3D printing of mineral–polymer bone substitutes based on sodium alginate and calcium phosphate

• Aleksey A. Egorov,
• Alexander Yu. Fedotov,
• Anton V. Mironov,
• Vladimir S. Komlev,
• Vladimir K. Popov and
• Yury V. Zobkov

Beilstein J. Nanotechnol. 2016, 7, 1794–1799, doi:10.3762/bjnano.7.172

• biomimetic approach in which 3D printing of composite structures involves a chemical interaction of the polymer slurry with a liquid “ink”, leading to in situ formation of a CP phase in the final product. It is well known that alginate allows precipitation of inorganic phases within its macromolecular

• printed samples can be adjusted further by chemical post-treatment. For instance, the hydrolysis of DCPD might lead to the development of an octacalcium phosphate phase and an adhesive effect between particles could take place [17]. Conclusion We propose a new “biomimetic + 3D printing” approach for

Biomechanics of selected arborescent and shrubby monocotyledons

• Tom Masselter,
• Tobias Haushahn,
• Samuel Fink and
• Thomas Speck

Beilstein J. Nanotechnol. 2016, 7, 1602–1619, doi:10.3762/bjnano.7.154

• ). This assumption is verified by the good accordance of the calculated values of the axial Young’s modulus via the Voigt model. The higher strength of fibrous bundles in the periphery is also vital for the support of (peripherally developing) branches in D. marginata. Biomimetic approaches and outlook

Viability and proliferation of endothelial cells upon exposure to GaN nanoparticles

• Tudor Braniste,
• Ion Tiginyanu,
• Tibor Horvath,
• Simion Raevschi,
• Serghei Cebotari,
• Marco Lux,
• Axel Haverich and
• Andres Hilfiker

Beilstein J. Nanotechnol. 2016, 7, 1330–1337, doi:10.3762/bjnano.7.124

• of premature tissue damage and dispensing of medications. Nature supplies many examples of biomimetic materials in the form of organic/inorganic components such as bone, teeth, and muscle. Based on biological examples, new and innovative biological materials can be designed through self-organization

Reconstitution of the membrane protein OmpF into biomimetic block copolymer–phospholipid hybrid membranes

• Matthias Bieligmeyer,
• Franjo Artukovic,
• Stephan Nussberger,
• Thomas Hirth,
• Thomas Schiestel and
• Michaela Müller

Beilstein J. Nanotechnol. 2016, 7, 881–892, doi:10.3762/bjnano.7.80

• , Germany 10.3762/bjnano.7.80 Abstract Structure and function of many transmembrane proteins are affected by their environment. In this respect, reconstitution of a membrane protein into a biomimetic polymer membrane can alter its function. To overcome this problem we used membranes formed by poly(1,4

• -isoprene-block-ethylene oxide) block copolymers blended with 1,2-diphytanoyl-sn-glycero-3-phosphocholine. By reconstituting the outer membrane protein OmpF from Escherichia coli into these membranes, we demonstrate functionality of this protein in biomimetic lipopolymer membranes, independent of the

• been assessed yet [46][47]. In the present work, we studied the reconstitution of OmpF from Escherichia coli into biomimetic lipopolymer membranes, generated by self-assembly of amphiphilic poly(1,4-isoprene-block-ethylene oxide) block copolymers (PIPEO) and 1,2-diphytanoyl-sn-glycero-3-phosphocholine

Comparative kinematical analyses of Venus flytrap (Dionaea muscipula) snap traps

• Simon Poppinga,
• Tim Kampowski,
• Amélie Metzger,
• Olga Speck and
• Thomas Speck

Beilstein J. Nanotechnol. 2016, 7, 664–674, doi:10.3762/bjnano.7.59

• . Moreover, opening kinematics of young and adult Dionaea snap traps reveal that reverse snap buckling is not performed, corroborating the assumption that growth takes place on certain trap lobe regions. Our findings are discussed in an evolutionary, biomechanical, functional–morphological and biomimetic

