Beilstein J. Org. Chem.2025,21, 490–499, doi:10.3762/bjoc.21.36
designing a photoswitchabledrug is to place the switch at a position in the pharmacophore that allows switching of the biological effect by irradiation with light without greatly reducing the overall activity by unselective interference with the inhibitor–receptor interaction. This is a difficult task
PDF
Graphical Abstract
Figure 1:
a) Structural similarity of N-acetyl diazocine 1 with known 17βHSD3-inhibitor tetrahydrodibenzazoci...
Beilstein J. Org. Chem.2019,15, 2812–2821, doi:10.3762/bjoc.15.274
.
Keywords: acetylcholine receptors; bidirectional; photoswitchabledrug; tetrafluoroazobenzene; visible light; Introduction
Starting in 1937, azobenzenes (ABs) have attracted much attention because they undergo a photoreversible chemical transformation of the thermodynamically favored trans configuration
decay is slow at 37 °C, frozen [14] such solutions could be used for many days without any change in pharmacological efficacy.
Our final set of biological experiments with photochrome 2 examined its ability to work as a dynamic, bidirectional photoswitchabledrug for nicotinic acetylcholine receptors
PDF
Graphical Abstract
Figure 1:
Fluoro-AB derivatives and spectra. Structures of 4FAB-diamides [13] cis and trans configurations, and t...