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Search for "activity" in Full Text gives 748 result(s) in Beilstein Journal of Nanotechnology. Showing first 200.
Development of a mucoadhesive drug delivery system and its interaction with gastric cells
Beilstein J. Nanotechnol. 2025, 16, 371–384, doi:10.3762/bjnano.16.28
- the drugs within the mucus microenvironment of the stomach and, thus, may lead to elevated local activity or absorption of the therapeutic agents from the mucosa. Results and Discussion Morphology of nanoparticles After the synthesis of alginate (Alg) and Eudragit-coated alginate (EudAlg
- 595 nm with a microplate reader (BioTek Synergy H1). From these optical density values, percent reduction values (representing the metabolic activity) were calculated for each time point. Data is represented as percent viability, which was calculated by the formula below. The viability percentages of
Pulsed laser in liquid grafting of gold nanoparticle–carbon support composites
Beilstein J. Nanotechnol. 2025, 16, 349–361, doi:10.3762/bjnano.16.26
- pulses in liquids has been reported [43]. A generation of similar concave edges occurs in twinning. Twinned gold nanoparticles have been found to exhibit enhanced electrocatalytic activity in reductions because of an increased number of undercoordinated surface sites [44]. XPS data corroborate the
- pulsed laser-grafted over conventionally prepared cathodes. Chronoamperometry data, collected at a constant applied potential of −1.3 V vs RHE, showed enhanced stability and mass activity of the pulsed laser-grafted gold nanoparticle–carbon fiber paper composite, compared to an analogous conventionally
- evaluation of the bicarbonate mass activity because larger gold nanoparticles have been found to be inferior reduction catalysts [69], especially gold nanoparticles larger than 10 nm [70]. Hence, we err on the side of underestimating the benefits of pulsed laser grafting for gold nanoparticle–carbon fiber
Fabrication and evaluation of BerNPs regarding the growth and development of Streptococcus mutans
Beilstein J. Nanotechnol. 2025, 16, 308–315, doi:10.3762/bjnano.16.23
- -transform infrared spectroscopy. The broth dilution method was used to determine the antimicrobial activity of the BerNPs against Streptococcus mutans (S. mutans). The impact of the BerNPs on the cell surface of S. mutans was evaluated through FE-SEM analysis, focusing on its ability to inhibit biofilm
- plaque formation associated with caries damage. Therefore, one of the initial steps in preventing dental caries is to reduce and inhibit the activity of S. mutans in the oral cavity [8]. Tooth decay and oral infections are typically controlled with antibiotics. However, the proliferation of drug
- -inflammatory properties [9]. With its antibacterial activity, berberine can accumulate in bacterial cells and bind to single- and double-stranded DNA, causing DNA damage. According to evaluations, berberine has a stronger antibacterial effect against gram-positive bacteria than against gram-negative bacteria
Enhancing mechanical properties of chitosan/PVA electrospun nanofibers: a comprehensive review
Beilstein J. Nanotechnol. 2025, 16, 286–307, doi:10.3762/bjnano.16.22
- improved the antimicrobial activity of the nanofibers against a wide range of bacteria [190]. In tissue engineering applications, aligned fibers are particularly effective as they better mimic the inductive environment, such as that of human tendon stem/progenitor cells, compared to random fibers [191
- unique properties such as biodegradability, biocompatibility, and antibacterial activity, which are considered effective in promoting wound healing. The presence of chemical structures like glycosaminoglycans in chitosan mimics the ECM and provides a hemostatic effect, thereby accelerating the healing
Emerging strategies in the sustainable removal of antibiotics using semiconductor-based photocatalysts
Beilstein J. Nanotechnol. 2025, 16, 264–285, doi:10.3762/bjnano.16.21
- advanced methods, including sol–gel, hydrothermal, solvothermal, precipitation and template-assisted techniques [53]. The synthesis method chosen often depends on factors such as the desired crystal structure, particle size, surface area, and photocatalytic activity required for the specific application
- effective segregation of light-induced charge carriers allows the CB of the second semiconductor and the VB of the first semiconductor to engage in reduction and oxidation processes, thus enhancing the photocatalytic activity. Although type-II heterojunctions can restrict photogenerated charge recombination
