Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine

• Zoran M. Marković,
• Milica D. Budimir,
• Martin Danko,
• Dušan D. Milivojević,
• Pavel Kubat,
• Danica Z. Zmejkoski,
• Vladimir B. Pavlović,
• Marija M. Mojsin,
• Milena J. Stevanović and
• Biljana M. Todorović Marković

Beilstein J. Nanotechnol. 2023, 14, 165–174, doi:10.3762/bjnano.14.17

• commercially available antibiotics. The main parameters that determine the antibacterial action of CQDs are generation of reactive oxygen species, cytoplasm leakage due to DNA binding, and gene expression modulation [28]. In addition, the CQD surface charge affects very much the antibacterial activity of CQDs

Antimicrobial and mechanical properties of functionalized textile by nanoarchitectured photoinduced Ag@polymer coating

• Jessica Plé,
• Marine Dabert,
• Helene Lecoq,
• Sophie Hellé,
• Lydie Ploux and
• Lavinia Balan

Beilstein J. Nanotechnol. 2023, 14, 95–109, doi:10.3762/bjnano.14.11

• , metal-based nanoparticles (MNPs) are of particular interest for such applications as they exhibit impressive antibacterial and antifungal properties. Unlike antibiotics for example, that target cell wall synthesis, translational machinery and DNA replication inside bacteria cells [7], MNPs simply attack

Photoelectrochemical water oxidation over TiO₂ nanotubes modified with MoS₂ and g-C₃N₄

• Phuong Hoang Nguyen,
• Thi Minh Cao,
• Tho Truong Nguyen,
• Hien Duy Tong and
• Viet Van Pham

Beilstein J. Nanotechnol. 2022, 13, 1541–1550, doi:10.3762/bjnano.13.127

• could replace noble metals are a research interest. Photocatalytic technology uses semiconductors for effective approaches to the degradation of dyes and antibiotics, the removal of pollutant gases, and water splitting to produce hydrogen using solar energy [12][13][14][15][16][17]. Among such

Hydroxyapatite–bioglass nanocomposites: Structural, mechanical, and biological aspects

• Olga Shikimaka,
• Mihaela Bivol,
• Bogdan A. Sava,
• Marius Dumitru,
• Christu Tardei,
• Beatrice G. Sbarcea,
• Daria Grabco,
• Constantin Pyrtsac,
• Daria Topal,
• Andrian Prisacaru,
• Vitalie Cobzac and
• Viorel Nacu

Beilstein J. Nanotechnol. 2022, 13, 1490–1504, doi:10.3762/bjnano.13.123

• medium with 10% FBS and antibiotics/antimycotics in 75 cm2 flasks until 70–80% confluence. The samples for the MTT tests were prepared in the form of discs of 3 mm diameter and 0.7 mm thickness. Before testing, the samples were sterilized in 70% alcohol for two hours and washed twice with HBSS (HiMedia

Supramolecular assembly of pentamidine and polymeric cyclodextrin bimetallic core–shell nanoarchitectures

• Alexandru-Milentie Hada,
• Nina Burduja,
• Marco Abbate,
• Claudio Stagno,
• Guy Caljon,
• Louis Maes,
• Nicola Micale,
• Massimiliano Cordaro,
• Angela Scala,
• Antonino Mazzaglia and
• Anna Piperno

Beilstein J. Nanotechnol. 2022, 13, 1361–1369, doi:10.3762/bjnano.13.112

• against bacteria, protozoa, and viruses [7][8][9][10]. They have been proposed to complement traditional antimicrobials, either to increase their potency or broaden their activity spectrum. Furthermore, their combination with classical antibiotics is considered a promising strategy to combat the ongoing

Recent trends in Bi-based nanomaterials: challenges, fabrication, enhancement techniques, and environmental applications

• Vishal Dutta,
• Ankush Chauhan,
• Ritesh Verma,
• C. Gopalkrishnan and
• Van-Huy Nguyen

