Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

Dual-functionalized architecture enables stable and tumor cell-specific SiO₂NPs in complex biological fluids

• Iris Renata Sousa Ribeiro,
• Raquel Frenedoso da Silva,
• Romênia Ramos Domingues,
• Adriana Franco Paes Leme and
• Mateus Borba Cardoso

Beilstein J. Nanotechnol. 2024, 15, 1238–1252, doi:10.3762/bjnano.15.100

AI-assisted models to predict chemotherapy drugs modified with C₆₀ fullerene derivatives

• Jonathan-Siu-Loong Robles-Hernández,
• Dora Iliana Medina,
• Katerin Aguirre-Hurtado,
• Marlene Bosquez,
• Roberto Salcedo and
• Alan Miralrio

Beilstein J. Nanotechnol. 2024, 15, 1170–1188, doi:10.3762/bjnano.15.95

• women globally, and about 685,000 died from this disease [8]. A recurrent problem with standard treatments are the side effects. Regarding the use of chemotherapeutic drugs, such issues are nephrotoxicity of cisplatin, cardiotoxicity of doxorubicin, and pulmonary fibrosis from the use of bleomycin [9

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

• Qixiong Lin,
• Yueyou Peng,
• Yanyan Wen,
• Xiaoqiong Li,
• Donglian Du,
• Weibin Dai,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24

• limited their clinical application [89][90]. To overcome these obstacles, cisplatin-loaded NPs encapsulated by 4T1 cell membranes were designed for breast cancer treatment and effectively increased the targeted accumulation in the tumor site. The immune evasion of cancer cell membranes prolong the time

• that drugs spend in the blood circulation [74]. The half-life of biomimetic NPs in mice was 18.4 h, which was significantly higher than that of bare NPs (6.6 h) and free cisplatin (3.7 h). Moreover, the retention of biomimetic NPs in the liver and spleen was notably lower than that of bare NPs [74

Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

• the Ras-Raf-Erk pathway, promoting angiogenesis via hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF) signaling [29][30][31]. According to preclinical data, a combination therapy consisting of erlotinib and cisplatin targets angiogenesis and manifests synergistic and

Cyclodextrins as eminent constituents in nanoarchitectonics for drug delivery systems

• Makoto Komiyama

Beilstein J. Nanotechnol. 2023, 14, 218–232, doi:10.3762/bjnano.14.21

• endogenous H2O2 by Fenton-type reactions without photoirradiation [83][84]. A nanomedicine was prepared from (i) β-CyD bearing both a ferrocene and a platinum(IV) complex (–O–PtIV(Cl2)2(NH3)2(OH)) as prodrug of cisplatin and (ii) poly(ethylene glycol) terminated by ferrocene [85]. The ferrocene molecules

• dissociated. The PtIV prodrug is converted to chemotherapeutic cisplatin. Cisplatin activates two enzymes (nicotinamide adenine dinucleotide phosphate oxidase and superoxide dismutase), which generate H2O2 from O2 in tumor tissue. Thus, this system is effective through a self-augmented cascade. 5 CyD-based

• poly(ethylene glycol) with α-CyDs, in which adjacent α-CyDs interact to provide physical crosslinkings. Cisplatin (purple circle) was loaded in the hydrogel. Under NIR-II laser irradiation, the localized photothermal effect directly ablates thermosensitive cancer cells. At the same time, the

Recent advances in green carbon dots (2015–2022): synthesis, metal ion sensing, and biological applications

• Aisha Kanwal,
• Naheed Bibi,
• Sajjad Hyder,
• Arif Muhammad,
• Hao Ren,
• Jiangtao Liu and
• Zhongli Lei

Beilstein J. Nanotechnol. 2022, 13, 1068–1107, doi:10.3762/bjnano.13.93

Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration

• Se-Kwon Kim,
• Sesha Subramanian Murugan,
• Pandurang Appana Dalavi,
• Sebanti Gupta,
• Sukumaran Anil,
• Gi Hun Seong and
• Jayachandran Venkatesan

Beilstein J. Nanotechnol. 2022, 13, 1051–1067, doi:10.3762/bjnano.13.92

• wettability of the chitosan/reduced graphene oxide composites with specific acetic acid and lactic acid shows water contact angles of (75.40° ± 4.32°) and (36.71° ± 4.53°) [60]. The anticancer agent cisplatin was loaded into graphene oxide/hydroxyapatite/chitosan composites to enable proliferation of

