Bacterial safety study of the production process of hemoglobin-based oxygen carriers

• Axel Steffen,
• Yu Xiong,
• Radostina Georgieva,
• Ulrich Kalus and
• Hans Bäumler

Beilstein J. Nanotechnol. 2022, 13, 114–126, doi:10.3762/bjnano.13.8

• Axel Steffen Yu Xiong Radostina Georgieva Ulrich Kalus Hans Baumler Institute of Transfusion Medicine, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany Department of Medical Physics, Biophysics and Radiology, Faculty of Medicine, Trakia University, 6000 Stara Zagora, Bulgaria 10.3762

• known to have an antibacterial effect and it is used as a disinfectant or for cold sterilization of medical instruments in hospitals at higher concentrations [22][23][24]. Glutaraldehyde is also widely used in biochemical applications and as a fixative for electron microscopy [25][26]. EDTA is used in

• the HbMP fabrication process to dissolve the manganese carbonate template to produce pure protein particles. EDTA is widely utilized in medical and biological applications. Because of its chelating properties, it is used as an anticoagulant in blood samples [27]. It has also long been used to

Theranostic potential of self-luminescent branched polyethyleneimine-coated superparamagnetic iron oxide nanoparticles

• Rouhollah Khodadust,
• Ozlem Unal and
• Havva Yagci Acar

Beilstein J. Nanotechnol. 2022, 13, 82–95, doi:10.3762/bjnano.13.6

• limits their processability and hence medical use [13][14]. However, in recent years, amine-containing branched polymers such as polyethyleneimine (PEI) [15][16][17][18][19] and dendrimers such as polyamidoamine (PAMAM) [20][21][22][23][24] are reported as weakly blue luminescing organic materials. The

Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy

• Xiaoteng Liang,
• Shuai Liu,
• Xiuchao Wang,
• Dan Xia and
• Qiang Li

Beilstein J. Nanotechnol. 2021, 12, 1372–1379, doi:10.3762/bjnano.12.101

• Chemistry of Ministry of Education, And School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, Shandong, China Tianjin Medical University Cancer Institute & Hospital, Tianjin, 300060, China 10.3762/bjnano.12.101 Abstract The mechanical properties of cells are key to the

Identifying diverse metal oxide nanomaterials with lethal effects on embryonic zebrafish using machine learning

• Richard Liam Marchese Robinson,
• Haralambos Sarimveis,
• Philip Doganis,
• Xiaodong Jia,
• Marianna Kotzabasaki,
• Christiana Gousiadou,
• Stacey Lynn Harper and
• Terry Wilkins

Beilstein J. Nanotechnol. 2021, 12, 1297–1325, doi:10.3762/bjnano.12.97

• delivery vehicles), diagnostic tools and medical devices, is a key application area [2][3]. However, as well as recognising the benefits associated with nanotechnology, it is also important to address potential negative impacts upon human health and the environment. Nanosafety concerns are reflected in

• international research efforts, such as the European Union’s NanoSafety Cluster [4] and associated research projects, such as BIORIMA [5], which has proposed a risk management framework for nanomaterials used in advanced therapeutic medicinal products and medical devices [6]. Indeed, in 2008, an iron oxide ENM

Morphology-driven gas sensing by fabricated fractals: A review

• Vishal Kamathe and
• Rupali Nagar

Beilstein J. Nanotechnol. 2021, 12, 1187–1208, doi:10.3762/bjnano.12.88

• of flammable, poisonous, and harmful gases present in the atmosphere. Gas sensors are alerting systems that are installed in industry setups at both small and large scale, automobile, medical, agriculture, defense, commercial, and residential sectors and thus are versatile regarding their eventual

• areas ranging from food packaging to medical diagnosis. Fractals can also help in mimicking the wound healing process as tissue grows to connect the torn skin across the wound and offer an insight into microfluids as part of wound healing management. Besides application-oriented research the

Self-assembly of amino acids toward functional biomaterials

• Huan Ren,
• Lifang Wu,
• Lina Tan,
• Yanni Bao,
• Yuchen Ma,
• Yong Jin and
• Qianli Zou

Beilstein J. Nanotechnol. 2021, 12, 1140–1150, doi:10.3762/bjnano.12.85

• Huan Ren Lifang Wu Lina Tan Yanni Bao Yuchen Ma Yong Jin Qianli Zou School of Pharmacy, Anhui Medical University, Hefei 230032, China 10.3762/bjnano.12.85 Abstract Biomolecules, such as proteins and peptides, can be self-assembled. They are widely distributed, easy to obtain, and biocompatible

Assessment of the optical and electrical properties of light-emitting diodes containing carbon-based nanostructures and plasmonic nanoparticles: a review

