Progress and challenges in the synthesis of sequence controlled polysaccharides

• Giulio Fittolani,
• Theodore Tyrikos-Ergas,
• Denisa Vargová,
• Manishkumar A. Chaube and
• Martina Delbianco

Beilstein J. Org. Chem. 2021, 17, 1981–2025, doi:10.3762/bjoc.17.129

Synthesis of C-glycosyl phosphonate derivatives of 4-amino-4-deoxy-α-ʟ-arabinose

• Lukáš Kerner and
• Paul Kosma

Beilstein J. Org. Chem. 2020, 16, 9–14, doi:10.3762/bjoc.16.2

• derivatives. These intermediates will be of value for their future conversion into transition state analogues as well as for the introduction of various lipid extensions at the anomeric phosphonate moiety. Keywords: antibiotic resistance; glycosyl phosphonate; glycosyl transferase; lipid A

Strategies toward protecting group-free glycosylation through selective activation of the anomeric center

• A. Michael Downey and
• Michal Hocek

Beilstein J. Org. Chem. 2017, 13, 1239–1279, doi:10.3762/bjoc.13.123

• remarkably simple protocol that allows for a C3′-regioselective glycosylation of unprotected sucrose under aqueous conditions has been described by Schepartz, Miller and colleagues [57]. They took advantage of the fact that most glycosyl transferase enzymes operate in a divalent metal cation-dependent

Glycoscience@Synchrotron: Synchrotron radiation applied to structural glycoscience

• Serge Pérez and
• Daniele de Sanctis

Beilstein J. Org. Chem. 2017, 13, 1145–1167, doi:10.3762/bjoc.13.114

• presented in Figure 14. The studies of the mechanism of blood group glycosyl transferase have been investigated by kinetic crystallography approaches with the aim of characterizing the double-displacement mechanism which involves the formation of a covalently bound glycosyl-enzyme intermediate, by trapping

• crystalline glycosyl transferase. The four steps of the “freeze-trigger” process could be validated throughout by elucidation of the crystal structure of the glycosyl transferase, which has the active site occupied in a semi-closed conformation of the substrate with various levels of ordering of the internal

Interactions between cyclodextrins and cellular components: Towards greener medical applications?

• Loïc Leclercq

Beilstein J. Org. Chem. 2016, 12, 2644–2662, doi:10.3762/bjoc.12.261

• properties. i) Native cyclodextrins As mentioned earlier, the ordinary starch hydrolysis (e.g., corn starch) by an enzyme (i.e., cyclodextrin glycosyl transferase, CGTase) allows the production of the native CDs [13]. To reduce the separation and the purification costs, selective α-, β- and γ-CGTases have

Superstructures with cyclodextrins: Chemistry and applications

• Helmut Ritter

Beilstein J. Org. Chem. 2012, 8, 1303–1304, doi:10.3762/bjoc.8.148

• ), 7 (β) and 8 (γ) 1,4-glycosidically linked α-D-glucose units. Production of these compounds is accomplished by enzymatic degradation of starch using CD-glycosyl transferase. Since their discovery more than 100 years ago, a significant development in CD research has taken place. Right after their

Kinetic studies and predictions on the hydrolysis and aminolysis of esters of 2-S-phosphorylacetates

• Milena Trmčić and
• David R. W. Hodgson

Beilstein J. Org. Chem. 2010, 6, 732–741, doi:10.3762/bjoc.6.87

• use of bromoacetate-based cross-linking agents with thiophosphate nucleophiles 3, where our aim was to generate nucleoside-pyrophosphate mimics as potential glycosyl transferase inhibitors under aqueous conditions. Initially, we focus on the use of the bromoacetic acid esters of N-hydroxybenzotriazole