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Search for "REACH" in Full Text gives 677 result(s) in Beilstein Journal of Nanotechnology. Showing first 200.

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

  • Selin Akpinar Adscheid,
  • Akif E. Türeli,
  • Nazende Günday-Türeli and
  • Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

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  • almost all large-molecule drugs and most small-molecule drugs. A noninvasive method, nose-to-brain delivery (N2B delivery) has been proposed to overcome this challenge. By exploiting the direct anatomical interaction between the nose and the brain, the drugs can reach the target, the brain. Moreover, the
  • , most systemically administered drugs cannot reach the brain as a site of action. The BBB is reported to limit the passage of 98% of small-molecule drugs and almost all large-molecule therapeutics to the brain [15]. The high density of the intact barrier prevents an easy penetration of the barrier. The
  • potential of mAbs for treating CNS diseases is limited. It is estimated that only 1 in 1000 antibodies can reach the brain with a concentration as low as 0.1% of the injected dose [138]. As an example, aducanumab can be mentioned. Although it has low BBB passage, it targets the brain amyloid plaque at high
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Published 12 Nov 2024

A biomimetic approach towards a universal slippery liquid infused surface coating

  • Ryan A. Faase,
  • Madeleine H. Hummel,
  • AnneMarie V. Hasbrook,
  • Andrew P. Carpenter and
  • Joe E. Baio

Beilstein J. Nanotechnol. 2024, 15, 1376–1389, doi:10.3762/bjnano.15.111

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  • 7.4, 150 mM NaCl). Plasma was then recalcified with 50 μL 25 mM CaCl2. Absorbance measurements were taken every 1 min for 60 min at 405 nm. Three separate experiments were performed for a total sample size of 18 per donor. Fibrin generation time was defined as the time to reach a 5% increase over the
  • no difference between PDA–FDT–PFD and BSA or COC. Fibrin generation time was defined as the time to reach a 5% increase in OD over the baseline. PDA–FDT–PFD clotted significantly slower than glass for both donors and all runs (α = 0.05). Adherent platelets per 3520 μm2 surface area for two donors, A1
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Published 08 Nov 2024

Investigation of Hf/Ti bilayers for the development of transition-edge sensor microcalorimeters

  • Victoria Y. Safonova,
  • Anna V. Gordeeva,
  • Anton V. Blagodatkin,
  • Dmitry A. Pimanov,
  • Anton A. Yablokov and
  • Andrey L. Pankratov

Beilstein J. Nanotechnol. 2024, 15, 1353–1361, doi:10.3762/bjnano.15.108

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  • ), can reach 0.005 eV. Now, we estimate how the energy resolution will deteriorate with increasing TES volume, but with preservation of the square shape. For this purpose, in addition to the already calculated dimensions of sample A4, let us consider several dimensions corresponding to samples A1–A3. For
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Published 06 Nov 2024

Interaction of graphene oxide with tannic acid: computational modeling and toxicity mitigation in C. elegans

  • Romana Petry,
  • James M. de Almeida,
  • Francine Côa,
  • Felipe Crasto de Lima,
  • Diego Stéfani T. Martinez and
  • Adalberto Fazzio

Beilstein J. Nanotechnol. 2024, 15, 1297–1311, doi:10.3762/bjnano.15.105

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  • ingested hazardous substances or materials and plays an important role in protecting other organs. Different studies show an increased intestinal permeability after exposure to GO, enabling the material to reach adjacent organs such as the gonads [14][51][52]. Wu et al. [51] found that prolonged exposure
  • of 60 × 60 × 60 Å filled with water molecules to reach a density of 1 g/cm3. In order to evaluate the effects of the GO oxidation level on the interactions with TA, we also performed MD simulations with periodic GO sheets with oxidation levels from 1 to 32%, the latter corresponding to the oxidation
  • molecules to reach the density of 1 g/cm3. DFT calculations were performed using VASP [75][76]. The Perdew–Burke–Ernzerhof (PBE) generalized gradient approximation was used for the exchange–correlation term [77]. The kinetic energy cutoff for the plane-wave expansion was 520 eV. Furthermore, the nonlocal
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Published 30 Oct 2024

Functional morphology of cleaning devices in the damselfly Ischnura elegans (Odonata, Coenagrionidae)

