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Search for "liposomes" in Full Text gives 73 result(s) in Beilstein Journal of Nanotechnology.

Ethosomal (−)-epigallocatechin-3-gallate as a novel approach to enhance antioxidant, anti-collagenase and anti-elastase effects

  • Çiğdem Yücel,
  • Gökçe Şeker Karatoprak,
  • Sena Yalçıntaş and
  • Tuğba Eren Böncü

Beilstein J. Nanotechnol. 2022, 13, 491–502, doi:10.3762/bjnano.13.41

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  • noted that the degradation of EGCG under UV was delayed by the ETHs and by the incorporation of tocopherol as an antioxidant in the formulation [35]. In another study, cream-based formulations of different vesicular systems (liposomes, ethosomes, and transfersomes) containing Curcuma longa extract were
  • liposomes, which have limited skin penetration and mostly remain in the upper layer of the stratum corneum. The release of the therapeutic agent occurs by the fusion of these vesicles with the cell membranes in the deeper layers of the skin [11]. ETHs have been reported to help many active substances to be
  • in comparison to studies using liposomes. An improvement of 81.84% was achieved in the area affected by psoriasis [34]. Likewise, it can be said that better therapeutic results are obtained with ethosomal-based systems. Kaur and Saraf prepared and characterized different vesicular systems (liposomes
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Published 31 May 2022

Micro- and nanotechnology in biomedical engineering for cartilage tissue regeneration in osteoarthritis

  • Zahra Nabizadeh,
  • Mahmoud Nasrollahzadeh,
  • Hamed Daemi,
  • Mohamadreza Baghaban Eslaminejad,
  • Ali Akbar Shabani,
  • Mehdi Dadashpour,
  • Majid Mirmohammadkhani and
  • Davood Nasrabadi

Beilstein J. Nanotechnol. 2022, 13, 363–389, doi:10.3762/bjnano.13.31

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  • delivery [50], in vitro diagnosis [51], in vivo imaging [52], and TE purposes. Various NPs can be prepared in the form of liposomes, nanocapsules, micelles, dendrimers, and nanospheres based on their composition and method of preparation. Basically, NPs are designed to function as carriers for bioactive
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Published 11 Apr 2022

Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals

  • Xiaoyan Ma,
  • Haoning Gong,
  • Kenji Ogino,
  • Xuehai Yan and
  • Ruirui Xing

Beilstein J. Nanotechnol. 2022, 13, 284–291, doi:10.3762/bjnano.13.23

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  • antioxidant peptides by proteases. The combination of liposomes or polymers with different payload materials has been reported, for example, PEG-modified liposomes loaded with resveratrol, layer-by-layer-coated gelatin nanoparticles, or Gelucire-based solid lipid and polymeric micelles [14][15][16][17][18][19
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Published 01 Mar 2022

Use of nanosystems to improve the anticancer effects of curcumin

  • Andrea M. Araya-Sibaja,
  • Norma J. Salazar-López,
  • Krissia Wilhelm Romero,
  • José R. Vega-Baudrit,
  • J. Abraham Domínguez-Avila,
  • Carlos A. Velázquez Contreras,
  • Ramón E. Robles-Zepeda,
  • Mirtha Navarro-Hoyos and
  • Gustavo A. González-Aguilar

Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78

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  • metabolism, low bioavailability, and fast elimination of the molecule. Considering this, the present work reviews the use of CUR-based nanosystems as anticancer agents, including conventional nanosystems (i.e., liposomes, nanoemulsions, nanocrystals, nanosuspensions, polymeric nanoparticles) and nanosystems
  • anticancer activity, including liposomes, nanoemulsions, nanocrystals, nanosuspensions, and polymeric nanoparticles, as well as dual effect nanosystems which respond to external stimuli (mainly magnetic nanoparticles and photodynamic therapy), in addition to internal ones. Furthermore, key design factors
  • the other hand, it has been reported that NLC have a higher loading capacity and greater stability than SLN. This is mainly attributed to the fact that NLC have an imperfect crystalline structure and due to the presence of liquid lipids it prevents the expulsion of the drug [61][66]. Liposomes
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Published 15 Sep 2021

