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Search for "proliferation" in Full Text gives 156 result(s) in Beilstein Journal of Nanotechnology.

Carbon nano-onions as fluorescent on/off modulated nanoprobes for diagnostics

  • Stefania Lettieri,
  • Marta d’Amora,
  • Adalberto Camisasca,
  • Alberto Diaspro and
  • Silvia Giordani

Beilstein J. Nanotechnol. 2017, 8, 1878–1888, doi:10.3762/bjnano.8.188

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  • changes in the cells and tissues. Some of these events include cell proliferation and apoptosis [1], ion transport [2] and other cellular process and diseases such as cancer [3][4][5], Parkinson's, and Alzheimer's disease [6]. Despite the large number of nanotechnology platforms available to date for
  • (Figure 8B,C), a progressive accumulation of fluo-CNOs was observed during the cell proliferation. Additionally, the efficient uptake was supported by a three dimensional reconstruction of cells treated with CNOs (Figure 9). Finally, we demonstrated that the on/off fluorescent emission properties of the
  • a positive control for cytotoxicity, the cells were incubated with 5% DMSO. Cell viability was determined using the cell proliferation reagent WST-1 (Roche Applied Sciences). After aspiration of the culture medium, a mixture of DMEM and WST1 reagent (1/10 volume) was added to each well. After 2 h of
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Published 07 Sep 2017

Optical techniques for cervical neoplasia detection

  • Tatiana Novikova

Beilstein J. Nanotechnol. 2017, 8, 1844–1862, doi:10.3762/bjnano.8.186

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  • characterized by loss of layered tissue architecture and an increase in tissue microstructural disorder in OCT images (Figure 12 b,c). The stromal layer demonstrates columnar proliferation towards the surface of tissue in the OCT image of a CIN 3 lesion (Figure 12b). The invasive carcinoma manifests itself in
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Published 06 Sep 2017

Uptake and intracellular accumulation of diamond nanoparticles – a metabolic and cytotoxic study

  • Antonín Brož,
  • Lucie Bačáková,
  • Pavla Štenclová,
  • Alexander Kromka and
  • Štěpán Potocký

Beilstein J. Nanotechnol. 2017, 8, 1649–1657, doi:10.3762/bjnano.8.165

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  • compared with the ND-free living control (i.e., cells grown in polystyrene wells in a medium without diamond nanoparticles). Similar results were also obtained in a study by Vaijayanthimala et al. [11], in which the proliferation of HeLa cells and 3T3-L1 pre-adipocytes exhibited no significant difference
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Published 10 Aug 2017

Surface functionalization of 3D-printed plastics via initiated chemical vapor deposition

  • Christine Cheng and
  • Malancha Gupta

Beilstein J. Nanotechnol. 2017, 8, 1629–1636, doi:10.3762/bjnano.8.162

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  • . Hong et al. demonstrated that simply dipping polycaprolactone/poly(lactic-co-glycolic acid) 3D scaffolds in mussel adhesive proteins promoted cellular adhesion, proliferation and differentiation, showing that a facile surface modification improved the viability of using 3D-printed scaffolds for tissue
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Published 08 Aug 2017

Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery

  • Gamze Varan,
  • Juan M. Benito,
  • Carmen Ortiz Mellet and
  • Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1457–1468, doi:10.3762/bjnano.8.145

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  • human breast cancer cell line. For this purpose, MCF-7 cells were incubated with different concentrations of PCX in dimethyl sulfoxide (DMSO). Non-treated cells were incubated with DMEM alone and were used as control group. Cell proliferation was determined and the IC50 value of PCX was calculated and
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Published 13 Jul 2017

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

  • Cem Varan and
  • Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1446–1456, doi:10.3762/bjnano.8.144

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  • an intracranial U87 glioma model. They demonstrated that active targeted and cationic core–shell nanoparticles could be effective in inhibition of tumor proliferation with higher accumulation in tumor area when they are administered intravenously [67]. Different studies also showed that nanoparticles
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Published 12 Jul 2017

Micro- and nano-surface structures based on vapor-deposited polymers

  • Hsien-Yeh Chen

Beilstein J. Nanotechnol. 2017, 8, 1366–1374, doi:10.3762/bjnano.8.138

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  • proliferation (FGF-2) and osteogenic differentiation (BMP-2) for adipose-derived stem cells [76]. Selective deposition The aforementioned methods rely on physical means to obtain spatially controlled surface modifications and patterned structures. A simpler approach is the selective inhibition of the vapor
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Published 04 Jul 2017

