Biocompatibility and cytotoxicity in vitro of surface-functionalized drug-loaded spinel ferrite nanoparticles

• Sadaf Mushtaq,
• Khuram Shahzad,
• Tariq Saeed,
• Anwar Ul-Hamid,
• Bilal Haider Abbasi,
• Nafees Ahmad,
• Waqas Khalid,
• Muhammad Atif,
• Zulqurnain Ali and
• Rashda Abbasi

Beilstein J. Nanotechnol. 2021, 12, 1339–1364, doi:10.3762/bjnano.12.99

• controls. The efficient retention of polymer-functionalized NPs in cancer cells, with the help of the EPR effect and a leaky vasculature system (pore diameter = 100 nm–2 µm) [7], reduces their nonspecific biological interactions with plasma proteins, contributing to a higher bioavailability [37]. SRB

• interaction between NPs a plasma membrane associated proteins [55]. In addition, the charge of polymeric coatings also governs NP uptake by cells. Positively charged polymers have been reported to enhance genotoxicity due to better internalization of NPs via the plasma membrane (electrostatic interaction) and

Plasmon-enhanced photoluminescence from TiO₂ and TeO₂ thin films doped by Eu³⁺ for optoelectronic applications

• Marcin Łapiński,
• Jakub Czubek,
• Katarzyna Drozdowska,
• Anna Synak,
• Wojciech Sadowski and
• Barbara Kościelska

Beilstein J. Nanotechnol. 2021, 12, 1271–1278, doi:10.3762/bjnano.12.94

• ethanol and dried at 50 °C. Plasmonic nanostructures were prepared by thermal dewetting of gold thin films. Thin Au films with a thickness of 2.8 nm were deposited using a tabletop DC magnetron sputtering coater (EM SCD 500, Leica) in pure Ar plasma (argon, Air Products, 99.999%) at a pressure of 0.2 Pa

The effect of cobalt on morphology, structure, and ORR activity of electrospun carbon fibre mats in aqueous alkaline environments

• Markus Gehring,
• Tobias Kutsch,
• Osmane Camara,
• Alexandre Merlen,
• Hermann Tempel,
• Hans Kungl and
• Rüdiger-A. Eichel

Beilstein J. Nanotechnol. 2021, 12, 1173–1186, doi:10.3762/bjnano.12.87

• spectroscopy, elemental analysis, and inductively coupled plasma optical emission spectrometry are used for characterisation. The modified fibre system is compared to a benchmark system without cobalt additives. Cobalt is known to catalyse the formation of graphite in carbonaceous materials at elevated

• electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Raman spectroscopy, elemental analysis, and inductively coupled plasma optical emission spectrometry (ICP-OES). In addition, the fibres were analysed in terms of their

pH-driven enhancement of anti-tubercular drug loading on iron oxide nanoparticles for drug delivery in macrophages

• Karishma Berta Cotta,
• Sarika Mehra and
• Rajdip Bandyopadhyaya

Beilstein J. Nanotechnol. 2021, 12, 1127–1139, doi:10.3762/bjnano.12.84

• sampled for ICP-AES (inductively coupled plasma-atomic emission spectrophotometer) (ACROS, Simultaneous ICP Spectrometer, SPECTRO Analytical Instruments GmbH, Germany) to estimate the amount of Fe present in each sample. Cell lysates were pelleted out and the supernatant was used for spectrofluorometric

First-principles study of the structural, optoelectronic and thermophysical properties of the π-SnSe for thermoelectric applications

• Muhammad Atif Sattar,
• Najwa Al Bouzieh,
• Maamar Benkraouda and
• Noureddine Amrane

Beilstein J. Nanotechnol. 2021, 12, 1101–1114, doi:10.3762/bjnano.12.82

• greater than its bandgap value. The electron energy loss curve achieves its peak value around 13 eV and then begins to abruptly fall until it reaches 13.5 eV. This observed highest peak of L(ω) represents the plasma resonance of the π-SnSe alloy and their correlated frequencies, called plasma frequencies