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

  • Sepand Tehrani Fateh,
  • Lida Moradi,
  • Elmira Kohan,
  • Michael R. Hamblin and
  • Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

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  • , and sonoporation. These effects can result in the release of encapsulated drugs or genes at the site of interest as well as cell death and considerable image enhancement. The present review discusses US-responsive theranostic nanomaterials under the following categories: MBs, micelles, liposomes
  • efficiency [1]. To overcome the limitations and drawbacks of conventional drugs, such as uncontrolled release and nonspecific biodistribution, drug delivery systems (DDS) such as liposomes, polymeric nanoparticles, or nanoemulsions (NEs) have been extensively explored. However, even conventional DDS often
  • therapeutic efficacy, and decrease undesirable systemic side effects [2]. Smart DDS (also known as stimulus-responsive drug delivery platforms) can be traced back to the late 1970s when thermosensitive liposomes were introduced. These liposomes could locally release drugs in response to externally applied
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Published 11 Aug 2021

Recent progress in magnetic applications for micro- and nanorobots

  • Ke Xu,
  • Shuang Xu and
  • Fanan Wei

Beilstein J. Nanotechnol. 2021, 12, 744–755, doi:10.3762/bjnano.12.58

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  • magnetic helices have been shown to be used as drug carriers delivering liposomes loaded with drugs or DNA to single cells [80]. This reflects the prominent role of tubular and helical spermbots and microrobotic for research on medical treatment. Different from the magnetic tubular and helical structures
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Published 19 Jul 2021

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

  • Nikola Geskovski,
  • Nadica Matevska-Geshkovska,
  • Simona Dimchevska Sazdovska,
  • Marija Glavas Dodov,
  • Kristina Mladenovska and
  • Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

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  • -targeting liposomes were among the first formulation types that employed this specific mechanism. Allen et al. reported that the lipid composition greatly affected the bone marrow affinity of the liposomes. The authors noted that phosphatidylserine and phosphatidylcholine increased the uptake of the
  • liposomes in cultured BM macrophages [26]. Schettini et al. made an attempt at BM targeting by incorporating negatively charged lipids in the liposomes. However, the employed lipid components (1,2-distearoyl-sn-glycero-3-phosphocholine, cholesterol, and dicetylphosphate) did not promote selective BM uptake
  • [27]. Moreover, the authors reported that the size reduction of the liposomes produced better results. The surface modification of liposomes with an anionic amphiphile (N-(3-carboxy-1-oxopropyl)-ʟ-glutamic acid 1,5-bis(hexadecyl ester)), reported by Sou and co-workers, resulted in significant
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Published 29 Apr 2021

PEG/PEI-functionalized single-walled carbon nanotubes as delivery carriers for doxorubicin: synthesis, characterization, and in vitro evaluation

  • Shuoye Yang,
  • Zhenwei Wang,
  • Yahong Ping,
  • Yuying Miao,
  • Yongmei Xiao,
  • Lingbo Qu,
  • Lu Zhang,
  • Yuansen Hu and
  • Jinshui Wang

Beilstein J. Nanotechnol. 2020, 11, 1728–1741, doi:10.3762/bjnano.11.155

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  • modification with PEG or PEI [40]. It should be noted that LE and EE of CNT carriers in this study are higher than those of other nanocarriers such as mesoporous silica nanoparticles (MSNs) or liposomes [39]. In vitro drug release Due to the encapsulation in the nanocarriers after drug loading, a premature
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Published 13 Nov 2020

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

  • Maria Suciu,
  • Corina M. Ionescu,
  • Alexandra Ciorita,
  • Septimiu C. Tripon,
  • Dragos Nica,
  • Hani Al-Salami and
  • Lucian Barbu-Tudoran

