Microfluidics as tool to prepare size-tunable PLGA nanoparticles with high curcumin encapsulation for efficient mucus penetration

• Nashrawan Lababidi,
• Valentin Sigal,
• Aljoscha Koenneke,
• Konrad Schwarzkopf,
• Andreas Manz and
• Marc Schneider

Beilstein J. Nanotechnol. 2019, 10, 2280–2293, doi:10.3762/bjnano.10.220

• vaccine delivery [1][2], in anticancer therapies [3][4], as well as for gene delivery [5][6]. Owing to the unique physicochemical properties of nanoparticles, the nanoparticle surface can be specifically modified to meet the needs of the desired application [7][8]. Such surface modifications can also be

Improved adsorption and degradation performance by S-doping of (001)-TiO₂

• Xiao-Yu Sun,
• Xian Zhang,
• Xiao Sun,
• Ni-Xian Qian,
• Min Wang and
• Yong-Qing Ma

Beilstein J. Nanotechnol. 2019, 10, 2116–2127, doi:10.3762/bjnano.10.206

• pollutants, as well as in electrocatalysis, solar cells and self-cleaning applications. Its wide use is based on its physicochemical properties, abundance, nontoxicity, environment-friendliness and low cost [1][2][3][4][5][6][7]. The photocatalytic properties of anatase TiO2 crystals are anisotropic since

Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells

• Liang Xu,
• Dekang Xu,
• Ziying Li,
• Yu Gao and
• Haijun Chen

Beilstein J. Nanotechnol. 2019, 10, 1933–1942, doi:10.3762/bjnano.10.189

• preparation technology are needed to improve the physicochemical properties of the phytosomes. Antiproliferative activity of P2P To determine the cytotoxicity of DiP and P2P in lung cancer cells, cells were treated with different concentrations of P, DiP and P2P for different incubation times. The toxicity of

High-tolerance crystalline hydrogels formed from self-assembling cyclic dipeptide

• Yongcai You,
• Ruirui Xing,
• Qianli Zou,
• Feng Shi and
• Xuehai Yan

Beilstein J. Nanotechnol. 2019, 10, 1894–1901, doi:10.3762/bjnano.10.184

• hydrogels with adjustable mechanical and physicochemical properties [29][30][31][32][33]. Peptide-based supramolecular hydrogels have been widely used in biological and nanotechnology fields [34]. However, linear peptide-based hydrogels usually have several deficiencies, such as poor molecular rigidity

Nanoporous smartPearls for dermal application – Identification of optimal silica types and a scalable production process as prerequisites for marketed products

• David Hespeler,
• Sanaa El Nomeiri,
• Jonas Kaltenbach and
• Rainer H. Müller

Beilstein J. Nanotechnol. 2019, 10, 1666–1678, doi:10.3762/bjnano.10.162

• name smartCrystals®) [8][9][10]. These materials have been on the market as commercial dermal cosmetic products since 2007 (e.g., hesperidin, la prairie Switzerland) [11][12]. They can be considered as the current “gold standard”. The trick with nanocrystals is that the physicochemical properties on

Tailoring the stability/aggregation of one-dimensional TiO₂(B)/titanate nanowires using surfactants

• Atiđa Selmani,
• Johannes Lützenkirchen,
• Kristina Kučanda,
• Dario Dabić,
• Engelbert Redel,
• Ida Delač Marion,
• Damir Kralj,
• Darija Domazet Jurašin and
• Maja Dutour Sikirić

Beilstein J. Nanotechnol. 2019, 10, 1024–1037, doi:10.3762/bjnano.10.103

• because of their unique physicochemical properties compared to the bulk material. TNMs play an important role in various applications such as photocatalytic degradation of organic pollutants [1][2], sensors [3][4], solid oxide fuel cells [5], water purification [6][7], adsorption of radioactive and heavy

