Nanoparticle delivery to metastatic breast cancer cells by nanoengineered mesenchymal stem cells

• Liga Saulite,
• Karlis Pleiko,
• Ineta Popena,
• Dominyka Dapkute,
• Ricardas Rotomskis and
• Una Riekstina

Beilstein J. Nanotechnol. 2018, 9, 321–332, doi:10.3762/bjnano.9.32

• and the development of new therapies [15][16]. Generally, a nonadherent surface coating (i.e., polyHEMA), hanging-drop assay or microfluidic devices are used to induce spheroid formation [16][19][20][21]. In the current study, we established a 3D co-culture model using QD-labelled MSCs to verify

Thermo- and electro-optical properties of photonic liquid crystal fibers doped with gold nanoparticles

• Agata Siarkowska,
• Miłosz Chychłowski,
• Daniel Budaszewski,
• Bartłomiej Jankiewicz,
• Bartosz Bartosewicz and
• Tomasz R. Woliński

Beilstein J. Nanotechnol. 2017, 8, 2790–2801, doi:10.3762/bjnano.8.278

• nematic–isotropic phase transition temperature [21][22], but with a specific surface coating, the effect can be reversed [23]. The presence of Au NPs in an LC has proven to influence the response time and lower the threshold voltage [24][25][26][27][28]. In this paper we compare four different

Involvement of two uptake mechanisms of gold and iron oxide nanoparticles in a co-exposure scenario using mouse macrophages

• Dimitri Vanhecke,
• Dagmar A. Kuhn,
• Dorleta Jimenez de Aberasturi,
• Sandor Balog,
• Ana Milosevic,
• Dominic Urban,
• Diana Peckys,
• Niels de Jonge,
• Wolfgang J. Parak,
• Alke Petri-Fink and
• Barbara Rothen-Rutishauser

Beilstein J. Nanotechnol. 2017, 8, 2396–2409, doi:10.3762/bjnano.8.239

• load. Both types of NPs have a similar polymeric surface coating. However, the core materials (gold versus iron oxide) and their overall size differ and can both influence the interaction with cells. The core material can, for example, cause catalytic effects, which have been reported to a higher

Optical techniques for cervical neoplasia detection

• Tatiana Novikova

Beilstein J. Nanotechnol. 2017, 8, 1844–1862, doi:10.3762/bjnano.8.186

• a size of less than 100 nm (i.e., which are much smaller than normal human cells) with biomolecules such as receptors, enzymes, and antibodies on the cell surface and inside the cell [87]. By surface coating, functionalization, and integration with different bioconjugated targeting agents those

Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery

• Gamze Varan,
• Juan M. Benito,
• Carmen Ortiz Mellet and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1457–1468, doi:10.3762/bjnano.8.145

• ]. As a result of the surface coating with chitosan, the zeta potential value of 6OCaproβCD nanoparticles increased from −29 mV to +44 mV as seen in Table 3. Unal et al., prepared uncoated and CS-coated 6OCaproβCD nanocapsules for oral camptothecin delivery. They reported that the CS coating increased

Nano-engineered skin mesenchymal stem cells: potential vehicles for tumour-targeted quantum-dot delivery

• Liga Saulite,
• Dominyka Dapkute,
• Karlis Pleiko,
• Ineta Popena,
• Simona Steponkiene,
• Ricardas Rotomskis and
• Una Riekstina

Beilstein J. Nanotechnol. 2017, 8, 1218–1230, doi:10.3762/bjnano.8.123

• lysosomes for degradation or, depending on their surface coating, recycled to the cell surface [48]. On the contrary, QDs taken up by caveolae-dependent endocytosis could bypass lysosomes and avoid lysosomal degradation [48]. Taken together, the accumulated experimental evidence suggests that the QD uptake

Preparation of thick silica coatings on carbon fibers with fine-structured silica nanotubes induced by a self-assembly process

• Benjamin Baumgärtner,
• Hendrik Möller,
• Thomas Neumann and
• Dirk Volkmer

Beilstein J. Nanotechnol. 2017, 8, 1145–1155, doi:10.3762/bjnano.8.116

• –gel techniques [6]. Even though the CVD method leads typically to a uniform and dense surface coating, low deposition rates can make this process time-consuming and expensive. The sol–gel method is advantageous owing to the low processing temperature, inexpensive and commercially available precursors