Carbon nanomaterials sensitize prostate cancer cells to docetaxel and mitomycin C via induction of apoptosis and inhibition of proliferation

  • Kati Erdmann,
  • Jessica Ringel,
  • Silke Hampel,
  • Manfred P. Wirth and
  • Susanne Fuessel

Beilstein J. Nanotechnol. 2017, 8, 1307–1317, doi:10.3762/bjnano.8.132

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  • combination with the carbon nanomaterials. The impact of the monotreatments and the combinatory treatments on cellular function was then systematically analyzed by using different experimental approaches (viability, short-term and long-term proliferation, cell death rate). DTX and MMC alone reduced the
  • contrast, the dose of platinum-based chemotherapeutics could only be reduced by up to 3-fold by combination with carbon nanomaterials. Furthermore, combinatory treatments with CNFs led mostly to an additive inhibition of short- and long-term proliferation compared to the individual treatments. Also, higher
  • proliferation as well as by an increased induction of apoptosis [27][28]. In order to further verify this concept and to avoid a bias that might be caused by the structurally similar platinum-based chemotherapeutics, we investigated other chemotherapeutics relevant for urological cancers, namely DTX and
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Published 23 Jun 2017

Nano-engineered skin mesenchymal stem cells: potential vehicles for tumour-targeted quantum-dot delivery

  • Liga Saulite,
  • Dominyka Dapkute,
  • Karlis Pleiko,
  • Ineta Popena,
  • Simona Steponkiene,
  • Ricardas Rotomskis and
  • Una Riekstina

Beilstein J. Nanotechnol. 2017, 8, 1218–1230, doi:10.3762/bjnano.8.123

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  • in skin MSCs was clathrin-mediated endocytosis. QDs were mainly localized in early endosomes after 6 h as well as in late endosomes and lysosomes after 24 h. QDs in concentrations ranging from 0.5 to 64 nM had no effect on cell viability and proliferation. The expression of MSC markers, CD73 and CD90
  • affect the osteogenesis and chondrogenesis capacities of bone marrow MSCs [17]. The impact of QD labelling on the biological properties of targeted stem cells, such as proliferation, cell cycle, and apoptosis, remains elusive. Therefore, further research on MSCs with regard to the delivery of QDs for
  • daughter cells (Figure 3c). Inhibition of proliferation was additionally confirmed by analysing the cell number in the respective medium (data not shown). The addition of QDs did not change the expression of Ki67 (data not shown). QD effect on immunophenotype, proliferation and differentiation of MSCs The
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Published 07 Jun 2017

Recombinant DNA technology and click chemistry: a powerful combination for generating a hybrid elastin-like-statherin hydrogel to control calcium phosphate mineralization

  • Mohamed Hamed Misbah,
  • Mercedes Santos,
  • Luis Quintanilla,
  • Christina Günter,
  • Matilde Alonso,
  • Andreas Taubert and
  • José Carlos Rodríguez-Cabello

Beilstein J. Nanotechnol. 2017, 8, 772–783, doi:10.3762/bjnano.8.80

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  • specific surface area and three-dimensional porous structures. In addition, osteoblast proliferation and apoptosis are affected by the size and shape of CP. Despite this interest, control of the formation of CP nanostructures with specific characteristics remains a challenge. Although dry methods and high
  • , ELR membranes with SNA15 epitopes and/or surface topographies have been conducted on the cell morphology, adhesion, proliferation and differentiation, and their potential for dental and orthopedic implants integration during the mineralization process. Although the mineralization activity of ELRs
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Published 04 Apr 2017

Silicon microgrooves for contact guidance of human aortic endothelial cells

  • Sara Fernández-Castillejo,
  • Pilar Formentín,
  • Úrsula Catalán,
  • Josep Pallarès,
  • Lluís F. Marsal and
  • Rosa Solà

Beilstein J. Nanotechnol. 2017, 8, 675–681, doi:10.3762/bjnano.8.72

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  • cell adhesion, morphology and proliferation were assessed, by comparing them to flat silicon substrates, used as control condition. Using human aortic endothelial cells, microscopy images demonstrate that the cellular response is different depending on the silicon surface, when it comes to cell
  • adhesion, morphology (alignment, circularity and filopodia presence) and proliferation. Moreover, these structures exerted no cytotoxic effect. Conclusion: The results suggest that topographical patterning influences cell response. Silicon groove substrates can be used in developing medical devices with
  • chemistry influence cellular behaviour such as adhesion, migration and proliferation [1][2][3][4][5][6]. It is important to understand and control cell behaviour by topography in order to modulate the functions of the cells. Cells react to topographic stimuli through a process known as mechanotransduction
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Published 22 Mar 2017

