Synthesis and optical resolution of 4,5-diaminohomoadamantane: a promising scaffold for chiral ligands and bioactive compounds

• Polina A. Man’kova,
• Vadim A. Shiryaev,
• Olga S. Podlipnova,
• Marat M. Khisyamov,
• Dmitry S. Nikerov,
• Alexander N. Reznikov and
• Yuri N. Klimochkin

Beilstein J. Org. Chem. 2026, 22, 1013–1022, doi:10.3762/bjoc.22.80

• -diaminohomoadamantane were obtained. Catalytic systems based on them have been studied in the asymmetric Michael and Henry reactions. Low enantioselectivity (up to 60% ee) was observed, but an enantiodivergent effect was noted in the Henry reaction. Examples of bioactive homoadamantanes. Examples of cage vicinal

Photoinduced homolytic C–H activation in N-(4-homoadamantyl)phthalimide

• Nikola Cindro,
• Margareta Horvat,
• Kata Mlinarić-Majerski,
• Axel G. Griesbeck and
• Nikola Basarić

Beilstein J. Org. Chem. 2011, 7, 270–277, doi:10.3762/bjoc.7.36

• for the abstraction. Keywords: homoadamantanes; photoinduced H-abstraction; phthalimides; Introduction Since the pioneering work of Ciamican and Paterno [1][2], the photochemistry of ketones has been intensively studied [3][4][5][6]. One important chemical pathway for the deactivation of ketones