• Haritha Sindhe,
• Malladi Mounika Reddy,
• Karthikeyan Rajkumar,
• Akshay Kamble,
• Amardeep Singh,
• Anand Kumar and
• Satyasheel Sharma

Beilstein J. Org. Chem. 2023, 19, 820–863, doi:10.3762/bjoc.19.62

• . These annulations can be either intermolecular or intramolecular and various substrates have been studied resulting in diverse products. Pyridine has been also reported for the construction of pyridine-fused heterocycles via C(sp2)–H functionalization and further annulation. In this aspect, considering

Eschenmoser coupling reactions starting from primary thioamides. When do they work and when not?

• Lukáš Marek,
• Jiří Váňa,
• Jan Svoboda and
• Jiří Hanusek

Beilstein J. Org. Chem. 2023, 19, 808–819, doi:10.3762/bjoc.19.61

• solutions (DMSO-d6, MeOD-d4, D2O), it was impossible to measure its NMR spectra and the only characterization involves MALDI–MS, IR, and melting point. The salt 6a was then treated in various solvents with or without additive (thiophile, base/acid) to give diverse products of cyclization (8a or 8a-Me), ECR

Cholyl 1,3,4-oxadiazole hybrid compounds: design, synthesis and antimicrobial assessment

• Anas J. Rasras,
• Mohamed El-Naggar,
• Nesreen A. Safwat and
• Raed A. Al-Qawasmeh

Beilstein J. Org. Chem. 2022, 18, 631–638, doi:10.3762/bjoc.18.63

• of 22 diverse compounds. Briefly, the alkyne 3 was treated with formaldehyde, a secondary amine, and CuI as catalyst in DMSO (Scheme 3). The three components were stirred at room temperature for 3 h to furnish the desired compounds 4a–v in moderate to excellent yields [14][34]. By this route, diverse

• products derived from piperazine derivatives with aromatic electron-donating (4d), electron-withdrawing (4b, 4c, and 4f), and aliphatic groups (4g, 4i, and 4j) were obtained. Moreover, the reaction with secondary aliphatic amines with various alkyl chains afforded products 4r–u, whereas products 4o and 4p

A study of the photochemical behavior of terarylenes containing allomaltol and pyrazole fragments

• Constantine V. Milyutin,
• Andrey N. Komogortsev,
• Boris V. Lichitsky and
• Valeriya G. Melekhina

Beilstein J. Org. Chem. 2022, 18, 588–596, doi:10.3762/bjoc.18.61

• in synthetic organic chemistry [1][2][3][4][5][6][7]. The advantage of photochemical methods is the possibility of the preparation of diverse products that are problematic to obtain using other chemical approaches. It should be noted that light can be considered as a traceless agent, therefore, UV

Extension of the 5-alkynyluridine side chain via C–C-bond formation in modified organometallic nucleosides using the Nicholas reaction

• Renata Kaczmarek,
• Dariusz Korczyński,
• James R. Green and
• Roman Dembinski

Beilstein J. Org. Chem. 2020, 16, 1–8, doi:10.3762/bjoc.16.1

• diverse products via formation of C–C bonds. Nucleophiles as diverse as electron-rich arenes or heteroarenes [41][42], alkenes [43], allylmetalloids [44][45][46], enol derivatives [47][48], and organometallics [49] are suitable for the Nicholas reaction. Allenic byproducts are rarely seen, and

An overview on recent advances in the synthesis of sulfonated organic materials, sulfonated silica materials, and sulfonated carbon materials and their catalytic applications in chemical processes

• Hashem Sharghi,
• Pezhman Shiri and
• Mahdi Aberi

Beilstein J. Org. Chem. 2018, 14, 2745–2770, doi:10.3762/bjoc.14.253

• structure of reused BBSI-HSO4 (56) and BBSI-Cl (57) ILs after the third run by use of 1H NMR spectra. The ILs showed no noteworthy change in their structures. The advantages of these catalytic systems are using solvent-catalyst ILs, mild reaction conditions, diverse products, short reaction times, good

Regiochemistry of cyclocondensation reactions in the synthesis of polyazaheterocycles

• Patrick T. Campos,
• Leticia V. Rodrigues,
• Andrei L. Belladona,
• Caroline R. Bender,
• Juliana S. Bitencurt,
• Fernanda A. Rosa,
• Davi F. Back,
• Helio G. Bonacorso,
• Nilo Zanatta,
• Clarissa P. Frizzo and
• Marcos A. P. Martins

Beilstein J. Org. Chem. 2017, 13, 257–266, doi:10.3762/bjoc.13.29

• block in the synthesis of heterocycles, because they have three different electrophilic carbonyl groups. This is expected to lead to different reaction pathways and thus, diverse products. However, the amide carbonyl of these compounds is considered to be less reactive, as its modification results in

Recent highlights in biosynthesis research using stable isotopes

• Jan Rinkel and
• Jeroen S. Dickschat

Beilstein J. Org. Chem. 2015, 11, 2493–2508, doi:10.3762/bjoc.11.271

• modular fashion [15]. In contrast to fatty acid synthases (FAS), PKSs do not necessarily process the initially formed 3-keto functions through a complete reductive cycle, which leads to structurally diverse products as shown in Figure 1 for lovastatin (1), an inhibitor of 3-hydroxy-3-methylglutaryl CoA

Recent advances in copper-catalyzed C–H bond amidation

• Jie-Ping Wan and
• Yanfeng Jing

Beilstein J. Org. Chem. 2015, 11, 2209–2222, doi:10.3762/bjoc.11.240

• nitrogen atom. On the other hand, designing cascade reactions by employing the C–H amidation constituted another issue of extensive interest since these reactions enabled the construction of more complex and diverse products via the formation of multiple chemical bonds in one step operation. Early in 2009

Multicomponent reactions in nucleoside chemistry

• Mariola Koszytkowska-Stawińska and
• Włodzimierz Buchowicz

Beilstein J. Org. Chem. 2014, 10, 1706–1732, doi:10.3762/bjoc.10.179

• : an aldehyde, a primary (or a secondary) amine, and an enolizable aldehyde (or ketone) (Scheme 1a) [47][48]. The use of a hydrogen active component other than an enolizable aldehyde or ketone leads to a variety of structurally diverse products (Scheme 1b). The Mannich reaction products (commonly named

The chemistry of bisallenes

• Henning Hopf and
• Georgios Markopoulos

Beilstein J. Org. Chem. 2012, 8, 1936–1998, doi:10.3762/bjoc.8.225