Beilstein J. Nanotechnol. 2020, 11, 1092–1109, doi:10.3762/bjnano.11.94

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  • microscopy (EM), iron oxide magnetic beads for the separation of cells and molecules, gold and silver nanoparticles as fiducials for EM, for immuno-EM labeling and surface-enhanced Raman spectroscopy, or for gene transfection, liposomes for drug delivery, and gadolinium or iron oxide nanoparticles for
  • , dendrimers, albumin, silicones, liposomes, poloxamer, poly-ʟ-lysine, sugars, or polyethylene glycol (PEG) [27][28][29][30][31][32][33]. Hyperthermia treatment for cancer therapy is still under scrutiny. It shows great potential due to the property of SPIONs to produce local heat when placed under an
  • infiltrated these macrophages in spheroids of tumor cells and destroyed the cells by hyperthermia in vitro [125]. Moghimi et al. [124] found that liposomes and polymeric nanospheres used as nanocarriers are also opsonized, which promotes their clearance by macrophage activation. The opsonization also leads to
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Published 27 Jul 2020

Key for crossing the BBB with nanoparticles: the rational design

  • Sonia M. Lombardo,
  • Marc Schneider,
  • Akif E. Türeli and
  • Nazende Günday Türeli

Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72

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  • nanoparticles (AuNPs); blood–brain barrier (BBB); drug delivery; liposomes; nanomedicine; polymeric nanoparticles; solid lipid nanoparticles; superparamagnetic iron oxide nanoparticles (SPIONs); Introduction Neurological disorders and brain diseases are real burdens for modern societies and healthcare systems
  • polymeric nanoparticles prepared with PBCA and polymers from the poly(ethylene) family such as poly(lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) [25][26]. Liposomes and other lipidic nanoparticles have also been reported as able to pass the BBB [27], as well as protein-based nanoparticles
  • and, secondly, angiopep-2 increased the accumulation of nanoparticles in glioma cells thanks to recognition of the LRP1 on the glioma cells surface. Lipid-based nanoparticles Liposomes: Liposomes are well-known and well-studied nanocarrier systems. They are composed of a lipid bilayer surrounding a
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Published 04 Jun 2020

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

  • Varsha Sharma and
  • Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

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  • inorganic particles, NPs, proteins, biological cells, liposomes, DNA, dyes and drugs have served as suitable sacrificial templates [22]. After serving as a support to develop multilayer assembly, the core is dissolved by using suitable solvents. Organic cores such as melamine formaldehyde (MF) and
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Published 27 Mar 2020

Brome mosaic virus-like particles as siRNA nanocarriers for biomedical purposes

  • Alfredo Nuñez-Rivera,
  • Pierrick G. J. Fournier,
  • Danna L. Arellano,
  • Ana G. Rodriguez-Hernandez,
  • Rafael Vazquez-Duhalt and
  • Ruben D. Cadena-Nava

Beilstein J. Nanotechnol. 2020, 11, 372–382, doi:10.3762/bjnano.11.28

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  • ]. The accumulation of nanoparticles in tumors, either passively or directed, is extensively documented [14]. Thus, there are multiple efforts to design nanoparticles that function as nanovehicles, mainly composed of liposomes, synthetic polymers, dendrimers, and virus-like particles (VLPs) [13][15
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Published 20 Feb 2020

Phase inversion-based nanoemulsions of medium chain triglyceride as potential drug delivery system for parenteral applications

  • Eike Folker Busmann,
  • Dailén García Martínez,
  • Henrike Lucas and
  • Karsten Mäder

Beilstein J. Nanotechnol. 2020, 11, 213–224, doi:10.3762/bjnano.11.16

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  • drug delivery systems such as solid lipid or polymeric nanoparticles, nanocapsules, liquid nanoemulsions, liposomes and micelles can be used to carry poorly water soluble ingredients of pharmaceuticals for parenteral applications [1][2][3]. Thereby, the physical entrapment of the active ingredients
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Published 17 Jan 2020