Uptake of the proteins HTRA1 and HTRA2 by cells mediated by calcium phosphate nanoparticles

  • Olga Rotan,
  • Katharina N. Severin,
  • Simon Pöpsel,
  • Alexander Peetsch,
  • Melisa Merdanovic,
  • Michael Ehrmann and
  • Matthias Epple

Beilstein J. Nanotechnol. 2017, 8, 381–393, doi:10.3762/bjnano.8.40

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  • this protein family in humans are HTRA1 and HTRA2 that are both involved in tumour suppression and in the control of proliferation, migration, and neurodegeneration [31]. The HTRA1 gene (previously termed PRSS11) was initially identified in human fibroblasts [32]. Numerous experimental findings suggest
  • a tumour suppressor function for HTRA1. In various cancer types, an epigenetic silencing of HTRA1 has been observed. Moreover, a decreased HTRA1 expression is correlated both with a reduced response to chemotherapeutics and an augmented cell migration. Additionally, a reduced proliferation of tumour
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Published 07 Feb 2017

Surface-enhanced Raman scattering of self-assembled thiol monolayers and supported lipid membranes on thin anodic porous alumina

  • Marco Salerno,
  • Amirreza Shayganpour,
  • Barbara Salis and
  • Silvia Dante

Beilstein J. Nanotechnol. 2017, 8, 74–81, doi:10.3762/bjnano.8.8

Graphical Abstract
  • surface roughness [3][4], the latter of which can play an important role in the adhesion and proliferation of cells [5][6][7]. The self-ordered nano-structured APA, also demonstrated recently as a possible nanolithographic mask [8][9] and for chemical sensors and biosensors [10], after coating with noble
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Published 09 Jan 2017

Facile fabrication of luminescent organic dots by thermolysis of citric acid in urea melt, and their use for cell staining and polyelectrolyte microcapsule labelling

  • Nadezhda M. Zholobak,
  • Anton L. Popov,
  • Alexander B. Shcherbakov,
  • Nelly R. Popova,
  • Mykhailo M. Guzyk,
  • Valeriy P. Antonovich,
  • Alla V. Yegorova,
  • Yuliya V. Scrypynets,
  • Inna I. Leonenko,
  • Alexander Ye. Baranchikov and
  • Vladimir K. Ivanov

Beilstein J. Nanotechnol. 2016, 7, 1905–1917, doi:10.3762/bjnano.7.182

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  • also known that the MTT assay is typically used for quantifying metabolically active cells, independently of proliferation [63]. Therefore, the highest concentration of sample that caused, in the treated cells, the activation of NADP-H-dependent oxidoreductases, not more than in the intact cells, was
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Published 02 Dec 2016

Low temperature co-fired ceramic packaging of CMOS capacitive sensor chip towards cell viability monitoring

  • Niina Halonen,
  • Joni Kilpijärvi,
  • Maciej Sobocinski,
  • Timir Datta-Chaudhuri,
  • Antti Hassinen,
  • Someshekar B. Prakash,
  • Peter Möller,
  • Pamela Abshire,
  • Sakari Kellokumpu and
  • Anita Lloyd Spetz

Beilstein J. Nanotechnol. 2016, 7, 1871–1877, doi:10.3762/bjnano.7.179

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  • cell proliferation thus seemed to be normal, the use of the LTCC package for the sensor chip was regarded as promising [23]. Here we have tested version 2 of the LTCC package made from DupontTM 951 LTCC tape instead of the Heraeus HeraLock® Tape HL2000 (no longer produced) used in our earlier version
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Published 29 Nov 2016

Nano- and microstructured materials for in vitro studies of the physiology of vascular cells

  • Alexandra M. Greiner,
  • Adria Sales,
  • Hao Chen,
  • Sarah A. Biela,
  • Dieter Kaufmann and
  • Ralf Kemkemer

