Review of advanced sensor devices employing nanoarchitectonics concepts

• Katsuhiko Ariga,
• Tatsuyuki Makita,
• Masato Ito,
• Taizo Mori,
• Shun Watanabe and
• Jun Takeya

Beilstein J. Nanotechnol. 2019, 10, 2014–2030, doi:10.3762/bjnano.10.198

• biomolecules including amino acids [156], peptides [157][158][159], sugars [160][161], nucleic acid bases [162][163], and nucleotides [164][165][166] at well-designed interfacial environments. In order to design and fabricate sensors with better performance, interfacial nanoarchitectonics should be crucial

High-tolerance crystalline hydrogels formed from self-assembling cyclic dipeptide

• Yongcai You,
• Ruirui Xing,
• Qianli Zou,
• Feng Shi and
• Xuehai Yan

Beilstein J. Nanotechnol. 2019, 10, 1894–1901, doi:10.3762/bjnano.10.184

• materials have shown outstanding characteristics, such as excellent biocompatibility, structural flexibility, versatile functionality, and low immunogenicity [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. Peptides can be deliberately engineered to self-assemble into well-ordered

• on the basic structures of heterocyclic 2,5-diketopiperazines, are a special kind of dipeptides. They are the smallest cyclic peptides and contain six-membered heterocyclic lactam ring cores. CDPs exhibit exceptional structural rigidity, stability, as well as biological activity as compared to their

• properties The rheological properties of hydrogels are key evaluation indicators for a variety of applications [50][51]. It is typically challenging for hydrogels based on linear peptides to maintain their original gel state for a long time or under shear force. Driven by a thermodynamic process, they tend

Engineered superparamagnetic iron oxide nanoparticles (SPIONs) for dual-modality imaging of intracranial glioblastoma via EGFRvIII targeting

• Xianping Liu,
• Chengjuan Du,
• Haichun Li,
• Ting Jiang,
• Zimiao Luo,
• Zhiqing Pang,
• Daoying Geng and
• Jun Zhang

Beilstein J. Nanotechnol. 2019, 10, 1860–1872, doi:10.3762/bjnano.10.181

• peptide on PNPs was calculated to be as high as 45.3%. Under our experimental conditions, it could be calculated that there were 240 PEPHC1 peptides for each PNP. The T2-weighted MR images of the PNP nanoprobes were evaluated in vitro with a 3.0 T clinical MRI scanner. As demonstrated in Figure 2a, the MR

Biocatalytic oligomerization-induced self-assembly of crystalline cellulose oligomers into nanoribbon networks assisted by organic solvents

• Yuuki Hata,
• Yuka Fukaya,
• Toshiki Sawada,
• Masahito Nishiura and
• Takeshi Serizawa

Beilstein J. Nanotechnol. 2019, 10, 1778–1788, doi:10.3762/bjnano.10.173

• harmonization of mutual interactions [1][2][3][4][5][6][7][8][9][10][11]. Such harmonized mechanisms are found ubiquitously in biological systems consisting of a huge number of components; biomolecules, such as DNAs and peptides, and even living cells have therefore attracted considerable attention in

Chiral nanostructures self-assembled from nitrocinnamic amide amphiphiles: substituent and solvent effects

• Hejin Jiang,
• Huahua Fan,
• Yuqian Jiang,
• Li Zhang and
• Minghua Liu

Beilstein J. Nanotechnol. 2019, 10, 1608–1617, doi:10.3762/bjnano.10.156

• of living matter and perhaps even a requirement for life [1][2]. For example, the α-helix of peptides, the DNA double helix, and the triple helix of collagens are vital biological structures. It is an important issue to understand how such chiral nanostructures can be formed from simple small

Materials nanoarchitectonics at two-dimensional liquid interfaces

• Katsuhiko Ariga,
• Michio Matsumoto,
• Taizo Mori and
• Lok Kumar Shrestha

Beilstein J. Nanotechnol. 2019, 10, 1559–1587, doi:10.3762/bjnano.10.153

• Liu and co-workers [131]), and supramolecular assemblies with short peptides and their bio-functions (by Yan and co-workers [132]) have been investigated. As examples of research efforts regarding two-dimensional nanoarchitectures, the enhanced reduction of nitrogen oxides by facet-engineered two

