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Search for "antibiotics" in Full Text gives 73 result(s) in Beilstein Journal of Nanotechnology.
Studies of probe tip materials by atomic force microscopy: a review
Beilstein J. Nanotechnol. 2022, 13, 1256–1267, doi:10.3762/bjnano.13.104
- to the reaction system. Therefore, the method is suitable for the field detection of antibiotics in liquid foods. More importantly, the proposed homogeneity method has been successfully applied to actual milk samples. This novel homogeneity method with high sensitivity and selectivity is a powerful
Microneedle-based ocular drug delivery systems – recent advances and challenges
Beilstein J. Nanotechnol. 2022, 13, 1167–1184, doi:10.3762/bjnano.13.98
- successfully applied to the cornea or sclera [103]. Microneedles in skin administration have been studied for many years, including delivery of various therapeutic agents. These included antibiotics [104][105] or antifungals [106] for the treatment of local skin infections but also other drugs intended to
Recent advances in green carbon dots (2015–2022): synthesis, metal ion sensing, and biological applications
Beilstein J. Nanotechnol. 2022, 13, 1068–1107, doi:10.3762/bjnano.13.93
Spindle-like MIL101(Fe) decorated with Bi2O3 nanoparticles for enhanced degradation of chlortetracycline under visible-light irradiation
Beilstein J. Nanotechnol. 2022, 13, 1038–1050, doi:10.3762/bjnano.13.91
- traditional measures were difficult to be popularized. Photocatalysis is considered as an alternative and promising strategy for degradation and mineralization of antibiotics due to its low cost, high efficiency, mild reaction condition, and no secondary pollution [9][10][11]. A variety of semiconductors have
Bioselectivity of silk protein-based materials and their bio-inspired applications
Beilstein J. Nanotechnol. 2022, 13, 902–921, doi:10.3762/bjnano.13.81
- . Engineering biomaterials that stimulate and interact with cell receptors to support binding and subsequent physiological responses of multicellular systems attracted much interest in the last years. Further to this, the increasing threat of multidrug resistance of pathogens against antibiotics to human health
- biomaterials and medical devices with antifouling and antibacterial properties, but with reduced susceptibility to enzymatic degradation [85]. General advantages of AMPs/HDPs and mimicking polymer systems over antibiotics as a new generation of antimicrobial agents are their functional diversity, broad
- biggest threats to human health worldwide is the rapid emergence of multidrug-resistant pathogens, due to the overuse of broad-spectrum antibiotics [100]. The rising rates of antimicrobial and antiviral resistance of infectious bacteria, viruses, and fungi and their related diseases impact all aspects of
Solar-light-driven LaFexNi1−xO3 perovskite oxides for photocatalytic Fenton-like reaction to degrade organic pollutants
Beilstein J. Nanotechnol. 2022, 13, 882–895, doi:10.3762/bjnano.13.79
- industry often contains biological drugs, such as antibiotics and pesticides. These drug residues in various industries would enter the drinking water source. It threatens human health and makes bacteria and viruses resistant to drugs, significantly impacting the environment [5]. Notably, wastewater
- [7]. On the other hand, pharmaceuticals' personal care products (PPCPs) are also sources of organic pollutants in wastewaters. PPCPs cover prescription drugs, nutritious foods, and personal health products that may cause environmental impacts. Among the medicines, tetracycline is antibiotics, which
- husbandry industry is relatively developed nowadays, leading to the wide use of antibiotics and drugs. However, most of these substances are eventually released into rivers or oceans, considerably impacting the domestic water and aquatic environments [9]. Several methods deal with wastewater with organic
Gelatin nanoparticles with tunable mechanical properties: effect of crosslinking time and loading
Beilstein J. Nanotechnol. 2022, 13, 778–787, doi:10.3762/bjnano.13.68
- % fetal bovine serum (South American origin, PAN-Biotech, Aidenbach, Germany) and 1% v/v antibiotics (penicillin (10.000 U/mL)/streptomycin (10.000 µg/mL), Gibco™, Fisher Scientific, Waltham, MA, USA). The human alveolar epithelial lentivirus immobilized cell line hAELVi [21], was obtained from InSCREENeX
