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Search for "chitosan" in Full Text gives 92 result(s) in Beilstein Journal of Nanotechnology.
Silver nanoparticles loaded on lactose/alginate: in situ synthesis, catalytic degradation, and pH-dependent antibacterial activity
Beilstein J. Nanotechnol. 2023, 14, 781–792, doi:10.3762/bjnano.14.64
- an in situ reduction process that requires no additional chemicals [16][17]. This technique using polysaccharides such as alginate [18] or chitosan [19] in conjunction with reducing agents enhanced cost efficiency and reduced the amounts of impurities or toxic compounds. AgNPs are widely used as
Nanoarchitectonics to entrap living cells in silica-based systems: encapsulations with yolk–shell and sepiolite nanomaterials
Beilstein J. Nanotechnol. 2023, 14, 522–534, doi:10.3762/bjnano.14.43
- microorganisms, that is, cyanobacteria and yeast cells, have been immobilized in silica and silicate-based substrates organized as nanostructured materials. In a first attempt, matrices based on bionanocomposites of chitosan and alginate incorporating sepiolite clay mineral and shaped as films, beads, or foams
- entrapment of microalgal species such as Chlorella vulgaris and Anabaena PCC7120 allowing for more than two months of viability [38]. In the present work, various bionanocomposites based on the combination of alginate and/or chitosan and sepiolite have been prepared and processed in different conformations
- to be tested as immobilization matrices of microalgae. Sepiolite–alginate beads, sepiolite–chitosan/alginate thin films, and sepiolite–chitosan foams were produced (Figure 1). Sepiolite and biopolymer concentration, synthesis temperature, and microorganism concentration were modified to study their
Quercetin- and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles: one-pot synthesis, characterization, and anticancer and antibacterial activities
Beilstein J. Nanotechnol. 2023, 14, 362–376, doi:10.3762/bjnano.14.31
- characterization of quercetin- and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles (Ch/Q- and Ch/CA-Ag NPs), and their antibacterial and anticancer activities. The formation of Ch/Q- and Ch/CA-Ag NPs has been confirmed by ultraviolet–visible (UV–vis) spectroscopy, Fourier-transform
- infrared (FTIR) spectroscopy, and transmission electron microscopy (TEM). The characteristic surface plasmon resonance (SPR) absorption band has been found at 417 and 424 nm for Ch/Q- and Ch/CA-Ag NPs, respectively. The formation of a chitosan shell comprising quercetin and caffeic acid, which surround the
- (P. aeruginosa and E. coli) and Gram-positive (S. aureus and S. epidermidis) bacteria was determined, and dose-dependent antibacterial effects were found. Keywords: Ag NPs; anticancer and antibacterial effects; caffeic acid; chitosan; one-pot synthesis; quercetin; U-118 MG and ARPE-19 cells
Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer
Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23
- )-functionalized nanoporous silica particles loaded with a poly(ʟ-glutamic acid) pH-cleavable linker–doxorubicin conjugate, which self-assembles into NPs after its release from the iNPG [114]. Li et al. designed a multistage nanocarrier for NSCLC targeting, composed of icotinib-loaded amphiphilic chitosan micelles
- such as cyclodextrin, inulin, and chitosan. These polymers are used alone or combined with amphiphilic polymers for core–shell nanoparticles such as the triblock polymer poly(ʟ-lactide)-poly(ethylene glycol)-poly(ʟ-lactide) (PLLA-PEG-PLLA) to increase the stability and decrease the immunogenicity of
Orally administered docetaxel-loaded chitosan-decorated cationic PLGA nanoparticles for intestinal tumors: formulation, comprehensive in vitro characterization, and release kinetics
Beilstein J. Nanotechnol. 2022, 13, 1393–1407, doi:10.3762/bjnano.13.115
- drug delivery system loaded with docetaxel (DCX) as an anticancer drug, using poly(lactic-co-glycolic acid) (PLGA) as nanoparticle material, and modified with chitosan (CS) to gain mucoadhesive properties. In this context, an innovative nanoparticle formulation that can protect orally administered DCX
- : chitosan; docetaxel; intestinal tumors; oral drug delivery; PLGA; Introduction Cancer is one of the most common chronic diseases in the world, characterized by the uncontrolled proliferation and spread of cells [1]. To date, effective and safe treatment approaches for cancer treatment have not been fully
- frequently used in research especially in the development of nanoparticulate drug formulations [17][22][23][24]. Chitosan (CS) is a common biocompatible polymer used extensively in drug delivery applications as a vehicle for drugs, proteins, and nucleic acids. Also, it is used as a coating polymer in nano
Design of surface nanostructures for chirality sensing based on quartz crystal microbalance
Beilstein J. Nanotechnol. 2022, 13, 1201–1219, doi:10.3762/bjnano.13.100
