Search results

Search for "biological effects" in Full Text gives 35 result(s) in Beilstein Journal of Nanotechnology.

Interaction of dermatologically relevant nanoparticles with skin cells and skin

  • Annika Vogt,
  • Fiorenza Rancan,
  • Sebastian Ahlberg,
  • Berouz Nazemi,
  • Chun Sik Choe,
  • Maxim E. Darvin,
  • Sabrina Hadam,
  • Ulrike Blume-Peytavi,
  • Kateryna Loza,
  • Jörg Diendorf,
  • Matthias Epple,
  • Christina Graf,
  • Eckart Rühl,
  • Martina C. Meinke and
  • Jürgen Lademann

Beilstein J. Nanotechnol. 2014, 5, 2363–2373, doi:10.3762/bjnano.5.245

Graphical Abstract
  • epidermis is of high relevance. As a result of the special architecture of the skin, levels of interactions include the translocation step across the skin barrier, cellular uptake as well as biological effects. In fact, biological responses to nanoparticle exposure may occur on the cellular level, but also
  • their ability to take up nanomaterial. The choice of the experimental system has a major influence on the generated information and a thorough quality control of the behavior of different particle batches in the experimental models is essential. Nanoparticle-induced biological effects in cells and whole
  • and that cellular particle uptake and biological effects vary with experimental settings and cell type. The combination of technologies and the joint discussion of results enabled us to look at nanoparticle–skin interactions and the biological relevance of our findings from different angles. Over the
PDF
Album
Full Research Paper
Published 08 Dec 2014

Effect of silver nanoparticles on human mesenchymal stem cell differentiation

  • Christina Sengstock,
  • Jörg Diendorf,
  • Matthias Epple,
  • Thomas A. Schildhauer and
  • Manfred Köller

Beilstein J. Nanotechnol. 2014, 5, 2058–2069, doi:10.3762/bjnano.5.214

Graphical Abstract
  • contact with tissues and cells. Despite incorporation of Ag-NP as an antibacterial agent in different products, the toxicological and biological effects of silver in the human body after long-term and low-concentration exposure are not well understood. In the current study, we investigated the effects of
  • healing [8]. In our previous studies on the biological effects of Ag-NP (PVP-coated, 80 nm) on human mesenchymal stem cells (hMSCs), we have shown that cell activation could occur at elevated but non-toxic silver concentrations [9][10]. In addition, we have shown that hMSCs are able to ingest Ag-NP
  • through clathrin-dependent endocytosis and by macropinocytosis and that silver agglomerates were formed in the cytoplasm following the uptake of these nanoparticles [11]. There is a general consensus that dissolved silver ions are responsible for the majority of the biological effects on various cells and
PDF
Album
Full Research Paper
Published 10 Nov 2014

Effects of surface functionalization on the adsorption of human serum albumin onto nanoparticles – a fluorescence correlation spectroscopy study

  • Pauline Maffre,
  • Stefan Brandholt,
  • Karin Nienhaus,
  • Li Shang,
  • Wolfgang J. Parak and
  • G. Ulrich Nienhaus

Beilstein J. Nanotechnol. 2014, 5, 2036–2047, doi:10.3762/bjnano.5.212

Graphical Abstract
  • the bare NP surface [2][18][19][20]. To control the biological effects of NPs (e.g., to accomplish targeted delivery to specific cells or tissues or to inhibit cellular uptake), it is extremely important to understand how the properties of the NP surface can control the structure and dynamics of the
PDF
Album
Full Research Paper
Published 07 Nov 2014

Rapid degradation of zinc oxide nanoparticles by phosphate ions

  • Rudolf Herrmann,
  • F. Javier García-García and
  • Armin Reller

Beilstein J. Nanotechnol. 2014, 5, 2007–2015, doi:10.3762/bjnano.5.209

Graphical Abstract
  • account when assessing the biological effects or the toxicology of zinc oxide nanoparticles. Keywords: degradation; phosphate; silica shell; zinc oxide nanoparticles; zinc phosphate; Introduction Crystalline nanoparticles of the semiconductor zinc oxide (ZnO-NP) show a broad fluorescence band in the
PDF
Album
Full Research Paper
Published 05 Nov 2014

PVP-coated, negatively charged silver nanoparticles: A multi-center study of their physicochemical characteristics, cell culture and in vivo experiments

  • Sebastian Ahlberg,
  • Alexandra Antonopulos,
  • Jörg Diendorf,
  • Ralf Dringen,
  • Matthias Epple,
  • Rebekka Flöck,
  • Wolfgang Goedecke,
  • Christina Graf,
  • Nadine Haberl,
  • Jens Helmlinger,
  • Fabian Herzog,
  • Frederike Heuer,
  • Stephanie Hirn,
  • Christian Johannes,
  • Stefanie Kittler,
  • Manfred Köller,
  • Katrin Korn,
  • Wolfgang G. Kreyling,
  • Fritz Krombach,
  • Jürgen Lademann,
  • Kateryna Loza,
  • Eva M. Luther,
  • Marcelina Malissek,
  • Martina C. Meinke,
  • Daniel Nordmeyer,
  • Anne Pailliart,
  • Jörg Raabe,
  • Fiorenza Rancan,
  • Barbara Rothen-Rutishauser,
  • Eckart Rühl,
  • Carsten Schleh,
  • Andreas Seibel,
  • Christina Sengstock,
  • Lennart Treuel,
  • Annika Vogt,
  • Katrin Weber and
  • Reinhard Zellner

