Electrospun one-dimensional nanostructures: a new horizon for gas sensing materials

• Muhammad Imran,
• Nunzio Motta and
• Mahnaz Shafiei

Beilstein J. Nanotechnol. 2018, 9, 2128–2170, doi:10.3762/bjnano.9.202

• reinforced with GO show better mechanical, electrical and thermal properties than the fibers without GO. These graphene-based composite electrospun fibers have been used for biosensor applications [65][68]. Hybrid nanofibers with various morphologies, including mixed nanocomposite, dual-layer, core–shell and

Preparation and morphology-dependent wettability of porous alumina membranes

• Dmitry L. Shimanovich,
• Alla I. Vorobjova,
• Daria I. Tishkevich,
• Alex V. Trukhanov,
• Maxim V. Zdorovets and
• Artem L. Kozlovskiy

Beilstein J. Nanotechnol. 2018, 9, 1423–1436, doi:10.3762/bjnano.9.135

• biotechnological and medical development. Some applications include the separation of organic macromolecules and proteins (bio-filtration), their use in biosensor devices and capsule drug delivery systems, use for coating implants, and as a matrix for the formation of biocompatible tissues [19][20][21][22

The effect of atmospheric doping on pressure-dependent Raman scattering in supported graphene

• Egor A. Kolesov,
• Mikhail S. Tivanov,
• Olga V. Korolik,
• Olesya O. Kapitanova,
• Xiao Fu,
• Hak Dong Cho,
• Tae Won Kang and
• Gennady N Panin

Beilstein J. Nanotechnol. 2018, 9, 704–710, doi:10.3762/bjnano.9.65

• nanoelectronics. The substrates may affect the adsorption of graphene, either enhancing it, an effect very useful for biosensor applications [2], or reducing it, which is desirable when undoped graphene is needed as a device functional element. A natural way for probing the adsorption properties of graphene is to

Laser processing of thin-film multilayer structures: comparison between a 3D thermal model and experimental results

• Babak B. Naghshine and
• Amirkianoosh Kiani

Beilstein J. Nanotechnol. 2017, 8, 1749–1759, doi:10.3762/bjnano.8.176

• the surface for biosensor fabrication is one of the applications that has not been fully explored yet. Modelling this process can be helpful in many ways. For instance, controlling the grain size of the resulting poly-Si layer is vital in the process of fabricating poly-Si TFTs [6][7]. This can be

A biofunctionalizable ink platform composed of catechol-modified chitosan and reduced graphene oxide/platinum nanocomposite

• Peter Sobolewski,
• Agata Goszczyńska,
• Małgorzata Aleksandrzak,
• Karolina Urbaś,
• Joanna Derkowska,
• Agnieszka Bartoszewska,
• Jacek Podolski,
• Ewa Mijowska and
• Mirosława El Fray

Beilstein J. Nanotechnol. 2017, 8, 1508–1514, doi:10.3762/bjnano.8.151

• polymerase chain reaction (PCR) products and low non-specific binding. Our results demonstrate that catechol-modified chitosan/rGO–Pt nanocomposites can be used as inks for piezoelectric printing and facilitate the attachment of biorecognition elements for biosensor applications. Keywords: biosensing

• proteomics, in particular) during the crucial process of diagnosis. Importantly, an ideal biosensor platform needs to not only be sensitive and specific, but also flexible and affordable [1]. The past ten years have seen the growth of several technologies that hold much promise for the field of biosensors

• range of inks, and scalable, as well as cost effective, thanks to reduced material waste and no mask or tooling requirement. Here we present a chitosan–catechol/graphene nanocomposite suitable for use as ink for piezoelectric non-contact printing that can serve as a platform for biosensor development

Selective detection of Mg²⁺ ions via enhanced fluorescence emission using Au–DNA nanocomposites

• Tanushree Basu,
• Khyati Rana,
• Niranjan Das and
• Bonamali Pal

Beilstein J. Nanotechnol. 2017, 8, 762–771, doi:10.3762/bjnano.8.79

• modifications in the plasmonic spectra. The biophysical properties of DNA make it compatible for linkage with metals, which are useful in a variety of applications such as biosensor development. They can also be stabilized with a wide variety of molecules because of the alkyl thiol adsorption phenomena [3

Comparison of four methods for the biofunctionalization of gold nanorods by the introduction of sulfhydryl groups to antibodies

• Xuefeng Wang,
• Zhong Mei,
• Yanyan Wang and
• Liang Tang

Beilstein J. Nanotechnol. 2017, 8, 372–380, doi:10.3762/bjnano.8.39

• immobilization onto the GNR surface, improved the efficacy of functionalized GNRs, and increased the sensitivity in response to target detection as a biosensor. Given that PEG6-CONHNH2 modification requires glycosylated biomolecules, Traut’s reagent and DTT thiolation are recommended as universal applications of