- applications where natural light is abundant. Although TiO2 has a high photocatalytic activity under UV light, its practical use is limited because of rapid electron–hole recombination and insufficient visible light absorption [65]. Hence, it is critical to develop effective strategies to enhance TiO2 activity
Preferential enrichment and extraction of laser-synthesized nanoparticles in organic phases
Beilstein J. Nanotechnol. 2025, 16, 254–263, doi:10.3762/bjnano.16.20
- of gold in acetone did not lead to carbon shells, whereas the formation of carbon shells during the LAL of copper in acetone has been reported [35]. This observation was discussed to be linked to the catalytic activity of copper for C–C bond formation [53][54]. Accordingly, a stronger carbon
Radiosensitizing properties of dual-functionalized carbon nanostructures loaded with temozolomide
Beilstein J. Nanotechnol. 2025, 16, 229–251, doi:10.3762/bjnano.16.18
- photodynamic therapy can be obtained [1][2][3][4][5]. It has been shown that CNs have an anti-amyloid aggregation activity, and some of them (i.e., carbon nanotubes (CNTs) and graphene) are able to interface with neurons and neuronal circuits and play an important role in the modulation of neurobiological
- processes, including neuroregeneration, neuronal differentiation, and stimulation of neuronal electrical signalization and brain activity. Thus, they are promising materials for new products regarding tissue engineering and prosthetic neuronal devices [6][7][8]. There is also an evidence that CNs manifest
- enable transport and delivery to brain tumors. Inorganic nanostructures as TMZ carriers have shown several advantages compared to organic ones with respect to physicochemical stability and potency/cytotoxic activity, overcoming their main disadvantages, that is, hydrophobicity/fluidity and toxicity by
Synthesis and the impact of hydroxyapatite nanoparticles on the viability and activity of rhizobacteria
Beilstein J. Nanotechnol. 2025, 16, 216–228, doi:10.3762/bjnano.16.17
- as Fe, Al, and Ca. Thus, soluble phosphate forms that plants can absorb are formed. The organic acids generated by rhizobacteria facilitate the formation of phosphate complexes, producing H2PO4− and the subsequent appearance of clear zones within the medium [35][36]. Nitrogen-fixing activity of
- rhizobacteria-nHA The nitrogen-fixing activity of rhizobacteria after loading onto the nHA carrier was evaluated qualitatively by monitoring the color transition in nitrogen-free bromothymol (NFB) medium from yellow to blue. The results presented in Table 6 and Figure 7 indicate that all rhizobacteria loaded
- rhizobacteria, Pd and Tb rhizobacteria, decreased. nHA utilized as a carrier for rhizobacteria demonstrated good compatibility, as the loaded rhizobacteria retained their phosphate-solubilization activity, evident from the appearance of clear zones. Additionally, the nitrogen-fixing activity was maintained as
Recent advances in photothermal nanomaterials for ophthalmic applications
Beilstein J. Nanotechnol. 2025, 16, 195–215, doi:10.3762/bjnano.16.16
- boundaries of thermal therapy, achieving unparalleled therapeutic effects through their diverse composite structures and demonstrating enormous potential in promoting retinal drug delivery and photoacoustic imaging. This paper provides a comprehensive summary of the structure–activity relationship between
- nanomaterials for treating various ophthalmic diseases, including ocular tumors, glaucoma, cataracts, vitreous opacity, endophthalmitis, and decreased visual acuity. It also summarizes the structure–activity relationships between the photothermal properties of these materials and novel therapeutic mechanisms
- synthesis of AuNPs and served as a surface coating for AuNPs, promoting the coupling of DOX, enhancing anti-tumor activity, and improving the biocompatibility of AuNPs. The significant extinction coefficient of these nanoparticles enhances the contrast in photoacoustic imaging within the tumor region
Clays enhanced with niobium: potential in wastewater treatment and reuse as pigment with antibacterial activity
Beilstein J. Nanotechnol. 2025, 16, 141–154, doi:10.3762/bjnano.16.13
- cereus (ATCC 10876) and Proteus mirabilis (ATCC 35649). The analysis revealed remarkable antibacterial activity against Proteus mirabilis, suggesting a preferential selectivity for Gram-negative bacteria. Keywords: adsorption; bentonite; hybrid pigment; niobium; photocatalysis; water remediation
