Search results

Search for "bioavailability" in Full Text gives 82 result(s) in Beilstein Journal of Nanotechnology.

Efficiency of single-pulse laser fragmentation of organic nutraceutical dispersions in a circular jet flow-through reactor

  • Tina Friedenauer,
  • Maximilian Spellauge,
  • Alexander Sommereyns,
  • Verena Labenski,
  • Tuba Esatbeyoglu,
  • Christoph Rehbock,
  • Heinz P. Huber and
  • Stephan Barcikowski

Beilstein J. Nanotechnol. 2025, 16, 711–727, doi:10.3762/bjnano.16.55

Graphical Abstract
  • goes along with an elevated specific surface area that improves solubility and bioavailability of these nutraceuticals. Consequently, the amount of degradation products per generated surface area within one laser passage is a particularly interesting assessment criterion for process efficiency
PDF
Album
Supp Info
Full Research Paper
Published 26 May 2025

Aprepitant-loaded solid lipid nanoparticles: a novel approach to enhance oral bioavailability

  • Mazhar Hussain,
  • Muhammad Farooq,
  • Muhammad Asad Saeed,
  • Muhammad Ijaz,
  • Sherjeel Adnan,
  • Zeeshan Masood,
  • Muhammad Waqas,
  • Wafa Ishaq and
  • Nabeela Ameer

Beilstein J. Nanotechnol. 2025, 16, 652–663, doi:10.3762/bjnano.16.50

Graphical Abstract
  • release (98.89% ± 4.11%) in PBS (pH 7.4) and followed the Higuchi release model (with exponent n = 0.542), indicating non-Fickian diffusion (anomalous transport). The maximum concentration of drug in plasma and the bioavailability of optimal formulation APT-CD-NP4 were higher than those of pure APT
  • . Therefore, the optimal SLN formulation APT-CD-NP4 is a promising tool for oral administration with sustained release to improve the bioavailability of the BCS class-IV drug APT. Keywords: aprepitant; β-cyclodextrin; pharmacokinetic study; poloxamer; solid lipid nanoparticles; Introduction Cancer is a
  • solitary tract in the brain. APT is equally effective in the prevention of pre/postoperative nausea and as rescue antiemetic, offering better control of vomiting after 24 and 48 h compared with conventional therapies [6]. APT has an oral bioavailability of 60–65%. The maximum concentration of drug in
PDF
Album
Full Research Paper
Published 15 May 2025

A formulation containing Cymbopogon flexuosus essential oil: improvement of biochemical parameters and oxidative stress in diabetic rats

  • Ailton Santos Sena-Júnior,
  • Cleverton Nascimento Santana Andrade,
  • Pedro Henrique Macedo Moura,
  • Jocsã Hémany Cândido dos Santos,
  • Cauãn Torres Trancoso,
  • Eloia Emanuelly Dias Silva,
  • Deise Maria Rego Rodrigues Silva,
  • Ênio Pereira Telles,
  • Luiz André Santos Silva,
  • Isabella Lima Dantas Teles,
  • Sara Fernanda Mota de Almeida,
  • Daniel Alves de Souza,
  • Jileno Ferreira Santos,
  • Felipe José Aidar Martins,
  • Ana Mara de Oliveira e Silva,
  • Sandra Lauton-Santos,
  • Guilherme Rodolfo Souza de Araujo,
  • Cristiane Bani Correa,
  • Rogéria De Souza Nunes,
  • Lysandro Pinto Borges and
  • Ana Amélia Moreira Lira

Beilstein J. Nanotechnol. 2025, 16, 617–636, doi:10.3762/bjnano.16.48

Graphical Abstract
  • after in vivo administration [8]. Among these systems, microemulsions (MEs) stand out for their ability to increase the solubility, absorption, and bioavailability of lipophilic compounds such as EOs. MEs are transparent, thermodynamically stable, low-viscosity systems containing oil and water
  • of MEs is advantageous when taken orally as it facilitates oral application and dose adjustment; it also improves absorption and bioavailability. Additionally, MEs can be administered to humans as self-microemulsifying drug delivery systems (SMEDDSs) delivered in soft gelatin capsules as they are low
  • such as superoxide dismutase and catalase. The microemulsion likely enhances the bioavailability of key phytoconstituents such as citral, thereby potentiating their biological activity. To strengthen this interpretation, we included comparisons with prior studies involving lemongrass essential oil and
PDF
Album
Supp Info
Full Research Paper
Published 07 May 2025

Nanomaterials in targeting amyloid-β oligomers: current advances and future directions for Alzheimer's disease diagnosis and therapy

  • Shiwani Randhawa,
  • Trilok Chand Saini,
  • Manik Bathla,
  • Rahul Bhardwaj,
  • Rubina Dhiman and
  • Amitabha Acharya

Beilstein J. Nanotechnol. 2025, 16, 561–580, doi:10.3762/bjnano.16.44

Graphical Abstract
  • , Parikh et al. developed a curcumin-loaded self-nanomicellizing solid dispersion system (Cur-SNSDS) to significantly enhance the in vivo bioavailability of curcumin. This novel NP system demonstrated superior safety and efficacy in mitigating Aβ42 oligomer-induced toxicity in SH-SY5Y695 APP human
PDF
Album
Review
Published 22 Apr 2025

Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

  • Ana Cubillo Alvarez,
  • Dylan Maguire and
  • Ruairí P. Brannigan

Beilstein J. Nanotechnol. 2025, 16, 435–463, doi:10.3762/bjnano.16.34

Graphical Abstract
  • . Additionally, the attachment of hydrophobic moieties, amino acids, and small peptides to linear and branched PEI has been explored as an alternative to improve the biostability and bioavailability of cationic polyplexes while offering a targeted delivery with reduced cytotoxicity that is frequently associated
PDF
Album
Review
Published 27 Mar 2025

