Safe and sustainable by design with ML/AI: A transformative approach to advancing nanotechnology

• Georgia Melagraki

Beilstein J. Nanotechnol. 2026, 17, 176–185, doi:10.3762/bjnano.17.11

• enhance public confidence, fostering an innovation ecosystem where safety and sustainability are fundamental to technological progress. While ML models are often referred to as being a black box, a recent paper up-ended this conception, suggesting that the current gold-standard of in vivo apical end-point

From shield to spear: Charge-reversible nanocarriers in overcoming cancer therapy barriers

• Madhuri Yeduvaka,
• Pooja Mittal,
• Ameer Boyalakuntla,
• Usman Bee Shaik,
• Himanshu Sharma,
• Thakur Gurjeet Singh,
• Siva Nageswara Rao Gajula and
• Lakshmi Vineela Nalla

Beilstein J. Nanotechnol. 2026, 17, 159–175, doi:10.3762/bjnano.17.10

• , nanocarriers encompass diverse types including polymeric nanoparticles, liposomes, micelles, dendrimers, lipid-based carriers, carbon-based nanomaterials, and gold nanoparticles. They exhibit versatile structures (1–100 nm) with diverse morphologies (e.g., spherical, tubular, or conical shapes [14]). With

• materials such as graphene, azobenzene, and gold nanorods [54]. Upon exposure to UV–vis or near-infrared (NIR) light, these materials undergo structural changes or generate ROS, triggering controlled release of their therapeutic cargo. This precise spatiotemporal control over drug release and therapeutic

• tumour photodynamic therapy. The study highlights the excellent light absorption and ROS generation capacity of the material, allowing targeted tumour cell damage while sparing healthy tissues [56]. Similarly, a study reports thermo-responsive gold nanorod vesicles (USGRV-17-AAG) integrate NIR-II

Subdigital integumentary microstructure in Cyrtodactylus (Squamata: Gekkota): do those lineages with incipiently expressed toepads exclusively exhibit adhesive setae?

• Philipp Ginal,
• Yannick Ecker,
• Timothy Higham,
• L. Lee Grismer,
• Benjamin Wipfler,
• Dennis Rödder,
• Anthony Russell and
• Jendrian Riedel

Beilstein J. Nanotechnol. 2026, 17, 38–56, doi:10.3762/bjnano.17.4

Chiral plasmonic nanostructures fabricated with circularly polarized light

• Tian Qiao and
• Ming Lee Tang

Beilstein J. Nanotechnol. 2025, 16, 2245–2264, doi:10.3762/bjnano.16.154

• of achiral PNSs to a more efficient seeded-growth approach in a colloidal phase. The Nam group achieved a significant breakthrough in 2018 with the large-scale synthesis of highly homogenous chiral gold nanostructures using amino acids and peptides [19]. The Tatasuma group developed the first CPL

• plasmonic nanostructures Studies of chirality (both geometrical and optical) on plasmonic nanostructures date back to the 2000s. The early studies were primarily enabled by lithographically fabricated [24] and self-assembled plasmonic nanostructures [25]. Quasi-two-dimensional planar gold propellers [26

• ] and three-dimensional gold helices [27] (Figure 1a) are two representative cPNSs fabricated by nanolithography. Using arrays of plasmonic seeds patterned by nanolithography, versatile cPNSs were also constructed with glancing angle deposition [28] (Figure 1b). Up to now, nanofabrication has produced

Optical bio/chemical sensors for vitamin B₁₂ analysis in food and pharmaceuticals: state of the art, challenges, and future outlooks

• Seyed Mohammad Taghi Gharibzahedi and
• Zeynep Altintas

Beilstein J. Nanotechnol. 2025, 16, 2207–2244, doi:10.3762/bjnano.16.153

• biosensing platforms in detecting Co2+ ions and VB12 using RNA aptamer–gold nanoparticles colorimetric sensors, surface plasmon resonance sensors, chemiluminescence and electrochemiluminescence biosensors, and fluorescence biosensors (i.e., chemosensors, nanoclusters/nanoparticles-based sensors, and carbon

• -based AuNP colorimetric biosensors In this sensing system, the recognition material is the RNA aptamer, the indicator material is the gold nanoparticle (AuNP), and the sensing signal is colorimetric. The excellent optical-electronic characteristics of AuNPs have been recently considered in point-of-care