• dispersions leads to a non-exhaustive coating of the surface. For a more or less complete surface coating, the fiber density in the dispersion should not exceed 1.5 g/L. This challenge and a potential interlocking of silicified fibers are insignificant for a coating process of carbon fiber felts. An activated

• surface coating (Figure 10, Supporting Information File 1, Figure S9). The fiber diameter increases from 17 µm, for the neat fibers, to about 35 µm, for the composite fibers including the nanostructured silica shell. Thermogravimetric analysis of the silica coated activated carbon felt shows that the

Needs and challenges for assessing the environmental impacts of engineered nanomaterials (ENMs)

• Michelle Romero-Franco,
• Hilary A. Godwin,
• Muhammad Bilal and
• Yoram Cohen

Beilstein J. Nanotechnol. 2017, 8, 989–1014, doi:10.3762/bjnano.8.101

• composition, surface coating, molecular structure, crystal structure, physical, form/shape, particle size, size distribution and surface area, agglomeration state, particle density, ENM bulk density, porosity, dispersibility, solubility in water and biologically relevant fluids, surface charge, and surface

Nano- and microstructured materials for in vitro studies of the physiology of vascular cells

• Alexandra M. Greiner,
• Adria Sales,
• Hao Chen,
• Sarah A. Biela,
• Dieter Kaufmann and
• Ralf Kemkemer

Beilstein J. Nanotechnol. 2016, 7, 1620–1641, doi:10.3762/bjnano.7.155

• techniques [76]. In UV-NIL, the mold is brought into contact with a wafer previously coated with photoresist and solidified with UV light. A resolution of 30 nm can be achieved [77]. Focused-ion beam nanolithography relies on a beam of ions to locally modify a surface coating, to mill a substrate or to

Efficient electron-induced removal of oxalate ions and formation of copper nanoparticles from copper(II) oxalate precursor layers

• Kai Rückriem,
• Sarah Grotheer,
• Henning Vieker,
• Paul Penner,
• André Beyer,
• Armin Gölzhäuser and
• Petra Swiderek

Beilstein J. Nanotechnol. 2016, 7, 852–861, doi:10.3762/bjnano.7.77

• layer-by-layer deposition of copper(II) oxalate by alternately dipping a carboxy-terminated surface into solutions of copper(II) acetate and oxalic acid is a robust process yielding a reproducible surface coating. As an extension of this work, the electron-induced decomposition of copper(II) oxalate and

Surface coating affects behavior of metallic nanoparticles in a biological environment

• Darija Domazet Jurašin,
• Marija Ćurlin,
• Ivona Capjak,
• Tea Crnković,
• Marija Lovrić,
• Michal Babič,
• Daniel Horák,
• Ivana Vinković Vrček and
• Srećko Gajović

Beilstein J. Nanotechnol. 2016, 7, 246–262, doi:10.3762/bjnano.7.23

• biocompatibility. This study is aimed to evaluate the effects of surface coating on colloidal stability and behavior of AgNPs and SPIONs in modelled biological environments using dynamic and electrophoretic light scattering techniques, as well as transmission electron microscopy to visualize the behavior of the NP

• ; protein interaction; silver; surface coating; Introduction Functional nanomaterials, including nanoparticles, nanocrystals, and nanoclusters, are promising tools for new medicinal applications, particularly for clinical use in disease diagnosis and treatment [1][2]. However, only a few nanomaterials are

• AgNPs and SPIONs with various coatings are used in many nanotherapeutic and consumer products [44], it has become critical to fill the knowledge gap surrounding the mechanisms of colloidal destabilization including the role of surface coating in the biocompatibility of metallic NP. The systematically

Electrochemical coating of dental implants with anodic porous titania for enhanced osteointegration

• Amirreza Shayganpour,
• Alberto Rebaudi,
• Pierpaolo Cortella,
• Alberto Diaspro and
• Marco Salerno

Beilstein J. Nanotechnol. 2015, 6, 2183–2192, doi:10.3762/bjnano.6.224

• shown in Figure 2b. In all cases, anodization was self-terminated after a very short time of 2–4 s. When the total passed charge was calculated, it appeared to be always comparable (≈12 C), which sets a limit to the surface coating of the implants with the passivating anodic oxide of ≈0.1 C/mm2. The

NanoE-Tox: New and in-depth database concerning ecotoxicity of nanomaterials

• Katre Juganson,
• Angela Ivask,
• Irina Blinova,
• Monika Mortimer and
• Anne Kahru

