Natural resorcylic lactones derived from alternariol

• Joachim Podlech

Beilstein J. Org. Chem. 2024, 20, 2171–2207, doi:10.3762/bjoc.20.187

• and 25 mM, respectively, and showed some larvicidal activity against Aedes aegypti. The 2-chlorinated dimethylated alternariol derivative, graphislactone G (28), was (similar as graphislactone H) not isolated from the lichen genus Graphis but was obtained from the fungus Cephalosporium acremonium [168

• with IC50 values of 25.5 and 37.3 μM, respectively [171], and exhibited significant larvicidal activity against Aedes aegypti (LC50: 7.2 μg/mL) [172]. Pestauvicolactone A (30) bearing an amino group in position C-4 of dimethylated alternariol was isolated from Pestalotiopsis uvicola [174]. It was

Fabclavine diversity in Xenorhabdus bacteria

• Sebastian L. Wenski,
• Harun Cimen,
• Natalie Berghaus,
• Sebastian W. Fuchs,
• Selcuk Hazir and
• Helge B. Bode

Beilstein J. Org. Chem. 2020, 16, 956–965, doi:10.3762/bjoc.16.84

• studies that revealed Xenorhabdus and Photorhabdus strains having ascaricidal or larvicidal activity. Here, especially X. szentirmaii-, X. indica-, X. stockiae-, as well as X. stockiae-related isolates showed the best activity [18][19][47]. Although these strains were confirmed as fabclavine producers in

Zanthoxoaporphines A–C: Three new larvicidal dibenzo[de,g]quinolin-7-one alkaloids from Zanthoxylum paracanthum (Rutaceae)

• Fidelis N. Samita,
• Louis P. Sandjo,
• Isaiah O. Ndiege,
• Ahmed Hassanali and
• Wilber Lwande

Beilstein J. Org. Chem. 2013, 9, 447–452, doi:10.3762/bjoc.9.47

• activity of some of the isolated compounds was investigated by using third-instar Anopheles gambiae larvae. Keywords: alkaloids; larvicidal activity; Zanthoxylum paracanthum; Introduction Zanthoxylum paracanthum is a tree belonging to the Rutaceae family. The mature tree is at least 10 m tall. It has

• often harmful to nontarget organisms, including human beings, and have negative environmental impacts. We herein report the bioassay-guided isolation of four compounds including three new ones and the larvicidal activity of two of them. Results and Discussion Stem bark of Z. paracanthum was successively

• extracted with hexane, methylene chloride, ethyl acetate and methanol, respectively, yielding four extracts A–D. Extract B showed significant larvicidal activity (Table 1), whereas the others did not exhibit reasonable activity against third-instar Anopheles gambiae larvae. Extract B was therefore subjected

A short stereoselective synthesis of (+)-(6R,2′S)-cryptocaryalactone via ring- closing metathesis

• Palakodety Radha Krishna,
• Krishnarao Lopinti and
• K. L. N. Reddy

Beilstein J. Org. Chem. 2009, 5, No. 14, doi:10.3762/bjoc.5.14

• the sub-classes of these 5,6-dihydro-2H-pyran-2-one compounds is the styryl lactones which possess a styryl moiety side chain. The styryl moiety of goniothalamin has been shown to be of importance for its cytotoxic effect on different cancer cells as well as its antimicrobial, larvicidal activity and