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Search for "dissolution" in Full Text gives 269 result(s) in Beilstein Journal of Nanotechnology. Showing first 200.
Development of a mucoadhesive drug delivery system and its interaction with gastric cells
Beilstein J. Nanotechnol. 2025, 16, 371–384, doi:10.3762/bjnano.16.28
- nanoparticles loaded with FAM-labeled peptide were suspended in different dissolution media (pH 1.2 and pH 6.8) and incubated for 7 days (Figure 3). At specified time intervals, the nanoparticles were centrifuged and resuspended in dissolution medium, and the fluorescence of the resuspended nanoparticles was
- measured. The purpose of the different dissolution media was to investigate possible release differences under different pH conditions. It is known that gastric mucus is acidic (around pH 2) at the luminal site and almost neutral (around 6) at the epithelial surface [9]. Since the drug delivery system is
- ) were resuspended in a freshly prepared dissolution medium (2 mL), that is, either simulated gastric fluid (pH 1.2) or phosphate buffer (pH 6.8), in the absence of enzymes. Alg or EudAlg nanoparticle suspensions were incubated for 7 days with a constant shaking of 50 rpm. At the end of specified time
Enhancing mechanical properties of chitosan/PVA electrospun nanofibers: a comprehensive review
Beilstein J. Nanotechnol. 2025, 16, 286–307, doi:10.3762/bjnano.16.22
- steps but minimizes the risk of incomplete dissolution or phase separation due to different solubility requirements of each polymer [84]. Nevertheless, the instabilities can still occur when blending the two solutions if the solvents are incompatible. Sequential electrospinning Sequential
Radiosensitizing properties of dual-functionalized carbon nanostructures loaded with temozolomide
Beilstein J. Nanotechnol. 2025, 16, 229–251, doi:10.3762/bjnano.16.18
- , one can see a faster release from the hybrid structure, which can be again explained by lower TMZ content in the tubes and higher content of surface-bound TMZ in the hybrid structure and the resulting faster diffusion in the dissolution medium. The higher content of surface-bound TMZ in the non
- blank CNs indicate that the structure of TMZ was preserved during irradiation. Upon its incorporation in the CNs, in vitro dissolution studies, in which UV–vis spectra of TMZ after its release from the irradiated CNs were recorded, were carried out. Raman spectroscopy The Raman spectra of single- and
Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects
Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118
- include their small particle size, high encapsulation efficiency, enhanced stability, and improved dissolution in harsh gastrointestinal (GI) fluids. Following oral administration, PLHNPs demonstrate superior intestinal absorption and bioavailability, attributed to their enhanced stability and dissolution
- water because it is highly lipophilic. After, oral administration, CUR shows very limited dissolution in GI fluids and low absorption from the intestine, which results in low oral bioavailability. CUR metabolizes rapidly in the biological system, which further lowers its bioavailability, and shows a
- exhibits significant anti-inflammatory, antioxidant, antiviral, anticancer, cardioprotective, neuroprotective, and anti-allergic properties [85][86]. QCT belongs to the BCS class-II drugs and shows very poor solubility. The low solubility of quercetin in aqueous environments leads to poor dissolution and
Nanoarchitectonics with cetrimonium bromide on metal nanoparticles for linker-free detection of toxic metal ions and catalytic degradation of 4-nitrophenol
Beilstein J. Nanotechnol. 2024, 15, 1312–1332, doi:10.3762/bjnano.15.106
Interaction of graphene oxide with tannic acid: computational modeling and toxicity mitigation in C. elegans
Beilstein J. Nanotechnol. 2024, 15, 1297–1311, doi:10.3762/bjnano.15.105
- and biological/environmental application. The properties of the materials in biological environments may differ significantly depending on the composition of the medium (e.g., aggregation state, surface charge, and dissolution) and determine their biological effects. Therefore, the initial step to
Electrospun polysuccinimide scaffolds containing different salts as potential wound dressing material
Beilstein J. Nanotechnol. 2024, 15, 781–796, doi:10.3762/bjnano.15.65
- atoms in the scaffolds. Our result showed that the salts influence the mechanical properties of the polymer scaffold, both in terms of specific load capacity and relative elongation values. According to the dissolution experiments, the whole amount of strontium nitrate was dissolved from the scaffold in
- scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), mechanical tests, investigation of salt dissolution from the scaffolds, examination of their antibacterial activity against four different bacterial strains (Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, and
- , and the graph was made using the Origin 2018 program (OriginLab, USA). Dissolution of the salts from the scaffolds To prove the dissolution of inorganic salts from the scaffolds, the conductivity of the dissolution medium was measured. Stock solutions (50 mL, 5% w/v) were prepared from Sr(NO3)2 and Zn
Gold nanomakura: nanoarchitectonics and their photothermal response in association with carrageenan hydrogels
Beilstein J. Nanotechnol. 2024, 15, 678–693, doi:10.3762/bjnano.15.56
- solution was kept under constant stirring at 800 rpm on a hot plate for complete dissolution. After the complete dissolution of k-CG, 7 mL of the stock solution was transferred to a 15 mL glass vial into which 1 mL of purified gold nanoparticles was dispersed. It is to be noted that a fixed number of
Laser synthesis of nanoparticles in organic solvents – products, reactions, and perspectives
Beilstein J. Nanotechnol. 2024, 15, 638–663, doi:10.3762/bjnano.15.54
- treatment found only particles with a size below 50 nm that resisted acid dissolution. They proposed the carbon solubility in the Au nanoparticles to be the reason for the coverage of particles with a size below 50 nm and calculated the carbon solubility as a function of particle radius according to
Radiofrequency enhances drug release from responsive nanoflowers for hepatocellular carcinoma therapy
Beilstein J. Nanotechnol. 2024, 15, 569–579, doi:10.3762/bjnano.15.49
- , China) [32][33]. First, trisodium citrate (0.40 g) was dissolved in pure EG (40 mL) and sonicated at room temperature until complete dissolution was achieved. Then, FeCl3·6H2O (1.35 g) was added with stirring. Next, NaOAc·3H2O (2.0 g) was added at room temperature with stirring for 30 min. The mixed
- = kHt1/2, where Qt is the amount of CUR in NFs released after time t, and kH is the Higuchi dissolution constant. Ritger–Peppas Model: Mt/M∞ = ktn, where Mt/M∞ is the fraction of CUR in NFs released at time t, k is the rate constant, and n is the diffusional release exponent. Cellular uptake of CUR-Fe
Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems
Beilstein J. Nanotechnol. 2024, 15, 465–474, doi:10.3762/bjnano.15.42
- and then to the in vitro Franz diffusion test with reservoir patch formulation as well as in vivo pharmacokinetics study with enteric capsules. We tested these formulations regarding their nanocrystal physical properties, size effect, and dissolution rate, respectively. We found that DCS nanocrystals
- showed good performance in the Franz diffusion test and rodent pharmacokinetic studies due to the nanoparticle size and faster dissolution as compared with the commercial DCS powder. These DCS nanocrystal formulations could offer a new approach for the development of an advanced drug delivery system for
- ]. Nanocrystals can improve many physicochemical properties of drugs such as solubility, size effect, dissolution rate, and adhesiveness to surface membranes [23]. The limitations of conventional medication delivery can be overcome by advanced drug delivery methodologies, such as transdermal drug delivery (TDD
Insect attachment on waxy plant surfaces: the effect of pad contamination by different waxes
Beilstein J. Nanotechnol. 2024, 15, 385–395, doi:10.3762/bjnano.15.35
- of insect adhesive pads by plant wax during the contact (contamination hypothesis), (3) absorption of the insect pad secretion by the wax coverage (fluid absorption hypothesis), (4) hydroplaning induced by dissolution of the wax in the pad fluid (wax dissolution hypothesis), and (5) detached wax
Nanomedicines against Chagas disease: a critical review
Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30
- , according to the Biopharmaceutical Classification System (BCS) [31], which means that it is a poorly soluble but permeable molecule. The limitation in the absorption of class-II drugs is due to their rate of dissolution, except at very high doses. Their bioavailability is variable but can be increased by
- augmenting their dissolution rate, and in vitro–in vivo correlation is normally applied [31]. These drugs are suitable for sustained release and controlled release formulations that provide more stable and predictable plasma levels. Drug solubility can be increased by employing strategies from classical