• osteoblasts and inhibition of the development of osteosarcoma cancer cells in the work by Sumathra et al. (2018). The in vitro experiment was carried out by using the osteosarcoma MG-63 cell line. The MTT assay for the composites showed cell expansion and growth. The anticancer activity of cisplatin-loaded

Irradiation-driven molecular dynamics simulation of the FEBID process for Pt(PF₃)₄

• Alexey Prosvetov,
• Alexey V. Verkhovtsev,
• Gennady Sushko and
• Andrey V. Solov’yov

Beilstein J. Nanotechnol. 2021, 12, 1151–1172, doi:10.3762/bjnano.12.86

• cisplatin (Pt(NH3)2Cl2) [51] by scaling the total number of electrons in the ligands. The accuracy of the cross section evaluation does not affect the results of FEBID simulations as a slight variation of the cross section (e.g., determined by means of more accurate theoretical or computational approaches

Self-assembly of amino acids toward functional biomaterials

• Huan Ren,
• Lifang Wu,
• Lina Tan,
• Yanni Bao,
• Yuchen Ma,
• Yong Jin and
• Qianli Zou

Beilstein J. Nanotechnol. 2021, 12, 1140–1150, doi:10.3762/bjnano.12.85

• linked by ester bonds, which help to maintain the camptothecin ring stability. The assembly can effectively enhance blood circulation, tumor accumulation and cellular uptake. In addition, arginine-modified camptothecin can be combined with anionic cisplatin–polyglutamic acid through electrostatic

Use of nanosystems to improve the anticancer effects of curcumin

• Andrea M. Araya-Sibaja,
• Norma J. Salazar-López,
• Krissia Wilhelm Romero,
• José R. Vega-Baudrit,
• J. Abraham Domínguez-Avila,
• Carlos A. Velázquez Contreras,
• Ramón E. Robles-Zepeda,
• Mirtha Navarro-Hoyos and
• Gustavo A. González-Aguilar

Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78

• %) [2]. The most commonly used treatments involve chemotherapy, surgery, or a combination of both. Chemotherapy is based on the use of molecules such as doxorubicin, paclitaxel, cisplatin, and some proteins and peptides that induce cell death [3]. Conventional or low molecular weight chemotherapeutics

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

• Nikola Geskovski,
• Nadica Matevska-Geshkovska,
• Simona Dimchevska Sazdovska,
• Marija Glavas Dodov,
• Kristina Mladenovska and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

• Maria Suciu,
• Corina M. Ionescu,
• Alexandra Ciorita,
• Septimiu C. Tripon,
• Dragos Nica,
• Hani Al-Salami and
• Lucian Barbu-Tudoran

Beilstein J. Nanotechnol. 2020, 11, 1092–1109, doi:10.3762/bjnano.11.94

• endosomal escape [113][114]. For the specific treatment of cisplatin-resistant nasopharyngeal carcinoma, Weng et al. [115] produced SPIONs covered with cisplatin and with TAT peptide (a HIV-derived cell penetrating peptide). Their nanoparticles had an increased endocytosis rate, which, combined with the

• Fenton reaction of the iron oxide core taking place in the lysosome and the cell cytoplasm, increased the cancer cell response to cisplatin and reversed the resistance of the cells to the drug [115]. The retention time of nanoparticles in tissues and the clearance from blood and/or specific organs is

• inefficient methodology of use, and inconsistent results [94]. The potential toxicity could be put to a good use, though. Hybrid Fe3O4/Gd2O3 loaded with cisplatin and tagged with lactoferrin and RGD (a cell endocytosis small peptide) was proved in vitro and in vivo to cross the blood–brain barrier and target

Bombesin receptor-targeted liposomes for enhanced delivery to lung cancer cells

• Mohammad J. Akbar,
• Pâmela C. Lukasewicz Ferreira,
• Melania Giorgetti,
• Leanne Stokes and
• Christopher J. Morris

Beilstein J. Nanotechnol. 2019, 10, 2553–2562, doi:10.3762/bjnano.10.246

• ]. In the lung cancer field, cisplatin formulated as a pegylated liposomal formulation (Lipoplatin®) has delivered comparable antitumour response against non-small cell lung cancer tumours with reduced side effects when delivered in combination with paclitaxel compared to when cisplatin and paclitaxel

