Prospects of nanotechnology and natural products for cancer and immunotherapy

• Jan Filipe Andrade Santos,
• Marcela Bernardes Brasileiro,
• Pamela Danielle Cavalcante Barreto,
• Ligiane Aranha Rocha and
• José Adão Carvalho Nascimento Júnior

Beilstein J. Nanotechnol. 2025, 16, 1644–1667, doi:10.3762/bjnano.16.116

• by Li et al. discussed patent CN115671277 [94]. Nanoparticles Nanoparticles are materials with at least one dimension ranging from 1 to 999 nm [95]. This technology possesses a high contact surface, a high concentration of surface-active centers, and low toxicity due to promoting a reduction in the

• dose of its active ingredients [96]. These characteristics have made nanoparticles widely used in medicines, medical applications, and the food industry, as they provide increased shelf life, improved drug delivery, and enhanced therapeutic efficacy [97]. Various methods, such as chemical reduction

• neutrophils or infiltration of CD4+ T cells to destroy tumors [145]. The process of nanosizing the CGCs in the patent involves shearing at high speed and ultrasonic cycles followed by freeze-drying. This resulted in a yield of 12.73% and a purity of 96.32%. The increased surface area due to the reduction in

Nanotechnology-based approaches for the removal of microplastics from wastewater: a comprehensive review

• Nayanathara O Sanjeev,
• Manjunath Singanodi Vallabha and
• Rebekah Rubidha Lisha Rabi

Beilstein J. Nanotechnol. 2025, 16, 1607–1632, doi:10.3762/bjnano.16.114

• semiconductor catalyst. In contrast, for reduction to occur, the redox potential must be lower than the conduction band edge. This is because, upon excitation, holes generated in the valence band participate in oxidation reactions, whereas the electrons excited to the conduction band drive the reduction

Bioinspired polypropylene-based functionally graded materials and metamaterials modeling the mistletoe–host interface

• Lina M. Rojas González,
• Naeim Ghavidelnia,
• Christoph Eberl and
• Max D. Mylo

Beilstein J. Nanotechnol. 2025, 16, 1592–1606, doi:10.3762/bjnano.16.113

• defined interfaces between the compounds. This can be explained by the reduction in heat transfer of polymer blends with higher glass fiber content [41] and needs to be considered when designing graded interfaces of fiber-reinforced polymers. The results show that interface structuring of FGMs is possible

• applied. The small deviation may be due to the volume reduction of PP during hot pressing, the burnt glass fibers at the edges, and inaccuracies in the post-processing threshold algorithms. The good fusion of the individual compartments and the gradual increase in fiber concentration along the specimen

• bidirectionally graded specimens compared to the linearly graded specimens (reduction of about 15% for the linearly graded specimens and about 24% for the specimens with V-shaped interface). For UTS, both groups show almost identical values (differences of 2–3%), which again can be attributed to the fact that the

Few-photon microwave fields for superconducting transmon-based qudit control

• Irina A. Solovykh,
• Andrey V. Pashchenko,
• Natalya A. Maleeva,
• Nikolay V. Klenov,
• Olga V. Tikhonova and
• Igor I. Soloviev

Beilstein J. Nanotechnol. 2025, 16, 1580–1591, doi:10.3762/bjnano.16.112

• the highest possible excited transmon state with n = k0. An increase in the nonlinearity of the transmons leads to a significant reduction in the period of Rabi oscillations, tR, and the beat frequency, tbeat, as shown in Figure 2a. When nonlinear interactions dominate, high-energy excitations are

Photocatalytic degradation of ofloxacin in water assisted by TiO₂ nanowires on carbon cloth: contributions of H₂O₂ addition and substrate absorbability