Use of nanosystems to improve the anticancer effects of curcumin

• Andrea M. Araya-Sibaja,
• Norma J. Salazar-López,
• Krissia Wilhelm Romero,
• José R. Vega-Baudrit,
• J. Abraham Domínguez-Avila,
• Carlos A. Velázquez Contreras,
• Ramón E. Robles-Zepeda,
• Mirtha Navarro-Hoyos and
• Gustavo A. González-Aguilar

Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78

• different sizes (20, 70, or 200 nm). For example, maximum plasma CUR concentration was found 5 min after administration (with concentration of 1250 ng/mL and particle size of 20 nm). In the lungs, spleen, and liver the maximum concentration was observed 10 min after administration (with concentrations and

• plasma area under the curve (AUC) were higher (27.52 mg/L and 37.25 mg/L·h, respectively), as compared to the one administered orally (3.64 mg/L and 11.75 mg/L·h, respectively). The value of T1/2 was 1.46 h when administered by the pulmonary route and 2.15 h when administered orally, which could be

• permanence in the plasma and in other organs. It should be noted that in a dose-escalation study in human volunteers, in which 10–12 g/day of CUR was administered, only 30–50 ng/mL of curcumin was detected in the serum (between 2 and 4 h after administration), which is associated with its low solubility

An overview of microneedle applications, materials, and fabrication methods

• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2021, 12, 1034–1046, doi:10.3762/bjnano.12.77

• chamber where a plasma of reactive ions is formed on the material surface. Etching can be either isotropic, at higher gas pressures, or anisotropic when lower pressures are employed. The most common silicon etchant is sulphur hexafluoride (SF6 + O2) in an inductively coupled plasma etch tool. High aspect

• etching using an inductively coupled plasma (ICP) etcher, then the polymer microneedles were replicated using a PDMS negative soft mould and hot embossing [100]. SU-8 photoresist has been used, not just for master moulds, but also as the final material for microneedles. Long hollow microneedles, ≈1500 μm

• layer of polymer introduced between the mould and the metal structure to facilitate chemical lift-off separation of the final array. For hollow metal microneedles, a plasma etching step was performed prior to metal deposition [106]. Unlike the ubiquitous stainless steel hypodermic needle, safety

Is the Ne operation of the helium ion microscope suitable for electron backscatter diffraction sample preparation?

• Annalena Wolff

Beilstein J. Nanotechnol. 2021, 12, 965–983, doi:10.3762/bjnano.12.73

The role of deep eutectic solvents and carrageenan in synthesizing biocompatible anisotropic metal nanoparticles

• Nabojit Das,
• Akash Kumar and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2021, 12, 924–938, doi:10.3762/bjnano.12.69

• adsorbed on the metal surface in a tightly packed bilayer structure. Among quaternary ammonium surfactants, CTAB has been extensively reported as cytotoxic even at low concentrations [44][45][46]. The positively charged CTAB interacts with the plasma membrane, which is negatively charged due to the

• asymmetric distribution of charged lipids between the two leaflets of the plasma membrane. This lead to a negative charged of the inner leaflet generating a surface potential and the binding affinity towards positively charged moieties. However, an interesting study revealed a structure-dependent

In situ transport characterization of magnetic states in Nb/Co superconductor/ferromagnet heterostructures

• Olena M. Kapran,
• Roman Morari,
• Taras Golod,
• Evgenii A. Borodianskyi,
• Vladimir Boian,
• Andrei Prepelita,
• Nikolay Klenov,
• Anatoli S. Sidorenko and
• Vladimir M. Krasnov

Beilstein J. Nanotechnol. 2021, 12, 913–923, doi:10.3762/bjnano.12.68

• the vacuum. We use a Nb target (99.95% purity) for deposition of S-layers, Co (99.95% purity) for F-layers, and Si (99.999%) for seeding bottom and protective top layers. MLs are grown on a Si(111) wafer. Prior to deposition, targets were precleaned by plasma-etching for 3 min and in addition for 1

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

• membrane after sonication. They provided evidence that during US exposure and sonoporation, repairable disruption and an increase in plasma membrane permeability occurred. They also suggested that the change in the cell membrane depended on the intensity of the US waves and the cavitation process. They

