Orally administered docetaxel-loaded chitosan-decorated cationic PLGA nanoparticles for intestinal tumors: formulation, comprehensive in vitro characterization, and release kinetics

• Sedat Ünal,
• Osman Doğan and
• Yeşim Aktaş

Beilstein J. Nanotechnol. 2022, 13, 1393–1407, doi:10.3762/bjnano.13.115

• the proliferation of cancer cells [32][33][34]. Its potent activity against a wide spectrum of cancers such as colon cancer, gastric cancer, breast cancer, recurrent ovarian cancer, and non-small cell lung cancer has been elucidated by in vitro and in vivo studies [35]. Its poor water solubility

Recent advances in green carbon dots (2015–2022): synthesis, metal ion sensing, and biological applications

• Aisha Kanwal,
• Naheed Bibi,
• Sajjad Hyder,
• Arif Muhammad,
• Hao Ren,
• Jiangtao Liu and
• Zhongli Lei

Beilstein J. Nanotechnol. 2022, 13, 1068–1107, doi:10.3762/bjnano.13.93

Effects of substrate stiffness on the viscoelasticity and migration of prostate cancer cells examined by atomic force microscopy

• Xiaoqiong Tang,
• Yan Zhang,
• Jiangbing Mao,
• Yuhua Wang,
• Zhenghong Zhang,
• Zhengchao Wang and
• Hongqin Yang

Beilstein J. Nanotechnol. 2022, 13, 560–569, doi:10.3762/bjnano.13.47

• the maturation of focal adhesions, and induces a downstream cascade of intracellular signals in the RhoA/ROCK pathway, thereby promoting breast cancer cell motility [11]. Dai et al. found that high-stiffness matrices regulate the morphology of MG63 osteosarcoma cells, promote actin polymerization and

• nuclear accumulation of the cardiomyosin-related transcription factor A, induce epithelial-mesenchymal transition (EMT) in osteosarcoma cells, and thus promote osteosarcoma metastasis [12]. Differences in ECM stiffness do not only affect the development of breast cancer and osteosarcoma. Recent studies on

• mobility of the cells is positively correlated with their ability to invade. Wullkopf et al. [40] found that, in a 3D breast cancer model, an increased viscosity might actually aid cells at an invasive front. Our study firstly shows that substrate stiffness could affect the migration and invasion of

Systematic studies into uniform synthetic protein nanoparticles

• Nahal Habibi,
• Ava Mauser,
• Jeffery E. Raymond and
• Joerg Lahann

Beilstein J. Nanotechnol. 2022, 13, 274–283, doi:10.3762/bjnano.13.22

• . Paclitaxel was traditionally formulated through solubilization with harsh solvents, which led to adverse side effects and special administration instrumentation [9]. While AbraxaneTM was first FDA-approved for the treatment of metastatic breast cancer, it has since been investigated for other cancers

• -loaded HSA particles with diameters of approximately 130 nm [10][11]. Since then, AbraxaneTM has been used for non-small cell lung cancer, late-stage pancreatic cancer, and as a treatment for metastatic breast cancer [12][13]. Nevertheless, nab-based nanoparticles suffer from significant drawbacks, such

Theranostic potential of self-luminescent branched polyethyleneimine-coated superparamagnetic iron oxide nanoparticles

• Rouhollah Khodadust,
• Ozlem Unal and
• Havva Yagci Acar

Beilstein J. Nanotechnol. 2022, 13, 82–95, doi:10.3762/bjnano.13.6

• @bPEI-Erb/pGFP was tested on HeLa, MCF7 (breast cancer cell line) and HCT116 (human colon cancer cell line) cells. The cells were grown onto 75T culture flasks in Dulbecco’s Modified Eagle’s culture Medium (DMEM) with 4.5 g/L ᴅ-glucose, ʟ-glutamine, and pyruvate (Life Technologies USA) and supplemented

Use of nanosystems to improve the anticancer effects of curcumin

• Andrea M. Araya-Sibaja,
• Norma J. Salazar-López,
• Krissia Wilhelm Romero,
• José R. Vega-Baudrit,
• J. Abraham Domínguez-Avila,
• Carlos A. Velázquez Contreras,
• Ramón E. Robles-Zepeda,
• Mirtha Navarro-Hoyos and
• Gustavo A. González-Aguilar

Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78

• characteristic of the tumor microenvironment (pH 6.5) and subcellular endosomes (pH 5.0). Regarding its apoptotic effects, a high anticancer activity was found when assayed against a breast cancer cell line (MDA-MB-231), an effect that was accompanied by an enhanced cellular uptake in cells that overexpressed

