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Search for "gene delivery" in Full Text gives 36 result(s) in Beilstein Journal of Nanotechnology.
Synthesis of cobalt nanowires in aqueous solution under an external magnetic field
Beilstein J. Nanotechnol. 2016, 7, 990–994, doi:10.3762/bjnano.7.91
- high-density magnetic storage media [1][2], in immune magnetic separation [3], in gene delivery [4] and as targeted drug carrier [5]. Hydrothermal and solvothermal methods are well-developed approaches to fabricate cobalt nanowires [6][7][8][9][10]. However, such methods set high requirements for the
Improved biocompatibility and efficient labeling of neural stem cells with poly(L-lysine)-coated maghemite nanoparticles
Beilstein J. Nanotechnol. 2016, 7, 926–936, doi:10.3762/bjnano.7.84
- electrostatic interaction between negatively charged ions of the cell membrane and the surface of the culture plate. Due to the presence of NH2 groups, which promote cell adhesion, PLL is as well used as a non-viral transfection agent for gene delivery and DNA complexation [20]. Our previous studies showed that
Silica-coated upconversion lanthanide nanoparticles: The effect of crystal design on morphology, structure and optical properties
Beilstein J. Nanotechnol. 2015, 6, 2290–2299, doi:10.3762/bjnano.6.235
- widespread applications as drug delivery systems in the diagnosis and treatment of various diseases [1][2]. Recently, upconversion nanoparticles have shown promise as optical materials [3] and a number of reviews [4][5][6] have described their applications in drug and gene delivery [7], cell labeling and
Pulmonary surfactant augments cytotoxicity of silica nanoparticles: Studies on an in vitro air–blood barrier model
Beilstein J. Nanotechnol. 2015, 6, 517–528, doi:10.3762/bjnano.6.54
- transfection and delivery studies using mainly cationic polymers or liposomes [8][24]. The positive NP surface charge enables better cellular contact and/or uptake than negatively charged or neutral molecules [25]. Nevertheless, the use of these positively charged drug and gene delivery carriers remains
- used for drug and gene delivery via the lung, as they demonstrate that model systems in vitro must take into account the complexity of the air–blood barrier, including the possible transport-modulating effects of surfactant components. Comparison of cytotoxic effects on A549 after 4 h stimulation with
Overview about the localization of nanoparticles in tissue and cellular context by different imaging techniques
Beilstein J. Nanotechnol. 2015, 6, 263–280, doi:10.3762/bjnano.6.25
- models following exposure with silica nanoparticles (SiO2-NP) [12][13][14]. Inorganic SiO2-NP hold great potential for several biomedical applications, including the selective targeting of cancer cells as well as drug or gene delivery systems due to their favorable biocompatibility and modification
- of cancer cells as well as drug or gene delivery systems due to their favorable biocompatibility and modification possibilities [15][16]. However, labeling of NP always possesses the risk of changing their bioreactivity [20]. Thus, the site of labeling and the properties of the fluorochrome may have
Synthesis of boron nitride nanotubes and their applications
Beilstein J. Nanotechnol. 2015, 6, 84–102, doi:10.3762/bjnano.6.9
- demonstrated that a low electric field was adequate for electroporation. The BNNTs acted as mediators for electroporation as they interacted with the cell membrane. These experimental findings indicated that the BNNTs are promising tools for drug and gene delivery using electroporation [87]. A theoretical
Nanoparticle interactions with live cells: Quantitative fluorescence microscopy of nanoparticle size effects
Beilstein J. Nanotechnol. 2014, 5, 2388–2397, doi:10.3762/bjnano.5.248
- critical size of ≈50 nm are likely to be packaged as a cluster in one vesicle with the optimal size. Of note, Aoyama and colleagues [48] studied size effects and receptor contributions in glycoviral gene delivery and concluded that receptor-mediated endocytosis is optimal for ≈50 nm artificial glycoviruses
Anticancer efficacy of a supramolecular complex of a 2-diethylaminoethyl–dextran–MMA graft copolymer and paclitaxel used as an artificial enzyme
Beilstein J. Nanotechnol. 2014, 5, 2293–2307, doi:10.3762/bjnano.5.238
- an anticancer agent can be prevented if the agent promotes positive allosteric modulation according to the enzyme reaction model of a 1:1 ratio of a substrate and enzyme, which is the ratio utilized in vivo. Gene delivery system On the other hand, development of the gene delivery system in field of
Carbon-based smart nanomaterials in biomedicine and neuroengineering
Beilstein J. Nanotechnol. 2014, 5, 1849–1863, doi:10.3762/bjnano.5.196
- the most important biological applications of these nanomaterials. CNTs: The previously mentioned large surface area and their excellent chemical stability confers CNTs the ability to conjugate and absorb several therapeutic molecules, paving the way for using them as drug- and gene-delivery systems
Precise quantification of silica and ceria nanoparticle uptake revealed by 3D fluorescence microscopy
Beilstein J. Nanotechnol. 2014, 5, 1616–1624, doi:10.3762/bjnano.5.173
- values. For example, Particle_in_Cell-3D was used to compare the uptake efficiency of therapeutic nanoparticles for gene delivery functionalized with different targeting ligands [30]. In addition, our method was successfully applied to measure the influence of flow conditions on the cellular uptake of
Protein-coated pH-responsive gold nanoparticles: Microwave-assisted synthesis and surface charge-dependent anticancer activity
Beilstein J. Nanotechnol. 2014, 5, 1452–1462, doi:10.3762/bjnano.5.158
- targeted drug and gene delivery [29][30][31]. Hence, MTT assays were used to study the cell viabilities of fibroblasts and cancer cells after treatment with AuNPs to check the cytotoxicity and the anticancer properties of the AuNPs for their future biomedical applications. Results and Discussion Synthesis
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