Design of a nanostructured mucoadhesive system containing curcumin for buccal application: from physicochemical to biological aspects

• Sabrina Barbosa de Souza Ferreira,
• Gustavo Braga,
• Évelin Lemos Oliveira,
• Jéssica Bassi da Silva,
• Hélen Cássia Rosseto,
• Lidiane Vizioli de Castro Hoshino,
• Mauro Luciano Baesso,
• Wilker Caetano,
• Craig Murdoch,
• Helen Elizabeth Colley and
• Marcos Luciano Bruschi

Beilstein J. Nanotechnol. 2019, 10, 2304–2328, doi:10.3762/bjnano.10.222

• for their chemical, rheological, mechanical and mucoadhesive characteristics. We also measured the in vitro drug release profile, permeation and the cytotoxic potential of these systems. Results and Discussion Interaction studies of curcumin in mucoadhesive nanostructured systems As CUR is highly

• fluorescence quenching, using iodide as a hydro-soluble suppressor [2][52][53][54]. The studies were performed at 25 °C (room and administration temperature) and 37 °C (body temperature). Using this assay, it is possible to evaluate the location of CUR in the polymeric system during drug release and to

• with the mechanical and rheological characteristics observed. One of the replicate images is showed in Figure 9B. In vitro drug release profile During the development of drug delivery systems for buccal application, in vitro drug release is highly important and is considered a prerequisite for

Targeted therapeutic effect against the breast cancer cell line MCF-7 with a CuFe₂O₄/silica/cisplatin nanocomposite formulation

• B. Rabindran Jermy,
• Vijaya Ravinayagam,
• Widyan A. Alamoudi,
• Dana Almohazey,
• Hatim Dafalla,
• Lina Hussain Allehaibi,
• Abdulhadi Baykal,
• Muhammet S. Toprak and
• Thirunavukkarasu Somanathan

Beilstein J. Nanotechnol. 2019, 10, 2217–2228, doi:10.3762/bjnano.10.214

• expected health crisis [1]. However, the single modal drug delivery system is hampered by low bioavailability (about 5–10%), burst release, and lower target efficiency. Multifunctional theranostic nanoparticles that can respond to an external magnetic field for drug release and assist in bioimaging

• for 30 min. A droplet (5 µL) of diluted suspension was deposited in a 300-mesh pure carbon grid and then kept in a pumping station for 1 h for further drying. The grids were examined by the JEM2100F instrument from JEOL. Drug release study The cumulative cisplatin release was studied using CuFe2O4

• and 600 nm shows the presence of octahedral coordinated Pt species (Figure 6b). The presence of such strong bonds of tetrahedral and octahedral Pt species indicates the high dispersity and interaction of Pt on HYPS silica support. The drug release ability of CuFe2O4/HYPS was compared with two

Incorporation of doxorubicin in different polymer nanoparticles and their anticancer activity

• Sebastian Pieper,
• Hannah Onafuye,
• Dennis Mulac,
• Jindrich Cinatl Jr.,
• Mark N. Wass,
• Martin Michaelis and
• Klaus Langer

Beilstein J. Nanotechnol. 2019, 10, 2062–2072, doi:10.3762/bjnano.10.201

• -like kinetics of the other preparations. In neuroblastoma cells, doxorubicin-loaded PLGA-PEG nanoparticles (presumably due to their small size) and PLGA nanoparticles prepared by solvent displacement at pH 7 (presumably due to their high drug load and superior drug release kinetics) exerted the

• their anticancer activity at the cellular level. Optimised preparation methods resulted in PLGA nanoparticles characterised by increased drug load, controlled drug release, and high anticancer efficacy. The design of drug-loaded nanoparticles with optimised anticancer activity at the cellular level is

• an important step in the development of improved nanoparticle preparations for anticancer therapy. Further research is required to understand under which circumstances nanoparticles can be used to overcome efflux-mediated resistance in cancer cells. Keywords: cancer; doxorubicin; drug release

Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells

• Liang Xu,
• Dekang Xu,
• Ziying Li,
• Yu Gao and
• Haijun Chen

Beilstein J. Nanotechnol. 2019, 10, 1933–1942, doi:10.3762/bjnano.10.189

• the lungs will be quickly eliminated due to large alveolar surface area, abundant capillaries and minimal transport distance, the sustained drug release delivery systems will improve the drug absorption and increase the activities [38]. Compared with DiP, P2P still showed better antiproliferative