• CD44. Besides, they reported complementary evidence in which in vivo studies in female BALB/c mice showed that CUR nanococrystals had better anticancer effects in a 4T1 orthotopic breast cancer model as compared to F-CUR. Ribas et al. [57] reported that supercritical solvents (and no cosolvents) were

• . Results showed that cells readily internalized MNP by endocytosis, which simultaneously allowed for imaging the affected cells [132]. Other report showed that, using the same breast cancer cells, alginate/chitosan MNP had a 3–6-fold increase in cellular uptake, as compared to F-CUR [133]. This has been

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

Recent progress in magnetic applications for micro- and nanorobots

• Ke Xu,
• Shuang Xu and
• Fanan Wei

Beilstein J. Nanotechnol. 2021, 12, 744–755, doi:10.3762/bjnano.12.58

• , with which cancer cells and non-cancerous cells can be distinguished. Furthermore, a cell sensor that uses MaBiDz for rapid detection and imaging of target mRNA biomarkers of metastatic breast cancer has been realized. Its function shows that it is likely to be used as a biomimetic organelle MNR in the

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

• Nikola Geskovski,
• Nadica Matevska-Geshkovska,
• Simona Dimchevska Sazdovska,
• Marija Glavas Dodov,
• Kristina Mladenovska and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

• common traits in many solid tumors and validated delivery targets for several cancers including lung, colorectal, and certain subtypes of breast cancer [69]. For instance, overexpression of EGFR and DNA mutations in the extracellular and intracellular portions of the protein have been observed in 43–89

The nanomorphology of cell surfaces of adhered osteoblasts

• Christian Voelkner,
• Mirco Wendt,
• Regina Lange,
• Max Ulbrich,
• Martina Gruening,
• Susanne Staehlke,
• Barbara Nebe,
• Ingo Barke and
• Sylvia Speller

Beilstein J. Nanotechnol. 2021, 12, 242–256, doi:10.3762/bjnano.12.20

• breast cancer cells [30], and on keratinocytes [35]. In general, these features are associated with migration, receptor internalization, and micropinocytosis [30][36][37]. Membrane ruffling is regulated by a distinct signaling pathway [38] and the supporting actin is denser and more cross-linked [35

• ] compared to flat membrane regions. Three types of ruffles can be discriminated, namely (linear) dorsal, peripheral, and circular dorsal ruffles [36]. Colocalization with hyaluronan synthase has been found in a breast cancer cell line (MCF-7) [30]. Usually the error current, that is, the deviation between

PEG/PEI-functionalized single-walled carbon nanotubes as delivery carriers for doxorubicin: synthesis, characterization, and in vitro evaluation

• Shuoye Yang,
• Zhenwei Wang,
• Yahong Ping,
• Yuying Miao,
• Yongmei Xiao,
• Lingbo Qu,
• Lu Zhang,
• Yuansen Hu and
• Jinshui Wang

Beilstein J. Nanotechnol. 2020, 11, 1728–1741, doi:10.3762/bjnano.11.155

• grade. Cell culture The human breast cancer cell line MCF-7 used in this study was obtained from American Type Culture Collection (ATCC, Manassas, VA), and cultured in RPMI 1640 medium containing 10% (v/v) fetal bovine serum (FBS) and 1% penicillin–streptomycin at 37 °C in a humidified atmosphere with 5

Electrokinetic characterization of synthetic protein nanoparticles

• Daniel F. Quevedo,
• Cody J. Lentz,
• Adriana Coll de Peña,
• Yazmin Hernandez,
• Nahal Habibi,
• Rikako Miki,
• Joerg Lahann and
• Blanca H. Lapizco-Encinas

Beilstein J. Nanotechnol. 2020, 11, 1556–1567, doi:10.3762/bjnano.11.138

• vaccines [5][6]. Significant advances in self-assembled PNPs via protein engineering techniques have also been observed [7][8]. PNPs have successfully reached the clinic with nab-paclitaxel (Abraxane®), a PNP made of human serum albumin, which is being used for the treatment of metastatic breast cancer

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

• Maria Suciu,
• Corina M. Ionescu,
• Alexandra Ciorita,
• Septimiu C. Tripon,
• Dragos Nica,
• Hani Al-Salami and
• Lucian Barbu-Tudoran

Beilstein J. Nanotechnol. 2020, 11, 1092–1109, doi:10.3762/bjnano.11.94

• occurred [84]. Polyvinylpyrrolidone (PVP)-coated SPIONs showed an unexpected effect on human breast cancer cells (BT-474) in vitro. At concentrations between 10 and 100 µg/mL, for up to three days, nanoparticles doubled the metabolic activity and the population number of cancer cells. Only at

