Reaction of oxiranes with cyclodextrins under high-energy ball-milling conditions

• László Jicsinszky,
• Federica Calsolaro,
• Katia Martina,
• Fabio Bucciol,
• Maela Manzoli and
• Giancarlo Cravotto

Beilstein J. Org. Chem. 2019, 15, 1448–1459, doi:10.3762/bjoc.15.145

• have different complexation properties to those of their classically prepared analogues. Keywords: crosslinked cyclodextrin polymers; (2-hydroxy)propylcyclodextrin; mechanochemistry; nucleophile reaction; planetary ball mill; solventless synthesis; Introduction The derivatisation of natural

One-pot multistep mechanochemical synthesis of fluorinated pyrazolones

• Joseph L. Howard,
• William Nicholson,
• Yerbol Sagatov and
• Duncan L. Browne

Beilstein J. Org. Chem. 2017, 13, 1950–1956, doi:10.3762/bjoc.13.189

• small range of compounds. Conclusion In summary, we have developed a one-pot, two-step mechanochemical synthesis of fluorinated pyrazolones. The experiments provide a logical approach to multistep solventless synthesis under milling conditions and more broadly will assist in the conversion of other