• functional biosensor of nanorods immobilized onto mercaptosilanized glass substrates as described in our previous work [17]. The nanorods were then functionalized by the thiolated antibodies described above. Consistent with the results of our previous work [17], we observed a longitudinal wavelength shift

• onto the GNR surface, improved the efficacy of functionalized GNRs, and increased the sensitivity in response to target detection as a biosensor. Given that PEG6-CONHNH2 modification requires a glycosylated antibody, Traut’s reagent and DTT thiolation are recommended as universal applications of the

A novel electrochemical nanobiosensor for the ultrasensitive and specific detection of femtomolar-level gastric cancer biomarker miRNA-106a

• Maryam Daneshpour,
• Kobra Omidfar and
• Hossein Ghanbarian

Beilstein J. Nanotechnol. 2016, 7, 2023–2036, doi:10.3762/bjnano.7.193

• Maryam Daneshpour Kobra Omidfar Hossein Ghanbarian Biotechnology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran

• poor reproducibility [9]. On the other hand, the technical challenges for the quantitative analysis of miRNA become more complex due to their small size, low abundance, and high sequence similarity. In an effort to resolve the mentioned limitations, biosensor technology was suggested as an alternative

• signal due to the presence of gold NPs. To the best of our knowledge, there is no report on using this kind of nanocomposite for the fabrication of a miRNA biosensor. In addition, we could not find any research on biosensor development for the detection miR-106a or other GC-specific biomarkers. Hence

Numerical investigation of depth profiling capabilities of helium and neon ions in ion microscopy

• Patrick Philipp,
• Lukasz Rzeznik and
• Tom Wirtz

Beilstein J. Nanotechnol. 2016, 7, 1749–1760, doi:10.3762/bjnano.7.168

• transistor-like switches, optical switches, and photodiodes. Cu implanted polycarbonate (PC) has a potential application in strain-sensing technologies and electrical biosensor [3]. Modification of the mechanical properties of the polymer surface has also been studied. N+ implantation in PC leads to a harder

Surface-enhanced infrared absorption studies towards a new optical biosensor

• Lothar Leidner,
• Julia Stäb,
• Jennifer T. Adam and
• Günter Gauglitz

Beilstein J. Nanotechnol. 2016, 7, 1736–1742, doi:10.3762/bjnano.7.166

• updated in [4]. Besides sensitivity, stability, and reversibility, selectivity is a vital requirement of a biosensor, which is the main issue of direct optical method: it is not selective as a matter of principle. Optical sensors monitor the interaction of electromagnetic radiation with matter. In many

• . Identification of the analyte type was obtained from the mid-infrared part of the spectrum [7]. Using fingerprint spectra extracted from biosensor signals for the identification of analytes is therefore promising. However, in many cases the absorption signal is weak. A sensor whose sensing volume is based on the

Graphene-enhanced plasmonic nanohole arrays for environmental sensing in aqueous samples

• Christa Genslein,
• Peter Hausler,
• Eva-Maria Kirchner,
• Rudolf Bierl,
• Antje J. Baeumner and
• Thomas Hirsch

Beilstein J. Nanotechnol. 2016, 7, 1564–1573, doi:10.3762/bjnano.7.150

• reproducibility it has been applied for biosensor development and theoretical studies. With high fabrication costs and long milling times it is not adaptable to large volume manufacturing [24][25][26]. Standard lithography techniques can instead be used such as soft embossing. An imprinting mask is prepared by e

Large-scale fabrication of achiral plasmonic metamaterials with giant chiroptical response

• Morten Slyngborg,
• Yao-Chung Tsao and
• Peter Fojan

Beilstein J. Nanotechnol. 2016, 7, 914–925, doi:10.3762/bjnano.7.83

• angle. In biosensor applications this allows for more precise, cheap and commercialized devices. As a proof of concept two different molecules were used to probe the sensitivity of the metamaterials. These proved the applicability to sense proteins through non-specific adsorption on the metamaterial

• CD response at = 0° has also been observed by ECMs produced with focused ion beam milling [13]. The ECM property that allows for the measurement of the enantiomeric structures from one sample, yields several advantages over PCMs in biosensor applications: 1) PCMs require fabrication of the two

• experiments are troublesome to interpret. All of these disadvantages with PCMs are totally avoided by the use of ECMs, which are both cheaper, more reliable and only require one experiment in biosensor applications. Probing the zero-response angle The zero-response angle of the ECM with 450 nm interpore