- characterized through colorimetric analysis (CIEL*a*b*) and UV–vis spectroscopy. Antimicrobial activity test The antimicrobial properties of the BEPh, BEOx, A-BEPh, A-BEOx, A-BEPhP, and A-BEOxP samples were investigated against the bacteria Bacillus cereus (ATCC 10876) (Gram-positive) and Proteus mirabilis
- of the TTC dye (0.125% w/v - 2,3,5-triphenyltetrazolium chloride 0.125%) (NEON®) was added to all wells, and the plate was kept in an oven for an additional two hours. The antibacterial activity was determined by MIC, observing the presence/absence of viable bacteria due to the reaction of the TTC
Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy
Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10
- characteristics [13][14]. This dynamic and complex spectrum of macrophage activity features nuanced challenges and opportunities in leveraging macrophage responses to enhance the therapeutic potential of NCs. Recent research has highlighted the dual role of macrophages in the context of nanomedicine. While their
- tissue damage and chronic inflammation. This prolonged M1 activity is a hallmark of diseases like rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). The activation of M1 macrophages is primarily mediated by the nuclear factor-κB (NF-κB), which is triggered by microbial ligands binding to
- immunity and enhancing cancer immunotherapy outcomes. Additionally, natural compounds such as berberine and quercetin can modulate macrophage polarization by inhibiting M1 pathways or promoting M2 activity, highlighting the therapeutic potential of targeting macrophage states in inflammatory and
Characterization of ZnO nanoparticles synthesized using probiotic Lactiplantibacillus plantarum GP258
Beilstein J. Nanotechnol. 2025, 16, 78–89, doi:10.3762/bjnano.16.8
- potential of −60 mV. Furthermore, the synthesized nanoparticles displayed significant antibacterial activity against selected human pathogens, with the biggest inhibition zone observed against Staphylococcus aureus (22 ± 0.57 mm) and the smallest inhibition zone observed against Salmonella enterica serovar
- . When ingested in sufficient quantities, they provide health advantages as they colonize the gut, and their metabolites generally show antimicrobial and health promotion activity to the host [6][7][8]. The thick peptidoglycan layers with crosslinks and the complex cell wall structures of Gram-positive
- semiconductors. Also, ZnO NPs exhibit antimicrobial activity, targeted drug delivery, catalytic activity, and antidiabetic, larvicidal, acaricidal and anticancer activity in addition to their usage in different medical devices and pharmaceuticals [11][12][13]. We report the ecologically safe production of ZnO
Instance maps as an organising concept for complex experimental workflows as demonstrated for (nano)material safety research
Beilstein J. Nanotechnol. 2025, 16, 57–77, doi:10.3762/bjnano.16.7
A nanocarrier containing carboxylic and histamine groups with dual action: acetylcholine hydrolysis and antidote atropine delivery
Beilstein J. Nanotechnol. 2025, 16, 11–24, doi:10.3762/bjnano.16.2
- of acetylcholine lead to serious disturbances in the functioning of the nervous system, including death. The need for rapid administration of an antidote to restore esterase activity is critical, but practical implementation of this is often difficult. One promising solution may be the development of
- CA-RA were 0.57 mM and 0.48 mM for WI38 and Chang liver, respectively. For these cell lines, p(Hist-CA) had an IC50 higher than 1.4 mg/mL (Table 2). The agglutination activity results are shown in Figure 3. Control plate wells with erythrocytes in saline exhibited a dense layer at the bottom
- was approved by the ethical committee of the FRC Kazan Scientific Center of RAS according to Russian national ethical guidelines (protocol No. 9–2013). No organs/tissues were procured from prisoners. Hemolysis of human red blood cells The hemolytic activity of Hist-RA, CA-RA, and p(Hist-CA) were
Mechanistic insights into endosomal escape by sodium oleate-modified liposomes
Beilstein J. Nanotechnol. 2024, 15, 1667–1685, doi:10.3762/bjnano.15.131
- cell viability assay To evaluate the cytotoxicity of the liposomal formulations, we employe the resazurin-based cell viability assay, a method widely employed and deemed reliable for assessing cell metabolic activity, which serves as an indicator of cell viability. The process involves the
Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications
Beilstein J. Nanotechnol. 2024, 15, 1619–1626, doi:10.3762/bjnano.15.127