Rational design of block copolymer self-assemblies in photodynamic therapy

  • Maxime Demazeau,
  • Laure Gibot,
  • Anne-Françoise Mingotaud,
  • Patricia Vicendo,
  • Clément Roux and
  • Barbara Lonetti

Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15

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Published 15 Jan 2020

The different ways to chitosan/hyaluronic acid nanoparticles: templated vs direct complexation. Influence of particle preparation on morphology, cell uptake and silencing efficiency

  • Arianna Gennari,
  • Julio M. Rios de la Rosa,
  • Erwin Hohn,
  • Maria Pelliccia,
  • Enrique Lallana,
  • Roberto Donno,
  • Annalisa Tirella and
  • Nicola Tirelli

Beilstein J. Nanotechnol. 2019, 10, 2594–2608, doi:10.3762/bjnano.10.250

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  • ., liposomes [26], amphiphilic polymers [31], and gold nanoparticles [32]. We refer the reader to the excellent review of Bushell in 2002 for an extensive physico-mathematical explanation of Dm [25]. Firstly, the AF4-DLS curves (Figure 3A, left) largely overlapped. Thus, it appears that DLS alone (Figure 1
  • to 0.5 mg/mL in both models (Figure 5A). Despite the fragile nature of macrophages, the low toxicity seen for HA-coated chitosan nanoparticles is in accordance with what reported in RAW 264.7 macrophages for other HA-based nanomaterials, such as HA-coated liposomes [36] and a library of lipid
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Published 30 Dec 2019

Bombesin receptor-targeted liposomes for enhanced delivery to lung cancer cells

  • Mohammad J. Akbar,
  • Pâmela C. Lukasewicz Ferreira,
  • Melania Giorgetti,
  • Leanne Stokes and
  • Christopher J. Morris

Beilstein J. Nanotechnol. 2019, 10, 2553–2562, doi:10.3762/bjnano.10.246

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  • vivo cancer imaging. In this report we decorated pegylated liposomes with a GRPR antagonist peptide and studied its interaction with, and accumulation within, lung cancer cells. Results: An N-terminally cysteine modified GRPR antagonist (termed cystabn) was synthesised and shown to inhibit cell growth
  • in vitro. Cystabn was used to prepare a targeted 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (DSPE-PEG2000) lipid conjugate that was formulated into liposomes. The liposomes displayed desirable colloidal properties and good stability under storage conditions
  • . Flow cytometric and microscopic studies showed that fluorescently labelled cystabn-decorated liposomes accumulated more extensively in GRPR over-expressing cells than matched liposomes that contained no cystabn targeting motif. Conclusion: The use of GRPR antagonistic peptides for nanoparticle
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Published 19 Dec 2019

Frontiers in pharmaceutical nanotechnology

  • Matthias G. Wacker

Beilstein J. Nanotechnol. 2019, 10, 2538–2540, doi:10.3762/bjnano.10.244

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  • applied in the development of semisolids. But we still have much to learn. Pharmaceutical science has indisputably become more complex with the discovery of nanocarrier-based delivery systems. Fueled by first successes in the 1990s, liposomes were at the forefront of cancer therapy [12][13]. The
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Published 17 Dec 2019

Small protein sequences can induce cellular uptake of complex nanohybrids

  • Jan-Philip Merkl,
  • Malak Safi,
  • Christian Schmidtke,
  • Fadi Aldeek,
  • Johannes Ostermann,
  • Tatiana Domitrovic,
  • Sebastian Gärtner,
  • John E. Johnson,
  • Horst Weller and
  • Hedi Mattoussi

