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Search for "targeting" in Full Text gives 176 result(s) in Beilstein Journal of Nanotechnology.
Preparation and in vivo evaluation of glyco-gold nanoparticles carrying synthetic mycobacterial hexaarabinofuranoside
Beilstein J. Nanotechnol. 2020, 11, 480–493, doi:10.3762/bjnano.11.39
- ], which enables the exchange of citrate ligands with amines. The amine-capped GNPs are stable enough to be used as targeting agents for drug-delivery applications [75], as antigens for the generation of antibodies [77], or as antimicrobial agents [78]. These nanoconjugates are nontoxic, effectively
Interactions at the cell membrane and pathways of internalization of nano-sized materials for nanomedicine
Beilstein J. Nanotechnol. 2020, 11, 338–353, doi:10.3762/bjnano.11.25
- exploit the cellular machinery to enter cells and be trafficked intracellularly, thus they can be used to overcome some of the cellular barriers to drug delivery. Nano-sized drug carriers of very different properties can be prepared, and their surface can be modified by the addition of targeting moieties
- size, charge, and shape, affect the mechanisms cells use for their internalization. Technical difficulties in characterizing these mechanisms are presented. A better understanding of the first interactions of nano-sized materials with cells will help to design nanomedicines with improved targeting
- . Keywords: cell receptors; drug targeting; endocytosis; nanoparticle corona; nanoparticle uptake; Introduction Nano-sized materials are widely studied in nanomedicine for their potential use as drug carriers, in imaging, and for diagnostic purposes [1][2][3]. Because of their size, they can interact with
Understanding nanoparticle flow with a new in vitro experimental and computational approach using hydrogel channels
Beilstein J. Nanotechnol. 2020, 11, 296–309, doi:10.3762/bjnano.11.22
- controlled release of the drug [4][5]. NPs, particularly magnetic iron oxide NPs, are highly attractive for drug delivery because they have a higher circulation time compared to the conventional drugs and can be easily delivered to the diseased location through passive, active, or physical targeting [6]. The
Rational design of block copolymer self-assemblies in photodynamic therapy
Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15
- the importance of intracellular targeting has been addressed. Keywords: intracellular targeting; micelles; photodynamic therapy (PDT); photochemistry; polymer; self-assembly; Review Introduction After Paul Ehrlich, in 1900, had the very first notion of a drug being delivered at will to a specific
- enable entities smaller than these gaps to leave the bloodstream. Secondly, defects of the lymphatic system in tumors prevent these macromolecular therapeutics to be cleared from the tumor, giving them additional time to release their active cargo. This was the first example of targeting tumor tissues
- , exploiting only the size of the therapeutics, and is usually referred to as passive targeting. At that time, researchers got on the lead to develop intravenous nanocarriers of appropriate size (typically 20–200 nm) to benefit from this EPR effect without being cleared too rapidly through kidneys [4]. This
Molecular architectonics of DNA for functional nanoarchitectures
Beilstein J. Nanotechnol. 2020, 11, 124–140, doi:10.3762/bjnano.11.11
- using three 55 nucleotide-long carboxylic acid-linked DNA strands and a tumor-targeting 87 nucleotide-long aptamer. The carboxylic acid groups of the DNA tetrahedron facilitated the interaction with oleic acid-coated iron oxide nanoparticles via a ligand exchange reaction. The aptamer–DNA tetrahedron
- -functionalized iron oxide nanoparticle system was capable of selectively targeting the cancer cells and, potentially, to act as an MRI contrast agent. The programmability of the DNA tetrahedrons provided an opportunity to conjugate other functional nucleic acid sequences, viz., DNA, siRNA, or DNAzymes, to serve
- co-workers showed that self-assembled DNA tetrahedron nanoarchitectures with narrow size distribution could deliver siRNA into tumor cells [71]. The programmable DNA strands were functionalized with tumor-targeting folate ligands. The nanoarchitecture consisted of six DNA strands having a total of
Internalization mechanisms of cell-penetrating peptides
Beilstein J. Nanotechnol. 2020, 11, 101–123, doi:10.3762/bjnano.11.10