• research and industrial applications. Gemini surfactants possess a unique molecular structure involving two hydrophobic moieties connected by a hydrophobic or hydrophilic spacer at the level of the head groups. Consequently, these surfactants display superior physicochemical properties and distinctly

Serum type and concentration both affect the protein-corona composition of PLGA nanoparticles

• Katrin Partikel,
• Robin Korte,
• Dennis Mulac,
• Hans-Ulrich Humpf and
• Klaus Langer

Beilstein J. Nanotechnol. 2019, 10, 1002–1015, doi:10.3762/bjnano.10.101

• for the biological response in terms of body biodistribution, cellular uptake, and toxicity. The corona is dynamic in nature and it is well known that the composition varies in dependence of the physicochemical properties of the NPs. In the present study we investigated the protein corona that forms

• serum; nanoparticles; poly(lactide-co-glycolic acid); protein corona; proteomics; Introduction Nanoparticle (NP)-based drug carrier systems offer outstanding opportunities in the treatment of many serious diseases. The unique physicochemical properties and the ability to bind a library of ligands make

• , and it has been extensively investigated and comprehensively reviewed that the corona composition varies in dependence of the physicochemical properties of the NPs [5][6]. However, it is emerging that the characteristics of the biological environment, e.g., protein concentration [7][8][9], protein

Effects of gold and PCL- or PLLA-coated silica nanoparticles on brain endothelial cells and the blood–brain barrier

• Aniela Bittner,
• Angélique D. Ducray,
• Hans Rudolf Widmer,
• Michael H. Stoffel and
• Meike Mevissen

Beilstein J. Nanotechnol. 2019, 10, 941–954, doi:10.3762/bjnano.10.95

• times higher. Besides the NP concentration, physicochemical properties, especially surface characteristics were demonstrated to be important for the interactions with cells [29][30][31]. Hence, variations in surface characteristics, composition and size of the NPs and the various cell types used are

• physicochemical properties, the formation of NP clusters before entry into the cell may modulate the cellular uptake [9][34]. NPs might not only cause cytotoxicity but also hinder proliferation, differentiation or lead to inflammation via activation or inhibition of various pathways including phosphatidylinositol

pH-mediated control over the mesostructure of ordered mesoporous materials templated by polyion complex micelles

• Emilie Molina,
• Mélody Mathonnat,
• Jason Richard,
• Patrick Lacroix-Desmazes,
• Martin In,
• Philippe Dieudonné,
• Thomas Cacciaguerra,
• Corine Gérardin and
• Nathalie Marcotte

Beilstein J. Nanotechnol. 2019, 10, 144–156, doi:10.3762/bjnano.10.14

• ; hybrid organic–inorganic interface; mesoporous materials; nanostructured materials; polyion complex micelles; polyion electrostatic complexation; Introduction Due to their unique physicochemical properties originating from their uniform pore size and periodically arranged network at the mesoscale

Characterization and influence of hydroxyapatite nanopowders on living cells

• Przemyslaw Oberbek,
• Tomasz Bolek,
• Adrian Chlanda,
• Seishiro Hirano,
• Sylwia Kusnieruk,
• Julia Rogowska-Tylman,
• Ganna Nechyporenko,
• Viktor Zinchenko,
• Wojciech Swieszkowski and
• Tomasz Puzyn

Beilstein J. Nanotechnol. 2018, 9, 3079–3094, doi:10.3762/bjnano.9.286

• their aggregates or agglomerates, the impact of their physicochemical properties (such as particle size, surface area, purity, details of structure and degree of agglomeration) on living cells is not yet fully understood. Significant differences in these properties, resulting from different

• manufactured using many different methods, such as hydrothermal synthesis, sol–gel synthesis, wet-chemical precipitation and microwave processing [16][17][18][19]. Many studies have shown that HAp can cause different biological responses depending on its physicochemical properties [20][21][22]. It is also