• Iram Hussain,
• Lisha Zhang,
• Zhizhen Ye and
• Jin-Ming Wu

Beilstein J. Nanotechnol. 2025, 16, 1567–1579, doi:10.3762/bjnano.16.111

• relative intensity of the hydroxyl peak decreases, and the peaks shift slightly (O–Ti at 529.7 eV and –OH at 531 eV), indicating a reduction in surface –OH groups due to dehydration and phase transformation from hydrogen titanate to anatase TiO2. Based on the area underneath the corresponding O 1s XPS peak

• all tested concentrations of OFL (50–200 ppm), indicating progressive mineralization of the pollutant. At 50 ppm, the TOC decreased from 51.04 to 17.31 mg·L−1 after 12 h, corresponding to a 66% reduction. At 200 ppm, the TOC decreased from 205.1 to 30.25 mg·L−1 (12 h), achieving an 85% reduction

• our system. The introduction of KBrO3 resulted in a relatively modest reduction in the removal to 41%, suggesting that the involvement of e− is minor in the process. These results indicate that the photocatalytic degradation mechanism is predominantly governed by photogenerated holes, followed by

Influence of laser beam profile on morphology and optical properties of silicon nanoparticles formed by laser ablation in liquid

• Natalie Tarasenka,
• Vladislav Kornev,
• Alena Nevar and
• Nikolai Tarasenko

Beilstein J. Nanotechnol. 2025, 16, 1533–1544, doi:10.3762/bjnano.16.108

• laser pulses. For example, laser beams with a donut shape were used for ablating gold, yttrium oxide, and high-entropy alloy targets in water. The donut beam enabled NP size reduction and narrower size distributions [28]. Application of femtosecond Bessel beams for the ablation of silver in a liquid was

Dendrimer-modified carbon nanotubes for the removal and recovery of heavy metal ions from water

• Thao Quynh Ngan Tran,
• Huu Trung Nguyen,
• Subodh Kumar and
• Xuan Thang Cao

Beilstein J. Nanotechnol. 2025, 16, 1522–1532, doi:10.3762/bjnano.16.107

• metal contamination. Consequently, the efficient removal of heavy metal ions remains a critical research challenge. Various methods have been employed including membrane filtration [1], flocculation [2], adsorption [3][4], precipitation [5], electrolytic removal [6], ion exchange [7], reduction [8], and

• sp3 on the surface of CNTs. Accordingly, it reflects the reduction of double bonds on the CNT surfaces, thus indicating the formation of new covalent bonds between MA and CNTs. The further growth of dendrimers was achieved by the successive reaction of EDA and MA under the reaction conditions

Cross-reactivities in conjugation reactions involving iron oxide nanoparticles

• Shoronia N. Cross,
• Katalin V. Korpany,
• Hanine Zakaria and
• Amy Szuchmacher Blum

Beilstein J. Nanotechnol. 2025, 16, 1504–1521, doi:10.3762/bjnano.16.106

• erroneous conclusions about the efficacy of conjugation reactions, which can have detrimental impacts on the functionality and safety of IONPs in biomedical applications. Keywords: click chemistry; copper-catalyzed azide–alkyne cycloaddition; disulfide reduction; iron oxide nanoparticles; thiol–maleimide

Laser processing in liquids: insights into nanocolloid generation and thin film integration for energy, photonic, and sensing applications

• Akshana Parameswaran Sreekala,
• Pooja Raveendran Nair,
• Jithin Kundalam Kadavath,
• Bindu Krishnan,
• David Avellaneda Avellaneda,
• M. R. Anantharaman and
• Sadasivan Shaji

Beilstein J. Nanotechnol. 2025, 16, 1428–1498, doi:10.3762/bjnano.16.104

• , suggesting that careful control of size reduction and surface properties is critical for optimizing photocatalyst performance, especially in water splitting applications. Further investigation is necessary to refine the process and mitigate the negative effects of fragmentation. LFL is a highly versatile

• spheres can be accomplished in a shorter time frame, leading to a productivity increase of about two orders of magnitude compared to LAL. This improvement is due to the reduction in particle size from bulk material to NPs, which enhances the laser absorption efficiency. PLIL offers several advantages over