• ]. Although molecular recognition via hydrogen bonding are quite difficult in a highly polar aqueous media, the molecular recognition of sugars [145][146], peptides [147][148][149], amino acids [150], nucleic acid bases [151][152], and nucleotides [153][154] is accomplishable at the air–water interface even

Enhanced inhibition of influenza virus infection by peptide–noble-metal nanoparticle conjugates

• Zaid K. Alghrair,
• David G. Fernig and
• Bahram Ebrahimi

Beilstein J. Nanotechnol. 2019, 10, 1038–1047, doi:10.3762/bjnano.10.104

• enhanced antiviral activity compared to the free peptides. The IC50 value of the FluPep-functionalised nanoparticles decreased as the grafting density of FluPep ligand increased from 0.03% to 5% (both mol/mol), with IC50 values down to about 10% of that of the corresponding free peptide. The data

• demonstrate that conjugation of FluPep to gold and silver nanoparticles enhances its antiviral potency; the antimicrobial activity of silver ions may enable the design of even more potent antimicrobial inhibitors, capable of targeting both influenza and bacterial co-infections. Keywords: antiviral peptides

• therapeutic use of other antiviral peptides has been demonstrated in HIV [8][9], hepatitis C [10], herpes simplex [11][12], influenza virus [13][14][15]. The infectivity of influenza A viruses, including the H1N1 subtype, is strongly inhibited by a peptide called FluPep [15]. FluPep was originally identified

Serum type and concentration both affect the protein-corona composition of PLGA nanoparticles

• Katrin Partikel,
• Robin Korte,
• Dennis Mulac,
• Hans-Ulrich Humpf and
• Klaus Langer

Beilstein J. Nanotechnol. 2019, 10, 1002–1015, doi:10.3762/bjnano.10.101

• human serum indicate a higher level of cationic proteins in the corona (Figure 3 and Figure 4) [28]. Additionally, the hard-corona proteins were identified by a shotgun proteomics-based approach. The adsorbed proteins were tryptically digested and the resulting peptides were analyzed by LC–MS/MS and

• the standard technique for the investigation of complex protein mixtures in recent years. Following tryptic digestion of the proteins, peptides were identified using LC–MS/MS on an orbitrap-based mass spectrometer and software-based data evaluation to interpret the peptide fragmentation data. In this

• spectrometry To prepare for a successful mass spectrometric analysis of the peptides the samples were purified by solid-phase extraction in order to remove salts and undesired impurities. Briefly, StrataTM-X 33u RP 30 mg/1 mL columns (Phenomenex, Aschaffenburg, Germany) were sequentially activated and

Polydopamine-coated Au nanorods for targeted fluorescent cell imaging and photothermal therapy

• Boris N. Khlebtsov,
• Andrey M. Burov,
• Timofey E. Pylaev and
• Nikolai G. Khlebtsov

Beilstein J. Nanotechnol. 2019, 10, 794–803, doi:10.3762/bjnano.10.79

• capacity for various cargo molecules such as drugs or photodynamic dyes. Third, the coating should have functional groups and be ready for click conjugation with target or “shadowing” molecules, e.g., antibodies, peptides, folates and PEG. Finally, the AuNR coating procedure should be robust and provide a

Targeting strategies for improving the efficacy of nanomedicine in oncology

• Gonzalo Villaverde and
• Alejandro Baeza

Beilstein J. Nanotechnol. 2019, 10, 168–181, doi:10.3762/bjnano.10.16

• occurs without any loss of the antibody binding capacity. Unfortunately, the use of antibodies as targeting moieties has an important drawback, which is the possibility to trigger immune responses due to the uncontrolled exposition of immunogenic regions (as Fc) on the particle surface. Peptides are

• the action of a cell surface-associated protease exposing the RGD, which then binds to neuropilin-1 triggering the particle endocytosis. Another cell-penetrating peptide (or CPP, which is the usual name of the peptides used for targeting purposes in nanomedicine) closely related to RGD is the

• vacuolating virus 40 (SV40), GRKKRRQRRRPQ in the TAT peptide present in human immunodeficiency virus (HIV), or KRPAATKKAGQAKKKKL in the case of nucleoplasmin [45]. These peptides have been anchored on the surface of different nanocarriers providing excellent results [46]. The aptamer AS1411 selective for

A comparison of tarsal morphology and traction force in the two burying beetles Nicrophorus nepalensis and Nicrophorus vespilloides (Coleoptera, Silphidae)