Targeted therapeutic effect against the breast cancer cell line MCF-7 with a CuFe₂O₄/silica/cisplatin nanocomposite formulation

• B. Rabindran Jermy,
• Vijaya Ravinayagam,
• Widyan A. Alamoudi,
• Dana Almohazey,
• Hatim Dafalla,
• Lina Hussain Allehaibi,
• Abdulhadi Baykal,
• Muhammet S. Toprak and
• Thirunavukkarasu Somanathan

Beilstein J. Nanotechnol. 2019, 10, 2217–2228, doi:10.3762/bjnano.10.214

• theranostic applications. In this study, 30 wt % CuFe2O4 was impregnated into a matrix of monodispersed spherical hydrophilic silica (HYPS) nanoparticles through a simple dry impregnation technique. The chemotherapy drug cisplatin was loaded through electrostatic equilibrium adsorption over 24 h in normal

• and pore volume of 0.35 cm3/g. The cisplatin/CuFe2O4/HYPS nanoformulation showed the accumulation of copper ferrite nanoparticles on the surface and in the pores of HYPS with a surface area of 45 m2/g, pore size of 16 nm and pore volume of 0.18 cm3/g. Transmission electron microscopy (TEM) and energy

• –vis analysis revealed the functionalization of cisplatin in tetrahedral and octahedral coordination in the CuFe2O4/HYPS composite. Compared to other supports such as mesocellular foam and silicalite, the release of cisplatin using the dialysis membrane technique was found to be superior when CuFe2O4

Polydopamine-coated Au nanorods for targeted fluorescent cell imaging and photothermal therapy

• Boris N. Khlebtsov,
• Andrey M. Burov,
• Timofey E. Pylaev and
• Nikolai G. Khlebtsov

Beilstein J. Nanotechnol. 2019, 10, 794–803, doi:10.3762/bjnano.10.79

• -targeted PPT and chemotherapy (via Cu(II) release) [34]; AuNR-PDA-pMBA-Ab for targeted SERS cell imaging [31]; AuNR-PDA-MB/DOX for notargeted combined photodynamic and chemotherapy in vivo [32]; AuNR-PDA-Cisplatin-Iodine125-RGDpeptide for targeted MRI imaging and chemotherapy in vivo [33]. However, AuNR

Biocompatible organic–inorganic hybrid materials based on nucleobases and titanium developed by molecular layer deposition

• Leva Momtazi,
• Henrik H. Sønsteby and
• Ola Nilsen

Beilstein J. Nanotechnol. 2019, 10, 399–411, doi:10.3762/bjnano.10.39

• and therapy, and probes for biosensing [1]. Nucleobases are constituents of DNA and RNA and can interact with different metals to form several molecular assemblies [2][3]. In the 1960s, a powerful antitumor agent named cisplatin (cis-[Pt(NH3)2Cl2]) was discovered by Rosenberg [4]. Later it was

Targeting strategies for improving the efficacy of nanomedicine in oncology

• Gonzalo Villaverde and
• Alejandro Baeza

Beilstein J. Nanotechnol. 2019, 10, 168–181, doi:10.3762/bjnano.10.16

• loaded with a platinum(IV) pro-drug that released active cisplatin(II) in the reductive environment of the intracellular space. Another targeting moiety that has been employed for delivering therapeutics to mitochondria is triphenylphosphine [44]. This positively charged group also binds to the

• inducing cell apoptosis, such as gamitrinibs and cisplatin [84]. One of the best ways to bring molecules or nanocarriers to mitochondria is by using positively charged groups. These motives are able to escape from the early endosome and reach to the mitochondria [85][86]. One of the most commonly used

Electron interaction with copper(II) carboxylate compounds

• Michal Lacko,
• Peter Papp,
• Iwona B. Szymańska,
• Edward Szłyk and
• Štefan Matejčík

Beilstein J. Nanotechnol. 2018, 9, 384–398, doi:10.3762/bjnano.9.38

• experiments using cisplatin [Pt(NH3)2Cl2] as precursor [31]. These latter experiments were motivated by gas phase DEA studies on this compound showing also that it can be evaporated intact [32]. Electron impact MS spectra analysis of [Cu(O2CR)2] (R = CnH2n−1, n = 1–3; CF3, CHF2, C6H5, p-F-C6H4, p-Cl-C6H4, o