• of 48 °C (after 1 h treatment at 15 mT and 150 kHz) and effectively killing breast cancer cells [145]. A high surface absorption rate can be obtained by increasing the frequency of the magnetic field, but that can only be done in a biologically safe limit, determined by Brezovich and Atkinson [146

• PEG and adsorbed on reduced graphene oxide sheets, which enhanced the thermal effect of hyperthermia and reduced the viability of breast cancer cells to less than 25% by reaching 43 °C [152]. Also, Zuvin et al. used 4–5 nm SPIONs conjugated with poly(acrylic acid) and anti-HER2 antibody against breast

Key for crossing the BBB with nanoparticles: the rational design

• Sonia M. Lombardo,
• Marc Schneider,
• Akif E. Türeli and
• Nazende Günday Türeli

Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72

• are P-glycoproteins (P-gp or ABCB1, MDR1 gene product), breast cancer resistance proteins (BCRP/ABCG2) and the multidrug resistance-associated proteins (MRP1, 2, 4 and 5, ABCC) [31][35][36][37][38]. With their ability to transport a large variety of compounds, these efflux proteins cause a significant

Examination of the relationship between viscoelastic properties and the invasion of ovarian cancer cells by atomic force microscopy

• Mengdan Chen,
• Jinshu Zeng,
• Weiwei Ruan,
• Zhenghong Zhang,
• Yuhua Wang,
• Shusen Xie,
• Zhengchao Wang and
• Hongqin Yang

Beilstein J. Nanotechnol. 2020, 11, 568–582, doi:10.3762/bjnano.11.45

• . The results are consistent with previous reports that the stiffness of normal cells is higher than that of breast cancer cells [35]. Therefore, the elasticity could be considered as an effective indicator to differentiate the state of tumor development. Another important characteristic is viscosity

• observations that drug stimulation caused mechanical stiffening of ovarian cancer cells [31]. Kim et al. showed the increased stiffness of highly metastatic human breast cancer cells after the activation of β-adrenergic signaling by βAR agonists, as well as an increased invasiveness of these cells in vitro [6

Luminescent gold nanoclusters for bioimaging applications

• Nonappa

Beilstein J. Nanotechnol. 2020, 11, 533–546, doi:10.3762/bjnano.11.42

• receptor-positive (FR+) oral squamous cell carcinoma (KB) and breast cancer adenocarcinoma MCF-7 cell lines [88]. Since then, there have been numerous other reports that have shown various surface modifications to image a wide variety of cell lines. Pan et al. reported composite core–shell nanoparticle

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

• Varsha Sharma and
• Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

• efficient carriers for controlled release. The later work on capsule/lipid systems incorporated with neoglycolipid or folate-linked lipid showed high affinity to lectin (concanavalin A) and breast cancer cells (MCF-7) [109]. The efficient delivery of the daunorubicin hydrochloride (DNR) anticancer drug to

Brome mosaic virus-like particles as siRNA nanocarriers for biomedical purposes

• Alfredo Nuñez-Rivera,
• Pierrick G. J. Fournier,
• Danna L. Arellano,
• Ana G. Rodriguez-Hernandez,
• Rafael Vazquez-Duhalt and
• Ruben D. Cadena-Nava

Beilstein J. Nanotechnol. 2020, 11, 372–382, doi:10.3762/bjnano.11.28

• the breast cancer cells. Representative confocal microscopy images showed NanoOrange fluorescence inside the cells (Figure 1A). It is important to point out that the capsids are able to internalize efficiently into tumor cells without any functionalization. The cell internalization has been quantified

• wild-type BMV: 3000 e− /capsid [21][22]. The synthesized VLP-siAkt with both BMV and CCMV capsids were assayed in vivo. The VLP-siAkt were inoculated into mice with previously induced breast cancer tumors. The tumors were induced in female mice using the mouse cell line 4T1. After ten days of tumor

• concentration of 50 nM. *Scale bar = 50 μm, **scale bar = 100 μm. Anti-tumor effect of virus nanoparticles. (A) Schematic illustration of the experimental design. (B) In vivo growth curves of 4T1 tumors on mice after treatments with the virus and VLPs. (C) Ex vivo images of 4T1 breast cancer tumor from BMV VLP

Using gold nanoparticles to detect single-nucleotide polymorphisms: toward liquid biopsy