• Liesa Schnee,
• Benjamin Sampalla,
• Josef K. Müller and
• Oliver Betz

Beilstein J. Nanotechnol. 2019, 10, 47–61, doi:10.3762/bjnano.10.5

• fraction has been investigated so far, polar components such as proteins/peptides and carbohydrates might contribute to its amphiphilic property. Directionality of friction force Our nanotribometer experiments (performed on the fore tarsi) clearly revealed a direction-dependent (anisotropic) friction

Nanoscale characterization of the temporary adhesive of the sea urchin Paracentrotus lividus

• Ana S. Viana and
• Romana Santos

Beilstein J. Nanotechnol. 2018, 9, 2277–2286, doi:10.3762/bjnano.9.212

• groove typically found on the surface of amyloid fibrils. Therefore, besides binding to amyloid proteins and peptides, thioflavin-T can also bind DNA, some polysaccharides and β-sheet-rich proteins [25]. Taken together, our results stress the importance of probing marine adhesives under native conditions

Colorimetric detection of Cu²⁺ based on the formation of peptide–copper complexes on silver nanoparticle surfaces

• Gajanan Sampatrao Ghodake,
• Surendra Krishna Shinde,
• Rijuta Ganesh Saratale,
• Avinash Ashok Kadam,
• Ganesh Dattatraya Saratale,
• Asad Syed,
• Fuad Ameen and
• Dae-Young Kim

Beilstein J. Nanotechnol. 2018, 9, 1414–1422, doi:10.3762/bjnano.9.134

• typical experiment, casein peptide-modified AgNPs were prepared by reduction of AgNO3 and the functionality of the AgNP–peptide conjugates to coordinate Cu2+ was improved by removing unbound casein peptides. Highly dispersed and stable 20 nm diameter AgNPs had an extinction peak at about 410 nm with a

• peak in the UV–vis spectra at approximately 410–420 nm. The wavelength of maximum absorbance (λmax) can be used to determine the approximate concentration and the size range of the stable AgNPs. Herein, synthesis of AgNPs was performed using just 0.06% (w/v) casein peptides in the solution, to

• casein peptides (Figure 1a). The minor red-shift (from 400 to 410 nm) and changes in the SPR peak width are indicative of the stable and dispersed nature of the AgNPs. Both peaks remained narrow, indicating a more homogeneous size distribution. Moreover, the absorption measurements revealed the stability

Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations

• Jaison Jeevanandam,
• Ahmed Barhoum,
• Yen S. Chan,
• Alain Dufresne and
• Michael K. Danquah

Beilstein J. Nanotechnol. 2018, 9, 1050–1074, doi:10.3762/bjnano.9.98

Enzymatically promoted release of organic molecules linked to magnetic nanoparticles

• Chiara Lambruschini,
• Silvia Villa,
• Luca Banfi,
• Fabio Canepa,
• Fabio Morana,
• Annalisa Relini,
• Paola Riani,
• Renata Riva and
• Fulvio Silvetti

Beilstein J. Nanotechnol. 2018, 9, 986–999, doi:10.3762/bjnano.9.92

• delivery; enzyme catalysis; magnetic nanoparticles; magnetic properties; peptides; Introduction A major challenge of current cancer therapies is to improve the selectivity of chemotherapeutic agents against tumour cells. This goal may be achieved by exploiting smart drug delivery approaches. Magnetic

Strategy to discover full-length amyloid-beta peptide ligands using high-efficiency microarray technology

• Clelia Galati,
• Natalia Spinella,
• Lucio Renna,
• Danilo Milardi,
• Francesco Attanasio,
• Michele Francesco Maria Sciacca and
• Corrado Bongiorno

Beilstein J. Nanotechnol. 2017, 8, 2446–2453, doi:10.3762/bjnano.8.243

• Aβ and blocking the early steps of amyloid aggregation. Here, we show the combination of high-efficiency slides (HESs) with peptide microarrays as a promising tool for identifying small peptides that bind Aβ monomers. To this aim, HESs with two immobilized reference peptides, (i.e., KLVFF and Semax

• , and scientists believe that the observed build-up of plaque between nerve cells could be the cause of cell death [1]. Two peptides, 40 and 42 amino acids long, known as Aβ40 and Aβ42 amyloid, are the main constituents of the fibrillar plaques [2]. Although amyloid fibrils were initially considered the

