Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

• Ana Cubillo Alvarez,
• Dylan Maguire and
• Ruairí P. Brannigan

Beilstein J. Nanotechnol. 2025, 16, 435–463, doi:10.3762/bjnano.16.34

Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• toxicity of BNZ. The project, however, failed in its attempt to incorporate BNZ into liposomes, while lipid nanoparticles could not be formulated into sublingual tablets. The project changed to formulate BNZ/hydroxypropyl-β-cyclodextrin complexes. These complexes were prepared on a scale seven times larger

Supramolecular assembly of pentamidine and polymeric cyclodextrin bimetallic core–shell nanoarchitectures

• Alexandru-Milentie Hada,
• Nina Burduja,
• Marco Abbate,
• Claudio Stagno,
• Guy Caljon,
• Louis Maes,
• Nicola Micale,
• Massimiliano Cordaro,
• Angela Scala,
• Antonino Mazzaglia and
• Anna Piperno

Beilstein J. Nanotechnol. 2022, 13, 1361–1369, doi:10.3762/bjnano.13.112

• nanostructures endowed with unique physicochemical properties. Recently, we have proposed a straightforward synthetic strategy that exploits the properties of polymeric β-cyclodextrin (PolyCD) to act as both the reducing and stabilizing agent to produce monodispersed and stable gold-based NPs either as

• ability of the β-cyclodextrin polymer (PolyCD) to act as a symbiont of both MNPs and BMNPs [14]. Specifically, functional groups of PolyCD (i.e., amines, primary and secondary alcohols, and hemiacetals) are involved in the direct reduction of gold ions to Au NPs (Figure 1). PolyCD-capped Au NPs showed an

Design of surface nanostructures for chirality sensing based on quartz crystal microbalance

• Yinglin Ma,
• Xiangyun Xiao and
• Qingmin Ji

Beilstein J. Nanotechnol. 2022, 13, 1201–1219, doi:10.3762/bjnano.13.100

• higher interaction energy for the host–guest complexes to discriminate the enantiomers in the inclusion process [66]. Fietzek et al. measured the selective adsorption of chiral limonene in three different β-cyclodextrin (β-CD) derivatives by QCM and artificial neural networks (ANN) to evaluate the chiral

• discrimination performance [67]. It was revealed that better chiral discrimination was achieved with heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-β-cyclodextrin and heptakis(2,3-di-O-ethyl-6-O-tert-butyldimethylsilyl)-β-cyclodextrin (Me- and Et-β-CD) than that with heptakis(2,3-di-O-acetyl-6-O-tert

• -butyldimethylsilyl)-β-cyclodextrin (Ac-β-CD). Combined with gas chromatography analysis, chiral separation factors could be estimated. Et-β-CD showed a more sensitive QCM response to R-limonene. It was also found that a higher chiral recognition factor was gained at the lowest limonene concentration due to more

Use of nanosystems to improve the anticancer effects of curcumin

• Andrea M. Araya-Sibaja,
• Norma J. Salazar-López,
• Krissia Wilhelm Romero,
• José R. Vega-Baudrit,
• J. Abraham Domínguez-Avila,
• Carlos A. Velázquez Contreras,
• Ramón E. Robles-Zepeda,
• Mirtha Navarro-Hoyos and
• Gustavo A. González-Aguilar

Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78

• against cancer cells [126]. Curcumin-loaded MNP (94.2 µg/mg of nanoparticles) were assayed against MDA-MB-231 cells. They contained iron oxide and β-cyclodextrin and were coated with Pluronic F68 polymer (polyethylene oxide-co-polypropylene oxide-co-polyethylene oxide) with an average size of 9 nm

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

• Nikola Geskovski,
• Nadica Matevska-Geshkovska,
• Simona Dimchevska Sazdovska,
• Marija Glavas Dodov,
• Kristina Mladenovska and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

Differences in surface chemistry of iron oxide nanoparticles result in different routes of internalization

• Barbora Svitkova,
• Vlasta Zavisova,
• Veronika Nemethova,
• Martina Koneracka,
• Miroslava Kretova,
• Filip Razga,
• Monika Ursinyova and
• Alena Gabelova