- in a broad spectrum of cell lines. It has a length of 21 amino acids and consists of three domains, each conferring a specific function: (i) a hydrophobic, tryptophan-rich sequence required for the interaction with macromolecules and cell-membrane targeting, (ii) a hydrophilic sequence, rich in
The different ways to chitosan/hyaluronic acid nanoparticles: templated vs direct complexation. Influence of particle preparation on morphology, cell uptake and silencing efficiency
Beilstein J. Nanotechnol. 2019, 10, 2594–2608, doi:10.3762/bjnano.10.250
- targeting therapies has already been reported [22][34][35]. It is worth mentioning that HCT-116 apparently shows a lower CD44 expression (see Supporting Information File 1, Section SI5), but this does not imply a lower CD44 endocytic activity. The cytotoxicity of the nanoparticles was assessed using the MTS
Advanced hybrid nanomaterials
Beilstein J. Nanotechnol. 2019, 10, 2563–2567, doi:10.3762/bjnano.10.247
- -art, as well as potential further developments, are reviewed in “Targeting strategies for improving the efficacy of nanomedicine in oncology” [32]. Nanocarriers for drugs were also decorated with suitable moieties to tune their affinity with specific biological membranes. More sophisticated strategies
- , including double targeting, are also highlighted in several articles. Among others, nanoparticles are often used as specific agents in dual therapy and diagnostics (i.e., theranostics). In “Size-selected Fe3O4–Au hybrid nanoparticles for improved magnetism-based theranostics”, a Fe3O4–Au hybrid nanomaterial
Bombesin receptor-targeted liposomes for enhanced delivery to lung cancer cells
Beilstein J. Nanotechnol. 2019, 10, 2553–2562, doi:10.3762/bjnano.10.246
- . Flow cytometric and microscopic studies showed that fluorescently labelled cystabn-decorated liposomes accumulated more extensively in GRPR over-expressing cells than matched liposomes that contained no cystabn targeting motif. Conclusion: The use of GRPR antagonistic peptides for nanoparticle
- targeting has potential for enhancing drug accumulation in resistant cancer cells. Keywords: bombesin; GRPR; liposome; lung cancer; targeting; Introduction Small-cell lung cancer (SCLC) accounts for approximately one in five lung cancer diagnoses. In spite of global efforts to reduce tobacco smoking in
- GRP/bombesin-based antagonists display superior in vivo targeting capacity cf. agonist peptides [11]. It is therefore reasonable to exploit the enhanced targeting capacity of the antagonist peptides for enhanced targeting of SCLC. Indeed, we postulate that high-affinity binding of antagonist peptides
pH-Controlled fluorescence switching in water-dispersed polymer brushes grafted to modified boron nitride nanotubes for cellular imaging
Beilstein J. Nanotechnol. 2019, 10, 2428–2439, doi:10.3762/bjnano.10.233
- were tested for their delivery potential, which showed promising results for imaging and drug targeting applications [60][61]. As a continuation of the work [60][61], we demonstrate the potential of BNNTs as a novel pH-switchable fluorescent water-dispersed material for cellular imaging. To study the
- -dependent fluorescence properties. Third, acrylic groups in P(AA-co-FA) can be easy modified for drugs and/or targeting agents similar to that reported in [61]. It is well known that the carboxyl group of acrylic acid can react with ammonia to form acrylamide, or with an alcohol to form an acrylate ester
Design of a nanostructured mucoadhesive system containing curcumin for buccal application: from physicochemical to biological aspects
Beilstein J. Nanotechnol. 2019, 10, 2304–2328, doi:10.3762/bjnano.10.222
- selectivity targeting cancer cells. Keywords: curcumin; mucoadhesion; oral squamous cell carcinoma; permeation; poloxamer 407; Introduction The development of nanostructured systems containing poloxamer 407 (P407) and Carbopol 974P® (C974P) have previously been shown to have rheological and mechanical
- determine the viability of oral mucosa as a targeting site for drug delivery [81][82]. These studies can be performed ex vivo, in vitro or in vivo and are dependent of the drug physicochemical characteristics and its behavior when incorporated in drug delivery systems and biological target tissue. The
Targeted therapeutic effect against the breast cancer cell line MCF-7 with a CuFe2O4/silica/cisplatin nanocomposite formulation
Beilstein J. Nanotechnol. 2019, 10, 2217–2228, doi:10.3762/bjnano.10.214