- -II drugs with low solubility, or low or irregular bioavailability, and promoting adhesion to the gastrointestinal wall [95]. The small size of the crystals is associated with a large surface area, which increases interactions with the dissolving medium and accelerates the dissolution rate. The latest
Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study
Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24
- taken. The concentration of the drug release was calculated using Equation 2 [42] with the calibration curve for VNB. In the in vitro dissolution test, the drug release (DR) was determined using Equation 3. The cumulative percentage of drug release (CPR %) was determined using Equation 4 [42] separately
Assessing phytotoxicity and tolerance levels of ZnO nanoparticles on Raphanus sativus: implications for widespread adoptions
Beilstein J. Nanotechnol. 2024, 15, 115–125, doi:10.3762/bjnano.15.11
- , there was probably less chance of intake of intact ZnO NPs than that of Zn2+ by R. sativus. Further, upon application or release into the environment, ZnO NPs undergo rapid dissolution and conversion while some NPs attach to the crop root surface [52]. The ability of ZnO NPs to adhere to the root
Development and characterization of potential larvicidal nanoemulsions against Aedes aegypti
Beilstein J. Nanotechnol. 2024, 15, 104–114, doi:10.3762/bjnano.15.10
- a transport exponent value (n) of 0.3, indicating a release mechanism primarily driven by Fickian diffusion [44]. The free terpenes exhibited a value of 0.6, suggesting an anomalous transport mechanism for drug release. This mechanism involves a combination of diffusion and dissolution processes for
Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency
Beilstein J. Nanotechnol. 2024, 15, 71–82, doi:10.3762/bjnano.15.7
- ]. The core/shell nanofiber structure can also prolong the drug release since the polymer shell plays a role as a rate-control barrier [15]. On the other hand, the nanofiber scaffolds fabricated using suitable hydrophilic or water-soluble polymers are used to improve the dissolution profile and
- value of n determined by the Ritger–Peppas model was in the range of 0.5 and 1.0, which means that the BBR NPs release mechanism could be represented by a non-Fickian diffusion. In other words, the release of BBR NPs was not only based on diffusion but also involved other processes, such as dissolution
Nanotechnological approaches in the treatment of schistosomiasis: an overview
Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2
- used in the future [8]. In another work, Gonzalez et al. [48] increased the dissolution of PZQ by producing nanocrystals through high-pressure homogenization, followed by drying through spray-drying. After that, they resuspended the powder in Oral plus® and Oral Sweet®, which are suspension vehicles
- use known drugs which have its effectivity attested, and aim to increase the dissolution of the drug in vitro [48][94]. Yang et al. [94] verified that PZQ nanocrystals had a more significant dissolution rate than that of the conventional drug due to the particle size and, consequently, it also showed
- a bioavailability improvement. That is because bioavailability of orally administered drugs depends on their ability to be absorbed in the gastrointestinal tract. For class II drugs (e.g., PZQ) the absorption process is limited by drug dissolution rate in gastrointestinal media. Therefore
TEM sample preparation of lithographically patterned permalloy nanostructures on silicon nitride membranes
Beilstein J. Nanotechnol. 2024, 15, 1–12, doi:10.3762/bjnano.15.1
- and the relatively long baking duration were chosen because the copolymer must be solid to prevent dissolution by the PMMA layer. In addition, the baking temperature can control the sensitivity of the copolymer. The higher the baking temperature of the copolymer, the more sensitive the copolymer gets
Fluorescent bioinspired albumin/polydopamine nanoparticles and their interactions with Escherichia coli cells
Beilstein J. Nanotechnol. 2023, 14, 1208–1224, doi:10.3762/bjnano.14.100
- = 18.2 MΩ·cm; Millipore® Reverse Osmosis system; Merck, Darmstadt, Germany). BSA/polydopamine nanoparticles Polydopamine nanoparticles (BSA/PDA NPs) were prepared according to Bergtold and co-workers [13] (Figure 2a–c). Tris buffer solution was prepared by dissolution of 6.055 g (5 × 10−2 mol) of Tris
Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study
Beilstein J. Nanotechnol. 2023, 14, 1127–1140, doi:10.3762/bjnano.14.93
