Characterization, bio-uptake and toxicity of polymer-coated silver nanoparticles and their interaction with human peripheral blood mononuclear cells

• Sahar Pourhoseini,
• Reilly T. Enos,
• Angela E. Murphy,
• Bo Cai and
• Jamie R. Lead

Beilstein J. Nanotechnol. 2021, 12, 282–294, doi:10.3762/bjnano.12.23

• ][57] and protect them from dissolution and aggregation in complex media [42][43]. Z-average hydrodynamic diameter and PDI of pristine PVP-AgNPs were measured using DLS with a Malvern Zetasizer NanoZS (Malvern Instruments, MA, USA). The colloidal stability (zeta potential) of PVP-AgNPs was measured by

Differences in surface chemistry of iron oxide nanoparticles result in different routes of internalization

• Barbora Svitkova,
• Vlasta Zavisova,
• Veronika Nemethova,
• Martina Koneracka,
• Miroslava Kretova,
• Filip Razga,
• Monika Ursinyova and
• Alena Gabelova

Beilstein J. Nanotechnol. 2021, 12, 270–281, doi:10.3762/bjnano.12.22

• 40–50 nm in diameter [14], or glycosylphosphatidylinositol (GPI)-anchored proteins [15]. Inorganic nanoparticles are frequently engineered with an organic surface coating to improve their biocompatibility, colloidal stability, and bioavailability. Moreover, the coating facilitates their further

Influence of the magnetic nanoparticle coating on the magnetic relaxation time

• Mihaela Osaci and
• Matteo Cacciola

Beilstein J. Nanotechnol. 2020, 11, 1207–1216, doi:10.3762/bjnano.11.105

• other hand, organic coating (particularly polymers) has a number of advantages over inorganic coating, such as better particle dispersion, good colloidal stability, biocompatibility, good nanoparticle circulation in the blood, reduced toxicity and low risk of blood capillary obstruction. In the last

Straightforward synthesis of gold nanoparticles by adding water to an engineered small dendrimer

• Sébastien Gottis,
• Régis Laurent,
• Vincent Collière and
• Anne-Marie Caminade

Beilstein J. Nanotechnol. 2020, 11, 1110–1118, doi:10.3762/bjnano.11.95

• located in this linkage with a noticeable electronic delocalization [42]. Thus, the presence of P=N–P=S linkages in the precursor is desirable. The precursor should induce the persistent colloidal stability of the nanoparticles in water. It has been already shown that the Girard’s T reagent (acethydrazide

• trimethylammonium chloride), used as a terminal function in dendrimers, can induce dendrimer solubility in water, allowing the colloidal stability of nanolatex covered by such a function and also the formation of structured hydrogels [43][44]. Hydrazine is a well-known reductant, which has been used for the seeded

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

• Maria Suciu,
• Corina M. Ionescu,
• Alexandra Ciorita,
• Septimiu C. Tripon,
• Dragos Nica,
• Hani Al-Salami and
• Lucian Barbu-Tudoran

Beilstein J. Nanotechnol. 2020, 11, 1092–1109, doi:10.3762/bjnano.11.94

• circulation time than dextran-coated SPIONs [39], having better colloidal stability and reduced agglomeration tendency. In addition, very importantly, the PEG coating did not degrade the magnetization properties of the nanoparticles [82]. Chen et al. [40] showed that SPIONs functionalized with PEG, grafted

• increase in macrophages. The general consideration is that polymer coating offers colloidal stability, but in fact PVA-coated SPIONs are only stable in water at a certain pH value. In cell culture medium they agglomerate. Studies showed that the components of the medium, and not the calf serum added to the

Identification of physicochemical properties that modulate nanoparticle aggregation in blood

• Ludovica Soddu,
• Duong N. Trinh,
• Eimear Dunne,
• Dermot Kenny,
• Giorgia Bernardini,
• Ida Kokalari,
• Arianna Marucco,
• Marco P. Monopoli and
• Ivana Fenoglio

Beilstein J. Nanotechnol. 2020, 11, 550–567, doi:10.3762/bjnano.11.44

• (Table 3). The low polydispersity index (PDI) indicates high colloidal stability and narrow size range distribution. The hydrodynamic diameter of the samples measured by DLS was similar to that measured by NTA, with the exception of the large samples, where the detected diameter with the latter technique

