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Search for "proteins" in Full Text gives 394 result(s) in Beilstein Journal of Nanotechnology. Showing first 200.

The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model

  • Qura Tul Ain,
  • Samina Hyder Haq,
  • Abeer Alshammari,
  • Moudhi Abdullah Al-Mutlaq and
  • Muhammad Naeem Anjum

Beilstein J. Nanotechnol. 2019, 10, 901–911, doi:10.3762/bjnano.10.91

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  • ability of PEGylated GO (PEG-GO) to deliver proteins into cells [26]. In addition, functionalized PEG-GO has been used as a nano-carrier of photosensitizers and synergistic anticancer agents [27]. PEG-GO has been widely used in vivo studies. Li et al. demonstrated that PEG coating reduced the retention of
  • generating free radicals [49]. These free radicals can attack the surrounding biological molecules such as proteins, lipids and even DNA, which could result in a loss or damage of their biological function. In the body of mammals, there are antioxidants to counter these free radicals and protect tissues from
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Published 18 Apr 2019

Outstanding chain-extension effect and high UV resistance of polybutylene succinate containing amino-acid-modified layered double hydroxides

  • Adam A. Marek,
  • Vincent Verney,
  • Christine Taviot-Gueho,
  • Grazia Totaro,
  • Laura Sisti,
  • Annamaria Celli and
  • Fabrice Leroux

Beilstein J. Nanotechnol. 2019, 10, 684–695, doi:10.3762/bjnano.10.68

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  • structurally well ordered organic species. Tentatively it may be ascribed to some degradative effect coming from the imidazole cycle since there is no such effect for the other PBS composites. It is well known that imidazole cycle is prone to coordinate to metal ions as in metallo-proteins [21]. The
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Published 12 Mar 2019

Mechanical and thermodynamic properties of Aβ42, Aβ40, and α-synuclein fibrils: a coarse-grained method to complement experimental studies

  • Adolfo B. Poma,
  • Horacio V. Guzman,
  • Mai Suan Li and
  • Panagiotis E. Theodorakis

Beilstein J. Nanotechnol. 2019, 10, 500–513, doi:10.3762/bjnano.10.51

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  • experimental observations. Keywords: β-amyloid; atomic force microscopy, mechanical deformation; molecular simulation; proteins; α-synuclein; Introduction All-atom molecular dynamics (MD) simulations have been employed to study the physical and chemical behaviour of the fundamental biomolecules of life (e.g
  • ., proteins [1], nucleic acids [2] and lipids [3]). Lipid membranes, viral capsids, and biological fibrils are common examples of large complexes that pose significant challenges for all-atom simulations. For example, the time scales of various biological processes are in the range from 10−6 to 10−3 s, and
  • certain conditions, the high mechanical stability (comparable to silk), and the ability to form ordered structures, albeit the monomeric units (proteins) of these fibrils are intrinsically disordered [21][22]. These are fundamental properties for applications in which the fragmentation of the material
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Published 19 Feb 2019

Mechanism of silica–lysozyme composite formation unravelled by in situ fast SAXS

  • Tomasz M. Stawski,
  • Daniela B. van den Heuvel,
  • Rogier Besselink,
  • Dominique J. Tobler and
  • Liane G. Benning

Beilstein J. Nanotechnol. 2019, 10, 182–197, doi:10.3762/bjnano.10.17

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  • inorganic nanoparticles (NPs) and proteins in aqueous media is of paramount interest for colloid chemistry. In particular, the interactions between silica (SiO2) NPs and lysozyme (LZM) have attracted attention, because LZM is well-known to adsorb strongly to silica NPs, while at the same time preserving its
  • : composite; lysozyme; scattering; silica; small-angle X-ray scattering (SAXS); Introduction A mechanistic understanding of aggregation in aqueous media leading to the formation of composites of inorganic nanoparticles and proteins is of paramount interest for colloid chemistry, Earth sciences, or the design
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Published 14 Jan 2019

