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Search for "photoswitchable drug" in Full Text gives 2 result(s) in Beilstein Journal of Organic Chemistry.

Synthesis of N-acetyl diazocine derivatives via cross-coupling reaction

  • Thomas Brandt,
  • Pascal Lentes,
  • Jeremy Rudtke,
  • Michael Hösgen,
  • Christian Näther and
  • Rainer Herges

Beilstein J. Org. Chem. 2025, 21, 490–499, doi:10.3762/bjoc.21.36

Graphical Abstract
  • designing a photoswitchable drug is to place the switch at a position in the pharmacophore that allows switching of the biological effect by irradiation with light without greatly reducing the overall activity by unselective interference with the inhibitor–receptor interaction. This is a difficult task
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Published 04 Mar 2025

Chemical tuning of photoswitchable azobenzenes: a photopharmacological case study using nicotinic transmission

  • Lorenzo Sansalone,
  • Jun Zhao,
  • Matthew T. Richers and
  • Graham C. R. Ellis-Davies

Beilstein J. Org. Chem. 2019, 15, 2812–2821, doi:10.3762/bjoc.15.274

Graphical Abstract
  • . Keywords: acetylcholine receptors; bidirectional; photoswitchable drug; tetrafluoroazobenzene; visible light; Introduction Starting in 1937, azobenzenes (ABs) have attracted much attention because they undergo a photoreversible chemical transformation of the thermodynamically favored trans configuration
  • decay is slow at 37 °C, frozen [14] such solutions could be used for many days without any change in pharmacological efficacy. Our final set of biological experiments with photochrome 2 examined its ability to work as a dynamic, bidirectional photoswitchable drug for nicotinic acetylcholine receptors
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Published 21 Nov 2019
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