• [47]. To evaluate the manufacturing methods and to analyse the interaction mechanisms of HAp with living cells, simple statistical correlations and regressions of physicochemical properties with biological activity expressed by cell viability were made (significance [p] set at α = 0.05). Results and

Effect of electrospinning process variables on the size of polymer fibers and bead-on-string structures established with a 2³ factorial design

• Paulina Korycka,
• Adam Mirek,
• Katarzyna Kramek-Romanowska,
• Marcin Grzeczkowicz and
• Dorota Lewińska

Beilstein J. Nanotechnol. 2018, 9, 2466–2478, doi:10.3762/bjnano.9.231

• structure. According to this study, the higher the concentration of polyvinylpyrrolidone (PVP) ethanolic solution (higher solution viscosity) used, the thicker the fibers. In addition, both the type of solvent (its physicochemical properties) and the water content in the solvent turned out to be influential

Hierarchical heterostructures of Bi₂MoO₆ microflowers decorated with Ag₂CO₃ nanoparticles for efficient visible-light-driven photocatalytic removal of toxic pollutants

• Shijie Li,
• Wei Jiang,
• Shiwei Hu,
• Yu Liu,
• Yanping Liu,
• Kaibing Xu and
• Jianshe Liu

Beilstein J. Nanotechnol. 2018, 9, 2297–2305, doi:10.3762/bjnano.9.214

• ] Ag2CO3/AgBr/ZnO [42], and Ag/Ag2CO3/Bi2MoO6 [32]. The band structure of Ag2CO3 matches well with that of Bi2MoO6 [32]. Moreover, morphology modulation is another significant way to enhance photocatalytic activity. Three-dimensional nanostructures endow materials with unique physicochemical properties

Uniform cobalt nanoparticles embedded in hexagonal mesoporous nanoplates as a magnetically separable, recyclable adsorbent

• Can Zhao,
• Yuexiao Song,
• Tianyu Xiang,
• Wenxiu Qu,
• Shuo Lou,
• Xiaohong Yin and
• Feng Xin

Beilstein J. Nanotechnol. 2018, 9, 1770–1781, doi:10.3762/bjnano.9.168

• : absorbent regeneration; CoAl layered double hydroxide; efficient adsorbent; hexagonal nanoplates; magnetic nanoparticles; polydopamine; Introduction Nanocomposites with unique electronic, mechanical, magnetic, and physicochemical properties have gained much attention because of their large specific surface

• critical significance due to their unprecedented physicochemical properties among mesoporous carbon-based nanocomposites with multiple and distinct morphologies. Layered double hydroxides (LDHs) have attracted much attention recently because of their low cost, unique 2D structure, and tunable chemical

Cryochemical synthesis of ultrasmall, highly crystalline, nanostructured metal oxides and salts

• Elena A. Trusova and
• Nikolai S. Trutnev

Beilstein J. Nanotechnol. 2018, 9, 1755–1763, doi:10.3762/bjnano.9.166

• metal-containing colloid and were incorporated in the titanium silicate (Ti0.03Si0.97O2) pores. It was found that chemical bonds are formed between the silicate surface and NiO crystallites, which leads to new physicochemical properties of the material. The high activity of NiO nanoparticles was

Preparation and morphology-dependent wettability of porous alumina membranes

• Dmitry L. Shimanovich,
• Alla I. Vorobjova,
• Daria I. Tishkevich,
• Alex V. Trukhanov,
• Maxim V. Zdorovets and
• Artem L. Kozlovskiy

Beilstein J. Nanotechnol. 2018, 9, 1423–1436, doi:10.3762/bjnano.9.135

• two surfaces: the front (or outer) and back (or inner) surfaces. Preliminary studies have shown that these surfaces possess different physicochemical properties due to different degrees of hydrophilicity (as well as wettability). This concerns both industrially manufactured commercial membranes (e.g

• contact angle, another highly influential factor is exerted by the physicochemical properties of a PAM surface, or as it is often called, the “surface chemistry”. In this study we did not change this factor so as to specify the intrinsic properties of the as-made amorphous membrane’s influence on the