  • Silvana Piersanti,
  • Gianandrea Salerno,
  • Wencke Krings,
  • Stanislav Gorb and
  • Manuela Rebora

Beilstein J. Nanotechnol. 2024, 15, 1260–1272, doi:10.3762/bjnano.15.102

Graphical Abstract
  • followed by dirt particle cleaning via the running of the tibial grooming structures through mouthparts (R and L tibia cleaning) (Figure 3a–f). Head rotation up to 90° was performed to allow antenna cleaning with the contralateral or ipsilateral tibia (R ant and L ant), in order to reach the side of the
  • contamination. Special attention is devoted by damselflies to their antennae. In particular, they rotate the head up to 90° to allow antenna cleaning with the contralateral or ipsilateral tibia, in order to reach the side of the antennal surface not previously cleaned with the head in horizontal position, thus
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Published 16 Oct 2024

Photocatalytic methane oxidation over a TiO2/SiNWs p–n junction catalyst at room temperature

  • Qui Thanh Hoai Ta,
  • Luan Minh Nguyen,
  • Ngoc Hoi Nguyen,
  • Phan Khanh Thinh Nguyen and
  • Dai Hai Nguyen

Beilstein J. Nanotechnol. 2024, 15, 1132–1141, doi:10.3762/bjnano.15.92

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  • gaseous reactants in batch reactor was established at 5 bar, and the photocatalytic system was kept in the dark (20 min) to reach equilibrium before exposure to simulated solar light. The temperature was kept at room temperature via a cooler. Characterization The crystalline structure and morphological
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Published 02 Sep 2024

Recent updates in applications of nanomedicine for the treatment of hepatic fibrosis

  • Damai Ria Setyawati,
  • Fransiska Christydira Sekaringtyas,
  • Riyona Desvy Pratiwi,
  • A’liyatur Rosyidah,
  • Rohimmahtunnissa Azhar,
  • Nunik Gustini,
  • Gita Syahputra,
  • Idah Rosidah,
  • Etik Mardliyati,
  • Tarwadi and
  • Sjaikhurrizal El Muttaqien

Beilstein J. Nanotechnol. 2024, 15, 1105–1116, doi:10.3762/bjnano.15.89

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  • dynamic endothelial fenestrations to reach HSCs in the perisinusoidal space or even hepatocytes [24][29]. Smaller nanocarriers (10–20 nm) can be taken up rapidly by hepatocytes [32]. Besides the size of the administered nanocarriers, surface properties also play an important role in dictating
  • activated HSCs in liver fibrosis resulted in a loss of the fenestrae, hindering plasma to reach the perisinusoidal space [43]. As the disease progresses, the reduced blood flow and the blockage of portal flow through the liver could diminish the efficiency of drug delivery. Nanoencapsulation as passive
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Published 23 Aug 2024

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

  • Shakhzodjon Uzokboev,
  • Khojimukhammad Akhmadbekov,
  • Ra’no Nuritdinova,
  • Salah M. Tawfik and
  • Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

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  • delivery methods that can effectively cross the blood–brain barrier are essential for delivering therapeutic agents to the brain [40]. Nanotechnology has emerged as a promising tool in smart delivery systems. Nanoparticles can be designed to pass through biological barriers and reach specific sites in the
  • digestive enzymes in the gastrointestinal tract can break down some medications before they reach the bloodstream [45]. In addition to this, lack of selectivity can minimize their effectiveness. Also, drug absorption may be high in detoxifying organs such as liver and kidneys, causing toxicity in those
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Published 22 Aug 2024

Interface properties of nanostructured carbon-coated biological implants: an overview

  • Mattia Bartoli,
  • Francesca Cardano,
  • Erik Piatti,
  • Stefania Lettieri,
  • Andrea Fin and
  • Alberto Tagliaferro

Beilstein J. Nanotechnol. 2024, 15, 1041–1053, doi:10.3762/bjnano.15.85

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  • in 1991 [56]. CNTs can be described as single or multiple cylindrical graphite sheets rolled up in a tubular structure forming single-walled CNTs (SWCNTs) or multiwalled CNTs (MWCNTs). SWCNTs are characterized by diameters from 0.3 nm [57] to 1 nm [58], while the diameters of MWCNTs can reach 100 nm
  • can reach 550 W·m−1·K−1 after sintering at high pressure [73]. Nevertheless, surface defects and the granular shape of the NDs represent boundaries for phonon transport reducing the thermal energy propagation [74]. Furthermore, the thermal conductivity of NDs increases with the increment of
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Published 16 Aug 2024

