Synthesis of medium and large phostams, phostones, and phostines

• Jiaxi Xu

Beilstein J. Org. Chem. 2023, 19, 687–699, doi:10.3762/bjoc.19.50

• of two ring bonds. This review includes the recent syntheses of seven to fourteen-membered phostam, phostone, and phostine derivatives. Keywords: azaphosphaheterocycle; oxaphosphaheterocycle; phostam; phostine; phostone; Introduction Phostams, phostones, and phostines are a class of important

• prepared, while numerous five-membered γ-phostams [11][12], γ-phostones and γ-phostines [13], and six-membered δ-phostams [14][15][16], δ-phostones [17][18] and δ-phostines [17][19][20] have been synthesized via various synthetic strategies. In comparison with common ring size phostam, phostone, and

• phostine derivatives, less attention has been paid to the synthesis of medium and large phostam, phostone, and phostine derivatives. They are also biologically active compounds, such as inhibitors of the human farnesyl pyrophosphate synthase [21][22], antitumor agents [23], and hapten for the production of

Synthetic strategies for the preparation of γ-phostams: 1,2-azaphospholidine 2-oxides and 1,2-azaphospholine 2-oxides

• Jiaxi Xu

Beilstein J. Org. Chem. 2022, 18, 889–915, doi:10.3762/bjoc.18.90

• synthesis of 1,2-azaphospholidine and 1,2-azaphospholine 2-oxides/sulfides and their fused derivatives. Keywords: azaphospholidine; azaphospholine; phosphonolactam; γ-phosphonolactam; phosphinolactam; γ-phosphinolactam; γ-phostam; Introduction Phosphaheterocycles are a class of important organic compounds