A nanocomplex of C₆₀ fullerene with cisplatin: design, characterization and toxicity

• Svitlana Prylutska,
• Svitlana Politenkova,
• Kateryna Afanasieva,
• Volodymyr Korolovych,
• Kateryna Bogutska,
• Andriy Sivolob,
• Larysa Skivka,
• Maxim Evstigneev,
• Viktor Kostjukov,
• Yuriy Prylutskyy and
• Uwe Ritter

Beilstein J. Nanotechnol. 2017, 8, 1494–1501, doi:10.3762/bjnano.8.149

• ., 25, 98693 Ilmenau, Germany 10.3762/bjnano.8.149 Abstract The self-organization of C60 fullerene and cisplatin in aqueous solution was investigated using the computer simulation, dynamic light scattering and atomic force microscopy techniques. The results evidence the complexation between the two

• lymphocytes and reduces the fraction of necrotic cells. Keywords: atomic force microscopy; C60 fullerene; cisplatin; comet assay; computer simulation; dynamic light scattering; flow cytometry; human lymphocytes; toxicity in vitro; Introduction The water-soluble inorganic bi-valent platinum derivative

• , cisplatin (cis-[Pt(II)(NH3)2Cl2], Cis), is currently one of the most effective therapeutic agents used against cancer deceases, in particular, ovarian cancer, bladder cancer, esophagus cancer, lung cancer, and cancer of head and neck [1]. As an antitumor metal-containing agent Cis exerts an alkylating

Carbon nanomaterials sensitize prostate cancer cells to docetaxel and mitomycin C via induction of apoptosis and inhibition of proliferation

• Kati Erdmann,
• Jessica Ringel,
• Silke Hampel,
• Manfred P. Wirth and
• Susanne Fuessel

Beilstein J. Nanotechnol. 2017, 8, 1307–1317, doi:10.3762/bjnano.8.132

• chemotherapeutics and cytotoxic agents by chemosensitizing cancer cells [16][23][24][25][26]. In our previous studies, CNTs and CNFs sensitized prostate and bladder cancer cells to the platinum-based chemotherapeutics carboplatin (CP) and cisplatin (CDDP) via an enhanced inhibition of short- and long-term

Release behaviour and toxicity evaluation of levodopa from carboxylated single-walled carbon nanotubes

• Julia M. Tan,
• Jhi Biau Foo,
• Sharida Fakurazi and
• Mohd Zobir Hussein

Beilstein J. Nanotechnol. 2015, 6, 243–253, doi:10.3762/bjnano.6.23

• impurities (Figure 4A) and after loading with LD (Figure 4B), several black spots were detected, indicating the possible locations of LD attached to the outer surface of SWCNT–COOH. A similar observation was also reported by Bhirde and coworkers using scanning TEM to detect the attachment of cisplatin

Synthesis of boron nitride nanotubes and their applications

• Saban Kalay,
• Zehra Yilmaz,
• Ozlem Sen,
• Melis Emanet,
• Emine Kazanc and
• Mustafa Çulha

Beilstein J. Nanotechnol. 2015, 6, 84–102, doi:10.3762/bjnano.6.9

• study revealed that platinum-based anticancer drugs preferentially interacted with Al-doped BNNTs as compared to pristine, zigzag and armchair BNNTs [88]. Cisplatin (cis-Pt) and nedaplatin (neda-Pt) molecules were used as platinum-based anticancer drugs. An aluminum (Al) atom is substituted for a boron

Anticancer efficacy of a supramolecular complex of a 2-diethylaminoethyl–dextran–MMA graft copolymer and paclitaxel used as an artificial enzyme

• Yasuhiko Onishi,
• Yuki Eshita,
• Rui-Cheng Ji,
• Masayasu Onishi,
• Takashi Kobayashi,
• Masaaki Mizuno,
• Jun Yoshida and
• Naoji Kubota

Beilstein J. Nanotechnol. 2014, 5, 2293–2307, doi:10.3762/bjnano.5.238

• ] analyzed expression profiles of 807 genes of non-small cell lung cancer PC-14 cells after treatment with cisplatin (CDDP) incorporated in polymeric micelles (CDDP/m) versus free cisplatin. A total of 50 genes of significant differential expression between cells treated with free CDDP and CDDP/m were