Targeting strategies for improving the efficacy of nanomedicine in oncology

  • Gonzalo Villaverde and
  • Alejandro Baeza

Beilstein J. Nanotechnol. 2019, 10, 168–181, doi:10.3762/bjnano.10.16

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  • transport drugs that exhibit very different nature such as lipophilic or hydrophilic drugs and big macromolecules as proteins or RNA. Moreover, the external surface of these carriers can be decorated with different moieties with high affinity for specific membrane receptors of the tumoral cells to direct
  • proteins. This fact hinders the penetration of the nanoparticles into tumoral tissues restraining their effect to the periphery of the neoplasia. In order to overcome this limitation, diverse alternatives have been proposed, from the application of ultrasounds for propelling the nanoparticles inside the
  • significant enhancement of the particle uptake due to multiple binding processes with tumoral receptors through a multivalence effect [25]. Nature usually employs antibodies for the recognition of cells and pathogenic bodies. Antibodies are large proteins that present a characteristic Y-shaped structure in
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Published 14 Jan 2019

A comparison of tarsal morphology and traction force in the two burying beetles Nicrophorus nepalensis and Nicrophorus vespilloides (Coleoptera, Silphidae)

  • Liesa Schnee,
  • Benjamin Sampalla,
  • Josef K. Müller and
  • Oliver Betz

Beilstein J. Nanotechnol. 2019, 10, 47–61, doi:10.3762/bjnano.10.5

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  • fraction has been investigated so far, polar components such as proteins/peptides and carbohydrates might contribute to its amphiphilic property. Directionality of friction force Our nanotribometer experiments (performed on the fore tarsi) clearly revealed a direction-dependent (anisotropic) friction
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Published 04 Jan 2019

Hybrid Au@alendronate nanoparticles as dual chemo-photothermal agent for combined cancer treatment

  • Anouchka Plan Sangnier,
  • Romain Aufaure,
  • Laurence Motte,
  • Claire Wilhelm,
  • Erwann Guenin and
  • Yoann Lalatonne

Beilstein J. Nanotechnol. 2018, 9, 2947–2952, doi:10.3762/bjnano.9.273

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  • . They inhibit the prenylation of GTPase proteins, which affects cell morphology, replication and signalling that can cause cell death by apoptosis [8][9]. However, the in vivo therapeutic use of HMBPs is limited by low bioavailability. Once intravenously injected, free HMBPs are only slightly
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Letter
Published 27 Nov 2018

Nanostructured liquid crystal systems and applications

  • Alexei R. Khokhlov and
  • Alexander V. Emelyanenko

Beilstein J. Nanotechnol. 2018, 9, 2644–2645, doi:10.3762/bjnano.9.245

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  • well as in food production. The molecules of the human body (e.g., DNA, proteins) can also form liquid crystal phases. Many applications of liquid crystals require the manipulation of structures on the nanometer scale. For example, these highly sensitive materials are capable of changing their
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Editorial
Published 05 Oct 2018

Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified γ-Fe2O3 nanoparticles towards human tumor cells

  • Zdeněk Plichta,
  • Yulia Kozak,
  • Rostyslav Panchuk,
  • Viktoria Sokolova,
  • Matthias Epple,
  • Lesya Kobylinska,
  • Pavla Jendelová and
  • Daniel Horák

Beilstein J. Nanotechnol. 2018, 9, 2533–2545, doi:10.3762/bjnano.9.236

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  • allows for a stable Dox concentration inside the cells, thus partially decreasing the effectiveness of ABC transporter proteins, which are responsible for drug efflux from the cytosol to the extracellular medium [24]. Other cell lines that are sensitive to chemotherapy (e.g., murine B16F10 melanoma
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Published 25 Sep 2018

Enhanced antineoplastic/therapeutic efficacy using 5-fluorouracil-loaded calcium phosphate nanoparticles

  • Shanid Mohiyuddin,
  • Saba Naqvi and
  • Gopinath Packirisamy

Beilstein J. Nanotechnol. 2018, 9, 2499–2515, doi:10.3762/bjnano.9.233

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  • cell death involves the generation of intracellular reactive oxygen species (ROS) molecules (e.g., O2−, OH·, H2O2) [44]. The elevated level of ROS species interferes with the normal metabolism of the cells by disrupting cell structures such as lipids, proteins and DNA [45]. This increased oxidative
  • apoptotic induction upon CaP@5-FU NP incubation occurred inside the cells. The 5-FU-mediated inhibition of the thymidylate synthase causes the release of cytochrome c from mitochondria through the mitochondrial membrane channel by the interaction of BAX and BAK proteins. Located on the outer mitochondrial
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Published 20 Sep 2018