Novel roles for well-known players: from tobacco mosaic virus pests to enzymatically active assemblies

• Claudia Koch,
• Fabian J. Eber,
• Carlos Azucena,
• Alexander Förste,
• Stefan Walheim,
• Thomas Schimmel,
• Alexander M. Bittner,
• Holger Jeske,
• Hartmut Gliemann,
• Sabine Eiben,
• Fania C. Geiger and
• Christina Wege

Beilstein J. Nanotechnol. 2016, 7, 613–629, doi:10.3762/bjnano.7.54

• ; enzyme biosensor; nanotechnology; tobacco mosaic virus; virus-like particles; Introduction In the early years of virology, viruses were primarily regarded as small infective agents sometimes causing fatal diseases. Today, viruses and virus-like particles (VLPs) are seen in a different light by a

• antioxidative effects on mitochondria, and might be of high value in biosensor setups for the enzymatic detection of reactive oxygen species [133]. Hence, the precise proteinaceous 3D structure of TMV may even be converted into novel types of designer rods with enzymatically active surfaces. Perspectives on

• methods in plants used as bioreactors [181] may be expected to promote the integration of viral nanocarriers in diagnostic systems and biosensor devices. Among those, the rigid TMV rods excel in their stable adjustable shape and durability. After simple conjugation of biotin linkers, they could be

Organized films

• Maurizio Canepa and
• Helmuth Möhwald

Beilstein J. Nanotechnol. 2016, 7, 406–408, doi:10.3762/bjnano.7.35

• a molecule in a controlled way for electronic and optoelectronic applications. In this respect, defined protein incorporation, for example, for designing a biosensor, seemed hopeless. Incidentally, these problems were largely shared by self-assembled monolayers (SAMs), as exemplified by the most

Hemolysin coregulated protein 1 as a molecular gluing unit for the assembly of nanoparticle hybrid structures

• Tuan Anh Pham,
• Andreas Schreiber,
• Elena V. Sturm (née Rosseeva),
• Stefan Schiller and
• Helmut Cölfen

Beilstein J. Nanotechnol. 2016, 7, 351–363, doi:10.3762/bjnano.7.32

• , Habsburgerstrasse 49, D-79104 Freiburg, Germany 10.3762/bjnano.7.32 Abstract Hybrid nanoparticle (NP) structures containing organic building units such as polymers, peptides, DNA and proteins have great potential in biosensor and electronic applications. The nearly free modification of the polymer chain, the

Functional fusion of living systems with synthetic electrode interfaces

• Oskar Staufer,
• Sebastian Weber,
• C. Peter Bengtson,
• Hilmar Bading,
• Joachim P. Spatz and
• Amin Rustom

Beilstein J. Nanotechnol. 2016, 7, 296–301, doi:10.3762/bjnano.7.27

• : biointerface; biosensor; energy harvesting; nanoelectrodes; Physarum polycephalum; Findings The formation process of nanoelectrode interfaces (NEIs) was based on track-etch template synthesis as schematically shown in Figure 1a. First, monocrystalline gold (Au) nanowires in parallel arrangement featuring

• (Figure 3, red) was even better, presumably due to their direct, low impedance access to the cell interior, proving the suitability of the system for electrophysiological recordings and biosensor applications. The fact that under these conditions the periodic potential changes were only rarely observed

Orthogonal chemical functionalization of patterned gold on silica surfaces

• Francisco Palazon,
• Didier Léonard,
• Thierry Le Mogne,
• Francesca Zuttion,
• Céline Chevalier,
• Magali Phaner-Goutorbe,
• Éliane Souteyrand,
• Yann Chevolot and
• Jean-Pierre Cloarec

Beilstein J. Nanotechnol. 2015, 6, 2272–2277, doi:10.3762/bjnano.6.233

• analyzed using WinCadence software. The mass calibration was performed on hydrocarbon secondary ions. Schematic representation of the use of orthogonal functionalization techniques to enhance the sensitivity of a plasmonic biosensor (with a constant number of molecules). (A) Functionalization is uniform

Optimized design of a nanostructured SPCE-based multipurpose biosensing platform formed by ferrocene-tethered electrochemically-deposited cauliflower-shaped gold nanoparticles

• Wicem Argoubi,
• Maroua Saadaoui,
• Sami Ben Aoun and
• Noureddine Raouafi

Beilstein J. Nanotechnol. 2015, 6, 1840–1852, doi:10.3762/bjnano.6.187

• concentrations of, e.g., biologically active analytes and disease-related biomarkers [9][10]. Many electrochemical biosensors use ferrocene to transduce the biological reactions into readily measurable electrical signals [11][12]. For instance, Chen and Diao developed a glucose biosensor using gold nanoparticles