Beilstein J. Nanotechnol. 2022, 13, 1316–1336, doi:10.3762/bjnano.13.109

• from bismuth oxyiodides at different temperatures (Figure 3a). The photoabsorption wavelength of these bismuth oxyiodides has been tuned between 400 and 700 nm. Also, these compounds have a distinctive microstructure and a controllable band structure. (Figure 3b). The breakdown of antibiotics and

Studies of probe tip materials by atomic force microscopy: a review

• Ke Xu and
• Yuzhe Liu

Beilstein J. Nanotechnol. 2022, 13, 1256–1267, doi:10.3762/bjnano.13.104

• to the reaction system. Therefore, the method is suitable for the field detection of antibiotics in liquid foods. More importantly, the proposed homogeneity method has been successfully applied to actual milk samples. This novel homogeneity method with high sensitivity and selectivity is a powerful

Microneedle-based ocular drug delivery systems – recent advances and challenges

• Piotr Gadziński,
• Anna Froelich,
• Monika Wojtyłko,
• Antoni Białek,
• Julia Krysztofiak and
• Tomasz Osmałek

Beilstein J. Nanotechnol. 2022, 13, 1167–1184, doi:10.3762/bjnano.13.98

• successfully applied to the cornea or sclera [103]. Microneedles in skin administration have been studied for many years, including delivery of various therapeutic agents. These included antibiotics [104][105] or antifungals [106] for the treatment of local skin infections but also other drugs intended to

Recent advances in green carbon dots (2015–2022): synthesis, metal ion sensing, and biological applications

• Aisha Kanwal,
• Naheed Bibi,
• Sajjad Hyder,
• Arif Muhammad,
• Hao Ren,
• Jiangtao Liu and
• Zhongli Lei

Beilstein J. Nanotechnol. 2022, 13, 1068–1107, doi:10.3762/bjnano.13.93

Spindle-like MIL101(Fe) decorated with Bi₂O₃ nanoparticles for enhanced degradation of chlortetracycline under visible-light irradiation

• Chen-chen Hao,
• Fang-yan Chen,
• Kun Bian,
• Yu-bin Tang and
• Wei-long Shi

Beilstein J. Nanotechnol. 2022, 13, 1038–1050, doi:10.3762/bjnano.13.91

• traditional measures were difficult to be popularized. Photocatalysis is considered as an alternative and promising strategy for degradation and mineralization of antibiotics due to its low cost, high efficiency, mild reaction condition, and no secondary pollution [9][10][11]. A variety of semiconductors have

Bioselectivity of silk protein-based materials and their bio-inspired applications

• Hendrik Bargel,
• Vanessa T. Trossmann,
• Christoph Sommer and
• Thomas Scheibel

Beilstein J. Nanotechnol. 2022, 13, 902–921, doi:10.3762/bjnano.13.81

• . Engineering biomaterials that stimulate and interact with cell receptors to support binding and subsequent physiological responses of multicellular systems attracted much interest in the last years. Further to this, the increasing threat of multidrug resistance of pathogens against antibiotics to human health

• biomaterials and medical devices with antifouling and antibacterial properties, but with reduced susceptibility to enzymatic degradation [85]. General advantages of AMPs/HDPs and mimicking polymer systems over antibiotics as a new generation of antimicrobial agents are their functional diversity, broad

• biggest threats to human health worldwide is the rapid emergence of multidrug-resistant pathogens, due to the overuse of broad-spectrum antibiotics [100]. The rising rates of antimicrobial and antiviral resistance of infectious bacteria, viruses, and fungi and their related diseases impact all aspects of

Solar-light-driven LaFe_xNi_1−xO₃ perovskite oxides for photocatalytic Fenton-like reaction to degrade organic pollutants

• Chao-Wei Huang,
• Shu-Yu Hsu,
• Jun-Han Lin,
• Yun Jhou,
• Wei-Yu Chen,
• Kun-Yi Andrew Lin,
• Yu-Tang Lin and
• Van-Huy Nguyen