• (NaYF4) upconversion nanoparticles (UCNPs) on gold nanotriangle arrays acted as the indicator system, and the enhanced near-infrared (NIR)-excited UV luminescence was the sensing signal. This approach relied on the synergistic effects of Tm3+-doped NaYF4 UCNPs on gold nanotriangle arrays created via

Ultrathin water layers on mannosylated gold nanoparticles

• Maiara A. Iriarte Alonso,
• Jorge H. Melillo,
• Silvina Cerveny,
• Yujin Tong and
• Alexander M. Bittner

Beilstein J. Nanotechnol. 2025, 16, 2183–2198, doi:10.3762/bjnano.16.151

• Physics Center (DIPC), Donostia, Spain Fritz-Haber-Institut der Max-Planck-Gesellschaft, Berlin, Germany Fakultät für Physik, Universität Duisburg, Germany Ikerbasque Basque Foundation for Science, Bilbao, Spain 10.3762/bjnano.16.151 Abstract We investigated the effect of air humidity on two gold

• transmission of airborne viruses, such as influenza. Keywords: AFM; humidity; hydrophilicity; hydrophobicity; nanoparticles; sum frequency generation spectroscopy; viruses; water; wetting; Introduction Gold nanoparticles (AuNPs) have been a staple in biomedical and biophysical research [1][2] for almost a

• carbohydrates to AuNPs provides particle stability and biocompatibility and allows for studying carbohydrate-mediated interactions and designing novel carbohydrate-based antiviral agents [8][9]. From a molecular point of view, glyconanoparticles are water-soluble gold nanoclusters with a three-dimensional

Electron transport through nanoscale multilayer graphene and hexagonal boron nitride junctions

• Aleksandar Staykov and
• Takaya Fujisaki

Beilstein J. Nanotechnol. 2025, 16, 2132–2143, doi:10.3762/bjnano.16.147

• sandwiched between conductive materials such as graphene, graphite, and gold. The authors fabricated vertical tunnel junctions with h-BN barriers ranging from one to four atomic layers and demonstrated that the tunneling current decreases exponentially with barrier thickness, confirming quantum mechanical

Quality by design optimization of microemulsions for topical delivery of Passiflora setacea seed oil

• Daniel T. Pereira,
• Douglas Dourado,
• Danielle T. Freire,
• Dayanne L. Porto,
• Cícero F. S. Aragão,
• Myla L. de Souza,
• Guilherme R. S. de Araujo,
• Ana Maria Costa,
• Wógenes N. Oliveira,
• Anne Sapin-Minet,
• Éverton N. Alencar and
• Eryvaldo Sócrates T. Egito

Beilstein J. Nanotechnol. 2025, 16, 2116–2131, doi:10.3762/bjnano.16.146

• assays that capture these dimensions. Ultimately, in vivo models remain the gold standard for assessing wound healing efficacy, as they replicate the dynamic, multicellular, and inflammatory nature of living tissue, providing crucial translational insights that cannot be obtained through in vitro testing

Beyond the shell: exploring polymer–lipid interfaces in core–shell nanofibers to carry hyaluronic acid and β-caryophyllene

• Aline Tavares da Silva Barreto,
• Francisco Alexandrino-Júnior,
• Bráulio Soares Arcanjo,
• Paulo Henrique de Souza Picciani and
• Kattya Gyselle de Holanda e Silva

Beilstein J. Nanotechnol. 2025, 16, 2015–2033, doi:10.3762/bjnano.16.139

• production conditions. This evaluation allowed for the observation of the cross-sectional structure before and after core removal. The nanofibers were coated with approximately 10 nm of gold via sputter deposition for 1 min at 30 mA. Micrographs were acquired using an acceleration voltage of 2 kV and 0.21 nA

The cement of the tube-dwelling polychaete Sabellaria alveolata: a complex composite adhesive material

• Emilie Duthoo,
• Aurélie Lambert,
• Pierre Becker,
• Carla Pugliese,
• Jean-Marc Baele,
• Arnaud Delfairière,
• Matthew J. Harrington and
• Patrick Flammang