Entry of nanoparticles into cells and tissues: status and challenges

  • Kirsten Sandvig,
  • Tore Geir Iversen and
  • Tore Skotland

Beilstein J. Nanotechnol. 2024, 15, 1017–1029, doi:10.3762/bjnano.15.83

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  • (key constituents in these products) may create immune responses; see discussion in [97]. How much of the injected dose reach the target? Most studies performed with drug-loaded NPs have been performed with the goal of targeting and treating tumors, and there are numerous reports showing that only a
  • may not be good enough, as the drug needs to reach its intracellular target (often in the cytosol) to be active. Thus, quantification of NPs in the tumor area is important to understand what happens with the NPs following i.v. injection; however, far from being sufficient to evaluate the therapeutic
  • potential of such NPs. Furthermore, in most articles describing the amount of drug taken up in the tumor area, it has not been investigated if the drug is still present inside the NPs and not able to reach its target. To our knowledge, there is only one publication describing a method to determine how much
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Published 12 Aug 2024

Recent progress on field-effect transistor-based biosensors: device perspective

  • Billel Smaani,
  • Fares Nafa,
  • Mohamed Salah Benlatrech,
  • Ismahan Mahdi,
  • Hamza Akroum,
  • Mohamed walid Azizi,
  • Khaled Harrar and
  • Sayan Kanungo

Beilstein J. Nanotechnol. 2024, 15, 977–994, doi:10.3762/bjnano.15.80

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  • encompasses an overview of emerging FET-based biosensors and useful guidelines to reach the best device dimensions, favorable design, and realization of FET-based biosensors. Consequently, it furnishes researchers with a detailed perspective on design considerations and applications for future generations of
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Published 06 Aug 2024

Electrospun nanofibers: building blocks for the repair of bone tissue

  • Tuğrul Mert Serim,
  • Gülin Amasya,
  • Tuğba Eren-Böncü,
  • Ceyda Tuba Şengel-Türk and
  • Ayşe Nurten Özdemir

Beilstein J. Nanotechnol. 2024, 15, 941–953, doi:10.3762/bjnano.15.77

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  • regeneration and give an insight about bone regeneration, production techniques of the electrospun nanofibers, and varying formulation parameters in order to reach different drug delivery goals. This review also provides an extensive market research of electrospun nanofibers and an overview on scientific
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Published 25 Jul 2024

The effect of age on the attachment ability of stick insects (Phasmatodea)

  • Marie Grote,
  • Stanislav N. Gorb and
  • Thies H. Büscher

Beilstein J. Nanotechnol. 2024, 15, 867–883, doi:10.3762/bjnano.15.72

Graphical Abstract
  • Heteropterygidae can reach impressive life expectancies [41][44], with anecdotal reports extending over five years. The change in attachment performance was quantified through attachment force measurements. Because of the different properties of arolium and euplantulae [31][33], the attachment forces of whole
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Published 15 Jul 2024

Investigation on drag reduction on rotating blade surfaces with microtextures

  • Qinsong Zhu,
  • Chen Zhang,
  • Fuhang Yu and
  • Yan Xu

Beilstein J. Nanotechnol. 2024, 15, 833–853, doi:10.3762/bjnano.15.70

Graphical Abstract
  • machining process and the spacing between tool paths. Thus, the machining coverage rate does not reach 100%, resulting in a residual height h as shown in Figure 20b. To sum up, the microtexture here meets the quality requirements. Results of the experiments The experimental results are given in Table 11 and
  • Figure 23, the drag reduction performance of the microtexture blade is the best when the angle of attack is 57°; ηξ in the experiment can reach −3.7%. Although the difference between the simulation results and the experimental results is large under the other two attack angles, the trend of ηξ of the two
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Published 10 Jul 2024

Electrospun polysuccinimide scaffolds containing different salts as potential wound dressing material

  • Veronika Pálos,
  • Krisztina S. Nagy,
  • Rita Pázmány,
  • Krisztina Juriga-Tóth,
  • Bálint Budavári,
  • Judit Domokos,
  • Dóra Szabó,
  • Ákos Zsembery and
  • Angela Jedlovszky-Hajdu