- nanoparticles [124]. Zhang et al. used ʟ-cysteine modified Au nanoparticles for chiral recognition of carnitine [125]. Jafari et al. used chitosan modified Ag nanoparticles for chiral sensing of tryptophan enantiomers [126]. Niu et al. reported the chiral recognition of tryptophan (Trp) on chiral Au facets
Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration
Beilstein J. Nanotechnol. 2022, 13, 1051–1067, doi:10.3762/bjnano.13.92
- , researchers have tried several ways to develop different materials using chitosan-based nanocomposites of silver, copper, gold, zinc oxide, titanium oxide, carbon nanotubes, graphene oxide, and biosilica. The combination of materials helps in the expression of ideal bone formation genes of alkaline
- tissue engineering applications. Keywords: antibacterial activity; biomimetic materials; bone graft substitutes; chitosan; gold; osteoinductive; silver; Introduction Bone-related defects and diseases are a serious concern to the life of patients [1]. Autografts, allografts, and synthetic grafts are
- , uniform raw materials quality, and are abundant. Chitosan is a natural polymeric substance and an extensively studied material for bone tissue engineering due to its biocompatibility, biodegradability, and antimicrobial properties [7][8][9][10]. Chitosan in combination with silver, gold, copper, titanium
Bioselectivity of silk protein-based materials and their bio-inspired applications
Beilstein J. Nanotechnol. 2022, 13, 902–921, doi:10.3762/bjnano.13.81
- bonding and/or ionic solvation has been reported for various materials such as poly(N-isopropylacrylamide) (PNIPAAm) [68][69], dextrans [69], poly(ethyleneimine) (PEI) [70][71], and chitosan [72]. Concerning proteins, several studies have reported different molecules to generate effective antiadhesive
- RGD and collagen to an antimicrobial polymeric multilayer composed of dextran sulfate and chitosan [103]. One way to achieve bioselective, biocompatible, and multifunctional materials for biomedical applications is the utilization of natural protein materials shown to accomplish the desired properties
Stimuli-responsive polypeptide nanogels for trypsin inhibition
Beilstein J. Nanotechnol. 2022, 13, 538–548, doi:10.3762/bjnano.13.45
- increased with the decrease of initial concentration of the 125I-radiolabeled BSA. The inverse effect was found when loading BSA onto poly(acrylic acid) and hybrid hydroxyapatite nanoparticles with chitosan/polyacrylic acid nanogels, where the loading was predominantly influenced by electrostatic
Ciprofloxacin-loaded dissolving polymeric microneedles as a potential therapeutic for the treatment of S. aureus skin infections
Beilstein J. Nanotechnol. 2022, 13, 517–527, doi:10.3762/bjnano.13.43
- microneedles are based on polymers such as PVA, PVP, chitosan, and poly(lactide-co-glycolide) [19]. In our study, polymer-based microneedles were optimized to achieve a formulation that can efficiently penetrate the skin. In this context, microneedles were studied regarding drug content and penetration of
- attributed to the shrinkage of the polymer gel upon drying as suggested by previous studies [32][33]. A similarly faceted shape of microneedles was observed with polymeric microneedles made of chitosan and alginate [34]. Also, a similar microneedle shape was obtained using hydroxypropyl methyl cellulose and
Micro- and nanotechnology in biomedical engineering for cartilage tissue regeneration in osteoarthritis
Beilstein J. Nanotechnol. 2022, 13, 363–389, doi:10.3762/bjnano.13.31
- mechanical properties and the simultaneous or sequential delivery of bioactive molecules. In this regard, an injectable gellan xanthan hydrogel containing chitosan NPs has been prepared as a scaffold for the delivery of multiple growth factors to regenerate bone [53]. The results of this study showed that
- the entrapment of the bone morphogenetic protein 7 (BMP7) and basic fibroblast growth factor (BFGF) within chitosan NPs inhibited the initial burst release and allowed for the controlled release of growth factors and therefore, improved the osteogenic differentiation of stem cells [53]. In another
- maleilated chitosan hydrogel containing micro-/nanoparticles of methacrylated silk fibroin, a natural fibrous protein mimicking the collagen structure, improved the mechanical properties of nanocomposites fabricated for cartilage TE [60]. The development of a magnetic nanocomposite hydrogel from poly(vinyl
Engineered titania nanomaterials in advanced clinical applications
Beilstein J. Nanotechnol. 2022, 13, 201–218, doi:10.3762/bjnano.13.15
- alginate, gelatin, and chitosan to enhance strength and durability [70]. In another strategy to improve the bioactivity of titania scaffolds, alkaline phosphatase (ALP) was functionalized onto 3D TiO2 scaffolds based on a simple dip-coating method. ALP catalyzes the hydrolysis of organic phosphate that
- by DOX exposure directly to healthy cells and tissues [108]. In another study, gentamicin was loaded onto nanostructures (nanotubes and nanopores) of a titanium/zirconium alloy nanocomposite (TiZr) coated with chitosan. This composite system followed the Lindner–Lippold mechanism of drug release. The