Beilstein J. Nanotechnol. 2015, 6, 1788–1804, doi:10.3762/bjnano.6.183

• , surface coating and/or functionalisation has been considered as an important parameter determining the biological effects of ENMs. For example, it has been discussed that coating on nanosilver plays an important role in Ag NPs toxicity [4][43][44]. However, information on initial coating or

Influence of surface chemical properties on the toxicity of engineered zinc oxide nanoparticles to embryonic zebrafish

• Zitao Zhou,
• Jino Son,
• Bryan Harper,
• Zheng Zhou and
• Stacey Harper

Beilstein J. Nanotechnol. 2015, 6, 1568–1579, doi:10.3762/bjnano.6.160

• late-onset mortality in coated particles is the result of decreased dissolution of these particles [7][21]. It has been reported that the release of zinc ion from ZnO NPs coated with organic molecule can be slower than uncoated ZnO NPs by up to 10 days, due to the protective effect of the surface

• coating [43]. The idea that coated particles were more benign overall is also supported by the most toxic response being noted for a bare particle (NGZ, Figure 3). In addition, the observed mortality at 24 hpf for some of the surface functionalized particles could have been due to either residual

Conformal SiO₂ coating of sub-100 nm diameter channels of polycarbonate etched ion-track channels by atomic layer deposition

• Nicolas Sobel,
• Christian Hess,
• Manuela Lukas,
• Anne Spende,
• Bernd Stühn,
• M. E. Toimil-Molares and
• Christina Trautmann

Beilstein J. Nanotechnol. 2015, 6, 472–479, doi:10.3762/bjnano.6.48

• coating of the entire membrane by an inorganic material would provide a well-defined reference surface. Coating by means of atomic layer deposition (ALD) is a novel approach to reduce the diameter of track-etched nanochannels in a controlled manner. Channels with diameter below 10 nm are extremely

Fundamental edge broadening effects during focused electron beam induced nanosynthesis

• Roland Schmied,
• Jason D. Fowlkes,
• Robert Winkler,
• Phillip D. Rack and
• Harald Plank

Beilstein J. Nanotechnol. 2015, 6, 462–471, doi:10.3762/bjnano.6.47

• Hybrid scan head and operated with a Nanoscope IV controller together with the C-AFM application module for the respective measurements. OMCL-C240-TS and ASYELEC-01 (TiIr surface coating) cantilevers have been used for AFM/KFM (2-pass tapping mode) and C-AFM (contact mode) measurements, respectively. The

Comparative evaluation of the impact on endothelial cells induced by different nanoparticle structures and functionalization

• Lisa Landgraf,
• Ines Müller,
• Peter Ernst,
• Miriam Schäfer,
• Christina Rosman,
• Isabel Schick,
• Oskar Köhler,
• Hartmut Oehring,
• Vladimir V. Breus,
• Thomas Basché,
• Carsten Sönnichsen,
• Wolfgang Tremel and
• Ingrid Hilger

Beilstein J. Nanotechnol. 2015, 6, 300–312, doi:10.3762/bjnano.6.28

• [7] are suggested. Gold nanorods were shown to have better optical imaging properties compared to spherical gold nanoparticles [8][9][10]. Importantly, the cytotoxicity of gold nanoparticles depends on the surface coating. Cetyltrimethylammonium bromide (CTAB), an important material during synthesis

• -like and spherical shapes. Furthermore, we 1) analyzed the behavior of spherical metal oxide nanoparticles in comparison to asymmetric elongated gold@metal oxide nanoparticles, 2) determined the impact of different nanoparticle materials on cell life, 3) investigated the effects of the surface coating

• noble metal and metal oxide nanoparticles the shape seems to have a higher influence on cell metabolism than the surface coating and the resulting charge. The number of ZnS monolayers (ML) and the surface coating of QDs influences cell viability The evaluation of the most suitable number of ZnS

Oxygen-plasma-modified biomimetic nanofibrous scaffolds for enhanced compatibility of cardiovascular implants

• Anna Maria Pappa,
• Varvara Karagkiozaki,
• Silke Krol,
• Spyros Kassavetis,
• Dimitris Konstantinou,
• Charalampos Pitsalidis,
• Lazaros Tzounis,
• Nikos Pliatsikas and
• Stergios Logothetidis

Beilstein J. Nanotechnol. 2015, 6, 254–262, doi:10.3762/bjnano.6.24

• the delivery of blood and nutrients [12][13]. Therefore, the major challenge towards the long-term success of implants, is to find an appropriate surface coating that maintains the intricate balance between promoting in situ endothelialization, while inhibiting thrombosis and other systemic post