• of snapping [2][20][21][22][23]. Our observations on the different modes of trap closing could be of potential interest for biomimetic approaches [24] where fast and large-scale deformation of thin shells as well as principles for generation, storage and release of elastic energy are important. As

Green and energy-efficient methods for the production of metallic nanoparticles

• Mitra Naghdi,
• Mehrdad Taheran,
• Satinder K. Brar,
• M. Verma,
• R. Y. Surampalli and
• J. R. Valero

Beilstein J. Nanotechnol. 2015, 6, 2354–2376, doi:10.3762/bjnano.6.243

• , biological and biomimetic processes are attracting the attention of researchers due to their viability and potential in minimization of waste [62][92]. For example, synthesis of NPs in bio-directed systems and using bio-molecules as templates for production of inorganic molecules has attracted biologists and

DNA–melamine hybrid molecules: from self-assembly to nanostructures

• Rina Kumari,
• Shib Shankar Banerjee,
• Anil K. Bhowmick and
• Prolay Das

Beilstein J. Nanotechnol. 2015, 6, 1432–1438, doi:10.3762/bjnano.6.148

• molecules can result in unique DNA-based nanostructures for application in molecular and cellular biophysics, as biomimetic systems, in energy transfer and photonics, and in diagnostics and therapeutics [18][19][20][21]. Moreover, as a bottom-up technique, such a methodology can contribute to molecular

Self-assembled anchor layers/polysaccharide coatings on titanium surfaces: a study of functionalization and stability

• Ognen Pop-Georgievski,
• Dana Kubies,
• Josef Zemek,
• Neda Neykova,
• Roman Demianchuk,
• Eliška Mázl Chánová,
• Miroslav Šlouf,
• Milan Houska and
• František Rypáček

Beilstein J. Nanotechnol. 2015, 6, 617–631, doi:10.3762/bjnano.6.63

• anchoring layers of self-assembled bisphosphonate neridronate monolayers and polymer films of 3-aminopropyltriethoxysilane and biomimetic poly(dopamine). These were further used to bind a bio-functional alginate coating. The success of the titanium surface activation, anchoring layer formation and alginate

• established continuity of the layers are examined by scanning electron microscopy, surface profilometry and atomic force microscopy. The changes in hydrophilicity after each modification step are further examined by contact angle goniometry. Keywords: alginate; biomimetic surfaces; bisphosphonates

Exploiting the hierarchical morphology of single-walled and multi-walled carbon nanotube films for highly hydrophobic coatings

• Francesco De Nicola,
• Paola Castrucci,
• Manuela Scarselli,
• Francesca Nanni,
• Ilaria Cacciotti and
• Maurizio De Crescenzi

Beilstein J. Nanotechnol. 2015, 6, 353–360, doi:10.3762/bjnano.6.34

• hierarchical morphology is reversed (bigger MWCNT scale superimposed on the smaller SWCNT scale), thereby losing the hierarchical fakir effect [7][43]. Therefore, the SWCNT/MWCNT sample has the best hydrophobic behavior because is the most biomimetic. We remark that the large deviation of the average value of

Oxygen-plasma-modified biomimetic nanofibrous scaffolds for enhanced compatibility of cardiovascular implants

• Anna Maria Pappa,
• Varvara Karagkiozaki,
• Silke Krol,
• Spyros Kassavetis,
• Dimitris Konstantinou,
• Charalampos Pitsalidis,
• Lazaros Tzounis,
• Nikos Pliatsikas and
• Stergios Logothetidis

Beilstein J. Nanotechnol. 2015, 6, 254–262, doi:10.3762/bjnano.6.24

• of these biomimetic tissue-engineering constructs as efficient coatings for enhanced compatibility of cardiovascular implants. Keywords: cardiovascular implants; electrospun nanofibers; plasma treatment; scaffold; tissue engineering; Introduction Cardiovascular diseases represent one of the major

• ideal material should degrade and remodel with autologous cells into a natural structure [3] while the surface should be able to guide the process of tissue formation. To this end, biomimetic surface coatings and modifications using appropriate durable and biocompatible nanomaterials have already been

