Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy

• Naths Grazia Sukubo,
• Paolo Bigini and
• Annalisa Morelli

Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10

• -specific receptors. Mannose-decorated NCs, for example, leverage the overexpression of mannose receptors (CD206) on polarized M2 cells. Hatami et al. demonstrated the efficacy of self-assembling Pluronic® F127 polymer and tannic acid cores decorated with mannose in enhancing macrophage uptake [56]. The

Therapeutic effect of F127-folate@PLGA/CHL/IR780 nanoparticles on folate receptor-expressing cancer cells

• Thi Ngoc Han Pham,
• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan Thang Cao,
• Thanh-Danh Nguyen,
• Vy Tran Anh and
• Hieu Vu_Quang

Beilstein J. Nanotechnol. 2024, 15, 954–964, doi:10.3762/bjnano.15.78

• chemotherapeutic agent chlorambucil (CHL) and the imaging agent IR780. The approach in this study incorporates Pluronic F127-folate onto the PLGA nanoparticles, which enables targeted delivery to folate receptor-expressing cancer cells. The F127-folate@PLGA/CHL/IR780 nanoparticles were formulated using a

• pluronic F127 (F127), can be used in the water phase to lower the surface tension of the organic phase and to produce the nanoemulsion during the homogenization process [5][6][7]. F127 is a copolymer made up of blocks of poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide), PEO100–PPO65–PEO100

• ) (MT35010CV), antibiotic (15-240-062), and trypsin (25-200-056) were purchased from Gibco, Fisher Scientific. Conjugation of pluronic F127 and folic acid The conjugation of folic acid to Pluronic F127 was done as described in our previous study [34]. Folic acid (0.4 mmol) was activated by 1,1

Cyclodextrin-assisted synthesis of tailored mesoporous silica nanoparticles

• Fuat Topuz and
• Tamer Uyar

Beilstein J. Nanotechnol. 2018, 9, 693–703, doi:10.3762/bjnano.9.64

• the SiO2–CTAC precursor particles that direct the growth of hexagonal mesoporous silica toward specific morphology [27][28]. Suzuki et al. also reported the synthesis of faceted MSNs using TEOS, CTAB and a copolymer of ethylene and propylene oxide (Pluronic F127), where the copolymer acted as a second

Multiwalled carbon nanotube hybrids as MRI contrast agents

• Nikodem Kuźnik and
• Mateusz M. Tomczyk

Beilstein J. Nanotechnol. 2016, 7, 1086–1103, doi:10.3762/bjnano.7.102

• cells (MSCs) [22]. MSCs labeled with MWCNT hybrids (MSC/Pol/MWCNT#Vittorio) were obtained by mixing Pluronic® F127 dispersion of MWCNTs (Pol/MWCNT#Vittorio) with incubated MSCs. One-month stability of the resulting dispersion was proven and a permanent binding of MWCNTs to the cells was observed in in

Influence of wide band gap oxide substrates on the photoelectrochemical properties and structural disorder of CdS nanoparticles grown by the successive ionic layer adsorption and reaction (SILAR) method

• Mikalai V. Malashchonak,
• Alexander V. Mazanik,
• Olga V. Korolik,
• Еugene А. Streltsov and
• Anatoly I. Kulak

Beilstein J. Nanotechnol. 2015, 6, 2252–2262, doi:10.3762/bjnano.6.231

• to attain рН 8. The indium hydroxide precipitate was carefully washed with distilled water and sonicated after adding of 1.5 mL of concentrated nitric acid (65%) as a stabilizer per 50 mL of sol. The obtained In(OH)3 sol with a concentration of 200 g/L was mixed with a Pluronic F127 block copolymer

PLGA nanoparticles as a platform for vitamin D-based cancer therapy

• Maria J. Ramalho,
• Joana A. Loureiro,
• Bárbara Gomes,
• Manuela F. Frasco,
• Manuel A. N. Coelho and
• M. Carmo Pereira

Beilstein J. Nanotechnol. 2015, 6, 1306–1318, doi:10.3762/bjnano.6.135

• cell growth, cell cycle arrest and morphological changes. Results Nanoparticle physicochemical properties PLGA NPs were prepared by a single emulsion solvent evaporation method and stabilized with Pluronic®F127. The obtained results for mean the diameter, polydispersity index (PDI) and zeta potential

• formulated as promising delivery systems to improve the therapeutic potential of calcitriol. The PLGA NPs were prepared by a single emulsion solvent evaporation method and stabilized with Pluronic®F127. The prepared NPs exhibited mean diameters smaller than 200 nm and negative zeta potential. The observed

• electrostatic forces due to the PLGA carboxylate groups at the NP surface, and the surfactant behavior that also plays a crucial role in maintaining nanosuspension stabilization. During particle formation, the Pluronic®F127 is adsorbed onto the NP surface, providing steric and thermodynamic stabilization

Optimizing the synthesis of CdS/ZnS core/shell semiconductor nanocrystals for bioimaging applications

• Li-wei Liu,
• Si-yi Hu,
• Ying Pan,
• Jia-qi Zhang,
• Yue-shu Feng and
• Xi-he Zhang