Beilstein J. Nanotechnol. 2022, 13, 882–895, doi:10.3762/bjnano.13.79

• industry often contains biological drugs, such as antibiotics and pesticides. These drug residues in various industries would enter the drinking water source. It threatens human health and makes bacteria and viruses resistant to drugs, significantly impacting the environment [5]. Notably, wastewater

• [7]. On the other hand, pharmaceuticals' personal care products (PPCPs) are also sources of organic pollutants in wastewaters. PPCPs cover prescription drugs, nutritious foods, and personal health products that may cause environmental impacts. Among the medicines, tetracycline is antibiotics, which

• husbandry industry is relatively developed nowadays, leading to the wide use of antibiotics and drugs. However, most of these substances are eventually released into rivers or oceans, considerably impacting the domestic water and aquatic environments [9]. Several methods deal with wastewater with organic

Gelatin nanoparticles with tunable mechanical properties: effect of crosslinking time and loading

• Agnes-Valencia Weiss,
• Daniel Schorr,
• Julia K. Metz,
• Metin Yildirim,
• Saeed Ahmad Khan and
• Marc Schneider

Beilstein J. Nanotechnol. 2022, 13, 778–787, doi:10.3762/bjnano.13.68

• % fetal bovine serum (South American origin, PAN-Biotech, Aidenbach, Germany) and 1% v/v antibiotics (penicillin (10.000 U/mL)/streptomycin (10.000 µg/mL), Gibco™, Fisher Scientific, Waltham, MA, USA). The human alveolar epithelial lentivirus immobilized cell line hAELVi [21], was obtained from InSCREENeX

• GmbH (Braunschweig, Germany) and cultured in SAGM™ (Small Airway Epithelial Cell Growth Medium BulletKit™, Lonza, Basel, Switzerland) supplemented with 1% v/v fetal calf serum (South American origin, Superior; Biochrom, Berlin, Germany) and 1% v/v antibiotics (penicillin (10.000 U/mL)/streptomycin

Ciprofloxacin-loaded dissolving polymeric microneedles as a potential therapeutic for the treatment of S. aureus skin infections

• Sharif Abdelghany,
• Walhan Alshaer,
• Yazan Al Thaher,
• Maram Al Fawares,
• Amal G. Al-Bakri,
• Saja Zuriekat and
• Randa SH. Mansour

Beilstein J. Nanotechnol. 2022, 13, 517–527, doi:10.3762/bjnano.13.43

• was demonstrated. This can be of great benefit for the painless topical/transdermal delivery of antibiotics, overcoming the barrier properties of the skin. Microneedle fabrication using the two-layer centrifugation method. PVA/PVP or PVA gel with ciprofloxacin is stirred at 70 °C and poured on 14 × 14

Effects of drug concentration and PLGA addition on the properties of electrospun ampicillin trihydrate-loaded PLA nanofibers

• Tuğba Eren Böncü and
• Nurten Ozdemir

Beilstein J. Nanotechnol. 2022, 13, 245–254, doi:10.3762/bjnano.13.19

• biodegradable, biocompatible, non-toxic, and provide high mechanical strength [1][8]. In this study, ampicillin trihydrate, FDA-approved β-lactam antibiotics, a broad-spectrum semi-synthetic derivative of aminopenicillin, was used. Ampicillin trihydrate acts by inhibiting the synthesis of peptidoglycan, a

• mechanical properties are examined. The study will also contribute to the production of implantable systems of ampicillin trihydrate, a hydrophobic antibiotic, with a controlled release. Thus, it will allow improvement in treatment efficiency with lower doses of antibiotics, reduce systemic side effects

Engineered titania nanomaterials in advanced clinical applications

• Padmavati Sahare,
• Paulina Govea Alvarez,
• Juan Manual Sanchez Yanez,
• Gabriel Luna-Bárcenas,
• Samik Chakraborty,
• Sujay Paul and
• Miriam Estevez

Beilstein J. Nanotechnol. 2022, 13, 201–218, doi:10.3762/bjnano.13.15

• with antibiotics is widespread. Antibiotics are proven to be highly efficient, but their uncontrolled use has led to the emergence of antibiotic-resistant species that do not respond to any existing drug. Even though new classes of antibiotics are constantly being developed, resistance to any class of