Beilstein J. Nanotechnol. 2019, 10, 2477–2482, doi:10.3762/bjnano.10.238

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  • [20][21]. This peptide is produced during viral capsid maturation and is thought to enable cellular internalization of the virus. It has been shown that the MBP-fused γ-peptide is able to disrupt artificial liposomes [20][21]. Recently, we have used this His6-MBP-γ to promote the uptake of QDs by
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Published 12 Dec 2019

BergaCare SmartLipids: commercial lipophilic active concentrates for improved performance of dermal products

  • Florence Olechowski,
  • Rainer H. Müller and
  • Sung Min Pyo

Beilstein J. Nanotechnol. 2019, 10, 2152–2162, doi:10.3762/bjnano.10.208

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  • with water. Controlled release is not possible due to the high diffusion coefficient, D, in oils of low viscosity (Einstein equation). Release typically takes place very fast within seconds or milliseconds [1]. The age of smart delivery systems for skin started with the introduction of liposomes to the
  • cosmetic market in 1986 from the company Dior with the product Capture. Liposomes have several advantages for dermal delivery, e.g., adhesiveness to skin due to the small nanometric size, increase of skin moisture related leading to wrinkle reduction, and a stabilization of active agents to some extent. In
  • status of many polymers used, expensive large-scale production and the lack of biodegradability (no “green” products possible, thus no certification after ECOCERT/COSMOS). There were also developments of various “somes”, being derived from the liposomes and finding few applications (e.g., niosomes
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Published 04 Nov 2019

Gold-coated plant virus as computed tomography imaging contrast agent

  • Alaa A. A. Aljabali,
  • Mazhar S. Al Zoubi,
  • Khalid M. Al-Batanyeh,
  • Ali Al-Radaideh,
  • Mohammad A. Obeid,
  • Abeer Al Sharabi,
  • Walhan Alshaer,
  • Bayan AbuFares,
  • Tasnim Al-Zanati,
  • Murtaza M. Tambuwala,
  • Naveed Akbar and
  • David J. Evans

Beilstein J. Nanotechnol. 2019, 10, 1983–1993, doi:10.3762/bjnano.10.195

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  • ; computed tomography (CT); gold; nanotechnology; viruses; targeting; Introduction Numerous types of nanomaterials are currently under investigation in medicine, including dendrimers, polymeric nanoparticles (NPs), liposomes and protein-based NPs. Each system has advantages and disadvantages in terms of its
  • contrast agents including gold nanoparticles (AuNPs) [13], bromine [14], platinum [15], ytterbium [16], gadolinium [4], and tungsten [15]. Many of the systems are made up of a core that is coated with a polymeric material such as liposomes [17], micelles [13], lipoproteins or polymeric nanoparticles [18
  • ]. One of the first examples of such NP-based systems was reported by Caride et al. using brominated phospholipids packaged into liposomes and administered to dogs. Contrast enhancement signals of 40 HU were observed in the liver of imaged animals [14]. Two hours after injection, micelles loaded with
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Published 07 Oct 2019

Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells

  • Liang Xu,
  • Dekang Xu,
  • Ziying Li,
  • Yu Gao and
  • Haijun Chen

Beilstein J. Nanotechnol. 2019, 10, 1933–1942, doi:10.3762/bjnano.10.189

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  • antiproliferative activity against HeLa cells, which is close to that of the clinical anticancer agent paclitaxel [14]. These successful examples demonstrated that the steroidal structure of Di is promising for the discovery of new anticancer drugs. Liposomes that usually consist of phospholipids and are stabilized
  • by cholesterol have been substantially investigated as drug carriers for targeting, modulating drug pharmacokinetics, and decreasing drug toxicity [15][16]. Liposomes also can be used as solubilizing media to enhance solubility and bioavailability of insoluble drugs [17]. Di and our prepared
  • targeted drug delivery to tumors. These nanoparticles can passively accumulate in tumors via enhanced permeability and retention (EPR) effect, thus decreasing the toxicity of nonselective bio-distribution [27]. Considering the advantages of liposomes as a drug delivery system for chemotherapeutic drugs and
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Published 24 Sep 2019