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

• Varsha Sharma and
• Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

• extended to weak PE assemblies [26]. The dissolution of a SiO2 core in a poly(allylamine hydrochloride) (PAH)/poly(methacrylic acid) (PMA) assembly with ammonium fluoride (NH4F) at a suitable pH contributed to both multilayer stability and colloidal stability as shown in the AFM images in Figure 2a–d [24

• at pH 4.5 resulted in a thin and smooth capsule [27]. Similarly, biodegradable cores of polylactic acid polymer have also been investigated with several PEs, but limited by poor colloidal stability [28]. In contrast to the above-mentioned studies, inorganic templates such as carbonates are larger in

Using gold nanoparticles to detect single-nucleotide polymorphisms: toward liquid biopsy

• María Sanromán Iglesias and
• Marek Grzelczak

Beilstein J. Nanotechnol. 2020, 11, 263–284, doi:10.3762/bjnano.11.20

• stability to the nanoparticles, thus ensuring colloidal stability at a higher salt concentrations. On the contrary, the perfect match sequence (mutation-free 5′ terminus) formed a rigid double-stranded DNA (dsDNA) on the particle surface, decreasing steric and electrostatic repulsions, thereby causing

• complementary DNA, the colloidal stability was recovered because of the hybridization of the negatively-charged DNA with the neutral PNA-modified AuNPs. The group of Graham has reported the functionalization of AuNPs (13 nm) with LNAs, revealing a remarkable binding affinity and selectivity towards DNA targets

• the formation of the branched junctions altered the colloidal stability of the nanoparticles, leading to a gradual aggregation. The detection limit of this method was 7.7 fM. With the aim of improving the sensitivity of the plasmon-based colorimetric sensor, Ying and co-workers [82] have used gold

Long-term stability and scale-up of noncovalently bound gold nanoparticle-siRNA suspensions

• Anna V. Epanchintseva,
• Julia E. Poletaeva,
• Dmitrii V. Pyshnyi,
• Elena I. Ryabchikova and
• Inna A. Pyshnaya

Beilstein J. Nanotechnol. 2019, 10, 2568–2578, doi:10.3762/bjnano.10.248

• suspension at 4 °C for different times resulted in the formation of particle clusters of high colloidal stability as demonstrated by conventional methods. These clusters completely disintegrated when albumin was added, indicating that they are agglomerates (and not aggregates) of AuNP-siRNA. The AuNPs-siRNA

• of physicochemical characteristics and siRNA surface density for a long period. Keywords: colloidal stability; gold nanoparticles; scale-up; siRNA delivery; siRNA duplex stability; therapeutic nucleic acids; Introduction Drug delivery to cells is only one application of nanoparticles in biomedicine

• that the freshly prepared suspension is homogeneous and has high colloidal stability in various solutions, except for the DMEM medium. A ten-fold increase in the reaction volume led to a decrease of about 10% in the surface density of AuNP-siRNA nanoconstructions, which caused changes in the

Bombesin receptor-targeted liposomes for enhanced delivery to lung cancer cells

• Mohammad J. Akbar,
• Pâmela C. Lukasewicz Ferreira,
• Melania Giorgetti,
• Leanne Stokes and
• Christopher J. Morris

Beilstein J. Nanotechnol. 2019, 10, 2553–2562, doi:10.3762/bjnano.10.246

• -PEG2000-cystabn conjugate (B). Colloidal stability of liposomes. Control and target liposomes were exposed to PBS (A,C) or 10% FBS in PBS (B,D) at three temperatures for 24/72 h then analysed by DLS. Data shown are mean ± SD, n = 3. GRPR targeting with cystabn increases cell accumulation of liposomes. (A

Small protein sequences can induce cellular uptake of complex nanohybrids

• Jan-Philip Merkl,
• Malak Safi,
• Christian Schmidtke,
• Fadi Aldeek,
• Johannes Ostermann,
• Tatiana Domitrovic,
• Sebastian Gärtner,
• John E. Johnson,
• Horst Weller and
• Hedi Mattoussi

Beilstein J. Nanotechnol. 2019, 10, 2477–2482, doi:10.3762/bjnano.10.238

• for this study, due to their compact size, enhanced colloidal stability, and reduced non-specific interactions in biological media [22][24][25][26][27][28][29][30][31]. The central QDs used to build up the hybrid assemblies were prepared via encapsulation within a polymer coating made of an amine

