An ISA-TAB-Nano based data collection framework to support data-driven modelling of nanotoxicology

• Richard L. Marchese Robinson,
• Mark T. D. Cronin,
• Andrea-Nicole Richarz and
• Robert Rallo

Beilstein J. Nanotechnol. 2015, 6, 1978–1999, doi:10.3762/bjnano.6.202

Nanocuration workflows: Establishing best practices for identifying, inputting, and sharing data to inform decisions on nanomaterials

• Christina M. Powers,
• Karmann A. Mills,
• Stephanie A. Morris,
• Fred Klaessig,
• Sharon Gaheen,
• Nastassja Lewinski and
• Christine Ogilvie Hendren

Beilstein J. Nanotechnol. 2015, 6, 1860–1871, doi:10.3762/bjnano.6.189

• (e.g., chemistry, toxicology, ecology, risk assessment, material science). The complexity of developing tools for accessing, sharing, and viewing data relevant to nanomaterials has generated an entire field known as nanoinformatics. This paper is one in a series and focuses on a particular aspect of

NanoE-Tox: New and in-depth database concerning ecotoxicity of nanomaterials

• Katre Juganson,
• Angela Ivask,
• Irina Blinova,
• Monika Mortimer and
• Anne Kahru

Beilstein J. Nanotechnol. 2015, 6, 1788–1804, doi:10.3762/bjnano.6.183

• Katre Juganson Angela Ivask Irina Blinova Monika Mortimer Anne Kahru Laboratory of Environmental Toxicology, National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, 12618 Tallinn, Estonia Department of Chemistry, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn

• nanotoxicology by 2005 and the ‘pioneering’ NPs in environmental safety studies were CNTs, fullerenes, TiO2, SiO2 and ZnO. The analysis of the journals that contributed to the database revealed that more than half of the relevant papers originated from seven journals: Environmental Toxicology and Chemistry (29

• papers), Environmental Science & Technology (25), Chemosphere (18), Environmental Pollution (12), Aquatic Toxicology (12), Science of the Total Environment (11), and Journal of Hazardous Materials (10 papers) (Table S4, Supporting Information File 1). Analysis of the database: physico-chemical

The Nanomaterial Data Curation Initiative: A collaborative approach to assessing, evaluating, and advancing the state of the field

• Christine Ogilvie Hendren,
• Christina M. Powers,
• Mark D. Hoover and
• Stacey L. Harper

Beilstein J. Nanotechnol. 2015, 6, 1752–1762, doi:10.3762/bjnano.6.179

• , NC, USA current affiliation: Office of Transportation and Air Quality, Office of Air and Radiation, U.S. EPA, Ann Arbor, MI, USA National Institute for Occupational Safety and Health, Morgantown, WV, USA Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA

• important to chemistry, materials science and toxicology fields as a whole. However, drawing on existing experience with standards development, data handling and data integration to address viable solutions for complex data integration within the scope of nanomaterial data may serve as a specific case that

The eNanoMapper database for nanomaterial safety information

• Nina Jeliazkova,
• Charalampos Chomenidis,
• Philip Doganis,
• Bengt Fadeel,
• Roland Grafström,
• Barry Hardy,
• Janna Hastings,
• Markus Hegi,
• Vedrin Jeliazkov,
• Nikolay Kochev,
• Pekka Kohonen,
• Cristian R. Munteanu,
• Haralambos Sarimveis,
• Bart Smeets,
• Pantelis Sopasakis,
• Georgia Tsiliki,
• David Vorgrimmler and
• Egon Willighagen

Beilstein J. Nanotechnol. 2015, 6, 1609–1634, doi:10.3762/bjnano.6.165

• , Lucca, Italy in silico toxicology Gmbh (IST), Basel, Switzerland 10.3762/bjnano.6.165 Abstract Background: The NanoSafety Cluster, a cluster of projects funded by the European Commision, identified the need for a computational infrastructure for toxicological data management of engineered nanomaterials

• originating from diverse systems. Within this cluster, eNanoMapper works towards supporting the collaborative safety assessment for ENMs by creating a modular and extensible infrastructure for data sharing, data analysis, and building computational toxicology models for ENMs. Results: The eNanoMapper database

• studies in which toxicology or biological interference of the nanomaterials have been studied, in addition to an accurate physicochemical characterisation. Data input, data formats, provenance, visualisation The framework should allow for the representation of data and facts compatible with regulatory

Influence of surface chemical properties on the toxicity of engineered zinc oxide nanoparticles to embryonic zebrafish

• Zitao Zhou,
• Jino Son,
• Bryan Harper,
• Zheng Zhou and
• Stacey Harper

Beilstein J. Nanotechnol. 2015, 6, 1568–1579, doi:10.3762/bjnano.6.160

• Zitao Zhou Jino Son Bryan Harper Zheng Zhou Stacey Harper School of Chemical, Biological and Environmental Engineering, Oregon State University, Corvallis, Oregon, 97330, United States Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon, 97330, United

• estimation; modelling; nanomaterials; nanotechnology; toxicology; Introduction Accelerated advancements in nanotechnology and nanoscience have found applications in a variety of scientific fields, leading to a rapid increase in the types of engineered nanoparticles on the market. In particular, zinc oxide