• properties along with the topographical nanoscale features of the scaffolds could be very useful in the design of novel biomimetic coatings, able to guide tissue regeneration especially in cardiovascular implant industry, where in situ vascular regeneration remains an unmet challenge. Experimental Scaffold

Multifunctional layered magnetic composites

• Maria Siglreitmeier,
• Baohu Wu,
• Tina Kollmann,
• Martin Neubauer,
• Gergely Nagy,
• Dietmar Schwahn,
• Vitaliy Pipich,
• Damien Faivre,
• Dirk Zahn,
• Andreas Fery and
• Helmut Cölfen

Beilstein J. Nanotechnol. 2015, 6, 134–148, doi:10.3762/bjnano.6.13

• Discussion Synthetic concept It is the aim to synthesize a material of larger dimensions by developing a multifunctional biomimetic composite structure, which combines properties of two biominerals in one and the same material, namely nacre and chiton teeth. To reach this goal we follow the key synthesis

The capillary adhesion technique: a versatile method for determining the liquid adhesion force and sample stiffness

• Daniel Gandyra,
• Stefan Walheim,
• Stanislav Gorb,
• Wilhelm Barthlott and
• Thomas Schimmel

Beilstein J. Nanotechnol. 2015, 6, 11–18, doi:10.3762/bjnano.6.2

• outgrowths such as hairs or trichomes, which widely occur on biological surfaces, sometimes have unique adhesive and elastic properties optimally adapted to specific functional requirements. As these are often mimicked in technical applications, their characterization is of great interest in a biomimetic

• interface by the trichome tips which hold it under perturbations without the loss of air by bubble formation. Although the adhesive force of small elastic structures play a key role in understanding biological and biomimetic structures (as well as sensors, micromechanical or microfluidic systems), the

• biomimetic surfaces. To demonstrate the wide range of applications of this method, we also investigated human head hairs as a second example. Finally, calibrated atomic force microscopy (AFM) cantilevers were tested as a representative for an artificial micromechanical system, which at the same time allowed

Nanobioarchitectures based on chlorophyll photopigment, artificial lipid bilayers and carbon nanotubes

• Marcela Elisabeta Barbinta-Patrascu,
• Stefan Marian Iordache,
• Ana Maria Iordache,
• Nicoleta Badea and
• Camelia Ungureanu

Beilstein J. Nanotechnol. 2014, 5, 2316–2325, doi:10.3762/bjnano.5.240

• (obtained by hydration of a dipalmitoyl phosphatidylcholine thin film) with and without cholesterol were labelled with a natural photopigment (chlorophyll a), which functioned as a sensor to detect modifications in the artificial lipid bilayers. These biomimetic membranes were used to build non-covalent

• interest in the fields of nanotechnology and biomedicine [1][2][3]. Special attention has been paid to biomimetic membranes that convey biocompatibility to the hybrid materials [4][5][6][7]. One of the building blocks used to construct nanomaterials are carbon nanotubes (CNTs), which are allotropes of

• cholesterol (Zaverage = 609.8 ± 112.7; PDI = 0.397 ± 0.053). Chla inserted into the lipid bilayers of liposomes was used as a spectral sensor to monitor the events occurring in the biomimetic membranes. The visible absorption spectra of the samples were normalized versus the absorption at the maximum peak

Anticancer efficacy of a supramolecular complex of a 2-diethylaminoethyl–dextran–MMA graft copolymer and paclitaxel used as an artificial enzyme

• Yasuhiko Onishi,
• Yuki Eshita,
• Rui-Cheng Ji,
• Masayasu Onishi,
• Takashi Kobayashi,
• Masaaki Mizuno,
• Jun Yoshida and
• Naoji Kubota

Beilstein J. Nanotechnol. 2014, 5, 2293–2307, doi:10.3762/bjnano.5.238

• been shown. In addition, proteins, Langmuir–Blodgett films (a self-organizing film), and liquid crystals have been studied as supramolecular assemblies. Moreover, the development of biomimetic polymers by using new supramolecular assemblies is expected, such as artificial enzymes with highly selective