- poorly water-soluble CUR. An effective submicron particle fabrication technique, namely co-precipitation–cross-linking–dissolution (CCD), has been established to produce biopolymer particles [24][25][26]. In this method, biopolymer particles are produced via co-precipitation, by simply mixing MnCl2 and
- -HSA-MPs and HSA was cross-linked. After dissolution of the MnCO3 template with EDTA, a colloidal particle suspension of CUR-HSA-MPs was obtained. Comparison of the different CUR samples demonstrated that the color of CUR in DMSO is light brown, indicating dissolved CUR; CUR in water is bright yellow
- albumin proteins [30]. CUR showed strong binding affinity towards HSA, likely at the tryptophan residue, which is present in the hydrophobic cavities of HSA [23][31]. The final CUR-HSA-MPs are obtained after dissolution of the MnCO3 template with EDTA. Characterization of CUR-HSA-MPs Dynamic light
Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one
Beilstein J. Nanotechnol. 2023, 14, 1028–1040, doi:10.3762/bjnano.14.85
- coprecipitation–crosslinking–dissolution (CCD) are promising as HBOCs. CCD provides particles that are malleable and show a consistent morphology and narrow size distribution, as well as a negative zeta potential [19][31][32][33]. It could be shown that neither NO scavenging nor vasoconstriction can be detected
N-Heterocyclic carbene-based gold etchants
Beilstein J. Nanotechnol. 2023, 14, 865–871, doi:10.3762/bjnano.14.71
- dissolution of gold. We present scanning electron micrographs and elemental imaging analyses by energy dispersive X-ray spectroscopy to examine the effect of solutions of each species on the gold film. This work highlights the risk of unwanted etching during some routes to NHC-based surface functionalization
- solubility) of 2 and 3 must also be considered as a contributing factor. Similarly, Figure S4 (Supporting Information File 1) shows no apparent gold film loss in a solution of triethylamine and potassium iodide in acetone (chosen instead of THF or DCM to allow for dissolution of KI) tested as a control for
- the present work we show that one must carefully consider the particular NHC-related species, the solvent, the exposure time, and the concentration in order to avoid deleterious effects such as dissolution of the gold film or nanoparticle substrate. At the same time, we introduce a molecular etchant
Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies
Beilstein J. Nanotechnol. 2023, 14, 804–818, doi:10.3762/bjnano.14.66
- BNZ within NLC because of its small quantity or to dissolution inside the NLC. The long period Bragg diffraction peaks for Myristyl myristate could be observed in SAXS patterns at the q range between 0.15 and 0.2 Å−1 (Figure 6). Bare myristyl myristate confirmed the presence of a β’ polymorph with
- at 324 nm. The volume of injection was 20 μL. In vitro benznidazole release assay The release of BNZ from the nanoparticles was performed in a rotating paddle apparatus (Vision Classic 6, Hanson Research, Chatsworth, CA, USA) at 75 rpm using 500 mL of KH2PO4 buffer (pH 6.8) as the dissolution medium
- . The bath temperature was set at 37.0 ± 0.5 °C. A volume of 5 mL of each formulation was placed in a pre-hydrated dialysis membrane (MWCO 10 kDa) and submerged into the dissolution vessels. A solution of free BNZ at the same concentration was used as control. At 0, 5, 10, 15, and 30 min, and at 1, 2, 3
Carboxylic acids and light interact to affect nanoceria stability and dissolution in acidic aqueous environments
Beilstein J. Nanotechnol. 2023, 14, 762–780, doi:10.3762/bjnano.14.63
- of nanoceria (i.e., cerium oxide in the form of nanoparticles) can store or release oxygen, cycling between Ce3+ and Ce4+; therefore, they can cause or relieve oxidative stress within living systems. Nanoceria dissolution occurs in acidic environments. Nanoceria stabilization is a known problem even
- dissolution and stabilization have been previously studied in vitro using acidic aqueous environments. Nanoceria agglomerated in the presence of some carboxylic acids over 30 weeks, and degraded in others, at pH 4.5 (i.e., the pH value in phagolysosomes). Plants release carboxylic acids, and cerium
- did not occur in the dark in the presence of most carboxylic acids. Light initiates free radicals generated by ceria nanoparticles. Nanoceria completely dissolved in the presence of citric, malic, and isocitric acid when exposed to light, attributed to nanoceria dissolution, release of Ce3+ ions, and
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