Beilstein J. Nanotechnol. 2021, 12, 270–281, doi:10.3762/bjnano.12.22

• inhibitors, that is, chlorpromazine (CPZ), monodansylcadaverine (MDC), and dynasore (Dyn). Only negligible changes in BSA-SO-MNP uptake were found in cells treated with CavME inhibitors, that is filipin (F), nystatin (N), and methyl-β-cyclodextrin (MBCD). A slight reduction in the internalized amount of BSA

• freshly before use from the stock solutions. The final concentrations were prepared by dilution in a culture medium with 2% FBS. The stock solutions of chlorpromazine (CPZ, 5 mM) and methyl-β-cyclodextrin (MBCD, 20 mM) were prepared in sterile distilled water and kept at 4 °C. The stock solutions of

• inhibitors on the internalization of BSA-SO-MNPs. MNPs – BSA-SO-MNPs (2 mM), CPZ – chlorpromazine (25 µM), MDC – monodansylcadaverine (150 µM), Dyn – dynasore (80 µM), F – filipin (5 µM), N – nystatin (20 µM), MBCD – methyl-β-cyclodextrin (100 uM), NOC – nocodazole (25 µM). Data are given as mean values ± SD

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

• Varsha Sharma and
• Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

• interactions [60][61][62][63]. For instance, positively charged ferrocene-modified PAA thin films over β-cyclodextrin dimer were first fabricated in 2002, showing that LbL assemblies can be formed by overcoming electrostatic repulsion [60]. Similar attempts were made to construct LbL films by interaction

• between β-cyclodextrin monolayers as host and polymers modified with adamantyl groups as guests, which also resulted in stable multilayers [61]. The first stimuli-responsive supramolecular hydrogels films based on these reactions were built in 2006 using β-cyclodextrin and adamantyl modified chitosan

• capsules that are switchable by two parameters, namely, solvent polarity and temperature [47]. Multilayer β-cyclodextrin films with ferrocene-modified PAA, adamantyl-modified dedrimer and adamantyl-modified poly(isobutene-alt-maleic acid) have been successfully reported with weak PE systems [60][61][88

Internalization mechanisms of cell-penetrating peptides

• Ivana Ruseska and
• Andreas Zimmer

Beilstein J. Nanotechnol. 2020, 11, 101–123, doi:10.3762/bjnano.11.10

• cells. Kaplan et al. investigated the internalization of the TAT peptide in living cells [56]. The active uptake of TAT was established after experiments were conducted at low temperature, at which all molecular movement in the cell membrane is essentially arrested. After exposing the cells to β

• -cyclodextrin (which depletes cell surface associated cholesterol) and macropinocytosis-specific inhibitors (such as cytochalasin D, an inhibitor of F-actin or EIPA, an inhibitor or the Na+/H+ exchange), a dose-dependent reduction of the internalized peptide was observed, which led to the conclusion that TAT

The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model

• Qura Tul Ain,
• Samina Hyder Haq,
• Abeer Alshammari,
• Moudhi Abdullah Al-Mutlaq and
• Muhammad Naeem Anjum

Beilstein J. Nanotechnol. 2019, 10, 901–911, doi:10.3762/bjnano.10.91

• ) [5], poly(ε-caprolactone) (PCL) [6], hydroxypropyl-β-cyclodextrin (HPCD) [7], and poly(L-lactic acid) (PLLA) [8]. Biocompatible GO has many prospective uses in tissue engineering [9], drug delivery [10], cancer therapy [11][12], and treatment of bacterial infections [13][14]. Dinescu et al. designed

A novel polyhedral oligomeric silsesquioxane-modified layered double hydroxide: preparation, characterization and properties

• Xianwei Zhang,
• Zhongzhu Ma,
• Hong Fan,
• Carla Bittencourt,
• Jintao Wan and
• Philippe Dubois

Beilstein J. Nanotechnol. 2018, 9, 3053–3068, doi:10.3762/bjnano.9.284

• ][19], amino acids [20], anionic dyes [11], and compounds of biological origin, such as β-cyclodextrin and eugenol derivatives [9][10][13][21]. However, most of these current modifiers do not have satisfactory thermal stability and are flammable, reducing the thermal and fire stability of the LDHs

Cyclodextrin inhibits zinc corrosion by destabilizing point defect formation in the oxide layer

• Abdulrahman Altin,
• Maciej Krzywiecki,
• Adnan Sarfraz,
• Cigdem Toparli,
• Claudius Laska,
• Philipp Kerger,
• Aleksandar Zeradjanin,
• Karl J. J. Mayrhofer,
• Michael Rohwerder and
• Andreas Erbe