Beilstein J. Nanotechnol. 2025, 16, 1998–2014, doi:10.3762/bjnano.16.138

• electron imaging, the anterior parts of a few worms as well as some reconstructed tube fragments were fixed in Bouin’s fluid for 24 h, dehydrated in graded ethanol, dried by the critical-point method, and mounted on aluminium stubs using carbon adhesive tabs. The samples were then coated with gold

Laser ablation in liquids for shape-tailored synthesis of nanomaterials: status and challenges

• Natalie Tarasenka

Beilstein J. Nanotechnol. 2025, 16, 1963–1997, doi:10.3762/bjnano.16.137

• nanowires was close to the diameter of the initial spherical NPs, so the suggested mechanism was laser-induced melting and fusion into nanowires. The formation of gold nanowires from gold NPs was further observed by several research groups [75][76]. Similar transformation of spherical silver NPs into one

Evaluating metal-organic precursors for focused ion beam-induced deposition through solid-layer decomposition analysis

• Benedykt R. Jany,
• Katarzyna Madajska,
• Aleksandra Butrymowicz-Kubiak,
• Franciszek Krok and
• Iwona B. Szymańska

Beilstein J. Nanotechnol. 2025, 16, 1942–1951, doi:10.3762/bjnano.16.135

• . These studies also enabled a clear distinction between the processes occurring under ion irradiation and under electron irradiation. Furthermore, investigations on the gold complex [AuMe2(hfac)] have allowed for the assessment of the influence of ion type (mass) and ion energy on molecular decomposition

Targeting the vector of arboviruses Aedes aegypti with nanoemulsions based on essential oils: a review with focus on larvicidal and repellent properties

• Laryssa Ferreira do Nascimento Silva,
• Douglas Dourado,
• Thayse Silva Medeiros,
• Mariana Alice Gonzaga Gabú,
• Maria Cecilia Queiroga dos Santos,
• Daiane Rodrigues dos Santos,
• Mylena Lemos dos Santos,
• Gabriel Bezerra Faierstein,
• Rosângela Maria Rodrigues Barbosa and
• Fabio Rocha Formiga

Beilstein J. Nanotechnol. 2025, 16, 1894–1913, doi:10.3762/bjnano.16.132

• ]. Additionally, repellents based on DEET (N,N-diethyl-meta-toluamide) are recognized as the gold standard for mosquito repellents; however, these repellents are not widely used in regions at risk for arbovirus transmission, mainly due to accessibility issues, cost, and concerns about long-term safety

On the road to sustainability – application of metallic nanoparticles obtained by green synthesis in dentistry: a scoping review

• Lorena Pinheiro Vasconcelos Silva,
• Joice Catiane Soares Martins,
• Israel Luís Carvalho Diniz,
• Júlio Abreu Miranda,
• Danilo Rodrigues de Souza,
• Éverton do Nascimento Alencar,
• Moan Jéfter Fernandes Costa and
• Pedro Henrique Sette-de-Souza

Beilstein J. Nanotechnol. 2025, 16, 1851–1862, doi:10.3762/bjnano.16.128

• widely studied nanomaterials are metallic nanoparticles, particularly silver (AgNPs), gold (AuNPs), and copper (CuNPs), and various metal oxide nanoparticles such as zinc oxide (ZnO-NPs), due to their high surface-to-volume ratio, chemical stability, and distinctive optical and antimicrobial properties

• nanoparticles synthesized via green chemistry in dentistry. Search strategy and information sources This review was guided by the PCC framework, that is, population (P): metallic nanoparticles (e.g., silver, gold, copper, zinc oxide); concept (C): green synthesis using plant-based extracts or eco-friendly

Electrical, photocatalytic, and sensory properties of graphene oxide and polyimide implanted with low- and medium-energy silver ions

• Josef Novák,
• Eva Štěpanovská,
• Petr Malinský,
• Vlastimil Mazánek,
• Jan Luxa,
• Ulrich Kentsch and
• Zdeněk Sofer

Beilstein J. Nanotechnol. 2025, 16, 1794–1811, doi:10.3762/bjnano.16.123

• Keithley 6317B electrometer. To quantify the sheet resistivity, two gold contacts, each with a thickness of 50 nm and a length of 10 mm, were deposited onto the surfaces of GO and PI thin films. The placement of these contacts adhered to a prescribed contact distance of 1 mm, ensuring a consistent and