• acid was administered, had levels of bioluminescence 11-fold higher than the colon tissue of mice that received mRNA alone. This was suggested to be caused by US-induced cavitation, creating transient pores in the plasma membrane which facilitated the cellular diffusion of macromolecules [87]. In

• biomedical interest. In biomedical ultrasound imaging, one has to deal with the radiation force exerted by pulsating gas bubbles and interactions with the components of blood plasma. Changes in the size of a droplet, the distance between the particles, the density of the drop, and the US frequency all affect

Recent progress in actuation technologies of micro/nanorobots

• Ke Xu and
• Bing Liu

Beilstein J. Nanotechnol. 2021, 12, 756–765, doi:10.3762/bjnano.12.59

• towards the platinum end, and a maximum movement speed of 4 μm/s was achieved. After that, Chen et al. [40] designed a Z-shaped platinum hybrid nanorobot in order to meet the growing demand for micro/nanorobots in the biomedical field. It was manufactured using a combination of focused ion beam and plasma

Fate and transformation of silver nanoparticles in different biological conditions

• Barbara Pem,
• Marija Ćurlin,
• Darija Domazet Jurašin,
• Valerije Vrček,
• Rinea Barbir,
• Vedran Micek,
• Raluca M. Fratila,
• Jesus M. de la Fuente and
• Ivana Vinković Vrček

Beilstein J. Nanotechnol. 2021, 12, 665–679, doi:10.3762/bjnano.12.53

• plasma (BP), or in 1% (w/v) liver, brain, and kidney homogenates. In most tissue homogenates, AgNPs were well dispersed as shown in Figure 3. Although some aggregates were also visible under these conditions, there were no large crystals in kidney, liver, or brain homogenates as observed in vivo (Figure

• puncture into a heparinised tube and the plasma was separated by centrifugation. The kidneys, liver, and brain were carefully removed and washed in ice-cold saline. Each tissue (1 g) was homogenised in 10 mL of PBS (0.05 M, pH 7.4) containing 0.1 mM of EDTA using a motor-driven homogenizer. Both WB and BP

• (liver), (f) AOT-AgNPs (brain), (g) PLL-AgNPs (kidney), (h) PLL-AgNPs (liver), (i) PLL-AgNPs (brain). Scale bars are 100 nm. TEM images of objects observed after 30 min of incubation of AgNPs or Ag+ in different test media at a concentration of 100 mg Ag/L. (a) PLL-AgNPs in 1% (w/v) of blood plasma, (b

A review of defect engineering, ion implantation, and nanofabrication using the helium ion microscope

• Frances I. Allen

Beilstein J. Nanotechnol. 2021, 12, 633–664, doi:10.3762/bjnano.12.52

• nanoscale. This brings certain advantages compared with the traditionally used large-scale experiments. For example, although experiments using ion accelerators and plasma ion sources enable investigations over a wide range of beam energies and give the experimenter much freedom in terms of sample

• in the development of radiation-tolerant structural materials for deployment in nuclear fission and future nuclear fusion reactors. It has been shown that the gas bubble superlattice can be created by both broad beam or plasma exposure, as well as by repeated scanning of a selected area with the

Nanoporous and nonporous conjugated donor–acceptor polymer semiconductors for photocatalytic hydrogen production

• Zhao-Qi Sheng,
• Yu-Qin Xing,
• Yan Chen,
• Guang Zhang,
• Shi-Yong Liu and
• Long Chen

Beilstein J. Nanotechnol. 2021, 12, 607–623, doi:10.3762/bjnano.12.50

• enhanced with increasing the content of FSO units. P66 achieved an AQY of 8.5%. Cooper et al. [82] systematically investigated the influence of plasma treatments on conjugated polymers as photocatalysts, for example, the fluorine–FSO-based P60 (Figure 8). For P60, a short time of plasma treatment

• significantly enhanced the wettability and photocatalytic performance due to the plasma oxidizing the polymer. In addition, they [83] prepared a crystalline benzo[1,2-b:4,5-b']bis[1]benzothiophene sulfone-containing covalent organic framework (P67) (Figure 8), which exhibited a higher HER than its amorphous or