• Keshav Nagpal,
• Erwan Rauwel,
• Frédérique Ducroquet and
• Protima Rauwel

Beilstein J. Nanotechnol. 2021, 12, 1078–1092, doi:10.3762/bjnano.12.80

• ) have shown the most significant technological progress in display applications. They are incorporated into smart phones, TVs, traffic signals, and medical devices [3]. Similarly, lighting systems employing LED have longer life times (>50000 h), much lower heating effects, ultrafast response times, and

Use of nanosystems to improve the anticancer effects of curcumin

• Andrea M. Araya-Sibaja,
• Norma J. Salazar-López,
• Krissia Wilhelm Romero,
• José R. Vega-Baudrit,
• J. Abraham Domínguez-Avila,
• Carlos A. Velázquez Contreras,
• Ramón E. Robles-Zepeda,
• Mirtha Navarro-Hoyos and
• Gustavo A. González-Aguilar

Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78

• . Liposomes are one of the most well-studied nanosystems. They are self-assembled vesicles with at least one phospholipid bilayer with a diameter size in the range of 50–450 nm when used for medical purposes, and are often used to deliver both hydrophilic and hydrophobic molecules [71][72]. Their main

An overview of microneedle applications, materials, and fabrication methods

• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2021, 12, 1034–1046, doi:10.3762/bjnano.12.77

• microelectromechanical systems (MEMS) and provided a platform for microfabrication of compact miniaturized medical devices for human health screening, monitoring, and diagnostic purposes. Microneedles are microstructures that are sharp and robust enough for skin penetration, made using MEMS technology. The application

• range of medical applications. However, the delivery of therapeutic agents by dissolving or coated microneedles has encountered problems, such as heating of carbohydrates and polymers, which can cause drug breakdown during moulding of microneedles at raised temperatures [36]. Research to overcome these

• methods, the number of licensed microneedle patch devices entering the medical devices market is still small. Most of the reported studies do not go beyond the proof-of-concept phase, and do not consider in much depth the translation aspects of their technology such as manufacturability and clinical

A Au/CuNiCoS₄/p-Si photodiode: electrical and morphological characterization

• Adem Koçyiğit,
• Adem Sarılmaz,
• Teoman Öztürk,
• Faruk Ozel and
• Murat Yıldırım

Beilstein J. Nanotechnol. 2021, 12, 984–994, doi:10.3762/bjnano.12.74

• great attention due their unique electronic, magnetic, optical, and gas sensing properties. Spinel compounds can be employed in data storage applications, lithium-ion batteries, gas sensors, and medical diagnostics [1][2]. Spinels have a cubic crystal structure with the general chemical formula AB2X4

The role of convolutional neural networks in scanning probe microscopy: a review

• Ido Azuri,
• Irit Rosenhek-Goldian,
• Neta Regev-Rudzki,
• Georg Fantner and
• Sidney R. Cohen

Beilstein J. Nanotechnol. 2021, 12, 878–901, doi:10.3762/bjnano.12.66

• , to locate objects and identify specific structures and boundaries, namely “pixel classification” [7][10]. For example, in medical image diagnosis, the segmentation of organs allows for the quantification of their volume and shape [11]. In many biological applications, nucleus identification

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

• Sepand Tehrani Fateh Lida Moradi Elmira Kohan Michael R. Hamblin Amin Shiralizadeh Dezfuli School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of

• Medical Sciences, Tehran, Iran Department of Science, University of Kurdistan, Kurdistan, Sanandaj, Iran Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein 2028, South Africa Physiology Research Center, Faculty of medicine, Iran University of Medical Sciences

• [54][55], and brain [56][57][58][59] tumors. Physics of ultrasound Ultrasound is a noninvasive and nonionizing acoustic wave with a frequency above 20 kHz, which is based on the human perception of sound. The range of US frequency used in medical applications varies from 1 to 15 MHz, in which 1 MHz

Silver nanoparticles nucleated in NaOH-treated halloysite: a potential antimicrobial material

• Yuri B. Matos,
• Rodrigo S. Romanus,
• Mattheus Torquato,
• Edgar H. de Souza,
• Rodrigo L. Villanova,
• Marlene Soares and
• Emilson R. Viana

Beilstein J. Nanotechnol. 2021, 12, 798–807, doi:10.3762/bjnano.12.63

• 10.3762/bjnano.12.63 Abstract Despite all recent advances in medical treatments, infectious diseases remain dangerous. This has led to intensive scientific research on materials with antimicrobial properties. Silver nanoparticles (Ag-NPs) are a well-established solution in this area. The present work

Silver nanoparticles induce the cardiomyogenic differentiation of bone marrow derived mesenchymal stem cells via telomere length extension

• Khosro Adibkia,
• Ali Ehsani,
• Asma Jodaei,
• Ezzatollah Fathi,
• Raheleh Farahzadi and
• Mohammad Barzegar-Jalali