• protein and he noted that when a protein is a giant molecule, it can react as an enzyme [31]. However, different from a general catalyst, the formation of an enzyme complex is possible in the presence of large molecular subunits within the enzyme. Accordingly, biomimetic supramolecular assemblies

Biopolymer colloids for controlling and templating inorganic synthesis

• Laura C. Preiss,
• Katharina Landfester and
• Rafael Muñoz-Espí

Beilstein J. Nanotechnol. 2014, 5, 2129–2138, doi:10.3762/bjnano.5.222

• origin and synthetic, have been used as controlling agents for crystallization. This field of the so-called “polymer-controlled crystallization” has been reviewed in detail in several publications of Cölfen and collaborators [9][10][11][12]. Among the different natural or biomimetic polymers studied, we

• vivo mineralization, trying to study the effects of natural macromolecules [30]. Silicateins, for instance, are proteins not only used ex vivo for understanding mineralization processes in sponges, but also applied to prepare novel biomimetic hybrid materials, as nicely revised in a recent publication

• groups were shown to have an effect on the growth and on the final properties of inorganic materials such as zinc oxide [40][41], calcium oxalate [38], or calcium carbonate [42][43]. It is expectable that analogous effects should be obtained when biopolymeric (or synthetic biomimetic chains) are attached

Electrostatic interplay: The interaction triangle of polyamines, silicic acid, and phosphate studied through turbidity measurements, silicomolybdic acid test, and ²⁹Si NMR spectroscopy

• Anne Jantschke,
• Katrin Spinde and
• Eike Brunner

Beilstein J. Nanotechnol. 2014, 5, 2026–2035, doi:10.3762/bjnano.5.211

• interactions [23][24]. However, they interact with the silicic acid/silica species via hydrogen bonding and possibly hydrophobic interactions. These interactions even result in the stabilization of mono- and disilicic acid species [22][23]. The described observations have meanwhile lead to numerous biomimetic

Carbon-based smart nanomaterials in biomedicine and neuroengineering

• Antonina M. Monaco and
• Michele Giugliano

Beilstein J. Nanotechnol. 2014, 5, 1849–1863, doi:10.3762/bjnano.5.196

• Computer Science, University of Sheffield, S1 4DP Sheffield, UK 10.3762/bjnano.5.196 Abstract The search for advanced biomimetic materials that are capable of offering a scaffold for biological tissues during regeneration or of electrically connecting artificial devices with cellular structures to restore

Real-time monitoring of calcium carbonate and cationic peptide deposition on carboxylate-SAM using a microfluidic SAW biosensor

• Anna Pohl and
• Ingrid M. Weiss

Beilstein J. Nanotechnol. 2014, 5, 1823–1835, doi:10.3762/bjnano.5.193

• a buffer system similar to biomineralizing compartments. It can be concluded that multichannel microfluidic SAW sensor systems are highly attractive for biomimetic mineralization studies in liquids and in real-time. It remains subject to further investigations whether this technique will bring the

From sticky to slippery: Biological and biologically-inspired adhesion and friction

• Stanislav N. Gorb and
• Kerstin Koch

Beilstein J. Nanotechnol. 2014, 5, 1450–1451, doi:10.3762/bjnano.5.157

• theoretical studies which range from insect adhesion, bacterial adhesion and skin friction to artificial biomimetic systems, e.g., snake-skin inspired polymer patterns or gecko tape. The Thematic Series does not attempt to give a comprehensive overview of the emerging field of biological contact mechanics

Model systems for studying cell adhesion and biomimetic actin networks

• Dorothea Brüggemann,
• Johannes P. Frohnmayer and
• Joachim P. Spatz

Beilstein J. Nanotechnol. 2014, 5, 1193–1202, doi:10.3762/bjnano.5.131

• various such integrins have been studied by incorporating the proteins into lipid membranes. These proteolipid structures lay the foundation for the development of artificial cells, which are able to adhere to substrates. To build biomimetic models for studying cell shape and spreading, actin networks can