Properties of graphene deposited on GaN nanowires: influence of nanowire roughness, self-induced nanogating and defects

• Jakub Kierdaszuk,
• Piotr Kaźmierczak,
• Justyna Grzonka,
• Aleksandra Krajewska,
• Aleksandra Przewłoka,
• Wawrzyniec Kaszub,
• Zbigniew R. Zytkiewicz,
• Marta Sobanska,
• Maria Kamińska,
• Andrzej Wysmołek and
• Aneta Drabińska

Beilstein J. Nanotechnol. 2021, 12, 566–577, doi:10.3762/bjnano.12.47

• the transfer onto NW substrates [31]. Therefore, we used stable orthogonal frames from polydimethylsiloxane (PDMS) polymer to stabilize the graphene during the transfer process [32]. The GaN NW substrates were fabricated by plasma-assisted molecular beam epitaxy (PAMBE) in N-rich conditions on (111

Influence of electrospray deposition on C₆₀ molecular assemblies

• Antoine Hinaut,
• Sebastian Scherb,
• Sara Freund,
• Zhao Liu,
• Thilo Glatzel and
• Ernst Meyer

Beilstein J. Nanotechnol. 2021, 12, 552–558, doi:10.3762/bjnano.12.45

• are visible, see the arrow in the contrast-modified inset of Figure 3c and in part 3 of Supporting Information File 1. They are similar to the pits created after electron and ion bombardment [40][41][42][43] or low-temperature plasma exposure of such a surface [44]. Such defects are known to increase

On the stability of microwave-fabricated SERS substrates – chemical and morphological considerations

• Limin Wang,
• Aisha Adebola Womiloju,
• Christiane Höppener,
• Ulrich S. Schubert and
• Stephanie Hoeppener

Beilstein J. Nanotechnol. 2021, 12, 541–551, doi:10.3762/bjnano.12.44

• available microscope glass coverslips, cut into rectangles with a dimension of 20 × 10 mm, were used as substrates. The glass substrates were first cleaned by washing with demineralized water and ethanol followed by plasma cleaning (argon plasma, 5 min, Diener Electronics). For all experiments, a single

The preparation temperature influences the physicochemical nature and activity of nanoceria

• Robert A. Yokel,
• Wendel Wohlleben,
• Johannes Georg Keller,
• Matthew L. Hancock,
• Jason M. Unrine,
• D. Allan Butterfield and
• Eric A. Grulke

Beilstein J. Nanotechnol. 2021, 12, 525–540, doi:10.3762/bjnano.12.43

• inductively coupled plasma mass spectrometry (ICP-MS; Agilent 7500cx or 7900, Agilent Technologies, Inc., Santa Clarita, CA) [41]. Spiked samples (cerium average recovery was 106%) and blank samples (that were below the detection limit) were included. At BASF, the eluate was diluted 10- to 100-fold and

Rapid controlled synthesis of gold–platinum nanorods with excellent photothermal properties under 808 nm excitation

• Jialin Wang,
• Qianqian Duan,
• Min Yang,
• Boye Zhang,
• Li Guo,
• Pengcui Li,
• Wendong Zhang and
• Shengbo Sang

Beilstein J. Nanotechnol. 2021, 12, 462–472, doi:10.3762/bjnano.12.37

• . Most of the reported Au–Pt bimetal nanoparticles are isotropic, such as alloys or core–shell structures [18][19][20]. However, the LSPR peaks of such alloys or core–shell structures are located in the visible light region and inhibit the plasma performance [21]. Significant efforts have been made to

A review on nanostructured silver as a basic ingredient in medicine: physicochemical parameters and characterization

• Gabriel M. Misirli,
• Kishore Sridharan and
• Shirley M. P. Abrantes

Beilstein J. Nanotechnol. 2021, 12, 440–461, doi:10.3762/bjnano.12.36

• inhibit virus replication by binding to and regulating cellular and viral proteins and RNAs [114]. Studies indicate that AgNPs did not affect cellular viability, according to mitochondrial cytotoxicity tests, or plasma membrane integrity. Interestingly, they exhibited potent ability to activate