- cisplatin [20][21]. To overcome these limitations and to ensure specific tumor targeting, cisplatin/CuFe2O4/HYPS nanoparticles were tested. To investigate the cytotoxic efficiency of cisplatin/CuFe2O4/HYPS nanoparticles, we assessed cell viability using the MTT assay. In that assay, healthy cells will be
Mannosylated brush copolymers based on poly(ethylene glycol) and poly(ε-caprolactone) as multivalent lectin-binding nanomaterials
Beilstein J. Nanotechnol. 2019, 10, 2192–2206, doi:10.3762/bjnano.10.212
- ), targeting a degree of polymerization (DP) equal to 5. Reaction conversions were monitored by means of 1H NMR analysis; almost full monomer conversion (99%) was obtained after 6 h. The dispersity of the purified polymer was 1.19. Subsequent methacrylation of the terminal hydroxy group was accomplished in
Liquid crystal tunable claddings for polymer integrated optical waveguides
Beilstein J. Nanotechnol. 2019, 10, 2163–2170, doi:10.3762/bjnano.10.209
- channels, corresponding to the positions D and F in Figure 4. A refractive index change from 1.535 to 1.546 could lead to a single channel switching corresponding to positions B and D. The importance of targeting the lower refractive indices (as in the D-to-F transition) becomes evident when considering
Nitrogen-vacancy centers in diamond for nanoscale magnetic resonance imaging applications
Beilstein J. Nanotechnol. 2019, 10, 2128–2151, doi:10.3762/bjnano.10.207
- diamond with unique properties for use in ultra-sensitive, high-resolution magnetometry. One of the most interesting and challenging applications is nanoscale magnetic resonance imaging (nano-MRI). While many review papers have covered other NV centers in diamond applications, there is no survey targeting
Microbubbles decorated with dendronized magnetic nanoparticles for biomedical imaging: effective stabilization via fluorous interactions
Beilstein J. Nanotechnol. 2019, 10, 2103–2115, doi:10.3762/bjnano.10.205
- and some limitations [25]. In both cases, the shells can be custom-made to enhance stability, circulation duration, drug-loading capacity and release rate, targeting the fusion with cell membranes [24]. Both types of constructs are generally more stable, but less echogenic than “true” gas microbubbles
Incorporation of doxorubicin in different polymer nanoparticles and their anticancer activity
Beilstein J. Nanotechnol. 2019, 10, 2062–2072, doi:10.3762/bjnano.10.201
- targeting can be achieved via the enhanced permeability and retention (EPR) effect, which is the consequence of increased leakiness of the tumour vasculature and a lack of lymph drainage [4]. Nano-sized drug carrier systems can also prolong the circulation time of anticancer drugs, protect them from
- effects, which were comparable to doxorubicin solution. Since nanoparticle preparations are known to have the capacity to improve the in vivo activity of anticancer drugs by tumour targeting through the EPR effect, this is an important step in the development of improved nanoparticle preparations. However
Gold-coated plant virus as computed tomography imaging contrast agent
Beilstein J. Nanotechnol. 2019, 10, 1983–1993, doi:10.3762/bjnano.10.195
- agent offer a fast scan time (less than 2 min), low cost, and biocompatibility and allow for high-resolution imaging with ca. 150 Hounsfield units (HU). The Au-CPMV surface was further modified allowing for the incorporation of targeting molecules of specific cell types. Keywords: biomedical imaging
- ; computed tomography (CT); gold; nanotechnology; viruses; targeting; Introduction Numerous types of nanomaterials are currently under investigation in medicine, including dendrimers, polymeric nanoparticles (NPs), liposomes and protein-based NPs. Each system has advantages and disadvantages in terms of its
- conclude that the prepared VCAM1-PEG5000Au-CPMV is an acceptable targeting model for further in vivo studies. STEM–EDX elemental maps Low-voltage STEM offers a contrast enhancement over conventional TEM analysis due to lower energy (20–30 kV). The higher electron scattering provides better insight into the
Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells
Beilstein J. Nanotechnol. 2019, 10, 1933–1942, doi:10.3762/bjnano.10.189
- by cholesterol have been substantially investigated as drug carriers for targeting, modulating drug pharmacokinetics, and decreasing drug toxicity [15][16]. Liposomes also can be used as solubilizing media to enhance solubility and bioavailability of insoluble drugs [17]. Di and our prepared
