Cytotoxic and proinflammatory effects of PVP-coated silver nanoparticles after intratracheal instillation in rats

• Nadine Haberl,
• Stephanie Hirn,
• Alexander Wenk,
• Jörg Diendorf,
• Matthias Epple,
• Blair D. Johnston,
• Fritz Krombach,
• Wolfgang G. Kreyling and
• Carsten Schleh

Beilstein J. Nanotechnol. 2013, 4, 933–940, doi:10.3762/bjnano.4.105

• times did not cause adverse health effects in rats as measured by lung function, hematology, and body weight chances [25][26]. The mechanisms of toxicity are proposed to be oxidative stress, DNA damage, and the modulation of cytokine production [20]. In addition, Liu et al. showed that AgNP undergo