High-throughput micro-nanostructuring by microdroplet inkjet printing

  • Hendrikje R. Neumann and
  • Christine Selhuber-Unkel

Beilstein J. Nanotechnol. 2018, 9, 2372–2380, doi:10.3762/bjnano.9.222

Graphical Abstract
  • also proteins [23][24][25][26][27]. In this way, even flexible materials can easily be patterned [28]. Therefore, with this method, we have the combined benefits of BCML with the advantages of inkjet printing to achieve nanoparticle structures in defined microarrays. Such micro-nanostructures have been
  • be controlled at the micrometer scale. For example, the nanoparticles can serve as biomimetic anchorage sites for proteins in biosensor and biomaterial applications. Experimental Block copolymer micelle nanolithography (BCML) The samples were functionalized with gold nanoparticles using BCML [13][22
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Published 04 Sep 2018

Nanoscale characterization of the temporary adhesive of the sea urchin Paracentrotus lividus

  • Ana S. Viana and
  • Romana Santos

Beilstein J. Nanotechnol. 2018, 9, 2277–2286, doi:10.3762/bjnano.9.212

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  • functional amyloid, suggesting that among its proteinaceous constituents there are most likely proteins with amyloid quaternary structures or rich in β-sheets. These results extend our knowledge on sea urchin adhesive composition and mechanical properties essential for the engineering of biomimetic adhesives
  • characteristic sawtooth appearance [4]. The freshwater cnidarian Hydra magnipapillata is a solitary polyp that lives temporarily attached during its whole lifecycle through its aboral adhesive disc, only detaching to search for better living conditions. The adhesive of H. magnipapillata is made up of proteins
  • allowing the sea cucumber to escape. During the elongation process, granular cells are exposed at the tubule surface and release their adhesive secretion composed of proteins and neutral sugars. However, the tissue integrity is compromised during the discharge and can only be used once. AFM was used to
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Published 24 Aug 2018

The role of adatoms in chloride-activated colloidal silver nanoparticles for surface-enhanced Raman scattering enhancement

  • Nicolae Leopold,
  • Andrei Stefancu,
  • Krisztian Herman,
  • István Sz. Tódor,
  • Stefania D. Iancu,
  • Vlad Moisoiu and
  • Loredana F. Leopold

Beilstein J. Nanotechnol. 2018, 9, 2236–2247, doi:10.3762/bjnano.9.208

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  • organic stabilizing agents such as citrate [19] or poly(N-vinylpyrrolidone) [20][21]. The photoreduction of AgCl crystals has also been previously reported; however, the photoconversion of AgCl to silver nanoparticles was performed in the presence of stabilizing agents, such as proteins [22] or DNA [23
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Published 22 Aug 2018

Electrospun one-dimensional nanostructures: a new horizon for gas sensing materials

  • Muhammad Imran,
  • Nunzio Motta and
  • Mahnaz Shafiei

Beilstein J. Nanotechnol. 2018, 9, 2128–2170, doi:10.3762/bjnano.9.202

Graphical Abstract
  • limited ability to uniformly disperse NPs. A solution could be the encapsulation of NPs in polar proteins that could repel each other resulting in uniform dispersion over the entire surface area. Kim et al. [75][189][190][191] reported protein (apoferritin) encapsulated catalytic/noble metal NP
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Published 13 Aug 2018

The structural and chemical basis of temporary adhesion in the sea star Asterina gibbosa

  • Birgit Lengerer,
  • Marie Bonneel,
  • Mathilde Lefevre,
  • Elise Hennebert,
  • Philippe Leclère,
  • Emmanuel Gosselin,
  • Peter Ladurner and
  • Patrick Flammang

Beilstein J. Nanotechnol. 2018, 9, 2071–2086, doi:10.3762/bjnano.9.196

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  • ]). Although single proteins of marine temporary adhesives have been identified [8][9][10], non-permanent adhesion remains poorly understood. Echinoderms represent promising organisms to study reversible adhesion, their hydraulic tube feet being able to repeatedly attach and detach [11][12]. All echinoderm
  • voluntary detachment, the adhesive substance is left behind on the substrate as a 'footprint' of approximately the same diameter as the tube feet [11][12][25][26]. In echinoderm footprints, the organic part consists of mainly proteins and carbohydrates [22][27]. The footprints are built by the overlay of a
  • meshwork was recently characterized and named sea star footprint protein-1 (Sfp1) [8]. Thirty-four additional proteins specific for footprints were identified and at least two were found to be glycosylated [28][29]. Additionally, lectin labelling of tube foot sections and footprints in A. rubens revealed
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Published 30 Jul 2018