Beilstein J. Nanotechnol. 2024, 15, 781–796, doi:10.3762/bjnano.15.65

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  • values, which could reach up to 565.99% [63]. Antibacterial activity of salt-containing scaffolds Suppose we apply a scaffold that contains an antibacterial agent (in our case, salt) for wound dressing. It is important to note that it would not just be a mechanical barrier from the pathogens but also an
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Published 02 Jul 2024

Exploring surface charge dynamics: implications for AFM height measurements in 2D materials

  • Mario Navarro-Rodriguez,
  • Andres M. Somoza and
  • Elisa Palacios-Lidon

Beilstein J. Nanotechnol. 2024, 15, 767–780, doi:10.3762/bjnano.15.64

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  • data point, tp ≈ 10−3 s, yields two opposite situations. For GO, tp < τGO, the surface charge distribution does not reach the equilibrium configuration during the acquisition time, while for rGO, tp ≫ τrGO, measurements are carried out in equilibrium. It is important to note that the time evolution in
  • height measurements in AM-AFM mode, the presence of an oscillating surface charge introduces additional dynamic effects typically overlooked, which, under certain conditions, should be considered when calculating the tip–sample interaction. Also, we have identified a relaxation time required to reach the
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Published 01 Jul 2024

Level set simulation of focused ion beam sputtering of a multilayer substrate

  • Alexander V. Rumyantsev,
  • Nikolai I. Borgardt,
  • Roman L. Volkov and
  • Yuri A. Chaplygin

Beilstein J. Nanotechnol. 2024, 15, 733–742, doi:10.3762/bjnano.15.61

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  • infinitesimal solid angle. Though the large fraction of the sputtered atoms is evacuated from the region affected by the ion beam and does not influence the milling process, some of the atoms can reach the irradiated surface. The flux of such redeposited atoms can be expressed as where is the flux of sputtered
  • Equation 7, taking into account that the atoms originate from the surface element dS and reach the surface element dS1 at the angle γ (see Figure 1b). Using the introduced fluxes and in accordance with [21], the rate was determined as where ni is the atomic density of the i-th material. The incident ion
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Published 24 Jun 2024

Simultaneous electrochemical determination of uric acid and hypoxanthine at a TiO2/graphene quantum dot-modified electrode

  • Vu Ngoc Hoang,
  • Dang Thi Ngoc Hoa,
  • Nguyen Quang Man,
  • Le Vu Truong Son,
  • Le Van Thanh Son,
  • Vo Thang Nguyen,
  • Le Thi Hong Phong,
  • Ly Hoang Diem,
  • Kieu Chan Ly,
  • Ho Sy Thang and
  • Dinh Quang Khieu

Beilstein J. Nanotechnol. 2024, 15, 719–732, doi:10.3762/bjnano.15.60

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  • its maximum when the GQDs reach 67% in mass (2:4)TiO2/GQDs and decreases at higher amounts of GQDs. Meanwhile, the HYP oxidation peak current is highest when the amount of GQDs reaches 80% in mass in (1:4)TiO2/GQDs. To balance between the peak currents of URI and HYP, the electrode modified by (1:4
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Published 20 Jun 2024

Laser synthesis of nanoparticles in organic solvents – products, reactions, and perspectives

  • Theo Fromme,
  • Sven Reichenberger,
  • Katharine M. Tibbetts and
  • Stephan Barcikowski

Beilstein J. Nanotechnol. 2024, 15, 638–663, doi:10.3762/bjnano.15.54

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  • (partially) reduced, under identical processing conditions with identical product nanoparticle diameters of 3 nm [72]. Moreover, the degree of reduction or oxidation was gradually tuned to reach a thermodynamically driven equilibrium with the cumulative laser pulse energy input [72][73]. It indicates a
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Published 05 Jun 2024

Radiofrequency enhances drug release from responsive nanoflowers for hepatocellular carcinoma therapy

  • Yanyan Wen,
  • Ningning Song,
  • Yueyou Peng,
  • Weiwei Wu,
  • Qixiong Lin,
  • Minjie Cui,
  • Rongrong Li,
  • Qiufeng Yu,
  • Sixue Wu,
  • Yongkang Liang,
  • Wei Tian and
  • Yanfeng Meng