• biosensor was prepared by simply drop-casting a mixture of the HRP enzyme solution and chitosan as displayed in Figure 1. The chitosan was used as a matrix to retain the enzyme on the nanostructured surface [39]. The stepwise preparation was also characterized using CV and EIS spectroscopy. CV showed an

• biosensor (Figure 6a and Figure 6b). Selective detection of H2O2 The simplicity of design and the ease of layer-by-layer modification make this surface an excellent electrochemical sensing platform for hydrogen peroxide detection. Figure 6c shows typical chronoamperometric responses of the ferrocene moiety

Nonlinear optical properties of near-infrared region Ag₂S quantum dots pumped by nanosecond laser pulses

• Li-wei Liu,
• Si-yi Hu,
• Yin-ping Dou,
• Tian-hang Liu,
• Jing-quan Lin and
• Yue Wang

Beilstein J. Nanotechnol. 2015, 6, 1781–1787, doi:10.3762/bjnano.6.182

• superior optical limiting. We discuss the physical mechanisms responsible for the nonlinear optical response of the QDs. The average size of the nanocrystals was 5.5 nm. Our results suggest the possibility of using these Ag2S QDs for photoelectric, biosensor, optical ranging, and self-adaptive technologies

Synthesis, characterization and in vitro biocompatibility study of Au/TMC/Fe₃O₄ nanocomposites as a promising, nontoxic system for biomedical applications

• Hanieh Shirazi,
• Maryam Daneshpour,
• Soheila Kashanian and
• Kobra Omidfar

Beilstein J. Nanotechnol. 2015, 6, 1677–1689, doi:10.3762/bjnano.6.170

• Hanieh Shirazi Maryam Daneshpour Soheila Kashanian Kobra Omidfar Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences

Mammalian cell growth on gold nanoparticle-decorated substrates is influenced by the nanoparticle coating

• Christina Rosman,
• Sebastien Pierrat,
• Marco Tarantola,
• David Schneider,
• Eva Sunnick,
• Andreas Janshoff and
• Carsten Sönnichsen

Beilstein J. Nanotechnol. 2014, 5, 2479–2488, doi:10.3762/bjnano.5.257

• , non-invasive biosensor, which permits the monitoring of morphological changes of living cells acting as dielectric bodies in real time [26][27]. The method measures the complex impedance, Z, of a small working electrode and a larger counter electrode (Supporting Information File 1, Figure S3). The

Biopolymer colloids for controlling and templating inorganic synthesis

• Laura C. Preiss,
• Katharina Landfester and
• Rafael Muñoz-Espí

Beilstein J. Nanotechnol. 2014, 5, 2129–2138, doi:10.3762/bjnano.5.222

• sol, followed by a gelation process, porous hybrid structures can be obtained. Starting from a colloidal suspension of laponite particles, Shi et al. [4] reported the preparation of a nanocomposite matrix of chitosan and clay that was applied as a glucose biosensor. Very recently, da Costa Neto et al

Effect of channel length on the electrical response of carbon nanotube field-effect transistors to deoxyribonucleic acid hybridization

• Hari Krishna Salila Vijayalal Mohan,
• Jianing An,
• Yani Zhang,
• Chee How Wong and
• Lianxi Zheng

Beilstein J. Nanotechnol. 2014, 5, 2081–2091, doi:10.3762/bjnano.5.217

• variation trend in response to the newly defined parameters. Keywords: biosensor; carbon nanotubes; channel length; field-effect transistor; hybridization; mobility; nucleic acid; Introduction Detection of nucleic acids such as deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) is an important issue in

Carbon nano-onions (multi-layer fullerenes): chemistry and applications

• Juergen Bartelmess and
• Silvia Giordani

Beilstein J. Nanotechnol. 2014, 5, 1980–1998, doi:10.3762/bjnano.5.207

• layers between the biomolecules and the gold surface of the sensor and led to an amplified signal of the biosensor, as determined by surface plasmon resonance spectroscopy. In addition, the biocompatibility of CNOs was investigated and found to be excellent. Environmental remediation: An application of

Carbon-based smart nanomaterials in biomedicine and neuroengineering

• Antonina M. Monaco and
• Michele Giugliano

Beilstein J. Nanotechnol. 2014, 5, 1849–1863, doi:10.3762/bjnano.5.196

• near-infrared region as a photothermal agent for in vivo cancer treatment, while scrutinising the effects originating from different graphene sizes and coatings [97]. Several research groups have focused on graphene as biosensors. Dey et al. [98] developed an amperometric cholesterol biosensor; Tang