Beilstein J. Nanotechnol. 2016, 7, 1620–1641, doi:10.3762/bjnano.7.155

Graphical Abstract
  • and their biological responses to micro- and nanostructured surfaces are reviewed. Emphasis is given to studies of cell morphology and motility, cell proliferation, the cytoskeleton and cell-matrix adhesions, and signal transduction pathways of vascular cells. We finalize with a short outlook on
  • following section, a brief summary of the most common methods for control of the surface biochemistry and of the mechanical properties of the substrate are given. 1.5 Surface (bio)functionalization The surface (bio)chemistry of a material may regulate cell adhesion, survival, proliferation and
  • ][173][174][175][176]. Thereby, a multitude of stimulating signals, such as messenger molecules, ECM, pulsatile blood flow and endogenous electrical fields exist in and around the vasculature [177][178][179]. Additionally, in blood vessels of healthy humans, the regulation of SMC proliferation and
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Published 08 Nov 2016

Influence of hydrothermal synthesis parameters on the properties of hydroxyapatite nanoparticles

  • Sylwia Kuśnieruk,
  • Jacek Wojnarowicz,
  • Agnieszka Chodara,
  • Tadeusz Chudoba,
  • Stanislaw Gierlotka and
  • Witold Lojkowski

Beilstein J. Nanotechnol. 2016, 7, 1586–1601, doi:10.3762/bjnano.7.153

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  • proliferation of such malignant cells was inhibited more efficiently by the occurrence of the nanoscale effect than by HAp particle morphology [9]. Another study analyzed the effects of different sized nano-HAp – ranging from 20 to 80 nm – on the proliferation of bone-related cells (bone marrow mesenchyme stem
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Published 04 Nov 2016

Viability and proliferation of endothelial cells upon exposure to GaN nanoparticles

  • Tudor Braniste,
  • Ion Tiginyanu,
  • Tibor Horvath,
  • Simion Raevschi,
  • Serghei Cebotari,
  • Marco Lux,
  • Axel Haverich and
  • Andres Hilfiker

Beilstein J. Nanotechnol. 2016, 7, 1330–1337, doi:10.3762/bjnano.7.124

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  • ) semiconductor nanoparticles. Cellular viability, adhesion, proliferation, and uptake of nanoparticles by endothelial cells were investigated. The effect of free GaN nanoparticles versus the effect of growing endothelial cells on GaN functionalized surfaces was examined. To functionalize surfaces with GaN, GaN
  • cells grown on surfaces functionalized with GaN nanoparticles demonstrated excellent adhesion and proliferation, suggesting good biocompatibility of the nanostructured GaN. Keywords: endothelial cells; GaN nanoparticles; proliferation; surface functionalization; Introduction The development of new
  • the mechanical load of incorporated nanoparticles, which could result in reduced migration and slowed proliferation process with increasing quantities of incorporated nanoparticles [20]. When nanoparticles were added after the cellular layer reached 50% confluence, we clearly observed how the same
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Published 23 Sep 2016

On the pathway of cellular uptake: new insight into the interaction between the cell membrane and very small nanoparticles

  • Claudia Messerschmidt,
  • Daniel Hofmann,
  • Anja Kroeger,
  • Katharina Landfester,
  • Volker Mailänder and
  • Ingo Lieberwirth

Beilstein J. Nanotechnol. 2016, 7, 1296–1311, doi:10.3762/bjnano.7.121

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  • . Similar results were reported by Zhang et al. comparing 80 nm SiNPs with 500 nm SiNPs on HepG2 cells [40]. Those investigated particles affect cell viability and the proliferation potential in a size-ascending-dependent manner. Nevertheless, these data were only focusing on large differences in size and
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Published 16 Sep 2016

Reasons and remedies for the agglomeration of multilayered graphene and carbon nanotubes in polymers

  • Rasheed Atif and
  • Fawad Inam

Beilstein J. Nanotechnol. 2016, 7, 1174–1196, doi:10.3762/bjnano.7.109

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  • conductive polymer nanocomposites can be produced. However, all these enhancements of the performance of polymers can only be achieved when the filler is uniformly dispersed and no agglomeration of filler in the polymer matrix takes place. MLG and CNTs have been reported to promote the proliferation of
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Published 12 Aug 2016

Improved biocompatibility and efficient labeling of neural stem cells with poly(L-lysine)-coated maghemite nanoparticles

  • Igor M. Pongrac,
  • Marina Dobrivojević,
  • Lada Brkić Ahmed,
  • Michal Babič,
  • Miroslav Šlouf,
  • Daniel Horák and
  • Srećko Gajović