- GmbH (Braunschweig, Germany) and cultured in SAGM™ (Small Airway Epithelial Cell Growth Medium BulletKit™, Lonza, Basel, Switzerland) supplemented with 1% v/v fetal calf serum (South American origin, Superior; Biochrom, Berlin, Germany) and 1% v/v antibiotics (penicillin (10.000 U/mL)/streptomycin
Ciprofloxacin-loaded dissolving polymeric microneedles as a potential therapeutic for the treatment of S. aureus skin infections
Beilstein J. Nanotechnol. 2022, 13, 517–527, doi:10.3762/bjnano.13.43
- was demonstrated. This can be of great benefit for the painless topical/transdermal delivery of antibiotics, overcoming the barrier properties of the skin. Microneedle fabrication using the two-layer centrifugation method. PVA/PVP or PVA gel with ciprofloxacin is stirred at 70 °C and poured on 14 × 14
Effects of drug concentration and PLGA addition on the properties of electrospun ampicillin trihydrate-loaded PLA nanofibers
Beilstein J. Nanotechnol. 2022, 13, 245–254, doi:10.3762/bjnano.13.19
- biodegradable, biocompatible, non-toxic, and provide high mechanical strength [1][8]. In this study, ampicillin trihydrate, FDA-approved β-lactam antibiotics, a broad-spectrum semi-synthetic derivative of aminopenicillin, was used. Ampicillin trihydrate acts by inhibiting the synthesis of peptidoglycan, a
- mechanical properties are examined. The study will also contribute to the production of implantable systems of ampicillin trihydrate, a hydrophobic antibiotic, with a controlled release. Thus, it will allow improvement in treatment efficiency with lower doses of antibiotics, reduce systemic side effects
Engineered titania nanomaterials in advanced clinical applications
Beilstein J. Nanotechnol. 2022, 13, 201–218, doi:10.3762/bjnano.13.15
- with antibiotics is widespread. Antibiotics are proven to be highly efficient, but their uncontrolled use has led to the emergence of antibiotic-resistant species that do not respond to any existing drug. Even though new classes of antibiotics are constantly being developed, resistance to any class of
- antibiotics has been observed, and multiple mechanisms of resistance to each type of antimicrobial agent have been discovered. Hence, to counter drug resistance, efficient bactericidal materials are needed, and nps have been identified as a promising solution for the abovementioned issue [75]. TiO2 is
- administration, certain drugs may show an effective concentration in the bloodstream. Yet, the concentration may suddenly fall below the effective dose obstructing effective treatment. Another shortcoming of oral drug administration is the inactivation of the medicine (antibiotics, enzymes, drugs, and other
Bacterial safety study of the production process of hemoglobin-based oxygen carriers
Beilstein J. Nanotechnol. 2022, 13, 114–126, doi:10.3762/bjnano.13.8
- . Especially the chelation of Mg2+ results in a destabilization of the negative charges of the outer membrane of Gram-negative bacteria [45]. The cells thus become permeable. This effect can be exploited to make the cells more receptive to antibiotics, biocides, or other substances [28][52]. Depending on the
pH-driven enhancement of anti-tubercular drug loading on iron oxide nanoparticles for drug delivery in macrophages
Beilstein J. Nanotechnol. 2021, 12, 1127–1139, doi:10.3762/bjnano.12.84
- release, too [15]. Fluoroquinolones, a class of broad-spectrum DNA gyrase inhibiting antibiotics, are used as therapeutics for many intracellular pathogens [16][17][18][19][20]. Recently, they have been explored for their activity as an anti-TB drug [16][17]. Currently, they are used as second-line anti
- antibiotics of this class, like ciprofloxacin and moxifloxacin. The quantification of the intra-macrophage accumulation of NOR shows that, cellular uptake is greatly facilitated by drug coated systems too, compared to free drug. Although both drug-coated nanoparticle systems enhance the drug uptake, due to
- , zwitterionic drugs can serve as both stabilizing agents and antibiotics, for drug delivery via iron oxide nanoparticles. Additionally, a mere adjustment of the drug coating pH to 5, can greatly enhance drug loading and achieve slower drug release, too. Interestingly, however, irrespective of the drug coating
Silver nanoparticles nucleated in NaOH-treated halloysite: a potential antimicrobial material
Beilstein J. Nanotechnol. 2021, 12, 798–807, doi:10.3762/bjnano.12.63
