Prediction of cytotoxicity of heavy metals adsorbed on nano-TiO₂ with periodic table descriptors using machine learning approaches

• Joyita Roy,
• Souvik Pore and
• Kunal Roy

Beilstein J. Nanotechnol. 2023, 14, 939–950, doi:10.3762/bjnano.14.77

• cause co-exposure effects on living organisms. The extensive use of heavy metals in areas such as medicine and agriculture increased the negative impact of heavy metals on environment and living organisms, raising the need for risk assessment. Unlike other pollutants, heavy metals do not decompose

Green SPIONs as a novel highly selective treatment for leishmaniasis: an in vitro study against Leishmania amazonensis intracellular amastigotes

• Brunno R. F. Verçoza,
• Robson R. Bernardo,
• Luiz Augusto S. de Oliveira and
• Juliany C. F. Rodrigues

Beilstein J. Nanotechnol. 2023, 14, 893–903, doi:10.3762/bjnano.14.73

• ][3][4][5]. These facts demonstrate the need to develop new treatments or alternatives that are safer, more effective, and more accessible to patients. In this context, nanomedicine is one of the most promising branches of contemporary medicine, currently concentrating a large part of the scientific

• effort on the search for new treatments for different diseases. Its main objective is to develop therapies with higher specificity, effectiveness, and safety, as well as less toxicity [6]. One interesting class of nanomaterials in medicine are superparamagnetic iron oxide nanoparticles (SPIONs). SPIONs

Industrial perspectives for personalized microneedles

• Remmi Danae Baker-Sediako,
• Benjamin Richter,
• Matthias Blaicher,
• Michael Thiel and
• Martin Hermatschweiler

Beilstein J. Nanotechnol. 2023, 14, 857–864, doi:10.3762/bjnano.14.70

• microneedles may become personalized according to a patient’s demographic in order to increase drug delivery efficiency and reduce healing times for patient-centric care. Keywords: 3D printing; microfabrication; microneedles; personalized medicine; transdermal drug delivery; two-photon polymerization

• challenges with trypanophobia and hospital-based needle injuries. Today’s needles penetrate the deepest parts of the dermis, where discomfort or pain may occur [10]; however, today, we know that the stratum corneum is the only dermal layer clinicians need to penetrate to deliver non-intravenous medicine

• personalized medicine, it is possible to develop optimized microneedles for different populations and injection areas at scale. For example, microneedles are a promising alternative to oral and systemic medications for pain relief [20][21][22]. Chronic and acute pain can occur anywhere in the body; however, if

Investigations on the optical forces from three mainstream optical resonances in all-dielectric nanostructure arrays

• Guangdong Wang and
• Zhanghua Han

Beilstein J. Nanotechnol. 2023, 14, 674–682, doi:10.3762/bjnano.14.53

• optical capturing of nanoscale particles and may have broad applications in medicine and biology. (a) Schematic overview of the metasurface structure composed of a silicon slotted-disk array on a quartz substrate. The trapped nanoscale particles and the incident plane wave are also illustrated. (b) Top

Microneedle patches – the future of drug delivery and vaccination?

• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2023, 14, 494–495, doi:10.3762/bjnano.14.40

• . Hypodermic syringe injections are, of course, ubiquitous in modern medicine for drug therapy and vaccination, where oral administration is either not desirable or not possible. Delivery may be intravenous, intramuscular or percutaneous. Hypodermic needles of various dimensions are also used to extract venous

A mid-infrared focusing grating coupler with a single circular arc element based on germanium on silicon

• Xiaojun Zhu,
• Shuai Li,
• Ang Sun,
• Yongquan Pan,
• Wen Liu,
• Yue Wu,
• Guoan Zhang and
• Yuechun Shi

Beilstein J. Nanotechnol. 2023, 14, 478–484, doi:10.3762/bjnano.14.38

• fields of biosensors and medicine [18]. In 2022, Chen et al. demonstrated a methodology of photonic clustered regularly interspaced short palindromic repeat (CRISPR) sensing for rapid and specific diagnosis of the Omicron variant of SARS-CoV-2 [19]. This innovative CRISPR-empowered surface plasmon

Molecular nanoarchitectonics: unification of nanotechnology and molecular/materials science

• Katsuhiko Ariga

Beilstein J. Nanotechnol. 2023, 14, 434–453, doi:10.3762/bjnano.14.35

• ][78], energy [79][80][81], environment [82][83][84][85], and medicine [86][87][88][89]. Since all the materials are composed of atoms and molecules, nanoarchitectonics is considered a universal unified concept that can be applied to all targets. Therefore, it can be considered as the method for

