Plasma-assisted synthesis and high-resolution characterization of anisotropic elemental and bimetallic core–shell magnetic nanoparticles

• M. Hennes,
• A. Lotnyk and
• S. G. Mayr

Beilstein J. Nanotechnol. 2014, 5, 466–475, doi:10.3762/bjnano.5.54

• as powerful nanotools in many areas of biology, biophysics and medicine [1]. Possible applications include their use as contrast agents for cell tracking via magnetic resonance imaging (MRI) [2], as colloidal mediators in cancer therapy (hyperthermia) [3] or as nanocarriers for targeted drug delivery

Near-infrared dye loaded polymeric nanoparticles for cancer imaging and therapy and cellular response after laser-induced heating

• Tingjun Lei,
• Alicia Fernandez-Fernandez,
• Romila Manchanda,
• Yen-Chih Huang and
• Anthony J. McGoron

Beilstein J. Nanotechnol. 2014, 5, 313–322, doi:10.3762/bjnano.5.35

• , Nova Southeastern University, 3200 S. University Dr., Fort Lauderdale, FL 33328, USA Department of Basic and Applied Sciences, Galgotias University, UP, 201308, India 10.3762/bjnano.5.35 Abstract Background: In the past decade, researchers have focused on developing new biomaterials for cancer therapy

• hyperthermia (HT). HT is currently used in clinical trials for cancer therapy in combination with radiotherapy and chemotherapy. One of the potential problems of HT is that it can up-regulate hypoxia-inducible factor-1 (HIF-1) expression and enhance vascular endothelial growth factor (VEGF) secretion. Results

• is slow, thus taking a fairly long time to reach the targeted temperature (39–43 °C). Therefore, the comparison between incubator HT and laser/NP HT may provide important information on the effects of different modes of HT used in cancer therapy. In a previous publication, we described the in vivo

Extracellular biosynthesis of gadolinium oxide (Gd₂O₃) nanoparticles, their biodistribution and bioconjugation with the chemically modified anticancer drug taxol

• Shadab Ali Khan,
• Sanjay Gambhir and
• Absar Ahmad

Beilstein J. Nanotechnol. 2014, 5, 249–257, doi:10.3762/bjnano.5.27

• systems for cancer therapy. Gadolinium compounds are used in neutron capture therapy (NCT) as an alternative for boron-10 [6][7]. NCT is mainly associated with tumor-specific delivery systems and involves the production of localized cytotoxic radiations by a non-radioactive nuclide delivered to tumor

• fungus based approach for the synthesis of this material for the first time. We show that the thermophilic fungus Humicola sp. can be used for the synthesis of Gd2O3 nanoparticles at 50 °C. Since Gd2O3 nanoparticles have proved their value in site-specific drug delivery systems for cancer therapy, we

Size-dependent characteristics of electrostatically actuated fluid-conveying carbon nanotubes based on modified couple stress theory

• Mir Masoud Seyyed Fakhrabadi,
• Abbas Rastgoo and
• Mohammad Taghi Ahmadian

Beilstein J. Nanotechnol. 2013, 4, 771–780, doi:10.3762/bjnano.4.88

• chemical and thermal stability, and their hollow geometries. For example, they can be used as hydraulic parts in support platforms or carry reactant molecules into reaction chambers [21]. Furthermore, CNTs have a potential usage as cancer therapy devices or nanovessels for conveying and storing fluids and

Nanolesions induced by heavy ions in human tissues: Experimental and theoretical studies

• Marcus Bleicher,
• Lucas Burigo,
• Marco Durante,
• Maren Herrlitz,
• Michael Krämer,
• Igor Mishustin,
• Iris Müller,
• Francesco Natale,
• Igor Pshenichnov,
• Stefan Schramm,
• Gisela Taucher-Scholz and
• Cathrin Wälzlein

Beilstein J. Nanotechnol. 2012, 3, 556–563, doi:10.3762/bjnano.3.64

• , Max-von-Laue-Str. 1, 60438 Frankfurt am Main, Germany 10.3762/bjnano.3.64 Abstract The biological effects of energetic heavy ions are attracting increasing interest for their applications in cancer therapy and protection against space radiation. The cascade of events leading to cell death or late

Radiation-induced nanostructures: Formation processes and applications

• Michael Huth

Beilstein J. Nanotechnol. 2012, 3, 533–534, doi:10.3762/bjnano.3.61

• passing through body tissues. On the other hand, this same observation has led to the rise of charged-particle cancer therapy over the past 20 years. Conceptually speaking, electrons that locally drive molecular dissociations, as well as swift heavy ions that locally cause damage in polymers or living

• understanding of the different dissociation pathways and bond-breaking mechanisms would be highly valuable. On the one hand, for FEBID this holds the promise of developing this technique towards electron-controlled chemistry on the nanometer scale. For cancer therapy and the understanding of DNA damage, a

Magnetic-Fe/Fe₃O₄-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages

• Hongwang Wang,
• Tej B. Shrestha,
• Matthew T. Basel,
• Raj K. Dani,
• Gwi-Moon Seo,
• Sivasai Balivada,
• Marla M. Pyle,
• Heidy Prock,
• Olga B. Koper,
• Prem S. Thapa,
• David Moore,
• Ping Li,
• Viktor Chikan,
• Deryl L. Troyer and
• Stefan H. Bossmann

Beilstein J. Nanotechnol. 2012, 3, 444–455, doi:10.3762/bjnano.3.51

• Mo/Ma cells. These cells feature a Tet-On Advanced system for intracellular carboxylesterase (InCE) expression. Upon addition of doxycycline, SN38 was released from the nanoplatform, as evidenced by HPLC analysis. Therefore, this nanoplatform can be potentially used as a multipurpose agent in cancer

• therapy through highly localized magnetic hyperthermia and triggered release/activation of the chemotherapeutic drug SN38 at the cancer site. Using the synergy between targeted chemotherapy and hyperthermia will make cell-delivered anticancer treatment a viable option. Scheme 3 summarizes this approach to