• antibiotics has been observed, and multiple mechanisms of resistance to each type of antimicrobial agent have been discovered. Hence, to counter drug resistance, efficient bactericidal materials are needed, and nps have been identified as a promising solution for the abovementioned issue [75]. TiO2 is

• administration, certain drugs may show an effective concentration in the bloodstream. Yet, the concentration may suddenly fall below the effective dose obstructing effective treatment. Another shortcoming of oral drug administration is the inactivation of the medicine (antibiotics, enzymes, drugs, and other

Bacterial safety study of the production process of hemoglobin-based oxygen carriers

• Axel Steffen,
• Yu Xiong,
• Radostina Georgieva,
• Ulrich Kalus and
• Hans Bäumler

Beilstein J. Nanotechnol. 2022, 13, 114–126, doi:10.3762/bjnano.13.8

• . Especially the chelation of Mg2+ results in a destabilization of the negative charges of the outer membrane of Gram-negative bacteria [45]. The cells thus become permeable. This effect can be exploited to make the cells more receptive to antibiotics, biocides, or other substances [28][52]. Depending on the

pH-driven enhancement of anti-tubercular drug loading on iron oxide nanoparticles for drug delivery in macrophages

• Karishma Berta Cotta,
• Sarika Mehra and
• Rajdip Bandyopadhyaya

Beilstein J. Nanotechnol. 2021, 12, 1127–1139, doi:10.3762/bjnano.12.84

• release, too [15]. Fluoroquinolones, a class of broad-spectrum DNA gyrase inhibiting antibiotics, are used as therapeutics for many intracellular pathogens [16][17][18][19][20]. Recently, they have been explored for their activity as an anti-TB drug [16][17]. Currently, they are used as second-line anti

• antibiotics of this class, like ciprofloxacin and moxifloxacin. The quantification of the intra-macrophage accumulation of NOR shows that, cellular uptake is greatly facilitated by drug coated systems too, compared to free drug. Although both drug-coated nanoparticle systems enhance the drug uptake, due to

• , zwitterionic drugs can serve as both stabilizing agents and antibiotics, for drug delivery via iron oxide nanoparticles. Additionally, a mere adjustment of the drug coating pH to 5, can greatly enhance drug loading and achieve slower drug release, too. Interestingly, however, irrespective of the drug coating

Silver nanoparticles nucleated in NaOH-treated halloysite: a potential antimicrobial material

• Yuri B. Matos,
• Rodrigo S. Romanus,
• Mattheus Torquato,
• Edgar H. de Souza,
• Rodrigo L. Villanova,
• Marlene Soares and
• Emilson R. Viana

Beilstein J. Nanotechnol. 2021, 12, 798–807, doi:10.3762/bjnano.12.63

• the emergence of antibiotics, but some bacterial diseases are still amongst the most dangerous to human life. In addition, as antibiotics become more popular, bacteria are evolving to become resistant, a phenomenon known as “antimicrobial resistance” and listed by the World Health Organization as one

• strongly inhibit the growth of common microorganisms and that they may be used as an alternative way to overcome bacterial resistance to antibiotics [10][11]. This is due to a combination of antimicrobial mechanisms including the generation of reactive oxygen species (ROS) and the diffusion of silver ions

A review on nanostructured silver as a basic ingredient in medicine: physicochemical parameters and characterization

• Gabriel M. Misirli,
• Kishore Sridharan and
• Shirley M. P. Abrantes

Beilstein J. Nanotechnol. 2021, 12, 440–461, doi:10.3762/bjnano.12.36

• antibiotics is dramatically increasing and the World Health Organization (WHO) has marked this concern as one of the greatest threats to health [18]. It is known that viruses are a major cause of illness and death in the world. However, even after much effort, vaccines could not be developed against some

• viral pathogens, such as the human immunodeficiency virus (HIV), due their high genetic variability which changes rapidly. Viruses have the fascinating ability to adapt to their host, move to a new host, and escape antiviral measures, and similarly, bacteria can also become resistant to antibiotics [19