Microfluidic manufacturing of different niosomes nanoparticles for curcumin encapsulation: Physical characteristics, encapsulation efficacy, and drug release

  • Mohammad A. Obeid,
  • Ibrahim Khadra,
  • Abdullah Albaloushi,
  • Margaret Mullin,
  • Hanin Alyamani and
  • Valerie A. Ferro

Beilstein J. Nanotechnol. 2019, 10, 1826–1832, doi:10.3762/bjnano.10.177

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  • unwanted side effects [8][9]. Liposomes, solid lipid nanoparticles, dendrimers, micelles, polymeric nanoparticles, gold nanoparticles, and carbon nanotubes are among the most common types of nanoparticle delivery systems [10]. These efforts have been reported in several studies. For example, Guo et al
  • of Span 60 and chol at a 70:30 molar ratio using the reverse evaporation method for nanoparticle preparation and achieved around 68% curcumin EE [19], which is comparable with our niosomes preparation using T85 at 3:1 FRR. Similarly, Manca et al., achieved curcumin EE of about 66% using liposomes
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Published 05 Sep 2019

Nanoporous smartPearls for dermal application – Identification of optimal silica types and a scalable production process as prerequisites for marketed products

  • David Hespeler,
  • Sanaa El Nomeiri,
  • Jonas Kaltenbach and
  • Rainer H. Müller

Beilstein J. Nanotechnol. 2019, 10, 1666–1678, doi:10.3762/bjnano.10.162

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  • solution, because the application of simple suspensions to the skin normally does not provide a sufficient dermal bioavailability. Classic delivery systems such as liposomes [3] or solid lipid nanoparticles (SLNs) [4][5] do not work because the active agents do not dissolve in the lipidic phase of these
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Published 08 Aug 2019

Targeting strategies for improving the efficacy of nanomedicine in oncology

  • Gonzalo Villaverde and
  • Alejandro Baeza

Beilstein J. Nanotechnol. 2019, 10, 168–181, doi:10.3762/bjnano.10.16

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  • anchored to different nanoparticles for enhancing their uptake into tumoral cells or for binding to tumour vessels. As an example, cyclic NGR, which binds to the aminopeptidase receptor (CD13), was grafted on the surface of temperature-sensitive liposomes loaded with doxorubicin (Dox) for the selective
  • destruction of CD13+ cancer cells as human fibrosarcoma cells (HT-1080) [36]. These liposomes released more than 75% of their payload when the temperature reached 41.3 °C whereas they maintained the Dox within their hydrophilic core at physiological temperature. Other systems widely employed for targeting
  • drug-loaded liposomes for glioblastoma treatment. Glioblastoma, localized in the brain, represents one of the major challenges in drug delivery due to the necessity to pass the blood brain barrier (BBB). BBB inhibits the passage of 98% of the medicines administered through the systemic route and
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Published 14 Jan 2019

Nanoconjugates of a calixresorcinarene derivative with methoxy poly(ethylene glycol) fragments for drug encapsulation

  • Alina M. Ermakova,
  • Julia E. Morozova,
  • Yana V. Shalaeva,
  • Victor V. Syakaev,
  • Aidar T. Gubaidullin,
  • Alexandra D. Voloshina,
  • Vladimir V. Zobov,
  • Irek R. Nizameev,
  • Olga B. Bazanova,
  • Igor S. Antipin and
  • Alexander I. Konovalov

Beilstein J. Nanotechnol. 2018, 9, 2057–2070, doi:10.3762/bjnano.9.195

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  • near the hydrophobic core, whereas the shell, which is composed of hydrophilic groups, ensures the stability of the system in solution. Examples for these amphiphilic compounds are surfactants [1], liposomes [2], polymers [3], and synthetic macrocycles [4]. Calixarenes and calixresorcinarenes are
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Published 27 Jul 2018
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