Hematopoietic and mesenchymal stem cells: polymeric nanoparticle uptake and lineage differentiation

• Ivonne Brüstle,
• Thomas Simmet,
• Gerd Ulrich Nienhaus,
• Katharina Landfester and
• Volker Mailänder

Beilstein J. Nanotechnol. 2015, 6, 383–395, doi:10.3762/bjnano.6.38

• Institute of Applied Physics, Karlsruhe Institute of Technology (KIT), Wolfgang-Gaede-Straße 1, 76131 Karlsruhe, Germany Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany Department of Physics

• functionality, etc. should be investigated. Additionally, even for industrial applications (e.g., coatings in automotive and other types of industries) toxicology studies are warranted. In this study, we demonstrated that polystyrene and polylactide particles are taken up not only by hMSCs, but also at a

Overview about the localization of nanoparticles in tissue and cellular context by different imaging techniques

• Anja Ostrowski,
• Daniel Nordmeyer,
• Alexander Boreham,
• Cornelia Holzhausen,
• Lars Mundhenk,
• Christina Graf,
• Martina C. Meinke,
• Annika Vogt,
• Sabrina Hadam,
• Jürgen Lademann,
• Eckart Rühl,
• Ulrike Alexiev and
• Achim D. Gruber

Beilstein J. Nanotechnol. 2015, 6, 263–280, doi:10.3762/bjnano.6.25

• are available on NP pharmacology and toxicology in humans and animals [8][9]. However, despite all advancements in in vitro testing including permanent or primary cell lines and ex vivo organ cultures, the complexity of a living organism cannot be modeled in a test tube or culture dish. In this regard

Size-dependent density of zirconia nanoparticles

• Agnieszka Opalinska,
• Iwona Malka,
• Wojciech Dzwolak,
• Tadeusz Chudoba,
• Adam Presz and
• Witold Lojkowski

Beilstein J. Nanotechnol. 2015, 6, 27–35, doi:10.3762/bjnano.6.4

• as a luminescent material, the luminescence intensity increases with crystallite size [17]. The size and surface properties of NPs are also important for toxicology and health applications. The size of the NPs can influence their distribution in the human body and the mechanism of their penetration

Proinflammatory and cytotoxic response to nanoparticles in precision-cut lung slices

• Stephanie Hirn,
• Nadine Haberl,
• Kateryna Loza,
• Matthias Epple,
• Wolfgang G. Kreyling,
• Barbara Rothen-Rutishauser,
• Markus Rehberg and
• Fritz Krombach

Beilstein J. Nanotechnol. 2014, 5, 2440–2449, doi:10.3762/bjnano.5.253

• to thank Alexander Dietrich and Thomas Gudermann from the Walther-Straub Institute for Pharmacology and Toxicology, LMU Munich, for providing the Krumdieck tissue slicer. Moreover, we would like to thank Claudia Fahney for her excellent technical assistance. Many thanks also to Tobias Stöger from the

Functionalized polystyrene nanoparticles as a platform for studying bio–nano interactions

• Cornelia Loos,
• Tatiana Syrovets,
• Anna Musyanovych,
• Volker Mailänder,
• Katharina Landfester,
• G. Ulrich Nienhaus and
• Thomas Simmet

Beilstein J. Nanotechnol. 2014, 5, 2403–2412, doi:10.3762/bjnano.5.250

• induce lung injury. Changes in material, size or the surface of the particles results in alternation of the toxicity, which makes it unlikely to integrate nanoparticle toxicology in a single unifying concept [24]. Macrophages are phagocytes that are equipped with specific receptors, which enable the

Nanoparticle interactions with live cells: Quantitative fluorescence microscopy of nanoparticle size effects

• Li Shang,
• Karin Nienhaus,
• Xiue Jiang,
• Linxiao Yang,
• Katharina Landfester,
• Volker Mailänder,
• Thomas Simmet and
• G. Ulrich Nienhaus

Beilstein J. Nanotechnol. 2014, 5, 2388–2397, doi:10.3762/bjnano.5.248

• Chemistry, Chinese Academy of Science, Changchun, 130022, China Max Planck Institute for Polymer Research, 55128 Mainz, Germany Institute of Pharmacology of Natural Products & Clinical Pharmacology, Ulm University, D-89081 Ulm, Germany Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of

Rapid degradation of zinc oxide nanoparticles by phosphate ions

• Rudolf Herrmann,
• F. Javier García-García and
• Armin Reller

Beilstein J. Nanotechnol. 2014, 5, 2007–2015, doi:10.3762/bjnano.5.209

• account when assessing the biological effects or the toxicology of zinc oxide nanoparticles. Keywords: degradation; phosphate; silica shell; zinc oxide nanoparticles; zinc phosphate; Introduction Crystalline nanoparticles of the semiconductor zinc oxide (ZnO-NP) show a broad fluorescence band in the

• environment to its comparatively high reactivity. We could show that phosphate ions are able to degrade ZnO-NP regardless if coated by silica or not. The results are of importance for any investigation of the interaction of ZnO-NP with biological systems and for toxicology studies when buffer solutions or