• layer-by-layer (LbL) assembly [132][133][134]. These conventional methodologies are now being used to create materials that can address social issues such as energy requirements [135][136], the environment [137][138], and medicine [139][140]. Many analytical studies have shown that high effectiveness

Plasmonic nanotechnology for photothermal applications – an evaluation

• A. R. Indhu,
• L. Keerthana and
• Gnanaprakash Dharmalingam

Beilstein J. Nanotechnol. 2023, 14, 380–419, doi:10.3762/bjnano.14.33

New trends in nanobiotechnology

• Pau-Loke Show,
• Kit Wayne Chew,
• Wee-Jun Ong,
• Sunita Varjani and
• Joon Ching Juan

Beilstein J. Nanotechnol. 2023, 14, 377–379, doi:10.3762/bjnano.14.32

• ; nanotechnology applied in biology, medicine, food, environmental and agriculture sectors; environmental engineering and chemical engineering; nanoscale electrochemisty in biotechnology; computational nanochemistry in biotechnology; and life cycle assessment of nanobiotechnology. The works presented in this

Quercetin- and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles: one-pot synthesis, characterization, and anticancer and antibacterial activities

• Akif Hakan Kurt,
• Elif Berna Olutas,
• Fatma Avcioglu,
• Hamza Karakuş,
• Mehmet Ali Sungur,
• Cansu Kara Oztabag and
• Muhammet Yıldırım

Beilstein J. Nanotechnol. 2023, 14, 362–376, doi:10.3762/bjnano.14.31

• Akif Hakan Kurt Elif Berna Olutas Fatma Avcioglu Hamza Karakus Mehmet Ali Sungur Cansu Kara Oztabag Muhammet Yildirim Department of Medicinal Pharmacology, Faculty of Medicine, Bolu Abant Izzet Baysal University, 14030 Bolu, Türkiye Department of Chemistry, Faculty of Arts and Sciences, Bolu Abant

• Izzet Baysal University, 14030 Bolu, Türkiye Department of Medical Microbiology, Faculty of Medicine, Bolu Abant Izzet Baysal University, 14030 Bolu, Türkiye Technology Transfer Application and Research Center, Bolu Abant Izzet Baysal University, 14030 Bolu, Türkiye Department of Biostatistics and

• Medical Informatics, Faculty of Medicine, Duzce University, 81620 Duzce, Türkiye Department of Interdisciplinary Neuroscience, Graduate Education Institute, Bolu Abant Izzet Baysal University, 14030 Bolu, Türkiye 10.3762/bjnano.14.31 Abstract The presented study comprises the one-pot synthesis and the

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

• Qixiong Lin,
• Yueyou Peng,
• Yanyan Wen,
• Xiaoqiong Li,
• Donglian Du,
• Weibin Dai,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24

• clinical translation prospects, and the associated challenges are discussed. Keywords: cancer cell biomimetics; nanoparticles; precision medicine; targeted therapy; theranostic nanomedicine; Review 1 Introduction Biomimetic nanotechnology, an emerging interdisciplinary field, involves different

• disciplines, such as nanomaterials science, mechanical engineering, pharmacology, and clinical medicine. Nanoparticle (NP)-based therapeutics are uniquely able to improve drug loading efficiency, control drug release, and protect drug molecules against undesired degradation [1][2]. NPs are widely used in

Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

• , North Macedonia College of Pharmacy, QU Health, Qatar University, PO Box 2713, Doha, Qatar Department of Pharmacology, Faculty of Medicine and Dentistry, University of Alberta, T6G 2R3 Edmonton, Canada 10.3762/bjnano.14.23 Abstract Genomic and proteomic mutation analysis is the standard of care for

Cyclodextrins as eminent constituents in nanoarchitectonics for drug delivery systems

• Makoto Komiyama

Beilstein J. Nanotechnol. 2023, 14, 218–232, doi:10.3762/bjnano.14.21

• nanoarchitectures are highly promising for future applications in medicine, pharmaceutics, and other relevant fields. Keywords: cyclodextrin; drug delivery system (DDS); nanoarchitecture; phototherapy; siRNA; Review 1 Introduction Recently, drug delivery systems (DDSs) have been attracting much interest [1][2][3

• ][4][5][6][7][8][9][10][11][12]. By delivering drugs selectively to disease sites, the drug dosage can be reduced, and undesired side-effects are minimized. Undoubtedly, these methodologies are essential for further progresses in medicine. In order to accomplish eminent DDS, drugs should be combined