• integrin reconstitution in GUVs to date was published in 2008. Streicher et al. developed a novel biomimetic system based on giant vesicles that mimicked the first steps of integrin-mediated cell adhesion [54]. GUVs were produced from small liposomes by electroformation and had a diameter of 20 to 40 μm

• cytoskeleton in natural cells is to stabilise more integrins in the adhesion zones to form focal adhesion spots by recruiting FAK and other cytoplasmic proteins. 3. Biomimetic actin cortices in lipid vesicles Due to the importance of actin in cell adhesion several studies have already been presented on the

Physical principles of fluid-mediated insect attachment - Shouldn’t insects slip?

• Jan-Henning Dirks

Beilstein J. Nanotechnol. 2014, 5, 1160–1166, doi:10.3762/bjnano.5.127

• [2][3][4][5][6][7]. In recent years more elaborate microscopes and better analytical tools have become available and the interest of biologists and engineers in biological and biomimetic adhesives has increased [8][9][10][11][12][13]. Imaging techniques such as atomic force microscopy (AFM) and

Insect attachment on crystalline bioinspired wax surfaces formed by alkanes of varying chain lengths

• Elena Gorb,
• Sandro Böhm,
• Nadine Jacky,
• Louis-Philippe Maier,
• Kirstin Dening,
• Sasha Pechook,
• Boaz Pokroy and
• Stanislav Gorb

Beilstein J. Nanotechnol. 2014, 5, 1031–1041, doi:10.3762/bjnano.5.116

• corrections of the manuscript. This study was partly supported by the SPP 1420 of the German Science Foundation ‘Biomimetic Materials Research: Functionality by Hierarchical Structuring of Materials’ (project GO 995 ⁄ 9-2) to SG.

Molecular biology approaches in bioadhesion research

• Marcelo Rodrigues,
• Birgit Lengerer,
• Thomas Ostermann and
• Peter Ladurner

Beilstein J. Nanotechnol. 2014, 5, 983–993, doi:10.3762/bjnano.5.112

• for the respective organism. The need for new strategies in adhesion research demands efforts in key molecular biology technologies. Enhancing our ability to understand in vivo adhesive molecules is essential for exploring biomimetic approaches to synthesising new adhesive products. A molecular

Direct observation of microcavitation in underwater adhesion of mushroom-shaped adhesive microstructure

• Lars Heepe,
• Alexander E. Kovalev and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2014, 5, 903–909, doi:10.3762/bjnano.5.103

• .; Gorb, S. N. Underwater adhesion of mushroom-shaped adhesive microstructure: An air-entrapment effect. In Biological and biomimetic adhesives: Challenges and opportunities; Santos, R.; Aldred, N.; Gorb, S. N.; Flammang, P., Eds.; The Royal Society of Chemistry: Cambridge, U.K., 2013; pp 65–71] rather

• in predominantly liquid environments. Keywords: bio-inspired; biomimetic; cavitation; contact mechanics; gecko; interface; negative pressure; pull-off; surface; tribology; Introduction During the past two decades, bio-inspired microstructured adhesives became a new class of adhesive materials with

Measuring air layer volumes retained by submerged floating-ferns Salvinia and biomimetic superhydrophobic surfaces

• Matthias J. Mayser,
• Holger F. Bohn,
• Meike Reker and
• Wilhelm Barthlott

Beilstein J. Nanotechnol. 2014, 5, 812–821, doi:10.3762/bjnano.5.93

• biomimetic applications like drag reduction in ship coatings of up to 30%. Here we present a novel method for measuring air volumes and air loss under water. We recorded the buoyancy force of the air layer on leaf surfaces of four different Salvinia species and on one biomimetic surface using a highly

• also allows to measure decrease or increase of air layers with high accuracy in real-time to understand dynamic processes. Keywords: air layer; biomimetic; drag reduction; functional surfaces; plastron; Salvinia effect; volume measurement; Introduction Since the description of hierarchically