• in the manufacture of medical devices to prevent adhesion, colonization, and formation of microbial biofilms on the surfaces of these devices. Moreover, the history of AgNPs as a broad spectrum microbicidal agent places it as a viable candidate to be one of the basic ingredients of antibiotics to be

Differences in surface chemistry of iron oxide nanoparticles result in different routes of internalization

• Barbora Svitkova,
• Vlasta Zavisova,
• Veronika Nemethova,
• Martina Koneracka,
• Miroslava Kretova,
• Filip Razga,
• Monika Ursinyova and
• Alena Gabelova

Beilstein J. Nanotechnol. 2021, 12, 270–281, doi:10.3762/bjnano.12.22

• maintained in Dulbecco’s Modified Eagle’s Medium (DMEM) supplemented with 10% fetal bovine serum (FBS) and antibiotics (penicillin, 100 U/mL; streptomycin and kanamycin, 100 µg/mL). Cells seeded at a density of 2 × 103 cm−2 to 1 × 104 cm−2, were cultured in a humidified atmosphere of 5% CO2 at 37 °C. In all

The nanomorphology of cell surfaces of adhered osteoblasts

• Christian Voelkner,
• Mirco Wendt,
• Regina Lange,
• Max Ulbrich,
• Martina Gruening,
• Susanne Staehlke,
• Barbara Nebe,
• Ingo Barke and
• Sylvia Speller

Beilstein J. Nanotechnol. 2021, 12, 242–256, doi:10.3762/bjnano.12.20

• , Merck, Darmstadt, Germany) and 1% antibiotics (gentamicin, Ratiopharm, Ulm, Germany) in a humidified atmosphere at 37 °C with 5% CO2. The differently coated borosilicate glass slides (22 mm × 22 mm) were cleaned with ethanol. Cells were seeded with a density of 4000/cm2 and cultured for 24 h. This

A review on the green and sustainable synthesis of silver nanoparticles and one-dimensional silver nanostructures

• Sina Kaabipour and
• Shohreh Hemmati

Beilstein J. Nanotechnol. 2021, 12, 102–136, doi:10.3762/bjnano.12.9

• , antimicrobial AgNPs can potentially act as alternatives for current antibiotics due to increased bacterial resistance [71]. In addition, the development of new generations of antibiotics is costly, which prevents pharmaceutical companies from manufacturing new classes of antibiotics [72][73]. Furthermore, the

Effect of different silica coatings on the toxicity of upconversion nanoparticles on RAW 264.7 macrophage cells

• Cynthia Kembuan,
• Helena Oliveira and
• Christina Graf

Beilstein J. Nanotechnol. 2021, 12, 35–48, doi:10.3762/bjnano.12.3

• %) was purchased from Grüssing. DMEM, FBS, antibiotics, and PBS (pH 7.4) were purchased from Life Technologies (Carlsbad, CA, USA). 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), dimethyl sulfoxide (DMSO), propidium iodide, and RNase were obtained from Sigma-Aldrich (St. Louis, MO

Bio-imaging with the helium-ion microscope: A review

• Matthias Schmidt,
• James M. Byrne and
• Ilari J. Maasilta

Beilstein J. Nanotechnol. 2021, 12, 1–23, doi:10.3762/bjnano.12.1

• attachment of bacterial parasites to the outer membranes of bacteria at high resolution in, at least compared to TEM, a relatively natural state makes HIM a very powerful tool for the investigation of living antibiotics. The work on the life cycle of the bacterial predator Bdellovibrio bacteriovorus by Said

• , they have long been considered as possible treatments for bacterial infections. In particular, because they are host-specific and, therefore, do not exhibit some of the side effects of the more broadly affecting chemical antibiotics, which can lead to evolution of strains with broad antibiotic

• candidates for “living anti-biotics” [87]. While bacteriophages are very host-specific, Bdellovibriones can be considered as broad-spectrum antibiotics, as they can potentially infect all gram-negative bacteria. Considering the 2017 priority list of antibiotic-resistant bacteria published by the World Health