- application of organic and inorganic compounds with activity against various diseases [10][11][12]. Faced with a physiological stimulus, the carrier decouples from the transported product and releases it at a specific interaction site (Figure 1-1). However, some challenges are encountered by these compounds
- (Figure 1-2C), which mask the nanocarriers and enhance biological activity (Figure 1-2D) [20]. This mimetic surface helps the device to mask epitopes potentially recognized by the immune system, thereby enhancing their biocompatibility. Additionally, the selectivity for targets and the circulation time of
- activity of polylactic glycolic acid (PLGA) nanoparticles coated with membranes, Zhang et al. (2021) tested nanoparticles loaded with gambogic acid and coated with red-blood-cell-derived membranes in colorectal cancer cells. They demonstrated a reduction in phagocytosis, increasing the circulation time of
Natural nanofibers embedded in the seed mucilage envelope: composite hydrogels with specific adhesive and frictional properties
Beilstein J. Nanotechnol. 2024, 15, 1603–1618, doi:10.3762/bjnano.15.126
- friction better fulfil their biological role than mucilaginous seeds with just low friction, which was demonstrated in our experiment with pigeons (see below). Friction after chemical and thermal treatments The antimicrobial activity of seed mucilage was previously described for Linum usitatissimum [105
- as food, agriculture, and medicine [20][114][115]. Diverse other substances and systems with antimicrobial activity (antibiotics, essential oils, phenolics, and metal nanoparticles) can be incorporated into the mucilage hydrogels, which after some additional modifications can be used for the
Liver-targeting iron oxide nanoparticles and their complexes with plant extracts for biocompatibility
Beilstein J. Nanotechnol. 2024, 15, 1593–1602, doi:10.3762/bjnano.15.125
- , unlike their complexes. All agents exert a hypolipidemic effect by lowering LDL, despite maintaining the synthetic functions of the liver. Fe3O4 NPs increase the activity of GPO, which is associated with their peroxidase-like properties. A multifaceted and diverse mechanism of action of all studied
- evaluation of hepatotoxicity based on alanine aminotransferase (ALT) activity values revealed no direct hepatotoxicity from the agents tested in groups I (3.54 ± 0.7 U/L), II (7.07 ± 0.7 U/L), V (3.54 ± 0.7 U/L), and VI (3.54 ± 0.7 U/L) compared to the control (for details on the compounds administered to
- each group, see Experimental section, “Animal experiment model”). However, co-administration of T. polium extract and Fe3O4 NPs (group III), as well as of rutin and Fe3O4 NPs (group IV), resulted in increased ALT activity relative to normal values (up to 10.6 ± 0.7 U/L) by 2.1 and 3.3 times
Facile synthesis of size-tunable L-carnosine-capped silver nanoparticles and their role in metal ion sensing and catalytic degradation of p-nitrophenol
Beilstein J. Nanotechnol. 2024, 15, 1576–1592, doi:10.3762/bjnano.15.124
- (2.8 μM) for As3+, and 245.49 ppb (4.7 μM) for Cr3+. Additionally, these nanoparticles demonstrated catalytic activity regarding the degradation of p-nitrophenol (P-NP), achieving complete degradation of 0.25 and 1 mM solutions within 5 and 10 min, respectively. This study reveals the potential of ʟ
- conductivity, and potent catalytic activity, make them ideal candidates for environmental monitoring and remediation [3]. Modifying silver nanoparticles with various biological molecules, peptides, proteins, and enzymes has further enhanced their functionality, stability, and selectivity towards specific
- through surface chemistry and other parameters such as size and shape [13]. Kästner and Thünemann described the catalytic degradation of P-NP using silver nanoparticles with the activity depending on the capping agents [14]. To design a dual-functional system for environmental applications, a potential
Green synthesis of silver nanoparticles derived from algae and their larvicidal properties to control Aedes aegypti
Beilstein J. Nanotechnol. 2024, 15, 1566–1575, doi:10.3762/bjnano.15.123
- as phenols, ascorbic acid, flavonoids, polyphenolics, alkaloids, and terpenes, which could act as reducing agents [21]. This review focuses on AgNPs produced in a green and sustainable way through the use of natural products as reducing agents, namely seaweed extracts. The activity of AgNPs upon A
- . These compounds act by reducing Ag+ ions to Ag0 and stabilize nanoparticles by capping [58] (Figure 2). Larvicidal activity of AgNPs against Aedes aegypti Aedes aegypti, also known as the dengue mosquito, is a vector of important arboviruses, including Dengue, Zika, Chikungunya and Yellow Fever [6][59