• ], osmolytes [8], curcumin [9], carnosine [10], peptide β-sheet breakers [11][12][13], epigallocatechin-3-gallate (ECGC) [14], D-enantiomeric peptides [15], nonpeptidic β-sheet breakers [16], Sylibins [17], and metal ionophores [18], have been investigated for their potential to treat AD by preventing Aβ

Self-assembly of chiral fluorescent nanoparticles based on water-soluble L-tryptophan derivatives of p-tert-butylthiacalix[4]arene

• Pavel L. Padnya,
• Irina A. Khripunova,
• Olga A. Mostovaya,
• Timur A. Mukhametzyanov,
• Vladimir G. Evtugyn,
• Vyacheslav V. Vorobev,
• Yuri N. Osin and
• Ivan I. Stoikov

Beilstein J. Nanotechnol. 2017, 8, 1825–1835, doi:10.3762/bjnano.8.184

• -tert-butylthiacalix[4]arene in cone conformation capable of recognizing peptides [35]. Similar compounds in cone and 1,3-alternate conformations containing peptide fragments as substituents were able to form complexes with DNA [36]. In both cases, solubility in water was achieved by introducing

Luminescent supramolecular hydrogels from a tripeptide and nitrogen-doped carbon nanodots

• Maria C. Cringoli,
• Slavko Kralj,
• Marina Kurbasic,
• Massimo Urban and
• Silvia Marchesan

Beilstein J. Nanotechnol. 2017, 8, 1553–1562, doi:10.3762/bjnano.8.157

• materials. Peptide self-assembled hydrogels are inherently biocompatible and biodegradable and thus are promising biomaterials for cell culture, regenerative medicine, tissue engineering, and drug delivery applications [22]. The identification of self-assembling peptides that are as short as possible is

• highly useful due to the low cost and simplicity of synthesis, as opposed to longer peptides that require solid-phase-peptide synthesis [23]. The most typical approach employs N-capped short peptides, especially whereby the N-capping group is a hydrophobic, aromatic moiety that assists self-assembly in

• useful approach to introduce additional properties to soft materials. In the case of self-assembling peptides, non-covalent π–π interactions between the nanocarbon and aromatic residues of the peptide offer a convenient means to bring the two components together into a supramolecular system [34]. This

Carbon nanomaterials sensitize prostate cancer cells to docetaxel and mitomycin C via induction of apoptosis and inhibition of proliferation

• Kati Erdmann,
• Jessica Ringel,
• Silke Hampel,
• Manfred P. Wirth and
• Susanne Fuessel

Beilstein J. Nanotechnol. 2017, 8, 1307–1317, doi:10.3762/bjnano.8.132

• various therapeutic drugs and to be internalized by cells. Furthermore, the functionalization with targeting ligands against cancer cell-specific molecules such as antibodies, peptides or aptamers represents another advantage of carbon nanomaterials [9][10][11][12]. We and others have previously shown

Selective photodissociation of tailored molecular tags as a tool for quantum optics

• Ugur Sezer,
• Philipp Geyer,
• Moritz Kriegleder,
• Maxime Debiossac,
• Armin Shayeghi,
• Markus Arndt,
• Lukas Felix and
• Marcel Mayor

Beilstein J. Nanotechnol. 2017, 8, 325–333, doi:10.3762/bjnano.8.35

• visionary sketch in Figure 7. Currently we are investigating the potential of the concept for biomolecules with tagged oligo- and poly-peptides. Sketch of the photocleavable 2-(phenoxymethyl)-1-nitrobenzene subunit and its intramolecular photon induced degradation sequence which leads to the release of the

Structural and tribometric characterization of biomimetically inspired synthetic "insect adhesives"

• Matthias W. Speidel,
• Malte Kleemeier,
• Andreas Hartwig,
• Klaus Rischka,
• Angelika Ellermann,
• Rolf Daniels and
• Oliver Betz

Beilstein J. Nanotechnol. 2017, 8, 45–63, doi:10.3762/bjnano.8.6

• performed analyses [15][18] have confirmed the presence of polysaccharides, peptides and (glycosylated) proteins in the adhesive secretion of the desert locust Schistocerca gregaria and the Madagascan hissing cockroach Gromphadorhina portentosa and have thus confirmed previous assumptions of Vötsch et al

Intercalation and structural aspects of macroRAFT agents into MgAl layered double hydroxides