Engineered superparamagnetic iron oxide nanoparticles (SPIONs) for dual-modality imaging of intracranial glioblastoma via EGFRvIII targeting
Beilstein J. Nanotechnol. 2019, 10, 1860–1872, doi:10.3762/bjnano.10.181
- Education, 826 Zhangheng Road, Shanghai 201203, China 10.3762/bjnano.10.181 Abstract In this work, a peptide-modified, biodegradable, nontoxic, brain-tumor-targeting nanoprobe based on superparamagnetic iron oxide nanoparticles (SPIONs) (which have been commonly used as T2-weighted magnetic resonance (MR
- construct the nanoprobe. Both in vitro and in vivo MR and optical imaging demonstrated that the as-constructed nanoprobe was effective and sensitive for tumor targeting with desirable biosafety. Given its desirable properties such as a 100 nm diameter (capable of penetration of the blood–brain barrier) and
- imaging [32][33][34]. There are many targeted probes for the diagnosis and treatment of GBM that have been constructed with high expression of EGFRvIII in the literature. Hadjipanayis and co-workers showed the specific EGFRvIII targeting and MRI contrast enhancement by means of EGFRvIII antibody
Materials nanoarchitectonics at two-dimensional liquid interfaces
Beilstein J. Nanotechnol. 2019, 10, 1559–1587, doi:10.3762/bjnano.10.153
- sophisticated strategy to realize chemotherapy targeting at cancer cells using the controlled assembly and disassembly of layer-by-layer hybrid structures made of two dimensional MoS2 nanosheets with DNA [87]. The preparation of functional low-dimensional materials requires preservation of nanoscale features in
Scavenging of reactive oxygen species by phenolic compound-modified maghemite nanoparticles
Beilstein J. Nanotechnol. 2019, 10, 1073–1088, doi:10.3762/bjnano.10.108
- , targeting tumor sites using an external magnetic field, MRI contrast agents, or magnetic hyperthermia. Under physiological conditions, the nanoparticle surface is exposed to the action of biomolecules, oxygen, peroxides, and radicals, which changes particle properties and behavior. Moreover, Fe2+ ions can
Enhanced inhibition of influenza virus infection by peptide–noble-metal nanoparticle conjugates
Beilstein J. Nanotechnol. 2019, 10, 1038–1047, doi:10.3762/bjnano.10.104
- demonstrate that conjugation of FluPep to gold and silver nanoparticles enhances its antiviral potency; the antimicrobial activity of silver ions may enable the design of even more potent antimicrobial inhibitors, capable of targeting both influenza and bacterial co-infections. Keywords: antiviral peptides
- density on the gold nanoparticles [17][22][26][30][31][32]. This can be determined by chromatography targeting specifically the grafted function, which also provides a means to purify the functionalised gold nanoparticles from those not functionalised, when the molar fraction of the functional ligand is
Correlation of surface-enhanced Raman scattering (SERS) with the surface density of gold nanoparticles: evaluation of the critical number of SERS tags for a detectable signal
Beilstein J. Nanotechnol. 2019, 10, 1016–1023, doi:10.3762/bjnano.10.102
- molecules (Raman reporters) resonant at the probe wavelength, where the entire structure is embedded in a stabilizing matrix [13][16][17][18][19]. When selectivity is required, the surface of the Raman tag should expose a targeting function for binding the analyte [13][16][17]. When the analytes can be
Tungsten disulfide-based nanocomposites for photothermal therapy
Beilstein J. Nanotechnol. 2019, 10, 811–822, doi:10.3762/bjnano.10.81
- , thereby offering the possibility of bonding of additional biologically active agents. The properties of the CAN-mag also enabled magnetism-based targeting. In order to maximize the benefit from TMDC nanostructures in different applications, their surface functionalization is important. The relative
- values of reduced aggregation, which leads to better targeting, and the possibility for attachments of additional cancer therapy agents. Experimental A schematic description of the experimental pathway leading to CAN-mag functionalized WS2 nanotubes is given in Figure 1, followed by fully detailed
- , namely increased cancerous-cell death and better targeting. Figure 7 shows zeta potential averages and distribution curves for WS2-NTs, CAN-mag, and their composites. The values for WS2-NT and CAN-mag are consistent with previous works [52][65][66]. For each composite, the zeta values reflect the
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