Microfluidic manufacturing of different niosomes nanoparticles for curcumin encapsulation: Physical characteristics, encapsulation efficacy, and drug release

• Mohammad A. Obeid,
• Ibrahim Khadra,
• Abdullah Albaloushi,
• Margaret Mullin,
• Hanin Alyamani and
• Valerie A. Ferro

Beilstein J. Nanotechnol. 2019, 10, 1826–1832, doi:10.3762/bjnano.10.177

Doxorubicin-loaded human serum albumin nanoparticles overcome transporter-mediated drug resistance in drug-adapted cancer cells

• Hannah Onafuye,
• Sebastian Pieper,
• Dennis Mulac,
• Jindrich Cinatl Jr.,
• Mark N. Wass,
• Klaus Langer and
• Martin Michaelis

Beilstein J. Nanotechnol. 2019, 10, 1707–1715, doi:10.3762/bjnano.10.166

• doxorubicin-loaded HSA (40%) nanoparticles. Together, these data confirm that administration of doxorubicin as HSA nanoparticles resulted in the circumvention of ABCB1-mediated drug efflux. The difference between HSA (40%) nanoparticles and the other two preparations may be explained by elevated drug release

• due to the lower degree of cross-linking. Interestingly, high concentrations of the cross-linker glutaraldehyde did not affect the efficacy of the resulting doxorubicin-loaded nanoparticles although high glutaraldehyde concentrations might have been expected to affect drug release and/or to covalently

• paclitaxel with albumin may differ from that of doxorubicin. Hence, variations in drug binding and drug release kinetics may be responsible for this difference. Despite the prominent role of ABCB1 as a drug resistance mechanism, attempts to exploit it as drug target have failed so far, despite the

Targeting strategies for improving the efficacy of nanomedicine in oncology

• Gonzalo Villaverde and
• Alejandro Baeza

Beilstein J. Nanotechnol. 2019, 10, 168–181, doi:10.3762/bjnano.10.16

• provided unique advantages such as the possibility to transport highly lipophilic drugs and to improve the pharmacokinetic profile of these drugs, enhancing their accumulation both in the tumoral tissue and within the malignant cells. Moreover, it is even possible to control the drug release process

• through the incorporation of stimuli-responsive mechanisms that regulate the drug release from the nanocarrier. The incorporation of targeting moieties on the carrier surface produces a significative increase in the particle accumulation inside tumoral cells, which could improve the efficacy of the

Characterization and influence of hydroxyapatite nanopowders on living cells

• Przemyslaw Oberbek,
• Tomasz Bolek,
• Adrian Chlanda,
• Seishiro Hirano,
• Sylwia Kusnieruk,
• Julia Rogowska-Tylman,
• Ganna Nechyporenko,
• Viktor Zinchenko,
• Wojciech Swieszkowski and
• Tomasz Puzyn

Beilstein J. Nanotechnol. 2018, 9, 3079–3094, doi:10.3762/bjnano.9.286

• delivery or more effective gene transfection based on hydroxyapatite. The degree of crystallinity can be a factor in determining how long an agglomerate will stay inside the cell and what will be the drug-release rate. Hydroxyapatites with exceptionally large surface area could be also used for

Enhanced antineoplastic/therapeutic efficacy using 5-fluorouracil-loaded calcium phosphate nanoparticles

• Shanid Mohiyuddin,
• Saba Naqvi and
• Gopinath Packirisamy

Beilstein J. Nanotechnol. 2018, 9, 2499–2515, doi:10.3762/bjnano.9.233

• the drug-loaded nanoparticles (CaP@5-FU). This might be due to fact that the drug was loaded in the aqueous core of the nanoparticles [26]. Furthermore, upon drug loading, insignificant changes were found in the absorption spectrum of the nanoparticles. pH-triggered drug release study To understand

• the rate of 5-FU release from CaP@5-FU NPs, we employed the dialysis bag method. An acidic (in vitro model for the tumour microenvironment) condition correlates with drug release in the acidic tumour regime. On the other hand, physiological conditions at pH 7.4 represent the healthy cell environment

• the acidic microenvironment [25]. In our study, we demonstrated a biphasic release of 5-FU from CaP@5-FU NPs with the characteristic initial burst release followed by slow and sustained release [27]. Within 12 hours, only 36% drug release in physiological pH was shown, whereas 47% was released in

Biomimetic and biodegradable cellulose acetate scaffolds loaded with dexamethasone for bone implants