Photochemical synthesis of silver nanoprisms via green LED irradiation and evaluation of SERS activity

• Tuan Anh Mai-Ngoc,
• Nhi Kieu Vo,
• Cong Danh Nguyen,
• Thi Kim Xuan Nguyen and
• Thanh Sinh Do

Beilstein J. Nanotechnol. 2025, 16, 1417–1427, doi:10.3762/bjnano.16.103

• nanostructures had occurred at this stage [4][7]. The IPD peak was still observed after 12 and 24 h but with progressively decreasing intensity, suggesting a reduction in the number of spherical silver seeds as the irradiation time increased. After 12 h, in addition to the IPD peak at 405 nm, a broad shoulder

• , the surfaces of the silver nanomaterials (initial AgNP seeds, planar twinned seeds) are continuously excited, and the growth of AgNPrs proceeds via two mechanisms (Figure 6). These mechanisms are: (1) TSC continues to be excited and promotes the reduction of Ag+, resulting in the deposition of Ag0 on

The role of biochar in combating microplastic pollution: a bibliometric analysis in environmental contexts

• Tuan Minh Truong Dang,
• Thao Thu Thi Huynh,
• Guo-Ping Chang-Chien and
• Ha Manh Bui

Beilstein J. Nanotechnol. 2025, 16, 1401–1416, doi:10.3762/bjnano.16.102

• composition, and microbial community. Regarding soil physical properties, MPs modify porosity and aeration, which in turn disrupt water and air circulation, leading to soil compaction and dryness that adversely affect root development [52][54][56]. These changes are exemplified by the reduction in water

• related to microplastics predominantly emphasize plastic waste reduction and recycling, without establishing clear regulatory thresholds for microplastic concentrations in water and soil [86]. Given the well-documented environmental and biological hazards posed by microplastic pollution, biochar’s

Parylene-coated platinum nanowire electrodes for biomolecular sensing applications

• Chao Liu,
• Peker Milas,
• Michael G. Spencer and
• Birol Ozturk

Beilstein J. Nanotechnol. 2025, 16, 1392–1400, doi:10.3762/bjnano.16.101

• nanowire growth occurs due to reduction of platinum ions from the solution. Frequency and peak-to-peak voltage parameters were optimized to grow a single platinum nanowire (needle-like) as opposed to dendritic nanowire branches or multiple nanowires. Starting values for growth frequency and peak-to-peak

• electrodes were used as above. The Gamry potentiostat was used for CV tests with scan range from −0.5 to 0.5 V, 30 mV/s, 1 mV step size (1 data point for 1 mV change, 30 data point per second), and four cycles. For noise reduction and statistical considerations, the mean value from the last three cycles were

Synthesis and antibacterial properties of nanosilver-modified cellulose triacetate membranes for seawater desalination

• Lei Wang,
• Shizhe Li,
• Kexin Xu,
• Wenjun Li,
• Ying Li and
• Gang Liu

Beilstein J. Nanotechnol. 2025, 16, 1380–1391, doi:10.3762/bjnano.16.100

• pollution in cellulose triacetate (CTA) membranes during seawater desalination, silver (Ag) nanoparticles were incorporated onto the CTA surface using polydopamine (PDA). PDA, which contains phenolic and amino groups, exhibits excellent adhesiveness and provides active sites for the attachment and reduction

• evaporation. The CNTs were functionalized with polyethylene imine (PEI) to enhance their dispersibility and to impart antibacterial properties to the membrane. The CNT@PEI/MCE membrane exhibited significant antibacterial activity against Escherichia coli [24]. In summary, the in situ reduction method is

• further functionalization (Figure 4c). This PDA layer imparts functional groups, such as catechol and amino groups, which facilitate the subsequent reduction and immobilization of Ag nanoparticles. Upon Ag deposition, the PCTA membrane’s surface exhibits evenly distributed Ag nanoparticles nestled within