Beilstein J. Nanotechnol. 2014, 5, 1944–1965, doi:10.3762/bjnano.5.205

Graphical Abstract
PDF
Album
Review
Published 03 Nov 2014

Silica nanoparticles are less toxic to human lung cells when deposited at the air–liquid interface compared to conventional submerged exposure

  • Alicja Panas,
  • Andreas Comouth,
  • Harald Saathoff,
  • Thomas Leisner,
  • Marco Al-Rawi,
  • Michael Simon,
  • Gunnar Seemann,
  • Olaf Dössel,
  • Sonja Mülhopt,
  • Hanns-Rudolf Paur,
  • Susanne Fritsch-Decker,
  • Carsten Weiss and
  • Silvia Diabaté

Beilstein J. Nanotechnol. 2014, 5, 1590–1602, doi:10.3762/bjnano.5.171

Graphical Abstract
  • South, Kaiserstraße 12, 76128 Karlsruhe, Germany Institute for Technical Chemistry, Karlsruhe Institute of Technology, Campus North, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany 10.3762/bjnano.5.171 Abstract Background: Investigations on adverse biological effects of
  • generated the aerosol with an atomizer which supplied agglomerates and thus allowed a particle deposition with a three orders of magnitude higher mass and of surface doses on lung cells that induced significant biological effects. The deposited dose was estimated and independently validated by measurements
  • calculated extremes and is given as (52 ± 26) µg·cm−2. Biological effects For the determination of biological effects the Transwell inserts covered with a confluent layer of A549 cells were exposed to filtered and unfiltered aerosol. Exposure to the unfiltered aerosol of Aerosil200 NP and SiO2-50 nm NP
PDF
Album
Supp Info
Full Research Paper
Published 19 Sep 2014

In vitro interaction of colloidal nanoparticles with mammalian cells: What have we learned thus far?

  • Moritz Nazarenus,
  • Qian Zhang,
  • Mahmoud G. Soliman,
  • Pablo del Pino,
  • Beatriz Pelaz,
  • Susana Carregal-Romero,
  • Joanna Rejman,
  • Barbara Rothen-Rutishauser,
  • Martin J. D. Clift,
  • Reinhard Zellner,
  • G. Ulrich Nienhaus,
  • James B. Delehanty,
  • Igor L. Medintz and
  • Wolfgang J. Parak

Beilstein J. Nanotechnol. 2014, 5, 1477–1490, doi:10.3762/bjnano.5.161

Graphical Abstract
  • such as Ag, ZnO, or CdSe is in particular triggered by the highly acidic pH in endo-/lysosomal compartments [156]. In both cases adverse biological effects are typically correlated with the production of reactive oxygen species (ROS) [157][158]. Also membrane damage plays a decisive role. In case of
PDF
Album
Review
Published 09 Sep 2014

The protein corona protects against size- and dose-dependent toxicity of amorphous silica nanoparticles

  • Dominic Docter,
  • Christoph Bantz,
  • Dana Westmeier,
  • Hajo J. Galla,
  • Qiangbin Wang,
  • James C. Kirkpatrick,
  • Peter Nielsen,
  • Michael Maskos and
  • Roland H. Stauber

Beilstein J. Nanotechnol. 2014, 5, 1380–1392, doi:10.3762/bjnano.5.151

Graphical Abstract
  • , the GI tract also contains additional biobarriers, such as mucous matrices and other biomolecules. Thus, future studies need to consider experimentally this layer of additional complexity to resolve the mechanisms and (patho)biological effects of silica nanoparticles in vitro and in vivo. Generally
PDF
Album
Full Research Paper
Published 27 Aug 2014

Nanolesions induced by heavy ions in human tissues: Experimental and theoretical studies

  • Marcus Bleicher,
  • Lucas Burigo,
  • Marco Durante,
  • Maren Herrlitz,
  • Michael Krämer,
  • Igor Mishustin,
  • Iris Müller,
  • Francesco Natale,
  • Igor Pshenichnov,
  • Stefan Schramm,
  • Gisela Taucher-Scholz and
  • Cathrin Wälzlein

Beilstein J. Nanotechnol. 2012, 3, 556–563, doi:10.3762/bjnano.3.64

Graphical Abstract
  • , Max-von-Laue-Str. 1, 60438 Frankfurt am Main, Germany 10.3762/bjnano.3.64 Abstract The biological effects of energetic heavy ions are attracting increasing interest for their applications in cancer therapy and protection against space radiation. The cascade of events leading to cell death or late
  • volume of the detector. The distributions of lineal energy (microdosimetric spectra) are directly related to the biological effects of radiation. The MCHIT model was used to simulate microdosimetry measurements at GSI [6]. In this experiment the microdosimetry yd(y) spectra (see [6] for their definition
PDF
Album
Supp Info
Full Research Paper
Published 25 Jul 2012

Characterization of protein adsorption onto FePt nanoparticles using dual-focus fluorescence correlation spectroscopy

  • Pauline Maffre,
  • Karin Nienhaus,
  • Faheem Amin,
  • Wolfgang J. Parak and
  • G. Ulrich Nienhaus

Beilstein J. Nanotechnol. 2011, 2, 374–383, doi:10.3762/bjnano.2.43

Graphical Abstract
  • issue for various fields including biotechnology (e.g., biosensors, bioanalytics) and biomedical devices (e.g., implants and catheters). To be able to control the biological effects of NPs, such as prevention of uptake or targeted delivery to specific cells or tissues, it is of utmost importance to
PDF
Album
Full Research Paper
Published 12 Jul 2011
Other Beilstein-Institut Open Science Activities