• Aikaterini-Rafailia Tsiapla,
• Varvara Karagkiozaki,
• Veroniki Bakola,
• Foteini Pappa,
• Panagiota Gkertsiou,
• Eleni Pavlidou and
• Stergios Logothetidis

Beilstein J. Nanotechnol. 2018, 9, 1986–1994, doi:10.3762/bjnano.9.189

• . Cytotoxicity studies were performed by using MTT assay, methylene-blue staining and SEM fixation and showed very good cell adhesion and proliferation, indicating the cytocompatibility of these fibrous scaffolds. Drug-release kinetics was measured for the evaluation of a controllable and sustained release of

• devices [15][16][17]. The use of micro- and nanofibers as carriers for drug release is more efficient because the drug is locally released to the target organ or tissue and as a result less amount of drug is required with fewer side effects [18][19]. Inflammation is the most common cause of aseptic

• is created [23]. Grounded aluminum foils, glass substrates and also coatings for orthopaedic pins were used as collectors to carry out the necessary studies. Drug-release kinetics and degradation study of scaffolds Degradation study was carried out in order to evaluate the mass loss of polymer and

A visible-light-controlled platform for prolonged drug release based on Ag-doped TiO₂ nanotubes with a hydrophobic layer

• Caihong Liang,
• Jiang Wen and
• Xiaoming Liao

Beilstein J. Nanotechnol. 2018, 9, 1793–1801, doi:10.3762/bjnano.9.170

• Caihong Liang Jiang Wen Xiaoming Liao College of Materials Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China 10.3762/bjnano.9.170 Abstract In this work, a visible-light-controlled drug release platform was constructed for localized and prolonged drug release based on two

• layer. To demonstrate the visible-light-controlled drug release, the Zn2+ release behavior of the samples was investigated. In the initial 12 h, TNTs without NDM displayed a faster release rate with 29.4% Zn2+ release, which was more than three times that of the TNTs with NDM (8.7% Zn2+ release). Upon

• visible-light illumination, drug release from the sample coated with NDM was shown to increase due to the photocatalytic decomposition of NDM. The amount of released Zn2+ for this sample increased up to 71.9% within 12 h, indicating visible-light-controlled drug release. This drug release system may

Atomic-level characterization and cilostazol affinity of poly(lactic acid) nanoparticles conjugated with differentially charged hydrophilic molecules

• María Francisca Matus,
• Martín Ludueña,
• Cristian Vilos,
• Iván Palomo and
• Marcelo M. Mariscal

Beilstein J. Nanotechnol. 2018, 9, 1328–1338, doi:10.3762/bjnano.9.126

• explorative tool or as a complementary approach to experiments, which is useful for the rational design of new drug delivery systems. In future work, this approximation will be correlated with maximum drug loading determined experimentally and the protective role of differentially charged PEG for drug release

Enzymatically promoted release of organic molecules linked to magnetic nanoparticles

• Chiara Lambruschini,
• Silvia Villa,
• Luca Banfi,
• Fabio Canepa,
• Fabio Morana,
• Annalisa Relini,
• Paola Riani,
• Renata Riva and
• Fulvio Silvetti

Beilstein J. Nanotechnol. 2018, 9, 986–999, doi:10.3762/bjnano.9.92

• previous experience in using the TAP/PMT strategy in activation of enediyne prodrugs [25][26], we decided to use a linker conceived to allow drug release by the action of a selective protease, such as plasmin. Plasmin is a serine protease that is formed upon cleavage of plasminogen by a urokinase-type

Nanoparticle delivery to metastatic breast cancer cells by nanoengineered mesenchymal stem cells

• Liga Saulite,
• Karlis Pleiko,
• Ineta Popena,
• Dominyka Dapkute,
• Ricardas Rotomskis and
• Una Riekstina

Beilstein J. Nanotechnol. 2018, 9, 321–332, doi:10.3762/bjnano.9.32

• , which could be sufficient time to release drugs into the tumour. The encapsulation of NP-linked anticancer drugs could ensure metered drug release in tumours [2]. QD linkage to photosensitisers, such as chlorin e6, causes damage to MiaPaCa2 cancer cells via light-induced cytotoxicity, demonstrating a

Bi-layer sandwich film for antibacterial catheters

• Gerhard Franz,
• Florian Schamberger,
• Hamideh Heidari Zare,
• Sara Felicitas Bröskamp and
• Dieter Jocham