- the emergence of antibiotics, but some bacterial diseases are still amongst the most dangerous to human life. In addition, as antibiotics become more popular, bacteria are evolving to become resistant, a phenomenon known as “antimicrobial resistance” and listed by the World Health Organization as one
- strongly inhibit the growth of common microorganisms and that they may be used as an alternative way to overcome bacterial resistance to antibiotics [10][11]. This is due to a combination of antimicrobial mechanisms including the generation of reactive oxygen species (ROS) and the diffusion of silver ions
A review on nanostructured silver as a basic ingredient in medicine: physicochemical parameters and characterization
Beilstein J. Nanotechnol. 2021, 12, 440–461, doi:10.3762/bjnano.12.36
- antibiotics is dramatically increasing and the World Health Organization (WHO) has marked this concern as one of the greatest threats to health [18]. It is known that viruses are a major cause of illness and death in the world. However, even after much effort, vaccines could not be developed against some
- viral pathogens, such as the human immunodeficiency virus (HIV), due their high genetic variability which changes rapidly. Viruses have the fascinating ability to adapt to their host, move to a new host, and escape antiviral measures, and similarly, bacteria can also become resistant to antibiotics [19
- in the manufacture of medical devices to prevent adhesion, colonization, and formation of microbial biofilms on the surfaces of these devices. Moreover, the history of AgNPs as a broad spectrum microbicidal agent places it as a viable candidate to be one of the basic ingredients of antibiotics to be
Differences in surface chemistry of iron oxide nanoparticles result in different routes of internalization
Beilstein J. Nanotechnol. 2021, 12, 270–281, doi:10.3762/bjnano.12.22
- maintained in Dulbecco’s Modified Eagle’s Medium (DMEM) supplemented with 10% fetal bovine serum (FBS) and antibiotics (penicillin, 100 U/mL; streptomycin and kanamycin, 100 µg/mL). Cells seeded at a density of 2 × 103 cm−2 to 1 × 104 cm−2, were cultured in a humidified atmosphere of 5% CO2 at 37 °C. In all
The nanomorphology of cell surfaces of adhered osteoblasts
Beilstein J. Nanotechnol. 2021, 12, 242–256, doi:10.3762/bjnano.12.20
- , Merck, Darmstadt, Germany) and 1% antibiotics (gentamicin, Ratiopharm, Ulm, Germany) in a humidified atmosphere at 37 °C with 5% CO2. The differently coated borosilicate glass slides (22 mm × 22 mm) were cleaned with ethanol. Cells were seeded with a density of 4000/cm2 and cultured for 24 h. This
A review on the green and sustainable synthesis of silver nanoparticles and one-dimensional silver nanostructures
Beilstein J. Nanotechnol. 2021, 12, 102–136, doi:10.3762/bjnano.12.9
- , antimicrobial AgNPs can potentially act as alternatives for current antibiotics due to increased bacterial resistance [71]. In addition, the development of new generations of antibiotics is costly, which prevents pharmaceutical companies from manufacturing new classes of antibiotics [72][73]. Furthermore, the
Effect of different silica coatings on the toxicity of upconversion nanoparticles on RAW 264.7 macrophage cells
Beilstein J. Nanotechnol. 2021, 12, 35–48, doi:10.3762/bjnano.12.3
- %) was purchased from Grüssing. DMEM, FBS, antibiotics, and PBS (pH 7.4) were purchased from Life Technologies (Carlsbad, CA, USA). 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), dimethyl sulfoxide (DMSO), propidium iodide, and RNase were obtained from Sigma-Aldrich (St. Louis, MO
Bio-imaging with the helium-ion microscope: A review
Beilstein J. Nanotechnol. 2021, 12, 1–23, doi:10.3762/bjnano.12.1
- attachment of bacterial parasites to the outer membranes of bacteria at high resolution in, at least compared to TEM, a relatively natural state makes HIM a very powerful tool for the investigation of living antibiotics. The work on the life cycle of the bacterial predator Bdellovibrio bacteriovorus by Said
- , they have long been considered as possible treatments for bacterial infections. In particular, because they are host-specific and, therefore, do not exhibit some of the side effects of the more broadly affecting chemical antibiotics, which can lead to evolution of strains with broad antibiotic
- candidates for “living anti-biotics” [87]. While bacteriophages are very host-specific, Bdellovibriones can be considered as broad-spectrum antibiotics, as they can potentially infect all gram-negative bacteria. Considering the 2017 priority list of antibiotic-resistant bacteria published by the World Health
