Beilstein J. Org. Chem.2025,21, 1170–1170, doi:10.3762/bjoc.21.93
reaction; tetrahydrochromenones; Lakshminarayana Satham is acknowledged as additional co-author of our original publication. It was subsequently determined that Lakshminarayana Satham made significant contributions to the published research.
The Funding section is updated as follows:
DN thanks UGC India
Beilstein J. Org. Chem.2024,20, 2016–2023, doi:10.3762/bjoc.20.177
in most cases. A triple Michael adduct, tetrahydrochromen-4-one, is also formed as a side product in a few cases with excellent diastereoselectivity.
Keywords: arylidenemalonates; curcumins; cyclohexanones; diastereoselective synthesis; Michael reaction; tetrahydrochromenones; Introduction
There is
base (KOH) and a phase-transfer catalyst (PTC) in a biphasic medium (toluene–H2O) at room temperature, leading to highly functionalized cyclohexanones and tetrahydrochromenones as major and minor products, respectively, in moderate to high yield and excellent diastereoselectivity.
Results and
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Graphical Abstract
Figure 1:
Biologically active derivatives of cyclohexanones.