The surface properties of nanoparticles determine the agglomeration state and the size of the particles under physiological conditions

• Christoph Bantz,
• Olga Koshkina,
• Thomas Lang,
• Hans-Joachim Galla,
• C. James Kirkpatrick,
• Roland H. Stauber and
• Michael Maskos

Beilstein J. Nanotechnol. 2014, 5, 1774–1786, doi:10.3762/bjnano.5.188

• inhalation toxicology. The preparation of the poly(organosiloxane) particles that we report on is based on previously described syntheses by our group [66][69]. These procedures were extended as follows [75]: First, core–shell particles with a dye-labelled core were synthesized by using the basic synthesis

Silica nanoparticles are less toxic to human lung cells when deposited at the air–liquid interface compared to conventional submerged exposure

• Alicja Panas,
• Andreas Comouth,
• Harald Saathoff,
• Thomas Leisner,
• Marco Al-Rawi,
• Michael Simon,
• Gunnar Seemann,
• Olaf Dössel,
• Sonja Mülhopt,
• Hanns-Rudolf Paur,
• Susanne Fritsch-Decker,
• Carsten Weiss and
• Silvia Diabaté

Beilstein J. Nanotechnol. 2014, 5, 1590–1602, doi:10.3762/bjnano.5.171

• Alicja Panas Andreas Comouth Harald Saathoff Thomas Leisner Marco Al-Rawi Michael Simon Gunnar Seemann Olaf Dossel Sonja Mulhopt Hanns-Rudolf Paur Susanne Fritsch-Decker Carsten Weiss Silvia Diabate Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Campus North, Hermann-von

In vitro interaction of colloidal nanoparticles with mammalian cells: What have we learned thus far?

• Moritz Nazarenus,
• Qian Zhang,
• Mahmoud G. Soliman,
• Pablo del Pino,
• Beatriz Pelaz,
• Susana Carregal-Romero,
• Joanna Rejman,
• Barbara Rothen-Rutishauser,
• Martin J. D. Clift,
• Reinhard Zellner,
• G. Ulrich Nienhaus,
• James B. Delehanty,
• Igor L. Medintz and
• Wolfgang J. Parak

Beilstein J. Nanotechnol. 2014, 5, 1477–1490, doi:10.3762/bjnano.5.161

• , Universitätsstraße 5, 45141 Essen, Germany Institute of Applied Physics and Institute of Toxicology and Genetics, Karlsruhe Institute of Technology (KIT), Wolfgang-Gaede-Straße 1, 76131 Karlsruhe, Germany Department of Physics, University of Illinois at Urbana-Champaign, 1110 West Green Street, Urbana, IL 61801, USA

Mimicking exposures to acute and lifetime concentrations of inhaled silver nanoparticles by two different in vitro approaches

• Fabian Herzog,
• Kateryna Loza,
• Sandor Balog,
• Martin J. D. Clift,
• Matthias Epple,
• Peter Gehr,
• Alke Petri-Fink and
• Barbara Rothen-Rutishauser

Beilstein J. Nanotechnol. 2014, 5, 1357–1370, doi:10.3762/bjnano.5.149

• applied via instillation [34] or by inhalation [35]. In order to reduce the number of animals used for research, continuous efforts are made towards sophisticated in vitro methods for toxicology testing [36]. The most commonly used in vitro setup for many studies are submerged cultured lung cells [30][36

Injection of ligand-free gold and silver nanoparticles into murine embryos does not impact pre-implantation development

• Ulrike Taylor,
• Wiebke Garrels,
• Annette Barchanski,
• Svea Peterson,
• Laszlo Sajti,
• Andrea Lucas-Hahn,
• Lisa Gamrad,
• Ulrich Baulain,
• Sabine Klein,
• Wilfried A. Kues,
• Stephan Barcikowski and
• Detlef Rath

Beilstein J. Nanotechnol. 2014, 5, 677–688, doi:10.3762/bjnano.5.80

• of nanoparticles seems a likely scenario, but apparently depends on a variety of factors which are not well understood. Embryo toxicology of nanoparticles has mainly been investigated on piscine embryos, mostly zebra fish. The tested materials include gold (AuNP) [13][14][15], silver (AgNP) [13][16

• -incubated with AuNP as reference particles. No effect on embryo development was observed for the AuNP control. The listed studies show that embryo-toxicology of nanoparticles seems to depend on a variety of factors. One major point is the chemical composition of the particles. However, even particles in

Porous polymer coatings as substrates for the formation of high-fidelity micropatterns by quill-like pens

• Michael Hirtz,
• Marcus Lyon,
• Wenqian Feng,
• Andrea E. Holmes,
• Harald Fuchs and
• Pavel A. Levkin

Beilstein J. Nanotechnol. 2013, 4, 377–384, doi:10.3762/bjnano.4.44

• Functional Materials (CNFM), University of Nebraska-Lincoln, USA Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Germany Physical Institute and Center for Nanotechnology (CeNTech), University of Münster, Germany Applied Physical Chemistry, Heidelberg University, Germany