• therapy (PDT) employs a light-sensitive medicine (photosensitizer) and a light source to destroy abnormal cells [72][73]. The photosensitizer absorbs the light and is activated to kill target tissue. In many cases, reactive oxygen species (ROSs) such as singlet oxygen (1O2) generated from 3O2 by a

Two-step single-reactor synthesis of oleic acid- or undecylenic acid-stabilized magnetic nanoparticles by thermal decomposition

• Mykhailo Nahorniak,
• Pamela Pasetto,
• Jean-Marc Greneche,
• Volodymyr Samaryk,
• Sandy Auguste,
• Anthony Rousseau,
• Nataliya Nosova and
• Serhii Varvarenko

Beilstein J. Nanotechnol. 2023, 14, 11–22, doi:10.3762/bjnano.14.2

• nanoparticles have been proposed as contrast agents for magnetic resonance imaging, high-precision biosensors, and carriers in magnetic-assisted drug delivery systems. Furthermore, they are used for tumor treatment via the hyperthermia method and in bone tissue regenerative medicine [5][6]. However, using iron

Hydroxyapatite–bioglass nanocomposites: Structural, mechanical, and biological aspects

• Olga Shikimaka,
• Mihaela Bivol,
• Bogdan A. Sava,
• Marius Dumitru,
• Christu Tardei,
• Beatrice G. Sbarcea,
• Daria Grabco,
• Constantin Pyrtsac,
• Daria Topal,
• Andrian Prisacaru,
• Vitalie Cobzac and
• Viorel Nacu

Beilstein J. Nanotechnol. 2022, 13, 1490–1504, doi:10.3762/bjnano.13.123

• , Romania Nicolae Testemitanu State University of Medicine and Pharmacy, 165 Stefan cel Mare si Sfant ave., MD-2004, Chisinau, Republic of Moldova 10.3762/bjnano.13.123 Abstract This research work focuses on the fabrication and study of a series of nanocomposites consisting of two types of hydroxyapatite

• of Tissue Engineering and Cells Culture of the Nicolae Testemitanu State University of Medicine and Pharmacy (NTSUMP) of the Republic of Moldova. The laboratory has the permission from the University Research Ethics Committee acting in accordance with the Statute of the Research Ethics Committee of

Frequency-dependent nanomechanical profiling for medical diagnosis

• Santiago D. Solares and
• Alexander X. Cartagena-Rivera

Beilstein J. Nanotechnol. 2022, 13, 1483–1489, doi:10.3762/bjnano.13.122

• Bioengineering, National Institutes of Health, Bethesda, Maryland, USA 10.3762/bjnano.13.122 Abstract Atomic force microscopy (AFM), developed in the early 1980s, has become a powerful characterization tool in micro- and nanoscale science. In the early 1990s, its relevance within biology and medicine research

Rapid and sensitive detection of box turtles using an electrochemical DNA biosensor based on a gold/graphene nanocomposite

• Abu Hashem,
• M. A. Motalib Hossain,
• Ab Rahman Marlinda,
• Mohammad Al Mamun,
• Khanom Simarani and
• Mohd Rafie Johan

Beilstein J. Nanotechnol. 2022, 13, 1458–1472, doi:10.3762/bjnano.13.120

• carbon electrode; Introduction The Southeast Asian box turtle (BT), Cuora amboinensis, is an endangered and protected turtle species. Due to its high value as an exotic food item and in traditional medicine, it ends up being a profitable item in the illicit wildlife trade [1]. Turtles contain active

Laser-processed antiadhesive bionic combs for handling nanofibers inspired by nanostructures on the legs of cribellate spiders

• Sebastian Lifka,
• Kristóf Harsányi,
• Erich Baumgartner,
• Lukas Pichler,
• Dariya Baiko,
• Karsten Wasmuth,
• Johannes Heitz,
• Marco Meyer,
• Anna-Christin Joel,
• Jörn Bonse and
• Werner Baumgartner

Beilstein J. Nanotechnol. 2022, 13, 1268–1283, doi:10.3762/bjnano.13.105

• .13.105 Abstract Nanofibers are drawing the attention of engineers and scientists because their large surface-to-volume ratio is favorable for applications in medicine, filter technology, textile industry, lithium-air batteries, and optical sensors. However, when transferring nanofibers to a technical

• applications in medicine, filter technology, textile industry, lithium-air batteries, and optical sensors [1][2][3][4][5][6][7]. The inherently small scale makes production as well as further processing of nanofibers challenging [8]. For the technical production of artificial nanofibers, different methods such

Design of surface nanostructures for chirality sensing based on quartz crystal microbalance