Enhancing the therapeutical potential of metalloantibiotics using nano-based delivery systems

• Alejandro Llamedo,
• Marina Cano,
• Raquel G. Soengas and
• Francisco J. García-Alonso

Beilstein J. Nanotechnol. 2025, 16, 1350–1366, doi:10.3762/bjnano.16.98

• antimicrobial testing of the liposomal formulation against clinical isolates revealed a remarkable reduction in MIC and MBC when compared to free tobramycin. Notably, the formulation eradicated a highly resistant P. aeruginosa strain at concentrations 1000-fold lower than the free antibiotic. The enhanced

Wavelength-dependent correlation of LIPSS periodicity and laser penetration depth in stainless steel

• Nitin Chaudhary,
• Chavan Akash Naik,
• Shilpa Mangalassery,
• Jai Prakash Gautam and
• Sri Ram Gopal Naraharisetty

Beilstein J. Nanotechnol. 2025, 16, 1302–1315, doi:10.3762/bjnano.16.95

• -enhanced Raman spectroscopy, reduction of friction and wear, fuel injection, and enhancement of tribological properties [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. Extensive research efforts have been directed toward understanding LIPSS, encompassing systematic investigations on

• falling around 1022 to 1023 cm−3 [73][74]. It is conceivable that the plasma frequency can have an effect at wavelengths exceeding 2000 nm, leading to a reduction in penetration depth for larger wavelengths (2200 and 2400 nm); detailed theory and experimental work are needed with pure metals to confirm

Enhancing the photoelectrochemical performance of BiOI-derived BiVO₄ films by controlled-intensity current electrodeposition

• Huu Phuc Dang,
• Khanh Quang Nguyen,
• Nguyen Thi Mai Tho and
• Tran Le

Beilstein J. Nanotechnol. 2025, 16, 1289–1301, doi:10.3762/bjnano.16.94

• charge carrier transport; however, their uneven porosity and high charge recombination rates hindered their PEC performance improvement. McDonald and Choi [19] introduced a facile electrodeposition method based on p-benzoquinone reduction to fabricate ultrathin BiOI films, which could be thermally

• deposition parameters indicates a reduction in the structural defects and lattice strain. The vibrational modes at 329 cm−1 and 370 cm−1, corresponding to the asymmetric and symmetric deformations of the V–O bond [30][31], respectively, showed a strong correlation with XRD-derived grain size variations

• efficient charge separation and transport. Previous studies have reported that the (121), (040), and (010) facets of monoclinic BiVO4 contribute to enhanced photocatalytic activity by serving as active sites for oxidation and reduction reactions [32][33]. In particular, the large surface area of the (010

Acrocomia aculeata oil-loaded nanoemulsion: development, anti-inflammatory properties, and cytotoxicity evaluation

• Verónica Bautista-Robles,
• Hady Keita,
• Edgar Julián Paredes Gamero,
• Layna Tayná Brito Leite,
• Jessica de Araújo Isaías Muller,
• Mônica Cristina Toffoli Kadri,
• Ariadna Lafourcade Prada and
• Jesús Rafael Rodríguez Amado

Beilstein J. Nanotechnol. 2025, 16, 1277–1288, doi:10.3762/bjnano.16.93

• marked reduction in droplet size, stabilizing between 110 and 120 nm across all time points. This reduction can be attributed to several interrelated physicochemical mechanisms. Primarily, the nonionic surfactants Span 80® and Tween 80® reduce interfacial tension between oil and aqueous phases, a

Hydrogels and nanogels: effectiveness in dermal applications

• Jéssica da Cruz Ludwig,
• Diana Fortkamp Grigoletto,
• Daniele Fernanda Renzi,
• Wolf-Rainer Abraham,
• Daniel de Paula and
• Najeh Maissar Khalil