• Dessislava Kostadinova,
• Ana Cenacchi Pereira,
• Muriel Lansalot,
• Franck D’Agosto,
• Elodie Bourgeat-Lami,
• Fabrice Leroux,
• Christine Taviot-Guého,
• Sylvian Cadars and
• Vanessa Prevot

Beilstein J. Nanotechnol. 2016, 7, 2000–2012, doi:10.3762/bjnano.7.191

• matrices [5][6][7]. For instance, hybrid LDH involving amino acids, peptides, nucleosides, nucleic acids [8][9][10], biopolymers [11][12] and various drugs [13][14][15] were investigated to develop efficient systems for therapeutic applications [16][17]. Various dyes (sulfonated spyrospiran, methyl orange

Nano- and microstructured materials for in vitro studies of the physiology of vascular cells

• Alexandra M. Greiner,
• Adria Sales,
• Hao Chen,
• Sarah A. Biela,
• Dieter Kaufmann and
• Ralf Kemkemer

Beilstein J. Nanotechnol. 2016, 7, 1620–1641, doi:10.3762/bjnano.7.155

• through electrostatic interactions [149][150]. A more native coating of artificial surfaces can be achieved by absorbing molecules from the extracellular matrix (ECM). Commonly used cell ligands enabling a specific cell adhesion are either the full molecules or peptides with motifs from ECM molecules such

• for ECs and SMCs on VE-cadherin decorated nanopatterns was also demonstrated here. Although both cell types adhere equally poor on VE-cadherin compared to the RGD and REDV peptides, a universally characteristic cell adhesion behavior depending on the ligand spacing was indicated [255]. 2.4 Signal

Antitumor magnetic hyperthermia induced by RGD-functionalized Fe₃O₄ nanoparticles, in an experimental model of colorectal liver metastases

• Oihane K. Arriortua,
• Eneko Garaio,
• Borja Herrero de la Parte,
• Maite Insausti,
• Luis Lezama,
• Fernando Plazaola,
• Jose Angel García,
• Jesús M. Aizpurua,
• Maialen Sagartzazu,
• Mireia Irazola,
• Nestor Etxebarria,
• Ignacio García-Alonso,
• Alberto Saiz-López and
• José Javier Echevarria-Uraga

Beilstein J. Nanotechnol. 2016, 7, 1532–1542, doi:10.3762/bjnano.7.147

• cells, being bound the RGD peptides by “click chemistry” due to its selectivity and applicability. The thermal decomposition of iron metallo-organic precursors yield homogeneous Fe3O4 nanoparticles that have been properly functionalized with RGD peptides, and the preparation of magnetic fluids has been

• molecule which remains on the cell surface [24][25]. The fact that RGD (arginylglycylaspartic acid) peptides are highly specific for integrins (such as αVβ3 and αVβ5, which are specifically expressed in tumor endothelia [26][27]) confirms the validity of this peptide as one of the most promising binding

• motifs. These molecules could also be easily modified with functional groups, from azides or amines to other amino acids and fluorophores that give them different specificities [28]. One of the procedures to bind RGD peptides due to its unique features such as high aqueous competency, efficiency and

Novel roles for well-known players: from tobacco mosaic virus pests to enzymatically active assemblies

• Claudia Koch,
• Fabian J. Eber,
• Carlos Azucena,
• Alexander Förste,
• Stefan Walheim,
• Thomas Schimmel,
• Alexander M. Bittner,
• Holger Jeske,
• Hartmut Gliemann,
• Sabine Eiben,
• Fania C. Geiger and
• Christina Wege

Beilstein J. Nanotechnol. 2016, 7, 613–629, doi:10.3762/bjnano.7.54

• (length: 300 nm) in combination with functional ligands such as peptides, enzymes, dyes, drugs or inorganic materials is advantageous for applications ranging from biomedical imaging and therapy approaches over surface enlargement of battery electrodes to the immobilization of enzymes. TMV building blocks

• , energy conversion, plasmonics or magnetic resonance imaging [82][92][100][114][115][116][117][118][119][120][121], and as carrier rods for effector peptides for distinct purposes from affinity binding, intravital targeting up to cell-culture supports [105][111][117][122][123][124], or as antigens for

• utilized RNA-free TMV-like rod assemblies fashioned with antigenic peptides as receptor layer, serving as haptens for the binding of specific antibodies. Its further development aims primarily at the construction of widely applicable biosensing devices recording biological antibody-target interactions, as