Beilstein J. Nanotechnol. 2021, 12, 786–797, doi:10.3762/bjnano.12.62

• Khosro Adibkia Ali Ehsani Asma Jodaei Ezzatollah Fathi Raheleh Farahzadi Mohammad Barzegar-Jalali Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran Department of Pharmaceutical Sciences, Faculty of Pharmacy, Tabriz University of Medical Sciences

• , Tabriz, Iran Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Pharmaceutical

• Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran 10.3762/bjnano.12.62 Abstract Finding new strategies for the treatment of heart failures using stem cells has attracted a lot of attention. Meanwhile, nanotechnology-based approaches to regenerative medicine hypothesize a

Recent progress in actuation technologies of micro/nanorobots

• Ke Xu and
• Bing Liu

Beilstein J. Nanotechnol. 2021, 12, 756–765, doi:10.3762/bjnano.12.59

• biomedical fields, such as medical diagnosis, nanoscale surgery, and targeted therapy. In this article, recent progress on micro/nanorobots is reviewed regarding actuation technologies. First, the different actuation mechanisms are divided into two types, external field actuation and self-actuation. Then, a

• proposed the idea of using microrobots in medical treatment. It has been envisioned that nanorobots could be implanted into human bodies to self-replicate and kill various viruses. Scientists have been more and more enthusiastic about the research on micro/nanorobots. The combination of micro/nanorobots

• with biomedicine can solve problems that cannot be solved by traditional medicine, and is expected to bring up a new medical revolution [13]. Therefore, scientists continue to explore and study micro/nanorobotics technology. However, due to the small size of micro/nanorobots, they are difficult to

Recent progress in magnetic applications for micro- and nanorobots

• Ke Xu,
• Shuang Xu and
• Fanan Wei

Beilstein J. Nanotechnol. 2021, 12, 744–755, doi:10.3762/bjnano.12.58

• used in medical MNRs [26]. For example, based on the combination of copolymer brushes and superparamagnetic nanoparticles, a biomimetic nanoreactor was proposed. It contained a magnetic field-responsive catalytic system, namely magnetic field-responsive binary deoxyribozyme (MaBiDZ) [27]. Also, it

• used in MNRs will be discussed. Finally, conclusions and an outlook will be provided. Review Magnetic materials used in MNRs Different magnetic materials exhibit different magnetic properties to external magnetic fields. When analyzing MNPs [30] in medical nanorobots, Martel [26] mentioned that

• low-level radiation shielding sheet with diamagnetic nanoparticles and wanted to develop a medical radiation fiber shielding, which is harmless to the human body. The uniform dispersion of magnetic nanoparticles into a polymer resin can not only reduce the weight of the material, but also avoid harm

Nanogenerator-based self-powered sensors for data collection

• Yicheng Shao,
• Maoliang Shen,
• Yuankai Zhou,
• Xin Cui,
• Lijie Li and
• Yan Zhang

Beilstein J. Nanotechnol. 2021, 12, 680–693, doi:10.3762/bjnano.12.54

• -powered sensors in data-driven intelligent systems are proposed. Review Human physiological data collection based on self-powered sensors Self-powered wearable sensors and electronic skin Self-powered wearable sensors to collect human motion data can provide a data set for medical diagnosis and

Fate and transformation of silver nanoparticles in different biological conditions

• Barbara Pem,
• Marija Ćurlin,
• Darija Domazet Jurašin,
• Valerije Vrček,
• Rinea Barbir,
• Vedran Micek,
• Raluca M. Fratila,
• Jesus M. de la Fuente and
• Ivana Vinković Vrček

Beilstein J. Nanotechnol. 2021, 12, 665–679, doi:10.3762/bjnano.12.53

• Barbara Pem Marija Curlin Darija Domazet Jurasin Valerije Vrcek Rinea Barbir Vedran Micek Raluca M. Fratila Jesus M. de la Fuente Ivana Vinkovic Vrcek Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10 000 Zagreb, Croatia University of Zagreb, School of Medicine, Šalata

• , which listed more than 100 AgNP-containing food products [4]. The biomedical use of AgNPs represents the largest proportion of the market share [1] encompassing antimicrobial coatings on medical devices (catheters, stents, implants), wound dressings, targeted drug delivery, cancer therapy and

• medical products may be related to human exposure and safety as AgNPs may undergo complex transformations in biological media [6]. It is well known that AgNP physicochemical characteristics, such as size, shape, surface charge, surface functionalization, or core composition determine their interactions

On the stability of microwave-fabricated SERS substrates – chemical and morphological considerations

• Limin Wang,
• Aisha Adebola Womiloju,
• Christiane Höppener,
• Ulrich S. Schubert and
• Stephanie Hoeppener