Beilstein J. Nanotechnol. 2016, 7, 926–936, doi:10.3762/bjnano.7.84

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  • their cellular uptake, the mechanism of internalization, cytotoxicity, viability and proliferation of neural stem cells, and compared them to the commercially available dextran-coated nanomag®-D-spio nanoparticles. Results: Light microscopy of Prussian blue staining revealed a concentration-dependent
  • intracellular uptake of iron oxide in neural stem cells. The methyl thiazolyl tetrazolium assay and the calcein acetoxymethyl ester/propidium iodide assay demonstrated that poly(L-lysine)-coated maghemite nanoparticles scored better than nanomag®-D-spio in cell labeling efficiency, viability and proliferation
  • follow the stem cells through their migration, distribution, proliferation and differentiation is an essential prerequisite to characterize the biology and behavior of stem cells, to design the therapeutic approaches and minimize possible side effects [8][9][10]. Magnetic nanoparticles are widely used to
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Published 27 Jun 2016

Tight junction between endothelial cells: the interaction between nanoparticles and blood vessels

  • Yue Zhang and
  • Wan-Xi Yang

Beilstein J. Nanotechnol. 2016, 7, 675–684, doi:10.3762/bjnano.7.60

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  • inhibited (79%) by silver nanoparticles (2–6 nm) [80]. Also, AuNPs have the ability to prevent vascular endothelial growth factor (VEGF)- and interleukin-1 beta (IL-1β)-induced proliferation and migration in bovine retinal pigment epithelial cells (BRPEs) through the suppression of the Src kinase pathway
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Published 06 May 2016

Unraveling the neurotoxicity of titanium dioxide nanoparticles: focusing on molecular mechanisms

  • Bin Song,
  • Yanli Zhang,
  • Jia Liu,
  • Xiaoli Feng,
  • Ting Zhou and
  • Longquan Shao

Beilstein J. Nanotechnol. 2016, 7, 645–654, doi:10.3762/bjnano.7.57

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  • expression. These stable alternations are not caused by changes to DNA sequence itself, but instead arise during development and cell proliferation [13][14]. DNA methylation is the one of the most extensively studied epigenetic mechanisms. Whether TiO2 NPs are able to induce neurotoxicity through altering
  • nasal administration for nine months, after which the glial cells showed over-proliferation and tissue necrosis was found in hippocampal area. Meanwhile, the expression of genes associated with neurotrophin signaling pathways, such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF
  • tumor necrosis factor-α (TNF-α) in the mouse hippocampus was promoted. At the same time, histopathological changes were observed in the hippocampus; over-proliferation of glial cells, impaired nuclei, and cellular degeneration were observed, all of which contributed to neuro-inflammation. In addition
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Published 29 Apr 2016

Antibacterial activity of silver nanoparticles obtained by pulsed laser ablation in pure water and in chloride solution

  • Brunella Perito,
  • Emilia Giorgetti,
  • Paolo Marsili and
  • Maurizio Muniz-Miranda

Beilstein J. Nanotechnol. 2016, 7, 465–473, doi:10.3762/bjnano.7.40

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  • about 2 h and increases at 3 h, with no detectable CFUs after 24 h of incubation (Table 3). Hence, according to our data on ns-ablated AgNPs, the minimum time necessary to achieve bactericidal effect was longer than 3 h. Nevertheless, such AgNPs are very quick at inhibiting bacterial proliferation, when
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Published 18 Mar 2016

Fabrication of hybrid nanocomposite scaffolds by incorporating ligand-free hydroxyapatite nanoparticles into biodegradable polymer scaffolds and release studies

  • Balazs Farkas,
  • Marina Rodio,
  • Ilaria Romano,
  • Alberto Diaspro,
  • Romuald Intartaglia and
  • Szabolcs Beke

Beilstein J. Nanotechnol. 2015, 6, 2217–2223, doi:10.3762/bjnano.6.227

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  • similarity to the mineral constituent of human bones, are bioactive and can be fairly easily bioconjugated [1]. HA NPs can enhance cell proliferation in bone tissue regeneration [2]. Tissue engineering is an interdisciplinary field that combines the principles of life sciences and engineering to improve
  • of HA enhanced hydrophilicity and serum protein adsorption, and as a result, this increased pre-osteoblast cell attachment, spreading, and proliferation after four days of culture. Different technical routes have been explored for the synthesis of HA NPs, including mechanochemical synthesis [10
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Published 25 Nov 2015
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