• María Sanromán Iglesias and
• Marek Grzelczak

Beilstein J. Nanotechnol. 2020, 11, 263–284, doi:10.3762/bjnano.11.20

• single-base changes associated with the breast cancer gene BRCA1. The detection limit was 0.26 nM, corresponding to 31.2 fmol of a target. Recently, advances in the development of DNA circuits based on hybridization and strand-exchange reactions have attracted much attention. Two examples of DNA circuits

Rational design of block copolymer self-assemblies in photodynamic therapy

• Maxime Demazeau,
• Laure Gibot,
• Anne-Françoise Mingotaud,
• Patricia Vicendo,
• Clément Roux and
• Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

Molecular architectonics of DNA for functional nanoarchitectures

• Debasis Ghosh,
• Lakshmi P. Datta and
• Thimmaiah Govindaraju

Beilstein J. Nanotechnol. 2020, 11, 124–140, doi:10.3762/bjnano.11.11

• the ECL quenching via formation of hydrogen peroxide. Kim and co-workers developed an innovative approach of intercalation of the anticancer drug doxorubicin within the DNA tetrahedron that showed improved therapeutic efficacy in drug-resistant breast cancer cells [70]. The doxorubicin-encapsulated

Advanced hybrid nanomaterials

• Andreas Taubert,
• Fabrice Leroux,
• Pierre Rabu and
• Verónica de Zea Bermudez

Beilstein J. Nanotechnol. 2019, 10, 2563–2567, doi:10.3762/bjnano.10.247

• is simultaneously employed as a contrast agent in magnetic resonance imaging (MRI) and for local heating therapy using magnetic particle hyperthermia [33]. In vitro hyperthermia tests showed efficiency in inoculating mouse breast cancer cells. Another study reports the use of alendronate-coated gold

Targeted therapeutic effect against the breast cancer cell line MCF-7 with a CuFe₂O₄/silica/cisplatin nanocomposite formulation

• B. Rabindran Jermy,
• Vijaya Ravinayagam,
• Widyan A. Alamoudi,
• Dana Almohazey,
• Hatim Dafalla,
• Lina Hussain Allehaibi,
• Abdulhadi Baykal,
• Muhammet S. Toprak and
• Thirunavukkarasu Somanathan

Beilstein J. Nanotechnol. 2019, 10, 2217–2228, doi:10.3762/bjnano.10.214

• /HYPS was applied as the support. An in vitro experiment was conducted to determine the potential of CuFe2O4/HYPS as an anticancer agent against the human breast cancer cell line MCF-7. The results show that the nanoparticle formulation can effectively target cancerous cells and could be an effective

• ), scanning electron microscopy (SEM) equipped with energy dispersive X-ray (EDX) spectroscopy and transmission electron microscopy (TEM) techniques. The study showed the high cisplatin release capability and targeted anticancer efficiency demonstrated in vitro in the breast cancer cell line MCF-7. Materials

• effectively reduce the viability of the human breast cancer cell line MCF7. Thus, cisplatin/CuFe2O4/HYPS nanoparticles can be considered an interesting option for drug delivery (Scheme 1). Conclusion An effective multifunctional CuFe2O4/HYPS nanocomposite system has been developed to deliver cisplatin

Review of advanced sensor devices employing nanoarchitectonics concepts

• Katsuhiko Ariga,
• Tatsuyuki Makita,
• Masato Ito,
• Taizo Mori,
• Shun Watanabe and
• Jun Takeya

Beilstein J. Nanotechnol. 2019, 10, 2014–2030, doi:10.3762/bjnano.10.198

• could be applicable for demands requiring the evaluation of small normal pressures even on dynamic surfaces such as natural tissues and is expected to be useful for in situ biomedical digital monitoring, such as palpation for breast cancer. Triboelectric nanogenerators to convert mechanical energy to

Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells

• Liang Xu,
• Dekang Xu,
• Ziying Li,
• Yu Gao and
• Haijun Chen

Beilstein J. Nanotechnol. 2019, 10, 1933–1942, doi:10.3762/bjnano.10.189

• anticancer activities, such as restraining the hTERT gene expression in A549 lung cancer cells [3], inhibiting breast cancer stem-like cells via Wnt β-catenin signaling [4], impeding hepatocellular carcinoma cells by increasing DDX3 expression [5], and inducing apoptosis of prostate cancer cells through

• [30]. Phytosomes have been used as drug delivery systems of several insoluble natural drugs in recent years. Sinigrin [31] and epigallocatechin-3-O-gallate [32] loaded in phytosomes showed stronger antiproliferative activity than free drugs against melanoma cells and breast cancer cells. In this work