- lead to oxidation and degradation of enzymes and organelles in the intracellular space of cells, affecting cellular physiological processes, leading to large-scale apoptosis and, consequently, larval death. Vinoth, et al. [51] evaluated the larvicidal activity of AgNPs from S. polycystum seaweed
Ultrablack color in velvet ant cuticle
Beilstein J. Nanotechnol. 2024, 15, 1554–1565, doi:10.3762/bjnano.15.122
- occurs in forested habitats adjoining open landscapes. Demonstrating remarkable mobility, it covers significant distances in pursuit of hosts on the ground. While sightings may occur throughout the day, peak activity typically coincides with the early morning and late afternoon, during periods of subdued
- defenses against predators. Given their characteristics and life habits, such as diurnal activity, striking colors, and inability to fly, it is expected that they would be frequent targets for predators. However, there is limited observational and experimental evidence documenting interactions between
The round-robin approach applied to nanoinformatics: consensus prediction of nanomaterials zeta potential
Beilstein J. Nanotechnol. 2024, 15, 1536–1553, doi:10.3762/bjnano.15.121
- a broad range of computational and data-driven methodologies for the exposure, hazard, and risk assessment of NMs, such as quantitative structure–activity relationship models adapted to the specificities of NMs (nanoQSAR) and grouping/read-across models, specifically developed to accurately predict
- [48]. Both the QSPR and read-across approaches are extensively used for data gap filling (predicting activity/property/toxicity values of compounds devoid of experimentally derived endpoint values). Recently, Luechtefeld et al. [49] introduced the concept of classification-based read-across structure
- –activity relationship (RASAR) by combining the concepts of read-across and QSAR using ML algorithms. Banerjee and Roy [50] merged chemical read-across and regression-based QSAR into quantitative RASAR (q-RASAR). Several ML models can be applied including partial least squares (PLS), linear support vector
Electrochemical nanostructured CuBTC/FeBTC MOF composite sensor for enrofloxacin detection
Beilstein J. Nanotechnol. 2024, 15, 1522–1535, doi:10.3762/bjnano.15.120
- extensively used in livestock and aquaculture as an antibacterial agent, showing high activity against both Gram-negative and Gram-positive bacteria [1][2]. ENR, like other fluoroquinolones, is used to treat susceptible bacteria responsible for infections of the skin and soft tissue. The overuse of ENR causes
- peak position shifted to more negative values compared to the CPE. This phenomenon highlights the significantly enhanced catalytic activity of the modified electrode. Additionally, the (Cu)(Fe)BTC@CPE electrode exhibited a significantly sharper, more symmetric, and higher peak than both the CuBTC@CPE
- and FeBTC@CPE electrodes. These observations support the conclusion regarding the synergistic effects of the catalytic activity of CuBTC and the good conductivity of FeBTC, which together contribute to the enhanced performance of the electrode. Effect of MOF content on the enrofloxacin signal The
Integrating high-performance computing, machine learning, data management workflows, and infrastructures for multiscale simulations and nanomaterials technologies
Beilstein J. Nanotechnol. 2024, 15, 1498–1521, doi:10.3762/bjnano.15.119
Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects
Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118
- physiological conditions, such as varying pH levels, temperature, and enzymatic activity. Degradation reduces the effective concentration of the phytochemical, diminishing its therapeutic potential [28][29]. Rapid metabolism and clearance further complicate phytochemical delivery. Phytochemicals are often
- PLHNPs can also involve the incorporation of stimuli-responsive moieties onto the nanoparticle surface. These moieties enable the nanoparticles to respond to specific stimuli, such as pH changes, temperature shifts, or enzyme activity, thereby triggering controlled drug release at the target site [70][71
- short half-life. Additionally, CUR is photosensitive and has limited chemical stability during manufacturing and storage [80][81]. To overcome these limitations, Kumar et al. developed CUR-encapsulated PLHNPs and evaluated their anticancer activity against MCF-7 cells [82]. The developed CUR-PLHNPs
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