Biomimetic and biodegradable cellulose acetate scaffolds loaded with dexamethasone for bone implants

  • Aikaterini-Rafailia Tsiapla,
  • Varvara Karagkiozaki,
  • Veroniki Bakola,
  • Foteini Pappa,
  • Panagiota Gkertsiou,
  • Eleni Pavlidou and
  • Stergios Logothetidis

Beilstein J. Nanotechnol. 2018, 9, 1986–1994, doi:10.3762/bjnano.9.189

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  • the synthesis of some proteins that are able to compromise multiple systems and inhibit growth. This might be due to the modification of other proteins that play crucial role in different cellular events. Nevertheless, cultured fibroblasts respond to glucocorticoids either with a positive or negative
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Published 13 Jul 2018

Closed polymer containers based on phenylboronic esters of resorcinarenes

  • Tatiana Yu. Sergeeva,
  • Rezeda K. Mukhitova,
  • Irek R. Nizameev,
  • Marsil K. Kadirov,
  • Polina D. Klypina,
  • Albina Y. Ziganshina and
  • Alexander I. Konovalov

Beilstein J. Nanotechnol. 2018, 9, 1594–1601, doi:10.3762/bjnano.9.151

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  • sensing of carbohydrates and glycoproteins [5][6][7][8][9][10][11], in separation techniques [12] and in labeling and manipulation of proteins [13][14][15]. In recent years, boronic acid derivatives were applied in the construction of functional materials, i.e., stimuli-responsive devices and carriers for
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Published 29 May 2018

Preparation and morphology-dependent wettability of porous alumina membranes

  • Dmitry L. Shimanovich,
  • Alla I. Vorobjova,
  • Daria I. Tishkevich,
  • Alex V. Trukhanov,
  • Maxim V. Zdorovets and
  • Artem L. Kozlovskiy

Beilstein J. Nanotechnol. 2018, 9, 1423–1436, doi:10.3762/bjnano.9.135

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  • biotechnological and medical development. Some applications include the separation of organic macromolecules and proteins (bio-filtration), their use in biosensor devices and capsule drug delivery systems, use for coating implants, and as a matrix for the formation of biocompatible tissues [19][20][21][22
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Published 15 May 2018

Nanoporous silicon nitride-based membranes of controlled pore size, shape and areal density: Fabrication as well as electrophoretic and molecular filtering characterization

  • Axel Seidenstücker,
  • Stefan Beirle,
  • Fabian Enderle,
  • Paul Ziemann,
  • Othmar Marti and
  • Alfred Plettl

Beilstein J. Nanotechnol. 2018, 9, 1390–1398, doi:10.3762/bjnano.9.131

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  • well as FIB-drilled single pores is carried out. Subsequently, molecular filtering as a direct application of our nanoporous membranes is demonstrated: Successful size-selective separation of dye molecules and labeled proteins is observed by real-time fluorescence microscopy. Results and Discussion
  • loan of measurement equipment and, together with S. Ernst, for the supply of labeled proteins. Many thanks also to K. Gottschalk for the opportunity to use his fluorescence microscopy equipment. Financial aid by the Collaborative Research Centre (SFB) 569 (Project G2), German Research Foundation (DFG
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Published 09 May 2018

A simple extension of the commonly used fitting equation for oscillatory structural forces in case of silica nanoparticle suspensions

  • Sebastian Schön and
  • Regine von Klitzing

Beilstein J. Nanotechnol. 2018, 9, 1095–1107, doi:10.3762/bjnano.9.101

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  • nature of this phenomenon it has implications for a broad range of applications in microfluidic devices, for the stability of colloidal suspensions, or in a biological context, e.g., transport processes between biological surfaces or crystallization of proteins. Confined molecules or particles
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Published 05 Apr 2018

Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations

  • Jaison Jeevanandam,
  • Ahmed Barhoum,
  • Yen S. Chan,
  • Alain Dufresne and
  • Michael K. Danquah