• Yinglin Ma,
• Xiangyun Xiao and
• Qingmin Ji

Beilstein J. Nanotechnol. 2022, 13, 1201–1219, doi:10.3762/bjnano.13.100

• several pregnant women causing fetal malformation [7], owing to the trace presence of teratogenic (S)-thalidomide in sedative (R)-thalidomide [8]. Hence, chirality detection keeps attracting much attention in the fields of chemistry, biology, and medicine. Especially for the pharmaceutical and food

Recent advances in green carbon dots (2015–2022): synthesis, metal ion sensing, and biological applications

• Aisha Kanwal,
• Naheed Bibi,
• Sajjad Hyder,
• Arif Muhammad,
• Hao Ren,
• Jiangtao Liu and
• Zhongli Lei

Beilstein J. Nanotechnol. 2022, 13, 1068–1107, doi:10.3762/bjnano.13.93

• , Charsadda Road, Larama, Peshawar, Pakistan Department of Botany, Government College Women University, Sialkot, Pakistan College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, China 10.3762/bjnano.13.93 Abstract Carbon dots (CDs) show extensive potential in various fields such as

• sensing, bioimaging, catalysis, medicine, optoelectronics, and drug delivery due to their unique properties, that is, low cytotoxicity, cytocompatibility, water-solubility, multicolor wavelength tuned emission, photo-stability, easy modification, strong chemical inertness, etc. This review article

Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration

• Se-Kwon Kim,
• Sesha Subramanian Murugan,
• Pandurang Appana Dalavi,
• Sebanti Gupta,
• Sukumaran Anil,
• Gi Hun Seong and
• Jayachandran Venkatesan

Beilstein J. Nanotechnol. 2022, 13, 1051–1067, doi:10.3762/bjnano.13.92

• , Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore, Karnataka 575018, India Department of Dentistry, Oral Health Institute, Hamad Medical Corporation, College of Dental Medicine, Qatar University, Doha, Qatar Department of Bionano Engineering, Center for Bionano

• medicine, the 3D scaffold system was used to imitate bone tissue anatomy. These scaffold systems consist of composite scaffolds of polymeric materials. Among other composite materials, chitosan composites were widely used in bone tissue engineering applications due to their porous nature and

Bioselectivity of silk protein-based materials and their bio-inspired applications

• Hendrik Bargel,
• Vanessa T. Trossmann,
• Christoph Sommer and
• Thomas Scheibel

Beilstein J. Nanotechnol. 2022, 13, 902–921, doi:10.3762/bjnano.13.81

• modern medicine. Recent outbreaks of severe diseases such as Ebola, influenza, and even more so the severe acute respiratory syndrome (SARS) and the pandemic SARS-CoV-2, have tremendously increased the urgency for new concepts and materials that prevent pathogenic microbial infestation and contact-based

Design and selection of peptides to block the SARS-CoV-2 receptor binding domain by molecular docking

• Kendra Ramirez-Acosta,
• Ivan A. Rosales-Fuerte,
• J. Eduardo Perez-Sanchez,
• Alfredo Nuñez-Rivera,
• Josue Juarez and
• Ruben D. Cadena-Nava

Beilstein J. Nanotechnol. 2022, 13, 699–711, doi:10.3762/bjnano.13.62

• common proteins (salivary and plasmatic proteins) found in physiological fluids. The procedure described here for the design of antiviral molecules can be extended against other viruses, both in human and veterinary medicine. SARS-CoV-2 bound to the ACE2 receptor. (a) Crystallized complex between the RBD

Effects of substrate stiffness on the viscoelasticity and migration of prostate cancer cells examined by atomic force microscopy

• Xiaoqiong Tang,
• Yan Zhang,
• Jiangbing Mao,
• Yuhua Wang,
• Zhenghong Zhang,
• Zhengchao Wang and
• Hongqin Yang

Beilstein J. Nanotechnol. 2022, 13, 560–569, doi:10.3762/bjnano.13.47

• Xiaoqiong Tang Yan Zhang Jiangbing Mao Yuhua Wang Zhenghong Zhang Zhengchao Wang Hongqin Yang Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fuzhou 350007, China

Stimuli-responsive polypeptide nanogels for trypsin inhibition

• Petr Šálek,
• Jana Dvořáková,
• Sviatoslav Hladysh,
• Diana Oleshchuk,
• Ewa Pavlova,
• Jan Kučka and
• Vladimír Proks

Beilstein J. Nanotechnol. 2022, 13, 538–548, doi:10.3762/bjnano.13.45

• trypsin because they contain suitable amino acids in their structures that effectively block the active site of trypsin. Keywords: α1-antitrypsin; inflammatory mediator; nanogel; polypeptide; trypsin; Introduction Despite significant and progressive advances in medicine, the global incidence of