Beilstein J. Nanotechnol. 2021, 12, 541–551, doi:10.3762/bjnano.12.44

• in chemical and bioanalytical research [1][2]. Its application in chemistry, biosensing, materials science, engineering, and medical diagnostics was successfully introduced and can provide valuable information [1][2][3][4]. Since it was discovered in 1974 by Fleischmann et al. that the intensity of

Simulation of gas sensing with a triboelectric nanogenerator

• Kaiqin Zhao,
• Hua Gan,
• Huan Li,
• Ziyu Liu and
• Zhiyuan Zhu

Beilstein J. Nanotechnol. 2021, 12, 507–516, doi:10.3762/bjnano.12.41

• gas and the different gas injection areas. This work contributes to the area of self-powered gas sensing. Keywords: gas; sensor; triboelectric nanogenerator (TENG); Introduction With economic development and social progress, there is an increasing demand for wearable [1][2][3][4], medical [5], and

• rate of utilization [19]. Characterized by low cost, light weight, environmental safety, and high conversion efficiency under low frequency, TENGs can provide continuous power supply for wearable devices [20], medical devices, and microelectronic systems [21]. In addition, triboelectric nanogenerators

Surface-enhanced Raman scattering of water in aqueous dispersions of silver nanoparticles

• Paulina Filipczak,
• Krzysztof Hałagan,
• Jacek Ulański and
• Marcin Kozanecki

Beilstein J. Nanotechnol. 2021, 12, 497–506, doi:10.3762/bjnano.12.40

• discovery of the SERS effect in 1974 [27], most of the research is focused on biomolecules and medical applications [28][29]. The SERS effect of water has been studied since 1980. There are reports on the SERS effect of water in aqueous solutions of electrolytes placed between metal electrodes (Ag, Au, Cu

Rapid controlled synthesis of gold–platinum nanorods with excellent photothermal properties under 808 nm excitation

• Jialin Wang,
• Qianqian Duan,
• Min Yang,
• Boye Zhang,
• Li Guo,
• Pengcui Li,
• Wendong Zhang and
• Shengbo Sang

Beilstein J. Nanotechnol. 2021, 12, 462–472, doi:10.3762/bjnano.12.37

• of Technology, Taiyuan 030024, Shanxi, China Department of Orthopedics, the Second Hospital of Shanxi Medical University, Taiyuan 030024, Shanxi, China 10.3762/bjnano.12.37 Abstract Noble metal nanomaterials are particularly suitable as photothermal transduction agents (PTAs) with high photothermal

A review on nanostructured silver as a basic ingredient in medicine: physicochemical parameters and characterization

• Gabriel M. Misirli,
• Kishore Sridharan and
• Shirley M. P. Abrantes

Beilstein J. Nanotechnol. 2021, 12, 440–461, doi:10.3762/bjnano.12.36

• in the manufacture of medical devices to prevent adhesion, colonization, and formation of microbial biofilms on the surfaces of these devices. Moreover, the history of AgNPs as a broad spectrum microbicidal agent places it as a viable candidate to be one of the basic ingredients of antibiotics to be

Intracranial recording in patients with aphasia using nanomaterial-based flexible electronics: promises and challenges

• Qingchun Wang and
• Wai Ting Siok

Beilstein J. Nanotechnol. 2021, 12, 330–342, doi:10.3762/bjnano.12.27

• -noise ratio (Figure 5c, right). The real-time signals of cortical activities in different medical and drug-induced epileptic states were precisely measured when the iWEBS array was used in freely moving mice. Combined with optogenetic mapping techniques, long-range cortical interactions were

Doxorubicin-loaded gold nanorods: a multifunctional chemo-photothermal nanoplatform for cancer management

• Uzma Azeem Awan,
• Abida Raza,
• Shaukat Ali,
• Rida Fatima Saeed and
• Nosheen Akhtar

Beilstein J. Nanotechnol. 2021, 12, 295–303, doi:10.3762/bjnano.12.24

• Uzma Azeem Awan Abida Raza Shaukat Ali Rida Fatima Saeed Nosheen Akhtar Department of Biological Sciences, National University of Medical Sciences (NUMS), Rawalpindi, Pakistan NILOP Nanomedicine Research Laboratories, National Institute of Lasers and Optronics College, (PIEAS), Islamabad, Pakistan

• Medical Toxicology Lab, Department of Zoology, Government College University Lahore, Lahore-54000, Pakistan 10.3762/bjnano.12.24 Abstract Two of the limitations associated with cancer treatment are the low efficacy and the high dose-related side effects of anticancer drugs. The purpose of the current

• based on chemotherapy and photothermal strategies appears to be a promising platform in cancer management. Keywords: chemotherapy; doxorubicin; gold nanorods; NIR laser; photothermal therapy; Introduction Despite the enormous advances in medical research, cancer is still the second most common cause