Beilstein J. Nanotechnol. 2018, 9, 936–944, doi:10.3762/bjnano.9.86

• . This work uses electrochemical impedance spectroscopy to show the cyclic oligosaccharide β-cyclodextrin (β-CD) to inhibit corrosion of zinc in 0.1M chloride with an inhibition efficiency of up to 85%. Only a monomolecular adsorption layer of β-CD is present on the surface of the oxide covered metal

• ) compounds, and environmentally friendly alternatives are needed [2][7]. Control experiments in a recent work on encapsulating poorly water soluble organic corrosion inhibitors in the cyclic oligosaccharide β-cyclodextrin (β-CD) for incorporation into model polymer coatings on zinc led to the surprising

Cyclodextrin-assisted synthesis of tailored mesoporous silica nanoparticles

• Fuat Topuz and
• Tamer Uyar

Beilstein J. Nanotechnol. 2018, 9, 693–703, doi:10.3762/bjnano.9.64

• hand, increasing the CD concentration led to larger particles. Experimental Materials Ethanol (EtOH, >99%) and tetraethyl orthosilicate (TEOS, 98%) were purchased from Sigma-Aldrich. Hexadecyltrimethylammonium chloride (CTAC, >98%) was received from TCI Chemicals (Germany). β-Cyclodextrin (β-CD

• , (Cavamax® W7)), hydroxypropyl-β-cyclodextrin (HP-β-CD (Cavasol® W7 HP), molar substitution per anhydroglucose unit: 0.60) and hydroxypropyl-γ-cyclodextrin (HP-γ-CD (Cavasol® W8 HP), molar substitution per anhydroglucose unit: 0.58–0.73) were kindly donated by Wacker Chemie AG (Germany). Sodium hydroxide

Preparation of alginate–chitosan–cyclodextrin micro- and nanoparticles loaded with anti-tuberculosis compounds

• Albert Ivancic,
• Fliur Macaev,
• Fatma Aksakal,
• Veaceslav Boldescu,
• Serghei Pogrebnoi and
• Gheorghe Duca

Beilstein J. Nanotechnol. 2016, 7, 1208–1218, doi:10.3762/bjnano.7.112

• density distribution. It has been detected that alginate–chitosan–cyclodextrin microparticulate systems loaded with INH and ISN are as effective as pure INH applied in higher dosages. Keywords: chitosan; β-cyclodextrin; density functional theory (DFT); isoconazole; isoniazid; molecular docking

• the delivery of a celecoxib–hydroxypropyl-β-cyclodextrin–PVP complex [3] and for the controlled release of insulin after oral delivery [4][5]. Since these were mainly administered through the digestive tract, their sizes were only determined by bioavailability, and not by aerosol stability as in the

• active site of InhA and isoconazole in order to discuss these interactions with the frontier molecular orbital (FMO) analysis of the electron density distribution. The main carriers used in our particles are β-cyclodextrin, sodium alginate, and chitosan. β-Cyclodextrin (β-CD), a cyclic oligosaccharide

Gold nanoparticles covalently assembled onto vesicle structures as possible biosensing platform

• M. Fátima Barroso,
• M. Alejandra Luna,
• Juan S. Flores Tabares,
• Cristina Delerue-Matos,
• N. Mariano Correa,
• Fernando Moyano and
• Patricia G. Molina

Beilstein J. Nanotechnol. 2016, 7, 655–663, doi:10.3762/bjnano.7.58

• per-6-thio-β-cyclodextrin accomplished via covalent gold–thiol bonds [10]. These AuNPs provide an excellent platform for drug delivery due to the functional versatility of their monolayers. The vesicles with AuNPs are suitable for applications such as transport inside cells [11], photodynamic

Optimized design of a nanostructured SPCE-based multipurpose biosensing platform formed by ferrocene-tethered electrochemically-deposited cauliflower-shaped gold nanoparticles

• Wicem Argoubi,
• Maroua Saadaoui,
• Sami Ben Aoun and
• Noureddine Raouafi

Beilstein J. Nanotechnol. 2015, 6, 1840–1852, doi:10.3762/bjnano.6.187

• that were tethered with a β-cyclodextrin/ferrocene inclusion complex as a transducing system. Connection between gold and the ferrocene host was achieved thanks to a thiol terminal group [13]. The ferrocene complex acted as an electron shuttle allowing for glucose oxidation at low potentials. Li et al

Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages

• Dagmar A. Kuhn,
• Dimitri Vanhecke,
• Benjamin Michen,
• Fabian Blank,
• Peter Gehr,
• Alke Petri-Fink and
• Barbara Rothen-Rutishauser

Beilstein J. Nanotechnol. 2014, 5, 1625–1636, doi:10.3762/bjnano.5.174

• , fluorescently labelled transferrin can be used to investigate clathrin-mediated endocytosis [32][41][42]. Caveolae and lipid raft internalizations are known to be inhibited by nystatin, filipin and methyl-β-cyclodextrin (mβcd) through depletion of the cholesterol from the cell membrane by forming inclusion

• (Dansylcadaverine, D4008, Sigma-Aldrich). Inhibition of caveolin-mediated endocytosis was performed in both cell lines using 10 mM methyl-β-cyclodextrin (mβcd) (C4555, Sigma-Aldrich). A 4 µM cytochalasin D (C8273, Sigma-Aldrich) solution was used to inhibit phagocytosis and macropinocytosis in both cell lines. Cell

• monodansylcadaverine (mdc) in J774A.1 cells and methyl-β-cyclodextrin (mβcd) in A549 cells. (D) Negative control. (E–G) Uptake of 1 µm PS particles (particles: green, cytosol: grey). (E) Untreated cells with 1 µm particles. (F–G) 1 µm particles with the same adequate inhibitors. Scale bar: 5 µm. White arrows represent

Cyclodextrin-poly(ε-caprolactone) based nanoparticles able to complex phenolphthalein and adamantyl carboxylate

• Daniela Ailincai and
• Helmut Ritter

Beilstein J. Nanotechnol. 2014, 5, 651–657, doi:10.3762/bjnano.5.76

• Chemie, Geb. 26.33, Eb. 00, Universitätsstr. 1, 40225 Düsseldorf, Germany 10.3762/bjnano.5.76 Abstract A new compound composed of poly(ε-caprolactone) and β-cyclodextrin (β-CD) was synthesized by click chemistry. This compound was used to obtain stable nanoparticles, which have been proven to be able to

• phenolphthalein is included in the hydrophobic cavity of β-cyclodextrin (Figure 6b) and the suspension changes its color from pink in white (Figure 5). The affinity of adamantyl carboxylate to β-cyclodextrin is higher than of phenolphthalein to β-cyclodextrin. Thus, the addition of adamantyl carboxylate results

• in phenolphthalein leaving the β-cyclodextrin cavity and adamantyl carboxylate entering it so that the suspension changes its color back to pink (Figure 5). Conclusion In conclusion, we successfully prepared nanoparticles in water by nano-precipitation of a solution of poly(ε-caprolactone) tailored

One pot synthesis of silver nanoparticles using a cyclodextrin containing polymer as reductant and stabilizer

• Arkadius Maciollek and
• Helmut Ritter

Beilstein J. Nanotechnol. 2014, 5, 380–385, doi:10.3762/bjnano.5.44

• using silver nitrate and a copolymer 1 from N-isopropylacrylamide (NIPAM) and mono-(1H-triazolylmethyl)-2-methylacryl-β-cyclodextrin acting as reductant and stabilizer without using any additional reducing agent is reported. The reduction was carried out in aqueous solution under pH neutral conditions

• -β-cyclodextrin [20] as reduction and steric stabilization agent without any additional reduction agent or energy source. Silver nitrate has been reduced under pH neutral conditions at room temperature. In this green one pot synthesis neither commonly used toxic reduction agent nor additional energy

• -cyclodextrin containing polymer 1 at room temperaure. The copolymer 1 was prepared from N-isopropylacrylamide and mono-(1H-triazolylmethyl)-2-methylacryl-β-cyclodextrin via free radical polymeraization (Scheme 1). The molar weight Mn = 2·103 g/mol was measured by aqueos SEC-MALS (D = 3.2). Through variation of

Self-assembled monolayers and titanium dioxide: From surface patterning to potential applications

• Yaron Paz

Beilstein J. Nanotechnol. 2011, 2, 845–861, doi:10.3762/bjnano.2.94