Synthesis of boron nitride nanotubes and their applications

• Saban Kalay,
• Zehra Yilmaz,
• Ozlem Sen,
• Melis Emanet,
• Emine Kazanc and
• Mustafa Çulha

Beilstein J. Nanotechnol. 2015, 6, 84–102, doi:10.3762/bjnano.6.9

• dispersibility in aqueous media (Table 2). However, this may mask the real toxicity of the BNNTs since mostly the surface coating comes in contact with the cells. Based on the reports to date, their toxicity depends on the concentration, cell type and surface modifications, as is the case for all nanomaterials

The capillary adhesion technique: a versatile method for determining the liquid adhesion force and sample stiffness

• Daniel Gandyra,
• Stefan Walheim,
• Stanislav Gorb,
• Wilhelm Barthlott and
• Thomas Schimmel

Beilstein J. Nanotechnol. 2015, 6, 11–18, doi:10.3762/bjnano.6.2

• . The effect of the surface coating of human head hair on its adhesive properties is highly relevant, for example, in the field of hair cosmetics. We investigated natural hair, hair with silicone-coated ends (poly(dimethylsiloxane) (PDMS), Sylgard 184, Dow Corning, water contact angle approx. 110°) and

Mammalian cell growth on gold nanoparticle-decorated substrates is influenced by the nanoparticle coating

• Christina Rosman,
• Sebastien Pierrat,
• Marco Tarantola,
• David Schneider,
• Eva Sunnick,
• Andreas Janshoff and
• Carsten Sönnichsen

Beilstein J. Nanotechnol. 2014, 5, 2479–2488, doi:10.3762/bjnano.5.257

• decorated with various amounts of surfactant-coated particles. A surface density of 65 particles/µm2 (which corresponds to 0.5% of surface coverage with nanoparticles) diminishes micromotion by 25% as compared to bare substrates after 35 hours of incubation. We conclude that the surface coating of the gold

Coating with luminal gut-constituents alters adherence of nanoparticles to intestinal epithelial cells

• Heike Sinnecker,
• Katrin Ramaker and
• Andreas Frey

Beilstein J. Nanotechnol. 2014, 5, 2308–2315, doi:10.3762/bjnano.5.239

• – directly on the cell membrane. This interaction-type can be abolished by treating the particles with proteins (“passivation” of particle surface). Coating of particles with constituents of the intestinal fluid, on the other hand, may result in more complex attachment mechanisms. The intestinal fluid is a

Effect of silver nanoparticles on human mesenchymal stem cell differentiation

• Christina Sengstock,
• Jörg Diendorf,
• Matthias Epple,
• Thomas A. Schildhauer and
• Manfred Köller

Beilstein J. Nanotechnol. 2014, 5, 2058–2069, doi:10.3762/bjnano.5.214

• comparing studies on the biological effects of nano-silver is the difference in the nature of the respective particle. In addition to the size, shape, or surface charge, the surface coating or functionalization used to stabilize the monodisperse nature is of critical importance. An important requirement is

Effects of surface functionalization on the adsorption of human serum albumin onto nanoparticles – a fluorescence correlation spectroscopy study

• Pauline Maffre,
• Stefan Brandholt,
• Karin Nienhaus,
• Li Shang,
• Wolfgang J. Parak and
• G. Ulrich Nienhaus

Beilstein J. Nanotechnol. 2014, 5, 2036–2047, doi:10.3762/bjnano.5.212

• . Functionalization with dihydrolipoic acid (DHLA) resulted in negatively charged QDs due to the DHLA carboxylic acid group. A surface coating with zwitterionic D-penicillamine (DPA), which has both an amino and a carboxyl functional group exposed to the solvent, created a QD with an overall negative net charge in

Influence of surface-modified maghemite nanoparticles on in vitro survival of human stem cells

• Michal Babič,
• Daniel Horák,
• Lyubov L. Lukash,
• Tetiana A. Ruban,
• Yurii N. Kolomiets,
• Svitlana P. Shpylova and
• Oksana A. Grypych

Beilstein J. Nanotechnol. 2014, 5, 1732–1737, doi:10.3762/bjnano.5.183

• report is to describe the labeling of human fibroblast-like cells with new surface-modified superparamagnetic maghemite nanoparticles both before and after their surface coating with D-mannose or poly(N,N-dimethylacrylamide) and to determine the survival of the cells. Possible cytotoxic effects of the