• ]. In a control experiment, using citrate-stabilized AuNPs in a similar assay, the hybrid self-assembly precipitated within few minutes. This behaviour is attributed to the nature of the citrate coating (weak stabilizer), and further proves that using LA-ZW-AuNPs enhances their colloidal stability of

• the bound MBP stays functional [8][23][28]. Further details are available in Supporting Information File 1. After confirming the structural integrity and colloidal stability of the nanohybrids, we then proceeded to probe their interactions with HeLa cell cultures. For this, dispersions made of

Coating of upconversion nanoparticles with silica nanoshells of 5–250 nm thickness

• Cynthia Kembuan,
• Maysoon Saleh,
• Bastian Rühle,
• Ute Resch-Genger and
• Christina Graf

Beilstein J. Nanotechnol. 2019, 10, 2410–2421, doi:10.3762/bjnano.10.231

• stepwise growth, falls below −40 mV, the particles can be dispersed in an ammoniacal ethanol solution and grown further by the continuous addition of tetraethyl orthosilicate to a diameter larger than 500 nm. Due to the high colloidal stability, a coalescence of the particles can be suppressed, and single

• −20 mV, which explains the low colloidal stability of these particles. The latter was also confirmed by the rather high hydrodynamic diameter of the particles derived from DLS compared to the diameter obtained by STEM (see below in Table 1). A similarly low colloidal stability of the NPs coated with

• indicate low colloidal stability of the particles, which is also supported by the high PDI values suggesting partial aggregation (Table 1). Repeated centrifugation and redispersion in ethanol were carried out in an attempt to improve the colloidal stability by removing the remaining surfactant from the

The role of Ag⁺, Ca²⁺, Pb²⁺ and Al³⁺ adions in the SERS turn-on effect of anionic analytes

• Stefania D. Iancu,
• Andrei Stefancu,
• Vlad Moisoiu,
• Loredana F. Leopold and
• Nicolae Leopold

Beilstein J. Nanotechnol. 2019, 10, 2338–2345, doi:10.3762/bjnano.10.224

• they provide a good trade-off between colloidal stability and surfactant affinity to the AgNP. We avoided the use of chloride-containing silver colloids [13][25] because of the competitive chemisorption between the anionic analyte and the Cl− capping agent to the Ca2+, Pb2+ or Al3+ activated AgNPs, Cl

Microbubbles decorated with dendronized magnetic nanoparticles for biomedical imaging: effective stabilization via fluorous interactions

• Da Shi,
• Justine Wallyn,
• Dinh-Vu Nguyen,
• Francis Perton,
• Delphine Felder-Flesch,
• Sylvie Bégin-Colin,
• Mounir Maaloum and
• Marie Pierre Krafft

Beilstein J. Nanotechnol. 2019, 10, 2103–2115, doi:10.3762/bjnano.10.205

• have been investigated for hyperthermia and magnetic resonance imaging owing to their increased stability in aqueous media and biocompatibility [27][28]. An even stronger anchoring agent consisting of a dendron structure bearing a bisphosphonate polar head provided increased colloidal stability in

Multicomponent bionanocomposites based on clay nanoarchitectures for electrochemical devices

• Giulia Lo Dico,
• Bernd Wicklein,
• Lorenzo Lisuzzo,
• Giuseppe Lazzara,
• Pilar Aranda and
• Eduardo Ruiz-Hitzky

Beilstein J. Nanotechnol. 2019, 10, 1303–1315, doi:10.3762/bjnano.10.129

• ][21]. However, one of the main problems limiting the preparation of HNT-based nanoarchitectured materials is the low colloidal stability of HNTs in aqueous media. This ultimately leads to inhomogeneous and badly performing nanocomposites in spite of the different approaches that have been developed to

Scavenging of reactive oxygen species by phenolic compound-modified maghemite nanoparticles

• Małgorzata Świętek,
• Yi-Chin Lu,
• Rafał Konefał,
• Liliana P. Ferreira,
• M. Margarida Cruz,
• Yunn-Hwa Ma and
• Daniel Horák

Beilstein J. Nanotechnol. 2019, 10, 1073–1088, doi:10.3762/bjnano.10.108

• oxidation under mildly acidic conditions. This high ζ-potential value is considered to be more than sufficient to ensure good colloidal stability of the particles in water. ATR-FTIR spectra were measured in the range of 800–4000 cm−1. The majority of the absorption peaks associated with the vibration of γ