Anchoring Fe₃O₄ nanoparticles in a reduced graphene oxide aerogel matrix via polydopamine coating

• Błażej Scheibe,
• Radosław Mrówczyński,
• Natalia Michalak,
• Karol Załęski,
• Michał Matczak,
• Mateusz Kempiński,
• Zuzanna Pietralik,
• Mikołaj Lewandowski,
• Stefan Jurga and
• Feliks Stobiecki

Beilstein J. Nanotechnol. 2018, 9, 591–601, doi:10.3762/bjnano.9.55

• ; polydopamine; reduced graphene oxide; Introduction Preparation of hybrid aerogels based on two-dimensional carbon nanomaterials with unique physicochemical properties is among the most popular recent nanotechnological trends [1]. With this respect, graphene oxide (GO) is one of the most exploited aerogel

• magnetite nanoparticles were prepared and the physicochemical properties of this hybrid system were studied. The investigations were focused on the influence of the involved constituents and their cross-interactions on the properties of the composite. It was found that coating the magnetite particles with

Fabrication and photoactivity of ionic liquid–TiO₂ structures for efficient visible-light-induced photocatalytic decomposition of organic pollutants in aqueous phase

• Anna Gołąbiewska,
• Marta Paszkiewicz-Gawron,
• Aleksandra Sadzińska,
• Wojciech Lisowski,
• Ewelina Grabowska,
• Adriana Zaleska-Medynska and
• Justyna Łuczak

Beilstein J. Nanotechnol. 2018, 9, 580–590, doi:10.3762/bjnano.9.54

• originated from the interaction of the bromide anion and molecular oxygen with the TiO2 surface with formation of surface complex [14]. Therefore, taking into account the ease of modification of the cation and anion structure of the IL, and as a consequence, the altering of their physicochemical properties

Electron interaction with copper(II) carboxylate compounds

• Michal Lacko,
• Peter Papp,
• Iwona B. Szymańska,
• Edward Szłyk and
• Štefan Matejčík

Beilstein J. Nanotechnol. 2018, 9, 384–398, doi:10.3762/bjnano.9.38

• = CnF2n+1, n = 1–6) were previously applied as Cu CVD precursors [34][38] for the formation of copper nanomaterials. This fact confirms that copper(II) carboxylate compounds can be considered as copper sources in vapor deposition processes. The influence of secondary ligands on the physicochemical

• properties and, with regards to FEBID, the electron-induced fragmentation behaviour of pentafluoropropionate Cu(II) complexes as studied here is thus of particular interest. Results Mass spectrum of [Cu2(µ-O2CC2F5)4] [Cu2(µ-O2CC2F5)4] represents the basic chemical structure for all discussed carboxylate

Involvement of two uptake mechanisms of gold and iron oxide nanoparticles in a co-exposure scenario using mouse macrophages

• Dimitri Vanhecke,
• Dagmar A. Kuhn,
• Dorleta Jimenez de Aberasturi,
• Sandor Balog,
• Ana Milosevic,
• Dominic Urban,
• Diana Peckys,
• Niels de Jonge,
• Wolfgang J. Parak,
• Alke Petri-Fink and
• Barbara Rothen-Rutishauser

Beilstein J. Nanotechnol. 2017, 8, 2396–2409, doi:10.3762/bjnano.8.239

• medium and delivery onto the cell surface A general summary about the physicochemical properties of polymer-coated AuNPs and FeOxNPs can be found in a recent overview article, in which also all methods are discussed in detail [27]. The measured particle size revealed an average hydrodynamic diameter (dh

Synthesis and characterization of noble metal–titania core–shell nanostructures with tunable shell thickness

• Bartosz Bartosewicz,
• Marta Michalska-Domańska,
• Malwina Liszewska,
• Dariusz Zasada and
• Bartłomiej J. Jankiewicz