Antimicrobial metal-based nanoparticles: a review on their synthesis, types and antimicrobial action
Beilstein J. Nanotechnol. 2020, 11, 1450–1469, doi:10.3762/bjnano.11.129
- attracted research interest [3][4]. Although several solutions have been proposed, microorganism incidence will continue to increase and will remain a complicated challenge to overcome. Due to the reoccurrence of infections, microorganisms have become resistant to antibiotics as a result of inherent genetic
- ]. With the advance of nanotechnology, the number of antibiotic-resistant bacteria has also increased, including strains that are resistant to more than 100 different types of antibiotics [75]. This problem, in addition to the environmental concerns, has inspired many researchers to develop ecologically
- photocatalytic, electrochemical, and catalytic properties. Furthermore, NiO NPs exhibit anti-inflammatory properties, generating interest in the biomedical field to use these NPs as antibiotics or in cancer treatments [116][133]. NiO NPs synthesized from Eucalyptus globulus leaf extract showed excellent
Photothermally active nanoparticles as a promising tool for eliminating bacteria and biofilms
Beilstein J. Nanotechnol. 2020, 11, 1134–1146, doi:10.3762/bjnano.11.98
- aggregates protected by self-generated extracellular polymeric substances [1][4]. Biofilms are resistant to mechanical abrasion and drug treatments, including antibiotics. The detachment of a single bacterial cell or biofilm fragments can result in systemic chronic infections [5]. As a consequence, when a
Gram-scale synthesis of splat-shaped Ag–TiO2 nanocomposites for enhanced antimicrobial properties
Beilstein J. Nanotechnol. 2020, 11, 1119–1125, doi:10.3762/bjnano.11.96
- Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Hangzhou 310018, China 10.3762/bjnano.11.96 Abstract The control over contagious diseases caused by pathogenic organisms has become a serious health issue. The extensive usage of antibiotics has led to the development of
- based on polymers and layer-by-layer coating to prevent pathogenic bacteria. Antibacterial agents, such as antibiotics, quaternary ammonium compounds and metal ions have been widely used. However, the extensive use of antibiotics against some bacteria might increase the bacterial resistance to these
- antibiotics, leading to environmental toxicity and damage of target organs in the human body [1]. Also, these materials rapidly dissolve in the human body creating numerous clinical risks [2][3]. In spite of the desirable antibacterial properties, the traditional quaternary ammonium salts (QASs) and the
A few-layer graphene/chlorin e6 hybrid nanomaterial and its application in photodynamic therapy against Candida albicans
Beilstein J. Nanotechnol. 2020, 11, 1054–1061, doi:10.3762/bjnano.11.90
- Ciencias, Universidad Autónoma de San Luis Potosí, México 10.3762/bjnano.11.90 Abstract The global emergence of multidrug resistance of fungal infections and the decline in the discovery of new antibiotics are increasingly prevalent causes of hospital-acquired infections, among other major challenges in
- the global health care sector. There is an urgent need to develop noninvasive, nontoxic, and new antinosocomial approaches that work more effectively and faster than current antibiotics. In this work, we report on a biocompatible hybrid nanomaterial composed of few-layer graphene and chlorin e6 (FLG
- ]. Among the reasons behind the increase of incidences of fungal infections are the indiscriminate use of antineoplastic and immunosuppressive drugs, the unnecessary use of broad-spectrum antibiotics, the growing application of prosthetic devices, and the increased number of invasive surgeries [2][3]. The
Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery
Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41
Brome mosaic virus-like particles as siRNA nanocarriers for biomedical purposes
Beilstein J. Nanotechnol. 2020, 11, 372–382, doi:10.3762/bjnano.11.28
- ). The medium for MCF-7 cells was also supplemented with recombinant human insulin (0.01 mg/mL; Sigma-Aldrich) and the medium of the RAW-Blue cells with 100 µg/mL of Normocin and 200 µg/mL of Zeocin antibiotics (InvivoGen). Cells were maintained at 37 °C in a humidified incubator with 5% CO2. Virus cell
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