• . The stabilizing effect of the heparin layer was also indicated by the changes in the ζ-potential of the particles before and after modification. Because the absolute value of the ζ-potential is a measure of the repulsion forces between particles in the medium, it indicates the colloidal stability of

• the dispersion. A higher absolute value of the ζ-potential indicates stronger repulsion forces and greater colloidal stability. Moreover, the change in the ζ-potential from positive to negative values indicated that heparin was successfully attached to the particle surface. In the ATR-FTIR spectrum of

Tailoring the stability/aggregation of one-dimensional TiO₂(B)/titanate nanowires using surfactants

• Atiđa Selmani,
• Johannes Lützenkirchen,
• Kristina Kučanda,
• Dario Dabić,
• Engelbert Redel,
• Ida Delač Marion,
• Damir Kralj,
• Darija Domazet Jurašin and
• Maja Dutour Sikirić

Beilstein J. Nanotechnol. 2019, 10, 1024–1037, doi:10.3762/bjnano.10.103

• Information Characterization of surfactants; Characterization of TNWs; SEM micrographs of TNWs in dispersions with DTAB/12-2-12; Colloidal stability of TNWs and TNW/surfactant dispersions. Supporting Information File 132: Additional experimental details. Acknowledgements The authors would like to thank to

• hydrophobic interactions [40], which are influenced by experimental conditions such as pH, ionic strength, concentration of NMs as well as the surfactants in different ways. Surfactant adsorption at the solid/solution interface was used to modify the surface of TNWs and hence influence their colloidal

• stability. As a direct consequence of their amphiphilic nature, surfactant adsorption behavior differs significantly from that of small molecules and ions. During the adsorption of the surfactant molecules on oppositely charged solid surfaces, several steps can be recognized on an adsorption isotherm

Serum type and concentration both affect the protein-corona composition of PLGA nanoparticles

• Katrin Partikel,
• Robin Korte,
• Dennis Mulac,
• Hans-Ulrich Humpf and
• Klaus Langer

Beilstein J. Nanotechnol. 2019, 10, 1002–1015, doi:10.3762/bjnano.10.101

• size distribution with a PDI below 0.1 (see Table 1). The zeta potential of about −40 mV indicated colloidal stability due to electrostatic particle repulsion [14]. In our experimental setup we always referred to a constant surface area of NPs incubated with varying concentrations of serum. Surface

Polydopamine-coated Au nanorods for targeted fluorescent cell imaging and photothermal therapy

• Boris N. Khlebtsov,
• Andrey M. Burov,
• Timofey E. Pylaev and
• Nikolai G. Khlebtsov

Beilstein J. Nanotechnol. 2019, 10, 794–803, doi:10.3762/bjnano.10.79

• ). Finally, the zeta potential of full nanocomposites AuNR-PDA-R123-folate demonstrated a dependence on the pH value similar to that of AuNR-PDA particles. The only difference was that the final nanocomposites demonstrated better colloidal stability and smaller absolute values of positive and negative zeta

Ceria/polymer nanocontainers for high-performance encapsulation of fluorophores

• Kartheek Katta,
• Dmitry Busko,
• Yuri Avlasevich,
• Katharina Landfester,
• Stanislav Baluschev and
• Rafael Muñoz-Espí

Beilstein J. Nanotechnol. 2019, 10, 522–530, doi:10.3762/bjnano.10.53

• inorganic components on the surface have attracted great interest because of the possibility to tune size, composition, porosity, stability, surface functionality, and colloidal stability [6][7][8][9][10][11][12]. Generally, fluorescent dye molecules are sensitive to the external environment, which leads to

Surface plasmon resonance enhancement of photoluminescence intensity and bioimaging application of gold nanorod@CdSe/ZnS quantum dots

• Siyi Hu,
• Yu Ren,
• Yue Wang,
• Jinhua Li,
• Junle Qu,
• Liwei Liu,
• Hanbin Ma and
• Yuguo Tang

Beilstein J. Nanotechnol. 2019, 10, 22–31, doi:10.3762/bjnano.10.3

• contributed to an enhanced lifetime. To make this multifunctional nanomaterial more biocompatible and specific to the cancer cell, we conjugated the FA with GNR@CdSe/ZnS nanoparticles. Firstly, we performed a colloidal stability study in which their hydrodynamic sizes were monitored using the dynamic light