Beilstein J. Nanotechnol. 2025, 16, 1216–1233, doi:10.3762/bjnano.16.90

• ][200], radiation [201], reduction potential [202], or concentration of specific compounds, including glucose [203] and reactive oxygen species [204], may result in the modification of particle conformation, leading to the release of the transported drug. Some nanogels can simultaneously respond to two

• nanogels showed responsiveness to pH and temperature variation. In an ex vivo test performed with rat skin, the nanogel activated by sodium carbonate revealed a significantly higher release of naproxen into the epidermis, with a 2.8-fold increase in the steady flow of the drug. A 50% reduction in the

• activity of the COX-2 enzyme and reduction of rat paw edema were also observed by comparing the base-activated nanogel with the nonactivated nanogel in tests confirmed by immunofixation, which corroborated the in vivo/ex vivo data [151]. Nanogels for the transdermal release of methotrexate (MTX), an

Chitosan nanocomposite containing rotenoids: an alternative bioinsecticidal approach for the management of Aedes aegypti

• Maria A. A. Bertonceli,
• Vitor D. C. Cristo,
• Ivo J. Vieira,
• Francisco J. A. Lemos,
• Arnoldo R. Façanha,
• Raimundo Braz-Filho,
• Gustavo V. T. Batista,
• Luis G. M. Basso,
• Sérgio H. Seabra,
• Thalya S. R. Nogueira,
• Felipe F. Moreira,
• Arícia L. E. M. Assis,
• Antônia E. A. Oliveira and
• Kátia V. S. Fernandes

Beilstein J. Nanotechnol. 2025, 16, 1197–1208, doi:10.3762/bjnano.16.88

• nanocomposite. Additionally, a noticeable reduction in the intensity of the amide-related bands in CS/TPP-β-CD-rot suggests possible interactions – such as hydrogen bonding or covalent bonding – between rotenoids and the chitosan matrix. These spectral features confirm the successful incorporation of rotenoids

Electronic and optical properties of chloropicrin adsorbed ZnS nanotubes: first principle analysis

• Prakash Yadav,
• Boddepalli SanthiBhushan and
• Anurag Srivastava

Beilstein J. Nanotechnol. 2025, 16, 1184–1196, doi:10.3762/bjnano.16.87

• , optical absorption, and optical conductivity of the ZnS NT-CP system. Our findings reveal that the interaction between CP and ZnS NT induces notable changes in the electronic and optical properties of the nanotube, including a substantial bandgap reduction of up to ≈40% for the specific orientation A. The

• ZnS NT with (3,3) chirality is illustrated in Figure 2. The structural analysis reveals an average Zn–S bond length of 2.29 Å, which is slightly shorter than the bond length of bulk ZnS (2.34 Å). This reduction in bond length can be attributed to the curvature of the NT structure, which induces a

• Figure 4. The pristine ZnS NT exhibits a bandgap of 3.03 eV (Figure 3i), consistent with previous studies [38][40][54][55][56][57][58]. Upon CP adsorption, the bandgap values for orientations A, B, C, and D were reduced to 1.92, 2.27, 2.31, and 2.47 eV, respectively. This reduction in the bandgap is

Crystalline and amorphous structure selectivity of ignoble high-entropy alloy nanoparticles during laser ablation in organic liquids is set by pulse duration

• Robert Stuckert,
• Felix Pohl,
• Oleg Prymak,
• Ulrich Schürmann,
• Christoph Rehbock,
• Lorenz Kienle and
• Stephan Barcikowski

Beilstein J. Nanotechnol. 2025, 16, 1141–1159, doi:10.3762/bjnano.16.84

• decomposition [4], oxygen evolution reactions (OER) [14], oxygen reduction reactions (ORR) [15], in CO oxidation [16], and in CO2 and CO reduction [17]. This high activity in catalysis has been attributed to adsorption energy distribution patterns (AEDP) during catalytic reactions [18], which may be tuned based