Beilstein J. Nanotechnol. 2017, 8, 1982–2001, doi:10.3762/bjnano.8.199

• ]. Drug-release catheters All other trials can be subsumed under drug-release catheters being at least bacteriostatic or even bactericidal. The first trials consisted of dipping catheters into a solution of an antibiotic drug (e.g., ciprofloxacin [14]) and subsequent drying of the solvent. Although, by

• ]). Physiological sodium salt solution, for example, never passes the limit of the solubility product at concentrations that are typical for these drug-release systems. Release rate: The coated substrates [two catheter pieces (outer diameter: 5.3 mm) with a length of 2 cm (13% of the length of a normal balloon

Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery

• Gamze Varan,
• Juan M. Benito,
• Carmen Ortiz Mellet and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1457–1468, doi:10.3762/bjnano.8.145

• therefore be suggested that the surface charge of nanoparticle is directly effective on the drug release profile. Cell culture studies In order to determine the safety of blank amphiphilic CD nanoparticles and the anticancer efficacy of PCX-loaded amphiphilic CD nanoparticles, L929 mouse fibroblast cells

• differences of CD nanoparticles may be related with drug release profiles. PCX shows anticancer activity by stabilizing microtubules and blocking the cell in G2 or M phase in cell cycle [55][56]. The duration of drug release of PCX-loaded amphiphilic CD nanoparticles increases in the order of 6OCaproβCD < CS

• were prepared and used as nanometer-sized delivery systems and compared in terms of mean particle size, zeta potential, drug loading capacity and drug release profile for PCX, which is an effective anticancer agent over the wide spectrum various types of cancer. The findings strongly suggest that

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

• Cem Varan and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1446–1456, doi:10.3762/bjnano.8.144

• particles, and the drug release rate from the nanoparticles was slowed down to 48 h by dispersing the nanoparticles in a hydroxypropyl cellulose film. Cell culture studies revealed that docetaxel-loaded nanoparticles cause higher cytotoxicity compared to the free docetaxel solution in DMSO. Conclusion

• . Nanoparticle-based drug delivery systems can be prepared with synthetic and natural polymers. As an advantage, their surface properties can be modified to increase cellular penetration and prolonged drug release. Additionally, suitable nanoparticle-based drug delivery systems can bypass biological barriers or

• after surgical operation of glioma treatment. All formulations were characterized in terms of mean particle size, polydispersity index, zeta potential, drug loading capacity, drug release profile and cytotoxicity. When nanoparticle formulations are compared with each other, mePEG-PCL nanoparticles have

Nanoscale isoindigo-carriers: self-assembly and tunable properties

• Tatiana N. Pashirova,
• Andrei V. Bogdanov,
• Lenar I. Musin,
• Julia K. Voronina,
• Irek R. Nizameev,
• Marsil K. Kadirov,
• Vladimir F. Mironov,
• Lucia Ya. Zakharova,
• Shamil K. Latypov and
• Oleg G. Sinyashin

Beilstein J. Nanotechnol. 2017, 8, 313–324, doi:10.3762/bjnano.8.34

• toxicity as well as to minimize drug degradation and to provide a controllable drug release [51][52][53]. The modification of nanostructures with conjugated π–π fragments leads to the absorption of anticancer drugs via π–π stacking interaction and increases the drug-loading capacity of nanoscale soft

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

• Huijuan Zhang,
• Fuqiang Wu,
• Yazhen Li,
• Xiping Yang,
• Jiamei Huang,
• Tingting Lv,
• Yingying Zhang,
• Jianzhong Chen,
• Haijun Chen,
• Yu Gao,
• Guannan Liu and
• Lee Jia

Beilstein J. Nanotechnol. 2016, 7, 1861–1870, doi:10.3762/bjnano.7.178

• preparation, has been extensively studied for obtaining nanocarrier systems with a good capacity of drug encapsulation and an adjustable drug release rate [22][23]. The aim of this work was to prepare MIF-encapsulated CNs (MCNs) to regulate the drug release rate of MIF for bioavailability improvement, and

• meanwhile, enhance the antitumor effect of MIF by the auxiliary anticancer functionality of Cs. The ionic gelation technique was used to prepare MCNs. The preparation conditions for MCNs were optimized and the physiochemical properties of MCNs were characterized. Then, the in vitro drug release behavior of