Beilstein J. Nanotechnol. 2024, 15, 569–579, doi:10.3762/bjnano.15.49

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  • the optimal concentration of CUR-Fe@MnO2 NFs was 50 µg/ mL, and the optimal RF heating time to reach 41 ± 1 °C was 20 min (Figure 6a). The cytotoxicity of NFs was measured in normal liver cells (THLE-2 cells), and the cell viability rate was 105%, indicating that NFs had no significant toxic effects
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Published 22 May 2024

On the additive artificial intelligence-based discovery of nanoparticle neurodegenerative disease drug delivery systems

  • Shan He,
  • Julen Segura Abarrategi,
  • Harbil Bediaga,
  • Sonia Arrasate and
  • Humberto González-Díaz

Beilstein J. Nanotechnol. 2024, 15, 535–555, doi:10.3762/bjnano.15.47

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  • , which limits the number of therapeutic substances able to reach the brain in order to induce a positive effect. Recently, many efforts have been made to develop systems that facilitate the passage of NDDs through the BBB. Interestingly, nanoparticle (NP) systems are gaining increasing interest among the
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Published 15 May 2024

Cholesterol nanoarchaeosomes for alendronate targeted delivery as an anti-endothelial dysfunction agent

  • Horacio Emanuel Jerez,
  • Yamila Roxana Simioni,
  • Kajal Ghosal,
  • Maria Jose Morilla and
  • Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 517–534, doi:10.3762/bjnano.15.46

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  • . Then, 50 μL of nanovesicles or ALN dilutions in RPMI medium with 1 μg/mL LPS was added to each well to reach the final concentration of 100 and 500 μg/mL TL or 5 and 25 μg/mL ALN. After incubation, plates were centrifuged at 125g for 5 min, the medium was removed, and cells were washed once with 100 µL
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Published 13 May 2024

Unveiling the nature of atomic defects in graphene on a metal surface

  • Karl Rothe,
  • Nicolas Néel and
  • Jörg Kröger

Beilstein J. Nanotechnol. 2024, 15, 416–425, doi:10.3762/bjnano.15.37

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  • reached. To this end, the tip has to be displaced further by Δz > Δzc to reach the energy minimum. The hysteresis loop in Δf and I data can, therefore, be rationalized in terms of a Au–C bond that is formed upon approaching the tip to the defect up to the point of maximum attraction at Δzc ≈ Δz0. This
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Published 15 Apr 2024

Insect attachment on waxy plant surfaces: the effect of pad contamination by different waxes

  • Elena V. Gorb and
  • Stanislav N. Gorb

Beilstein J. Nanotechnol. 2024, 15, 385–395, doi:10.3762/bjnano.15.35

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  • the plant species. The insects demonstrated significantly lower values of both the maximum traction force and the first peak of the traction force and needed significantly longer time to reach the maximum force value in the gl2 test than in the gl1 test. These effects were especially pronounced in
  • maximal traction force Fmax, the value of the first peak of the traction force Fpeak1, and the time TFmax needed to reach the maximum traction force value were measured (Figure 5a). Values of Fmax, Fpeak1, and TFmax were compared among different surfaces inside the experimental set (gl1 vs plant for Fmax
  • first peaks of the traction force Fpeak1 measured from the force–time curves obtained in the first and second experiment on glass (gl1 vs gl2) showed significantly lower values in the second experiment gl2 (paired t-test: t = 5.962, p = 0.033) (Figure 6b). To reach the maximum traction force values, all
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Published 11 Apr 2024

Nanomedicines against Chagas disease: a critical review

  • Maria Jose Morilla,
  • Kajal Ghosal and
  • Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

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  • countries’ institutions (Brazil and Argentina), and private pharmaceutical companies. The project started proposing a sublingual formulation of BNZ within liposomes or lipid nanoparticles, assuming the intact formulations could reach the blood, avoid the hepatic first-pass metabolism, and reduce the
  • that the process in mammalian hosts is certainly more complex. Acceptable formulations for the treatment of the chronic phase [136], for example, should reach intracellular targets. But what is the nature of these targets and how feasible for nanomedicines is it to access them? Recently, the presence
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Published 27 Mar 2024
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