Beilstein J. Nanotechnol. 2017, 8, 2083–2093, doi:10.3762/bjnano.8.208

• ][5][6][7][8][9][10][11]. For many applications, however, the use of titanium dioxide in CSNs would be of much greater interest. Useful physicochemical properties of titanium dioxide in its crystalline forms, rutile and anatase, such as high refractive index and photocatalytic activity have led to its

Two-dimensional carbon-based nanocomposites for photocatalytic energy generation and environmental remediation applications

• Suneel Kumar,
• Ashish Kumar,
• Ashish Bahuguna,
• Vipul Sharma and
• Venkata Krishnan

Beilstein J. Nanotechnol. 2017, 8, 1571–1600, doi:10.3762/bjnano.8.159

• the surface physicochemical properties of g-C3N4 can be tuned by introducing impurities into the crystal lattice of polymeric g-C3N4. Mainly the hydrogen impurities can produce the basic primary and secondary amines on its layer edges [68]. The presence of such basic groups (=NH, −NH2) on the surface

Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery

• Gamze Varan,
• Juan M. Benito,
• Carmen Ortiz Mellet and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1457–1468, doi:10.3762/bjnano.8.145

• complexes with non-polar drugs or active molecules [10]. CDs are easily able to modulate physicochemical properties of guest molecules, including solubility and/or stability in biological medium. Despite all the advantages, CDs have some challenges. For instance, it is well known that β-CD has low

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

• Cem Varan and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1446–1456, doi:10.3762/bjnano.8.144

• nanoparticles. Physical stability of nanoparticles The physicochemical properties of all formulations have been monitored to investigate their physical stability in aqueous medium for 30 days; the results are shown in Figure 3. The diameter of anionic and cationic PCL nanoparticles increased by 8–10 nm and

• , ± SD). RG2 cell viability with blank and DOC-loaded nanoparticles for 24 and 48 h (n = 3, ± SD). The effect of different preparation methods on physicochemical properties of blank PCL and mePEG-PCL nanoparticles (n = 3 ± SD). The effect of different preparation methods on the physicochemical properties

• of blank PCL and mePEG-PCL nanoparticles (n = 3 ± SD). The effect of chitosan concentration on the physicochemical properties of blank PCL and mePEG-PCL nanoparticles (n = 3 ± SD). Pre-formulation parameters for nanoparticle preparation.

Characterization of ferrite nanoparticles for preparation of biocomposites

• Urszula Klekotka,
• Magdalena Rogowska,
• Dariusz Satuła and
• Beata Kalska-Szostko

Beilstein J. Nanotechnol. 2017, 8, 1257–1265, doi:10.3762/bjnano.8.127

• ferrite nanoparticles. Detailed studies in this subject on particular systems provide conclusions and give ideas as to how to apply magnetic nanoparticles in the fields of medical, biological or environment protection. Nevertheless, precise studies on the physicochemical properties of the ferrite core is

Needs and challenges for assessing the environmental impacts of engineered nanomaterials (ENMs)

• Michelle Romero-Franco,
• Hilary A. Godwin,
• Muhammad Bilal and
• Yoram Cohen

Beilstein J. Nanotechnol. 2017, 8, 989–1014, doi:10.3762/bjnano.8.101

• present frameworks and tools to meet those needs. Keywords: engineered nanomaterials; environmental impacts; risk assessment; Introduction Engineered nanomaterials (ENMs) are increasingly being used in numerous industrial products and processes owing to their unique physicochemical properties. There are

• analysis (e.g., environmental fate and transport data, physicochemical properties; toxicological information including dose–response information); The outputs/results obtained from the analysis such as description of the outcome (e.g., predicted values of environmental concentration, probability of risk

• with similar structures and/or physicochemical properties will exhibit similar hazard profiles [36]. The Nano Task Force proposed that this framework could be useful for categorizing substances into common groups based on similarity of structural and physicochemical properties that induce similar