• on density functional theory calculations of binding energies and machine learning algorithms for an efficient catalyst design [15][17][19]. The synthesis of HEA NPs has been realized by many methods, including carbothermal shock synthesis (CTS) [20][21], chemical reduction [22][23], fast-moving bed

• , colloidal nanoparticles can be synthesized and/or processed by laser ablation in liquid (LAL) [51][52][53][54][55], laser fragmentation in liquid (LFL) [56][57], and laser reduction in liquid (LRL) [58][59][60], making LSPC an efficient method for nanoparticle research but also for scale-up, as it has been

Deep learning for enhancement of low-resolution and noisy scanning probe microscopy images

• Samuel Gelman,
• Irit Rosenhek-Goldian,
• Nir Kampf,
• Marek Patočka,
• Maricarmen Rios,
• Marcos Penedo,
• Georg Fantner,
• Amir Beker,
• Sidney R. Cohen and
• Ido Azuri

Beilstein J. Nanotechnol. 2025, 16, 1129–1140, doi:10.3762/bjnano.16.83

• shows deep learning models to be superior for super-resolution tasks and enables significant reduction in AFM measurement time, whereby low-pixel-resolution AFM images are enhanced in both resolution and fidelity through deep learning. Keywords: atomic force microscopy; deep learning; fast scanning

Influence of ion beam current on the structural, optical, and mechanical properties of TiO₂ coatings: ion beam-assisted vs conventional electron beam evaporation

• Agata Obstarczyk and
• Urszula Wawrzaszek

Beilstein J. Nanotechnol. 2025, 16, 1097–1112, doi:10.3762/bjnano.16.81

• occurred for all coatings. In particular, an increase in ion beam current led to a reduction in crystallite size by approximately 30% compared to coatings prepared by conventional EBE process. The average anatase crystallite size for annealed films was in the range of 30.8 to 43.5 nm. A detailed SEM

• such as substrate temperature, deposition rate, substrate biasing, and ion beam gun settings. Moreover, post-process annealing can lead to a reduction in thermal stress due to the difference in thermal expansion coefficients between the film and the substrate and can also affect internal stress by

Fabrication of metal complex phthalocyanine and porphyrin nanoparticle aqueous colloids by pulsed laser fragmentation in liquid and their potential application to a photosensitizer for photodynamic therapy

• Taisei Himeda,
• Risako Kunitomi,
• Ryosuke Nabeya,
• Tamotsu Zako and
• Tsuyoshi Asahi

Beilstein J. Nanotechnol. 2025, 16, 1088–1096, doi:10.3762/bjnano.16.80

• [30][31]. A halogen lamp light with a wide spectral range of 500–800 nm using optical filters was used as light source for 10 min at an output power of 35 mW·cm−2 (Figure S6 and Figure S7, Supporting Information File 1). For AlClPc and PtOEP nanoparticles, a significant reduction in the cell viability

Piezoelectricity of hexagonal boron nitrides improves bone tissue generation as tested on osteoblasts

• Sevin Adiguzel,
• Nilay Cicek,
• Zehra Cobandede,
• Feray B. Misirlioglu,
• Hulya Yilmaz and
• Mustafa Culha

Beilstein J. Nanotechnol. 2025, 16, 1068–1081, doi:10.3762/bjnano.16.78

• . However, the viability of cells treated with hBNs+US for 24 h was decreased to 80% for all concentrations of hBNs. Both hBNs and BaTiO3 showed the same behavior with the US exposure for 24 h. This reduction in cell viability can be attributed to the transient mechanical effects by ultrasound exposure

• , the scratch width was significantly reduced in cells treated with hBNs+US (5 and 10 µg/mL) and BaTiO3+US (5 and 10 µg/mL). However, cells treated with hBNs+US exhibited a significantly greater scratch width reduction than those treated with BaTiO3+US. The enhanced migration ability can be attributed