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Search for "modified amino acids" in Full Text gives 5 result(s) in Beilstein Journal of Organic Chemistry.

A versatile route towards 6-arylpipecolic acids

  • Erich Gebel,
  • Cornelia Göcke,
  • Carolin Gruner and
  • Norbert Sewald

Beilstein J. Org. Chem. 2025, 21, 1104–1115, doi:10.3762/bjoc.21.88

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  • accordance with coupling constants and resulting dihedral angles. Keywords: conformational restraints; dihedral angle NMR; half-chair conformation; modified amino acids; pipecolic acid; stereoselective hydrogenation; Suzuki–Miyaura cross-coupling; Introduction Non-proteinogenic amino acids play an
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Published 04 Jun 2025

Methyltransferases from RiPP pathways: shaping the landscape of natural product chemistry

  • Maria-Paula Schröder,
  • Isabel P.-M. Pfeiffer and
  • Silja Mordhorst

Beilstein J. Org. Chem. 2024, 20, 1652–1670, doi:10.3762/bjoc.20.147

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  • analogues [48][49][50][51][52]. The PURE system is a well-established method for rapidly expressing functional proteins. However, synthesising peptides with unnatural amino acids remains a labour-intensive process. tRNAs charged with unnatural or modified amino acids cannot be easily replenished within the
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Published 18 Jul 2024

Position-dependent impact of hexafluoroleucine and trifluoroisoleucine on protease digestion

  • Susanne Huhmann,
  • Anne-Katrin Stegemann,
  • Kristin Folmert,
  • Damian Klemczak,
  • Johann Moschner,
  • Michelle Kube and
  • Beate Koksch

Beilstein J. Org. Chem. 2017, 13, 2869–2882, doi:10.3762/bjoc.13.279

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  • , backbone-extended or chemically modified amino acids [1]. In this regard, the incorporation of fluorine into amino acids has become a promising strategy. Fluorine’s unique properties, namely low polarizability, a strong inductive effect, and high electronegativity, as well as its small size, result in
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Published 22 Dec 2017

Physalin H from Solanum nigrum as an Hh signaling inhibitor blocks GLI1–DNA-complex formation

  • Midori A. Arai,
  • Kyoko Uchida,
  • Samir K. Sadhu,
  • Firoj Ahmed and
  • Masami Ishibashi

Beilstein J. Org. Chem. 2014, 10, 134–140, doi:10.3762/bjoc.10.10

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  • assay (EMSA) for the detection of the GLI1–DNA complex. The assay uses a slightly modified biotin-tagged DNA and modified amino acids sequences of GLI1 compared to those reported in literature [30][31][32]. In a similar manner as described in [22], GLI1 protein was expressed in Escherichia coli as a 171
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Published 13 Jan 2014

A one-pot synthesis of 3-trifluoromethyl-2-isoxazolines from trifluoromethyl aldoxime

  • Raoni S. B. Gonçalves,
  • Michael Dos Santos,
  • Guillaume Bernadat,
  • Danièle Bonnet-Delpon and
  • Benoit Crousse

Beilstein J. Org. Chem. 2013, 9, 2387–2394, doi:10.3762/bjoc.9.275

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  • causes remarkable changes of their physicochemical properties, which allows the development of substances with improved pharmacological characteristics. Some examples are the synthesis of modified amino acids and peptides, carbohydrates, natural products and the development of more selective enzyme
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Published 07 Nov 2013
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