• crosslinking agent for controlled drug release of CNs. In vitro anticancer effects The cytotoxicity of the MCNs was tested in four different cancer cell lines A549 (human lung adenocarcinoma), Hela (human cervical epithelioid carcinoma), RL95-2 (human endometrial carcinoma), and HepG2 (human liver

The role of morphology and coupling of gold nanoparticles in optical breakdown during picosecond pulse exposures

• Yevgeniy R. Davletshin and
• J. Carl Kumaradas

Beilstein J. Nanotechnol. 2016, 7, 869–880, doi:10.3762/bjnano.7.79

• spectroscopy [20][21], cell nanosurgery [19], drug release [62][63], fabrication of functional gold-antibody nanoconjugates [64] and imaging [65]. Schematic of the model geometry for a nanosphere trimer. The model contains three concentric domains. The most outer domain (grey) represents a combination of a

Fabrication of hybrid nanocomposite scaffolds by incorporating ligand-free hydroxyapatite nanoparticles into biodegradable polymer scaffolds and release studies

• Balazs Farkas,
• Marina Rodio,
• Ilaria Romano,
• Alberto Diaspro,
• Romuald Intartaglia and
• Szabolcs Beke

Beilstein J. Nanotechnol. 2015, 6, 2217–2223, doi:10.3762/bjnano.6.227

• osteoconductive and osteoinductive capabilities [5][6], made it a platform for large-scale biomedical applications, such as controlled drug release and bone tissue engineering materials [7][8]. Lee et al. [9] reported on cellular responses to crosslinkable poly(propylene fumarate)/hydroxyapatite nanocomposites

Nanofibers for drug delivery – incorporation and release of model molecules, influence of molecular weight and polymer structure

• Jakub Hrib,
• Jakub Sirc,
• Radka Hobzova,
• Zuzana Hampejsova,
• Zuzana Bosakova,
• Marcela Munzarova and
• Jiri Michalek

Beilstein J. Nanotechnol. 2015, 6, 1939–1945, doi:10.3762/bjnano.6.198

• primary factors that affect the diffusion mechanism and drug release. For homogenous nanofibers, the rate of release decreases with time, because the drug must travel progressively longer distances to diffuse to the fiber periphery, which requires more time. Contrary, the core–shell design provides the

• delivery system with the diffusion rate of the therapeutic agent stable throughout the life. The structure of the nanofibrous drug delivery system plays a key role in the drug release process. The fiber diameter, specific surface area, size and total volume of pores significantly influence the convection

• and diffusion of the liquid in which the nanofibers are immersed. Therefore, the drug release is also influenced. The great advantage of nanofibrous materials is that their structure, i.e., their fiber diameter, density and thickness of the nanofibrous layer, can be tailored to various requirements by

Analyzing collaboration networks and developmental patterns of nano-enabled drug delivery (NEDD) for brain cancer

• Ying Huang,
• Jing Ma,
• Alan L. Porter,
• Seokbeom Kwon and
• Donghua Zhu

Beilstein J. Nanotechnol. 2015, 6, 1666–1676, doi:10.3762/bjnano.6.169

• network analyses, at country, institution, and individual levels, to explore the patterns of scientific networking for a key nano area – nano-enabled drug delivery (NEDD). NEDD has successfully been used clinically to modulate drug release and to target particular diseased tissues. The data for this

Formation of substrate-based gold nanocage chains through dealloying with nitric acid

• Ziren Yan,
• Ying Wu and
• Junwei Di

Beilstein J. Nanotechnol. 2015, 6, 1362–1368, doi:10.3762/bjnano.6.140

• to their solid counterparts because of the high surface area, low density, and near-infrared localized surface plasmon resonance (LSPR). All these make Au NC an attractive material for various applications in optical [4][5] and electrochemical sensing [6], immunoassay [7], drug release [8], surface

PLGA nanoparticles as a platform for vitamin D-based cancer therapy

• Maria J. Ramalho,
• Joana A. Loureiro,
• Bárbara Gomes,
• Manuela F. Frasco,
• Manuel A. N. Coelho and
• M. Carmo Pereira

Beilstein J. Nanotechnol. 2015, 6, 1306–1318, doi:10.3762/bjnano.6.135

• internalized by targeted cells, increasing intracellular drug delivery [20], allowing a sustained and controlled drug release over time [19]. Moreover, PLGA NPs could offer selective drug delivery to tumor tissue either by passive targeting with the enhanced permeability and retention effect (EPR) [18] or by