Recent advances in oxidative radical difunctionalization of N-arylacrylamides enabled by carbon radical reagents

• Jiangfei Chen,
• Yi-Lin Qu,
• Ming Yuan,
• Xiang-Mei Wu,
• Heng-Pei Jiang,
• Ying Fu and
• Shengrong Guo

Beilstein J. Org. Chem. 2025, 21, 1207–1271, doi:10.3762/bjoc.21.98

• quinolinone products. Beyond electrochemical protocols, photochemical activation – particularly visible-light photoredox catalysis – has become a powerful and sustainable strategy for generating carbon radicals under mild conditions. In 2023, Fan’s group discovered a radical cyclization of N-arylacrylamides

Advancements in hydrochlorination of alkenes

• Daniel S. Müller

Beilstein J. Org. Chem. 2024, 20, 787–814, doi:10.3762/bjoc.20.72

• addition. Therefore, anti-Markovnikov products are generally not observed. b) In contrast to the reactions with HBr (peroxide effect) [31][32], the formation of anti-Markovnikov products is low even in the presence of peroxides or photochemical activation. For instance, Whitmore and co-workers observed

Controlled decomposition of SF₆ by electrochemical reduction

• Sébastien Bouvet,
• Bruce Pégot,
• Stéphane Sengmany,
• Erwan Le Gall,
• Eric Léonel,
• Anne-Marie Goncalves and
• Emmanuel Magnier

Beilstein J. Org. Chem. 2020, 16, 2948–2953, doi:10.3762/bjoc.16.244

• degradation of SF6 [17][18]. Other elegant approaches have described the use of SF6 as precursor of reagent for fluorination or pentafluorosulfanylation. Very interestingly, the photochemical activation of this gas was described and allowed the in situ transformation of alcohols into alkyl fluorides [19][20

Dawn of a new era in industrial photochemistry: the scale-up of micro- and mesostructured photoreactors

• Emine Kayahan,
• Mathias Jacobs,
• Leen Braeken,
• Leen C.J. Thomassen,
• Simon Kuhn,
• Tom van Gerven and
• M. Enis Leblebici

Beilstein J. Org. Chem. 2020, 16, 2484–2504, doi:10.3762/bjoc.16.202

• Leuven, Leuven, Belgium 10.3762/bjoc.16.202 Abstract Photochemical activation routes are gaining the attention of the scientific community since they can offer an alternative to the traditional chemical industry that mainly utilizes thermochemical activation of molecules. Photoreactions are fast and

CF₃SO₂X (X = Na, Cl) as reagents for trifluoromethylation, trifluoromethylsulfenyl-, -sulfinyl- and -sulfonylation. Part 1: Use of CF₃SO₂Na

• Hélène Guyon,
• Hélène Chachignon and
• Dominique Cahard

Beilstein J. Org. Chem. 2017, 13, 2764–2799, doi:10.3762/bjoc.13.272

• reactions with K2S2O8, I2O5 or a hypervalent iodine reagent, and (iii) photochemical activation. Most of the works concerned cascade intramolecular reactions in which a C–C bond is formed after the initial trifluoromethylation. Therefore, Lipshutz and co-workers reported a copper-catalysed intramolecular

Diastereoselective anodic hetero- and homo-coupling of menthol-, 8-methylmenthol- and 8-phenylmenthol-2-alkylmalonates

• Matthias C. Letzel,
• Hans J. Schäfer and
• Roland Fröhlich

Beilstein J. Org. Chem. 2017, 13, 33–42, doi:10.3762/bjoc.13.5

• intermolecular diastereoselective radical coupling reactions [10][11][12][13][14][15][16]. There are some examples of high diastereoselectivity in the coupling of radicals generated from azo compounds [10][11], in intramolecular coupling of radicals, that are obtained by photochemical activation [12][13][14

On the mechanism of imine elimination from Fischer tungsten carbene complexes

• Philipp Veit,
• Christoph Förster and
• Katja Heinze

Beilstein J. Org. Chem. 2016, 12, 1322–1333, doi:10.3762/bjoc.12.125

• ( = 2018 cm−1) and trans ( = 1938, 1889 cm−1) configuration [89][90] as well as imine E-3 ( = 1614 cm−1). Hence, the initial thermally induced dissociation of a CO ligand is more favourable than carbene dissociation in agreement with the DFT calculations (vide supra). Similarly, photochemical activation

[3 + 2]-Cycloadditions of nitrile ylides after photoactivation of vinyl azides under flow conditions

• Stephan Cludius-Brandt,
• Lukas Kupracz and
• Andreas Kirschning

Beilstein J. Org. Chem. 2013, 9, 1745–1750, doi:10.3762/bjoc.9.201

• photochemical process can efficiently be achieved. These facts led us to initiate an investigation on the photochemical activation of vinyl azides and the trapping of the intermediate nitrile ylides 3 [19] by different dipolarophiles exploiting the advantages of photo flow-chemistry [20][21]. Here, we report on

Organotellurium-mediated living radical polymerization under photoirradiation by a low-intensity light-emitting diode

• Yasuyuki Nakamura and
• Shigeru Yamago

Beilstein J. Org. Chem. 2013, 9, 1607–1612, doi:10.3762/bjoc.9.183

• conditions [8][9][10][11]. In addition, photochemical activation is beneficial for increasing the fidelity of the polymer-end structure [12]. However, the experimental setup required for the reaction provides problems, as distinctive light sources such as γ-rays or high-intensity UV irradiation are required

Spectroscopic characterization of photoaccumulated radical anions: a litmus test to evaluate the efficiency of photoinduced electron transfer (PET) processes

• Maurizio Fagnoni,
• Stefano Protti,
• Davide Ravelli and
• Angelo Albini

Beilstein J. Org. Chem. 2013, 9, 800–808, doi:10.3762/bjoc.9.91

• intermediates. Keywords: aromatic nitriles; persistent radical anion; photochemical activation; photoinduced electron transfer (PET); photooxidant; reactive intermediates; Introduction Redox reactions between organic molecules have a limited scope because of the rarely matched redox potential. On the other