A comprehensive review on electrospun nanohybrid membranes for wastewater treatment
Beilstein J. Nanotechnol. 2022, 13, 137–159, doi:10.3762/bjnano.13.10
- , modified chitin, cellulose acetate (CA) and chitosan (CS) have been electrospun as nanohybrids and have been used in a variety of applications [7][8]. Regarding the health sector, the enhanced biocompatibility, antibacterial properties, and cell compatibility has made ENHs great candidates to deliver
Use of nanosystems to improve the anticancer effects of curcumin
Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78
- . Results showed that cells readily internalized MNP by endocytosis, which simultaneously allowed for imaging the affected cells [132]. Other report showed that, using the same breast cancer cells, alginate/chitosan MNP had a 3–6-fold increase in cellular uptake, as compared to F-CUR [133]. This has been
- superparamagnetic iron oxide nanoparticles functionalized with sodium dodecyl sulfate (SDS) and coated with chitosan (40–45 nm), were able to induce apoptosis (IC50 30 µg/mL) in HeLa (cervical cancer) cells by damaging the DNA and increasing caspase-3 [136]. Curcumin-loaded, pH-sensitive Janus magnetic mesoporous
The role of deep eutectic solvents and carrageenan in synthesizing biocompatible anisotropic metal nanoparticles
Beilstein J. Nanotechnol. 2021, 12, 924–938, doi:10.3762/bjnano.12.69
- monodispersed nanoparticles, an essential criterion for their intended application and a limitation of the green synthesis of nanoparticles using plant extracts. Several biocompatible counterparts such as polymers, lipids, and chitosan-based nanoparticles have been successfully used in the synthesis of safe
- , these nanomaterials are far away from a substantial use in biological applications due to toxic capping agents employed during synthesis. Several counterparts such as polymers, lipids, and chitosan-based nanoparticles are extensively explored in drug delivery and therapeutic applications due to their
- of nanotechnology. The use carrageenan in nanomaterial synthesis and application has been tabulated in Table 3 [32][110][111][112][113][114][115]. Carrageenan has been complexed with chitosan in a recent study, forming a composite for wound healing dressing. Silver nanoparticles, widely known for
Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications
Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64
- (conventional and echogenic), niosomes, nanoemulsions, polymeric nanoparticles, chitosan nanocapsules, dendrimers, hydrogels, nanogels, gold nanoparticles, titania nanostructures, carbon nanostructures, mesoporous silica nanoparticles, fuel-free nano/micromotors. Keywords: smart nanomaterials; sonodynamic
The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors
Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31
- chitosan-complexed nilotinib, while the shell was loaded with a protease-sensitive dextrane–IM complex. In addition, the core was loaded with sodium bicarbonate and potassium tartrate, a mixture that quickly generates CO2 in an acidic environment and, thus, produces large pores in the nanoparticles
- , resulting in a burst release of the core contents. In this way, the authors managed to achieve a stimuli-responsive sequential drug release pattern. IM will be released in the cytoplasm from the dextrane complexes due to the activity of intracellular protease while the nilotinib–chitosan complexes will be
- . Also, in contrast to C225-NPs, free C225 antibody did not induce autophagy in cells [75]. Maya et al. reported the design and evaluation of EGFR-targeted cetuximab–chitosan cross-linked γ-poly(glutamic acid) nanoparticles loaded with docetaxel. The NPs were prepared by cross-linking the NH2 groups of
Photothermally active nanoparticles as a promising tool for eliminating bacteria and biofilms
Beilstein J. Nanotechnol. 2020, 11, 1134–1146, doi:10.3762/bjnano.11.98
- . The local photothermal effect triggered by the NIR irradiation of PVA-GNS films was highly efficient in eliminating E. coli bacteria, as shown in Figure 4. In a very recent study, the antimicrobial activity of a chitosan-based hydrogel with embedded gold nanorods under low-power (200 mW) diode laser
- with strong NIR absorption and peroxidase-like activity displayed in vitro fast antibacterial action on Gram-negative ampicilin-resistant E. coli and Gram-positive endospore-forming B. subtilis [96]. In another publication multifunctional chitosan-functionalized magnetic MoS2 nanoparticles were
Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements
Beilstein J. Nanotechnol. 2020, 11, 1092–1109, doi:10.3762/bjnano.11.94
- therefore give incorrect results. Stable and well dispersed nanoparticles are internalized to a higher extent [54]. A lot of effort has been spent in this area and today there are methods to obtain very stable SPIONs functionalized with PVA, PEG, dextran, chitosan, and poloxamers, which can be used in
Wet-spinning of magneto-responsive helical chitosan microfibers