Beilstein J. Nanotechnol. 2014, 5, 919–926, doi:10.3762/bjnano.5.105

• intensity, stronger stability and exhibited a longer lifetime compared to uncapped CdS. The CdS/ZnS nanocrystals were stabilized in Pluronic F127 block copolymer micelles, offering an optically and colloidally stable contrast agents for in vitro and in vivo imaging. Photostability test exhibited that the

• applications and may offer a new direction for the early detection of cancer in humans. Keywords: bioimaging; CdS/ZnS quantum dots; Pluronic F127; Introduction Over the past decade, the use of semiconductor nanocrystals or quantum dots (QDs) has developed remarkably due to their unique features. Compared to

• biocompatible polymer nanocarriers for in vivo studies there are Pluronic F127 triblock-copolymer micelle nanoparticles [20][21]. They can serve as a candidate for therapeutic and biomedical applications in vitro and in vivo. A particular material for QDs, CdS, is an important direct-band semiconductor with a

In vitro toxicity and bioimaging studies of gold nanorods formulations coated with biofunctional thiol-PEG molecules and Pluronic block copolymers

• Tianxun Gong,
• Douglas Goh,
• Malini Olivo and
• Ken-Tye Yong

Beilstein J. Nanotechnol. 2014, 5, 546–553, doi:10.3762/bjnano.5.64

• (Na3C6H5O7), Pluronic F127, and the cell counting kit (CCK8) were purchased from Sigma-Aldrich. PEG-SH (CH3O–PEG-SH) was purchased from Rapp Polymere. Dulbecco’s modified Eagles’s medium (DMEM) and 1× phosphate buffer sulphate (PBS) were prepared in-house. Fetal bovine serum (FBS) and penicillin/streptomycin

• are passivated. The hydrophilic PEO chains of the copolymer are then favorably interacting with the aqueous phase thereby maintaining the overall colloidal solubility of the AuNRs passivated by the Pluronic copolymer. Pluronic F127 was chosen as it has PPO and PEO chains of comparable length

• encapsulation layer on a particle. Mean hydrodynamic diameter of AuNRs encapsulated with different concentrations of PEG-SH or Pluronic. Dark-field images of OSCC cells with AuNRs encapsulated with (a) 10 nM, (b) 1 µM, (c) 1 mM of PEG-SH and (d) 10 nM, (e) 100 µM (f) 1 mM of Pluronic F127. Supporting

Photoelectrochemical and Raman characterization of In₂O₃ mesoporous films sensitized by CdS nanoparticles

• Mikalai V. Malashchonak,
• Sergey K. Poznyak,
• Eugene A. Streltsov,
• Anatoly I. Kulak,
• Olga V. Korolik and
• Alexander V. Mazanik

Beilstein J. Nanotechnol. 2013, 4, 255–261, doi:10.3762/bjnano.4.27

• thoroughly washed and ultrasonically treated after the addition of a small amount of nitric acid as a stabilizer to obtain a stable sol at a concentration of 120 g/L. To prepare indium oxide In2O3(400) films with mesoporous structure, block-copolymer Pluronic F127 (100 g/L) as a template material was added

• In2O3 films. The cross-sectional SEM image of a film deposited on an ITO substrate shows that the film thickness is about 40 nm (Figure 2a). According to the BET data, the surface areas of the In2O3(400) films prepared with and without Pluronic F127 are 119 and 53 m2/g, respectively. It should be noted

• time to depth in AES profiles was done on the basis of cross-sectional SEM data. Barrett–Joyner–Halenda desorption-model pore-volume distribution of the In2O3(400) mesoporous films prepared with (1) and without (2) Pluronic F127. Absorption spectra of the In2O3(400) and In2O3(400)/CdS films deposited

FTIR nanobiosensors for Escherichia coli detection

• Stefania Mura,
• Gianfranco Greppi,
• Maria Laura Marongiu,
• Pier Paolo Roggero,
• Sandeep P. Ravindranath,
• Lisa J. Mauer,
• Nicoletta Schibeci,
• Francesco Perria,
• Massimo Piccinini,
• Plinio Innocenzi and
• Joseph Irudayaraj

Beilstein J. Nanotechnol. 2012, 3, 485–492, doi:10.3762/bjnano.3.55

• ) oriented (one side polished and one side etched) were obtained from Jocam (Italy). Film preparation Titania (TiO2) thin films were prepared by dipping silicon wafers in a solution composed of TiCl4/Pluronic F127/H2O/EtOH (1:0.005:10:40) under controlled conditions of temperature and RH (relative humidity

Mesoporous MgTa₂O₆ thin films with enhanced photocatalytic activity: On the interplay between crystallinity and mesostructure

• Jin-Ming Wu,
• Igor Djerdj,
• Till von Graberg and
• Bernd M. Smarsly

Beilstein J. Nanotechnol. 2012, 3, 123–133, doi:10.3762/bjnano.3.13

• characterization of crystallized, mesoporous MgTa2O6 thin films, obtained through an evaporation-induced self-assembly (EISA) approach, with the help of the KLE template. The photocatalytic activity of the nanoarchitectured MgTa2O6 thin film was compared both to that achieved by using the BASF Pluronic F127 (block