• . Photoluminescence lifetime spectrum of CdSe/ZnS and GNR@CdSe/ZnS. The colloidal stability of GNR@CdSe/ZnS@FA. Microscopy images of MCF-7 breast cancer cell labelled with CdSe/ZnS@FA and GNR@CdSe/ZnS@FA. Lifetime data of the samples. Supporting Information Supporting Information File 2: Relative cell viability of

Hybrid Au@alendronate nanoparticles as dual chemo-photothermal agent for combined cancer treatment

• Anouchka Plan Sangnier,
• Romain Aufaure,
• Laurence Motte,
• Claire Wilhelm,
• Erwann Guenin and
• Yoann Lalatonne

Beilstein J. Nanotechnol. 2018, 9, 2947–2952, doi:10.3762/bjnano.9.273

• suggest that alendronate was grafted onto the nanocrystal surface through the phosphonate groups and could be activated for further biocoupling [10]. The excellent coating density led to a good colloidal stability, as confirmed by dynamic light scattering (DLS) measurements at physiological pH values. A

• concentrations, reaching very high values (over 8000 W/g) at low concentrations. These photothermal properties are in good agreement with those of other thermal agents [23] and show the applicability of Au@alendronate gold NPs as potential photothermal agents. The colloidal stability of Au@alendronate NPs at

Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified γ-Fe₂O₃ nanoparticles towards human tumor cells

• Zdeněk Plichta,
• Yulia Kozak,
• Rostyslav Panchuk,
• Viktoria Sokolova,
• Matthias Epple,
• Lesya Kobylinska,
• Pavla Jendelová and
• Daniel Horák

Beilstein J. Nanotechnol. 2018, 9, 2533–2545, doi:10.3762/bjnano.9.236

• a minimally invasive method that increases the exposure of affected tissues to drug-loaded magnetic nanoparticles [5]. Colloidal stability, high drug-loading capacity, and relatively long circulation time are of primary importance for diverse biomedical applications of magnetic nanoparticles ranging

• contrast agents have been approved by the regulatory authorities. It is well-known that the in vivo distribution of iron oxide nanoparticles is strongly influenced by their surface coatings. The coating ensures colloidal stability, prevents particles from aggregation, introduces functional groups for

• relatively high values of Dh. The ζ-potential of the particles amounted to −35 mV (pH 7.3), which is sufficient for short-term colloidal stability of the particles. Coating of γ-Fe2O3 nanoparticles with poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) Surface modification of nanoparticles is a general

Enhanced antineoplastic/therapeutic efficacy using 5-fluorouracil-loaded calcium phosphate nanoparticles

• Shanid Mohiyuddin,
• Saba Naqvi and
• Gopinath Packirisamy

Beilstein J. Nanotechnol. 2018, 9, 2499–2515, doi:10.3762/bjnano.9.233

•  2A). The particles showed less polydispersity (i.e., a lower polydispersity index (PDI), 0.112) in the aqueous medium and high colloidal stability. The size-controllable synthetic procedure offers enhanced therapeutic efficacy in real time. The size of the aqueous dispersed particles was confirmed by

• agglomeration and enhanced colloidal stability [29]. Since the particle stability mainly depends on the electrical charge of the surface, properties such as cellular uptake, rate of drug release, and blood retention time are directly correlated with the zeta potential value. Furthermore, the zeta potential

• formation as previous reports of the zeta potential for calcium phosphate nanoparticles were −23 mV [31]. The colloidal stability of synthesized CaP@5-FU NPs was monitored for one month in regular intervals and no significant change in the zeta potential value was observed, confirming the stability of the

SERS active Ag–SiO₂ nanoparticles obtained by laser ablation of silver in colloidal silica

• Cristina Gellini,
• Francesco Muniz-Miranda,
• Alfonso Pedone and
• Maurizio Muniz-Miranda

Beilstein J. Nanotechnol. 2018, 9, 2396–2404, doi:10.3762/bjnano.9.224

• unchanged at the same wavelength and with the same bandwidth. Ten minutes of laser ablation are sufficient to obtain a plasmon absorbance more than 2.5 in a 10 mm cuvette. However, a much larger silver content could be obtained with longer ablation times without compromising the colloidal stability. We have

• colloidal stability. The changes in the plasmonic bands observed in the UV–visible absorption spectrum after ligand addition indicate that the adsorbed molecules induce the aggregation of the nanoparticles, therefore favoring a good SERS activity. This is reinforced by the matching of the exciting radiation