Beilstein J. Nanotechnol. 2020, 11, 991–999, doi:10.3762/bjnano.11.83
- biotechnological and tissue engineering applications. However, there are only a few methods available for the production of biocompatible helical microfibers. Given that, we present here a simple technique for the fabrication of helical chitosan microfibers with embedded magnetic nanoparticles. Composite fibers
- were prepared by wet-spinning and coagulation in an ethanol bath. Thereby, no toxic components were introduced into the wet-spun chitosan fibers. After drying, the helical fibers had a diameter of approximately 130 µm. Scanning electron microscopy analysis of wet-spun helices revealed that the magnetic
- helical chitosan microfibers exhibited an average Young’s modulus of 14 MPa. By taking advantage of the magnetic properties of the feedstock solution, the production of the helical fibers could be automated. The fabrication of the helical fibers was achieved by utilizing the magnetic properties of the
Key for crossing the BBB with nanoparticles: the rational design
Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72
- both formulations were able to cross the BBB and deliver their cargo. On the other hand, in another study, coumarin-6-loaded PLGA nanoparticles coated with either chitosan or PS80 showed a better crossing ability than P188-coated nanoparticles [57]. This result seems to be in accordance with the
- transcytosis through the AMT pathway. Multiple CPPs have been used to deliver nanoparticles to the brain such as the HIV-1 trans-activating transcriptor (TAT) [77][106][107], penetratin [108] or SynB [109]. Finally, conjugating nanoparticles with positively charged polymers or proteins such as chitosan or
- brain delivery such as polycaprolactone (PCL) [68] or chitosan [80][82] but to a lesser extent than PBCA and PLA/PLGA nanoparticles. For instance, enhanced accumulation in an in vivo intracranial glioma mice model of PEG-PCL nanoparticles functionalized with angiopep-2 could be observed by real-time
Soybean-derived blue photoluminescent carbon dots
Beilstein J. Nanotechnol. 2020, 11, 606–619, doi:10.3762/bjnano.11.48
- luminescence properties. Hydrothermal carbonization (HTC), which can be considered as a “green technology”, has been used to produce photoluminescent CDs from biomass, including glucose, sucrose, citric acid [19], chitosan [20], orange juice [21], grass [22] and soy milk [10]. For example, Sahu et al. [21
Adsorptive removal of bulky dye molecules from water with mesoporous polyaniline-derived carbon
Beilstein J. Nanotechnol. 2020, 11, 597–605, doi:10.3762/bjnano.11.47
- , activated carbon. Moreover, KOH-900 had the highest Q0, compared with any reported adsorbent, so far. Additionally, KOH-900 showed a Q0 of more than 2 times that of a chitosan–alunite composite (previously the highest Q0) [71] even though the pH of adsorption solution was not the same. If the pH effect
- (vide supra, including Figure 7) is considered, the difference in Q0 between KOH-900 and chitosan–alunite composite will increase. Based on Table 2, KOH-900 was also very competitive in JGB adsorption against the reported adsorbents. To begin with, KOH-900 had a q6h for JGB 11.5 times that of AC. The
- value of more than 2 times that of a chitosan–alunite composite which previously showed the highest Q0 to date. The remarkable adsorption of AR1 and JGB over KOH-900 could be explained with combined mechanisms such as hydrophobic, π–π, electrostatic and van der Waals interactions. Finally, the PDC
Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery
Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41
- (e.g., dextran sulfate (DS), heparin and chitosan) and various synthetic polymers (e.g., PAH, PMA and poly(ethyleneimine) (PEI)). When a negatively charged template is dipped in a solution of positively charged PE, or vice versa, a monolayer of excessively adsorbed PEs is formed that leads to the
- between β-cyclodextrin monolayers as host and polymers modified with adamantyl groups as guests, which also resulted in stable multilayers [61]. The first stimuli-responsive supramolecular hydrogels films based on these reactions were built in 2006 using β-cyclodextrin and adamantyl modified chitosan
- material itself as a core or co-precipitation of encapsulation material within the core. Very few such studies are reported using a weak PE capsule. An anti-inflammatory drug, ibuprofen crystals of 5–40 µm in size, were encapsulated by chitosan/DS and chitosan/carboxymethyl cellulose multilayers [65]. The
Preparation and in vivo evaluation of glyco-gold nanoparticles carrying synthetic mycobacterial hexaarabinofuranoside
Beilstein J. Nanotechnol. 2020, 11, 480–493, doi:10.3762/bjnano.11.39
- -dextran [79] and chitosan [80] have been reported to bind to GNPs in a pH-dependent manner as the energy of the Au–N interaction is intermediate between those of Au–S and Au–O [81]. The affinity of different functional groups to the surface of GNPs decreases in the series Au–S > Au–NH2 > Au–COOH [82
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