This special issue is dedicated to the memory of Prof. Carsten Schmuck, who passed away in 2019. Based on his long-term research interests in supramolecular chemistry and intermolecular interactions, the memorial issue will be focused on the topic of “molecular recognition”. This includes molecular recognition between synthetic molecules, molecular recognition of synthetic molecules by biological targets or even recognition processes between biological entities. From an application point of view, the issue will feature a broad spectrum of topics, including (but not limited to) topics like physical organic chemistry, self-assembly, host-guest chemistry, chemosensing, systems chemistry, supramolecular materials or biosupramolecular chemistry.