Beilstein J. Nanotechnol. 2018, 9, 1050–1074, doi:10.3762/bjnano.9.98

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  • protein capsids were used to encapsulate drugs, genes, enzymes or proteins for targeted delivery with biocompatibility and bioavailability [128]. Recent research efforts have focused on using viral NPs as conjugation templates to produce novel nanostructures [129][130] and cages for compound encapsulation
  • and protein that are aligned in a column and layers of calcite, forms the thin and strong eggshell. During the eggshell formation, the CaCO3 NPs begin as an amorphous mineral which is transformed by the c-type lectin proteins into ordered crystals. The crystal transformation is initiated by the
  • attachment of proteins towards ACC NPs and later detach when the crystal continues to grow [242]. Nanoparticles and nanostructures in the human body The human body consists of nanostructures without which normal function of the body is impossible. It is formed by nanostructures such as bones, enzymes
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Published 03 Apr 2018

Bioinspired self-healing materials: lessons from nature

  • Joseph C. Cremaldi and
  • Bharat Bhushan

Beilstein J. Nanotechnol. 2018, 9, 907–935, doi:10.3762/bjnano.9.85

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  • cell size/shape [14]. Figure 2A shows the hierarchical levels of muscle structure in a human, building from the basic components of actin and myosin proteins to sarcomeres and muscle fibers that form a muscle [39]. Skeletal muscle is striated and used for voluntary movements. Smooth, or nonstriated
  • function such as digestion, locomotion, or flight. Unlike vertebrates, however, all insect muscle is striated and under voluntary control [17]. Despite the variation in characteristics and usage, all muscle is dependent on the interaction between the proteins actin and myosin at the most basic level. A
  • great deal of research has been put into the current understanding of muscle movement, as described by [42]. Through regulation and interaction, these two proteins slide past one another, causing a reversible extension/contraction and then relaxation of muscle on a macroscale, as detailed by [43]. This
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Published 19 Mar 2018

Comparative study of antibacterial properties of polystyrene films with TiOx and Cu nanoparticles fabricated using cluster beam technique

  • Vladimir N. Popok,
  • Cesarino M. Jeppesen,
  • Peter Fojan,
  • Anna Kuzminova,
  • Jan Hanuš and
  • Ondřej Kylián

Beilstein J. Nanotechnol. 2018, 9, 861–869, doi:10.3762/bjnano.9.80

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  • through mechanisms based on (i) metal ion selectivity (replacement of original metals leading to cellular dysfunction); (ii) metal reduction potential (generating or catalysing the formation of reactive oxygen species (ROS) damaging cellular proteins, lipids and DNA) and (iii) direct nanoparticle (NP
  • antibacterial effect. Furthermore, Cu NPs under ambient conditions can easily lead to the formation of CuO, which also displays a direct toxicity for microorganisms [18]. They already disturb microorganisms when being in contact with the bacterial surface by reacting with proteins forming pores in the membrane
  • and perturbing the membrane potential leading to cell death. Furthermore, ions can be transported through the membrane into the cell and by replacing the original ions disturb proteins in the cytosol. Taken all these processes into consideration, metallic NPs with direct toxicity are expected to act
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Published 12 Mar 2018

Noble metal-modified titania with visible-light activity for the decomposition of microorganisms

  • Maya Endo,
  • Zhishun Wei,
  • Kunlei Wang,
  • Baris Karabiyik,
  • Kenta Yoshiiri,
  • Paulina Rokicka,
  • Bunsho Ohtani,
  • Agata Markowska-Szczupak and
  • Ewa Kowalska

Beilstein J. Nanotechnol. 2018, 9, 829–841, doi:10.3762/bjnano.9.77

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  • nourishment for mould fungi is probably caused by sorption of macromolecules (e.g., proteins and sugars) on titania, as suggested by Raffaini and Ganzoli [77] and Ellingsen [78]. On the other hand, our previous study showed that Au-modified faceted titania was inactive against C. albicans, in contrast to the
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Published 07 Mar 2018

Colloidal solution of silver nanoparticles for label-free colorimetric sensing of ammonia in aqueous solutions

  • Alessandro Buccolieri,
  • Antonio Serra,
  • Gabriele Giancane and
  • Daniela Manno

Beilstein J. Nanotechnol. 2018, 9, 499–507, doi:10.3762/bjnano.9.48

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  • compared to physiological systems of ammonia in organic fluids (blood or urine). However, this study is preliminary to address the problem of interfering species, e.g., proteins, enzymes and mineral salts. We highlighted that colloidal AgNPs solutions synthesized using both glucose and sucralose as
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Published 09 Feb 2018
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