Advances of aptamers in esophageal cancer diagnosis, treatment and drug delivery

• Yang Fei,
• Hui Xu,
• Chunwei Zhang,
• Jingjing Wang and
• Yong Jin

Beilstein J. Nanotechnol. 2025, 16, 1734–1750, doi:10.3762/bjnano.16.121

• a single biometric element to directly analyze biomarkers [45][46], while dual-system biosensors combine two antibodies and/or aptamers [47] into a better composite material to improve the specificity and sensitivity of the sensor. Figure 3 is a schematic diagram of a gold nanoparticle aptasensor

• diagnostic outcomes. The establishment of a multiprotein model [49] confirms this conjecture. There are already gold nanoparticle aptamer biosensors and fluorescent aptamer sensors that show great potential in esophageal cancer diagnosis (Table 1). 3.1 Gold nanoparticle–aptamer sensors Scholars reviewed

• -EGFR antibody was combined with gold nanoparticles to form a complex. The target EGFR in test samples was specifically captured by the aptamer, subsequently forming a sandwich detection complex. While the preparation and detection workflow demonstrates notable simplicity, its clinical performance was

Beyond the bilayer: multilayered hygroscopic actuation in pine cone scales

• Kim Ulrich,
• Max David Mylo,
• Tom Masselter,
• Fabian Scheckenbach,
• Sophia Fischerbauer,
• Martin Nopens,
• Silja Flenner,
• Imke Greving,
• Linnea Hesse and
• Thomas Speck

Beilstein J. Nanotechnol. 2025, 16, 1695–1710, doi:10.3762/bjnano.16.119

• imaging beamline P05 operated by Helmholtz-Zentrum Hereon at PETRA III (DESY Deutsches Elektronen Synchrotron, Hamburg, Germany). Phase contrast-based near-field holotomography was used to image our samples, utilizing a 300 µm gold Fresnel zone plate to focus the monochromatic beam with an energy of 11

Ambient pressure XPS at MAX IV

• Mattia Scardamaglia,
• Ulrike Küst,
• Alexander Klyushin,
• Rosemary Jones,
• Jan Knudsen,
• Robert Temperton,
• Andrey Shavorskiy and
• Esko Kokkonen

Beilstein J. Nanotechnol. 2025, 16, 1677–1694, doi:10.3762/bjnano.16.118

• thick liquid films can be used to infer charge transfer processes, since the emitted kinetic energy of a photoelectron is dependent on the potential of the probed liquid relative to the grounded working electrode [69][70]. Specifically, the interfaces of gold, copper oxide, and LiNi1/3Mn1/3Co1/3O2 with

Prospects of nanotechnology and natural products for cancer and immunotherapy

• Jan Filipe Andrade Santos,
• Marcela Bernardes Brasileiro,
• Pamela Danielle Cavalcante Barreto,
• Ligiane Aranha Rocha and
• José Adão Carvalho Nascimento Júnior

Beilstein J. Nanotechnol. 2025, 16, 1644–1667, doi:10.3762/bjnano.16.116

• nanoparticles can be subdivided into five groups according to the type used in the product. Patents WO2016178224 and CN117534780 utilized polysaccharide nanoparticles, while patent KR20220169108 used gold nanoparticles, CN427216811 implemented quantum dot nanoparticles, CN367902299 and CN115887415 employed

• , cellular absorption, and slow release of drugs [38]. Polymeric nanoparticles are colloidal polymer systems used as drug carriers for targeted therapies and diagnostics [39]. Gold nanoparticles have properties such as chemical reactivity, anti-inflammatory effects, and protein-binding abilities, while

• , nanoparticles can be subdivided into various structures, such as carrier-free self-assembly nanoparticles, polymeric nanoparticles, polysaccharide nanoparticles, gold nanoparticles, and quantum dot nanoparticles. Carrier-free self-assembly nanoparticles Carrier-free self-assembly nanoparticles are formed

Transient electronics for sustainability: Emerging technologies and future directions

• Jae-Young Bae,
• Myung-Kyun Choi and
• Seung-Kyun Kang

Beilstein J. Nanotechnol. 2025, 16, 1545–1556, doi:10.3762/bjnano.16.109

• challenges for applications requiring complete resorption within a short timeframe. In terms of electrical conductivity, bioresorbable metals still lag conventional interconnect materials such as copper, gold, and silver, showing reductions of up to 1.96- to 3.65-fold [60]. Despite these limitations