• effective in inhibiting SARS-CoV-2 by using AgNPs to coat facial masks [77][120]. These results are suggestive of the development of new measures in which AgNPs can be used to prevent SARS-CoV-2 infection. Biological interactions of AgNPs When in contact with human plasma, AgNPs adsorb biomolecules such as

• , UV–vis spectroscopy, inductively coupled plasma optical emission spectrometry (ICP-OES), dynamic light scattering (DLS), among other techniques [33]. The basic principles of the techniques mentioned here are detailed in the following sections. Each AgNPs is unique, depending on its size, state of

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

• Nikola Geskovski,
• Nadica Matevska-Geshkovska,
• Simona Dimchevska Sazdovska,
• Marija Glavas Dodov,
• Kristina Mladenovska and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

• , and regardless of the steric barrier, somehow managed to interact with the sinusoidal endothelial cells of the BM. One possible explanation is that the recognition may be mediated by a plasma component (such as erythropoietin, transferrin, or transcobalamin) or an endothelial factor that specifically

• , threefold and eightfold higher BM drug concentrations relative to the plasma concentration in the 48th hour post-administration in healthy mice. In contrast, the combination of free drugs (cytarabine and daunorubicin) reached maximum BM concentrations in one hour, which decreased rapidly. The authors

Structural and optical characteristics determined by the sputtering deposition conditions of oxide thin films

• Petronela Prepelita,
• Florin Garoi and
• Valentin Craciun

Beilstein J. Nanotechnol. 2021, 12, 354–365, doi:10.3762/bjnano.12.29

• Petronela Prepelita Florin Garoi Valentin Craciun National Institute for Laser, Plasma and Radiation Physics, 409 Atomistilor Street, PO Box MG-36, Magurele 077125, Ilfov, Romania 10.3762/bjnano.12.29 Abstract The influence of film thickness on the structural and optical properties of silicon

• be, later on, integrated into metamaterial structures to improve their functionality. Experimental The VARIAN ER 3119 EletroRava deposition equipment (available at the National Institute for Laser, Plasma and Radiation Physics, INFLPR) is provided with a deposition chamber, two magnetrons, and in

• , especially for thicker samples. For ZnO films an increase in the film thickness resulted in an increase in the atomic oxide (from 45.73% to 49.38 %), as a result of plasma chemical processes. The analysis of optical properties, by the absorption of light in the dielectric films of ZnO and SiO2 with various

The patterning toolbox FIB-o-mat: Exploiting the full potential of focused helium ions for nanofabrication

• Victor Deinhart,
• Lisa-Marie Kern,
• Jan N. Kirchhof,
• Sabrina Juergensen,
• Joris Sturm,
• Enno Krauss,
• Thorsten Feichtner,
• Sviatoslav Kovalchuk,
• Michael Schneider,
• Dieter Engel,
• Bastian Pfau,
• Bert Hecht,
• Kirill I. Bolotin,
• Stephanie Reich and
• Katja Höflich

Beilstein J. Nanotechnol. 2021, 12, 304–318, doi:10.3762/bjnano.12.25

• an oxygen plasma before ion beam machining. Generally, all samples should be introduced into the vacuum system one day in advance to allow possible contaminants to desorb from the samples and be pumped out. While these protocols can improve the technical conditions for the machining with light ions

Doxorubicin-loaded gold nanorods: a multifunctional chemo-photothermal nanoplatform for cancer management

• Uzma Azeem Awan,
• Abida Raza,
• Shaukat Ali,
• Rida Fatima Saeed and
• Nosheen Akhtar

Beilstein J. Nanotechnol. 2021, 12, 295–303, doi:10.3762/bjnano.12.24

• at 500g for 10 min. Supernatant containing plasma was aspirated and the buffy coat was washed thrice and diluted with normal saline to a 50% packed cell volume (hematocrit) adjusted at pH 7.4 and stored at 4 °C. Different concentrations of PSS-GNRs (100 μL each) were incubated with 100 μL of RBCs