Search results

Search for "SQSTM1/p62" in Full Text gives 1 result(s) in Beilstein Journal of Nanotechnology.

Graphene oxide–chloroquine conjugate induces DNA damage in A549 lung cancer cells through autophagy modulation

  • Braham Dutt Arya,
  • Sandeep Mittal,
  • Prachi Joshi,
  • Alok Kumar Pandey,
  • Jaime E. Ramirez-Vick,
  • Govind Gupta and
  • Surinder P. Singh

Beilstein J. Nanotechnol. 2025, 16, 316–332, doi:10.3762/bjnano.16.24

Graphical Abstract
  • -damage response. GO–Chl causes loss of plasma membrane integrity, cell cycle arrest, and significant genotoxicity in A549 cells. Further, elevated expression of key autophagy proteins beclin-1, ATG-7, LC-3-I/II, and SQSTM1/p62 reveal that inhibition of autophagy plays a crucial role in regulating DDR
  • ; nanoconjugates; SQSTM1/p62; Introduction Despite of advances in basic and clinical research, an increased mortality rate is seen worldwide in cancer-associated deaths [1]. The heterogeneous and complex tumor microenvironment along with intrinsic and/or acquired drug resistance mechanisms, such as increased drug
  • -3-I/II, and SQSTM1/p62, which could regulate the DNA-damage response in cancer cells [67]. Therefore, to investigate the molecular mechanism responsible for inducing DNA damage through autophagy modulation in A549 cells upon GO–Chl nanoconjugate exposure, we performed immunoblot analysis of various
PDF
Album
Supp Info
Full Research Paper
Published 03 Mar 2025
Other Beilstein-Institut Open Science Activities