Influence of laser beam profile on morphology and optical properties of silicon nanoparticles formed by laser ablation in liquid

• Natalie Tarasenka,
• Vladislav Kornev,
• Alena Nevar and
• Nikolai Tarasenko

Beilstein J. Nanotechnol. 2025, 16, 1533–1544, doi:10.3762/bjnano.16.108

• laser pulses. For example, laser beams with a donut shape were used for ablating gold, yttrium oxide, and high-entropy alloy targets in water. The donut beam enabled NP size reduction and narrower size distributions [28]. Application of femtosecond Bessel beams for the ablation of silver in a liquid was

Nanomaterials for biomedical applications

• Iqra Zainab,
• Zohra Naseem,
• Syeda Rubab Batool,
• Filippo Pierini,
• Seda Kizilel and
• Muhammad Anwaar Nazeer

Beilstein J. Nanotechnol. 2025, 16, 1499–1503, doi:10.3762/bjnano.16.105

• ]. Polymeric nanoparticles, dendrimers, and carbon-based structures such as carbon nanotubes are very promising when it comes to delivering drugs and genes to certain parts of the body [3]. Conversely, metallic nanoparticles such as gold and iron oxide, and fluorescent quantum dots have applications in

• and can be adjusted to emit different colors based on their size. This reason makes them ideal for simultaneously spotting and examining various biological environments, which aids both laboratory and clinical research [16]. Gold nanoparticles are also an essential group in this field. Optical

• properties of these particles are highly dependent on their size and shape. In a diagnostic test, these nanoparticles remarkably improve imaging contrast and even create noticeable color changes, which is useful in biosensors [17]. Gold nanoparticles were being used in certain COVID-19 test kits that change

Laser processing in liquids: insights into nanocolloid generation and thin film integration for energy, photonic, and sensing applications

• Akshana Parameswaran Sreekala,
• Pooja Raveendran Nair,
• Jithin Kundalam Kadavath,
• Bindu Krishnan,
• David Avellaneda Avellaneda,
• M. R. Anantharaman and
• Sadasivan Shaji

Beilstein J. Nanotechnol. 2025, 16, 1428–1498, doi:10.3762/bjnano.16.104

• including mono- and bimetallic NPs with distinctive structural features such as unique catalytic and plasmonic properties that cannot be achieved by conventional methods [13][14]. The latest review on gold-based NPs by PLAL discusses how laser parameters (e.g., wavelength, pulse duration, and fluence) and

• to a broader range of particle sizes compared to lower laser energy. Fujiwara et al. [32] also observed similar kind of features on thionicotinamide (TNA)-capped gold NPs irradiated at 532 nm (Q-switched Nd:YAG laser, 18 ps). TNA-capped gold NPs underwent fusion as well as fragmentation upon laser

• engineering, and energy storage. LFL can be applied to a wide range of materials, including metals such as gold, silver, or copper, semiconductors, and perovskites materials. The method is versatile enough to cater to the synthesis of NPs across different compositions, making it a valuable tool for

Parylene-coated platinum nanowire electrodes for biomolecular sensing applications

• Chao Liu,
• Peker Milas,
• Michael G. Spencer and
• Birol Ozturk

Beilstein J. Nanotechnol. 2025, 16, 1392–1400, doi:10.3762/bjnano.16.101

• -volume ratio, enhancing sensitivity and functionalization capabilities. Baetsen-Young et al. used dextrin-capped gold nanoparticles (12 nm) with ssDNA to detect the presence of Pseudoperonospora cubensis DNA, where the results show the ability to detect 18 spores/µL crude extractions [11]. However, the

Automated collection and categorisation of STM images and STS spectra with and without machine learning

• Dylan Stewart Barker and
• Adam Sweetman

Beilstein J. Nanotechnol. 2025, 16, 1367–1379, doi:10.3762/bjnano.16.99

• was operated using an RC5 Nanonis controller, with all experiments carried out in UHV (base pressure ≤5 × 10−11 mbar) cooled to 5 K. Gold and silver crystals (spl.eu) were prepared via repeated sputter–anneal cycles, sputtering under an argon pressure of ≈5 × 10−5 mbar, with a beam energy of 1.5 kV