Fabrication and evaluation of BerNPs regarding the growth and development of Streptococcus mutans

  • Tuyen Huu Nguyen,
  • Hong Thanh Pham,
  • Kieu Kim Thanh Nguyen,
  • Loan Hong Ngo,
  • Anh Ngoc Tuan Mai,
  • Thu Hoang Anh Lam,
  • Ngan Thi Kim Phan,
  • Dung Tien Pham,
  • Duong Thuy Hoang,
  • Thuc Dong Nguyen and
  • Lien Thi Xuan Truong

Beilstein J. Nanotechnol. 2025, 16, 308–315, doi:10.3762/bjnano.16.23

Graphical Abstract
  • prepared using a wet-milling method with zirconium balls to enhance bioavailability and expand potential applications. The particle size and physicochemical properties of the BerNPs were analyzed using field-emission scanning electron microscopy (FE-SEM), UV–vis spectroscopy, X-ray diffraction, and Fourier
  • . It also exhibits antifungal activity against Aspergillus, Penicillium, Candida, and Cryptococcus [10]. While having several benefits, berberine has limited therapeutic usage since it is poorly soluble in water, absorbs poorly through the intestinal wall, and has a very low bioavailability (about 5
  • materials with novel properties. The development of substances and methods with enhanced water dispersibility and bioavailability from materials such as berberine and curcumin is a current trend. Several studies on the nanofabrication of berberine aimed at improving its bioavailability and evaluating its
PDF
Album
Full Research Paper
Published 27 Feb 2025

Radiosensitizing properties of dual-functionalized carbon nanostructures loaded with temozolomide

  • Radmila Milenkovska,
  • Nikola Geskovski,
  • Dushko Shalabalija,
  • Ljubica Mihailova,
  • Petre Makreski,
  • Dushko Lukarski,
  • Igor Stojkovski,
  • Maja Simonoska Crcarevska and
  • Kristina Mladenovska

Beilstein J. Nanotechnol. 2025, 16, 229–251, doi:10.3762/bjnano.16.18

Graphical Abstract
  • a matter of increasing importance in the field of neurology, neuro-oncology, and neuropharmacology. This is because of their specific intrinsic physicochemical, biopharmaceutical, and pharmacological properties such as good bioavailability, relatively low toxicity, low weight and large surface area
PDF
Album
Full Research Paper
Published 19 Feb 2025

Recent advances in photothermal nanomaterials for ophthalmic applications

  • Jiayuan Zhuang,
  • Linhui Jia,
  • Chenghao Li,
  • Rui Yang,
  • Jiapeng Wang,
  • Wen-an Wang,
  • Heng Zhou and
  • Xiangxia Luo

Beilstein J. Nanotechnol. 2025, 16, 195–215, doi:10.3762/bjnano.16.16

Graphical Abstract
  • penetration and deposition [163]. Moreover, common ocular drug delivery methods have disadvantages such as short intraocular retention time, low drug accumulation, and low bioavailability [164]. Because of the transparency of the cornea and crystalline lens, the eye allows various wavelengths of light to
PDF
Album
Review
Published 17 Feb 2025

Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy

  • Naths Grazia Sukubo,
  • Paolo Bigini and
  • Annalisa Morelli

Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10

Graphical Abstract
  • to enhance drug delivery, improve bioavailability, and target specific cells makes them valuable tools for managing conditions affecting these organs. Figure 1 illustrates these approaches within a pathological context. 6.1 Targeting liver diseases The liver, a key organ in metabolic processes, is an
  • expressed on KCs have also been targeted using molecules like phosphatidylserine (PS), which serves as a recognition signal for the phagocytosis of apoptotic cells. In a study by Wang et al., PS-modified lipid carriers loaded with curcumin (Cur–mNLCs) demonstrated improved retention time, bioavailability
PDF
Album
Review
Published 31 Jan 2025

Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications

  • Hugo Felix Perini,
  • Beatriz Sodré Matos,
  • Carlo José Freire de Oliveira and
  • Marcos Vinicius da Silva

Beilstein J. Nanotechnol. 2024, 15, 1619–1626, doi:10.3762/bjnano.15.127

Graphical Abstract
  • bioavailability and drug delivery. Additionally, the capacity of these nanocarriers to react with reactive oxygen species at inflammation sites offers an anti-inflammatory response, reducing tissue damage [76][77]. Within this scope, manganese dioxide nanocarriers have been studied to address a challenge in
PDF
Album
Perspective
Published 16 Dec 2024

Liver-targeting iron oxide nanoparticles and their complexes with plant extracts for biocompatibility

  • Shushanik A. Kazaryan,
  • Seda A. Oganian,
  • Gayane S. Vardanyan,
  • Anatolie S. Sidorenko and
  • Ashkhen A. Hovhannisyan

Beilstein J. Nanotechnol. 2024, 15, 1593–1602, doi:10.3762/bjnano.15.125

Graphical Abstract
  • adverse reactions. The toxicity of MNPs depends on various factors such as size, shape, structure, surface modification, concentration, dosage, biodistribution, bioavailability, solubility, immunogenicity, and pharmacokinetics [23][24]. Their use in some clinical applications is limited by low solubility
  • obtained results is explained by the ability of Fe3O4 NPs to increase the bioavailability and intracellular concentration of the associated compounds, thereby reducing their therapeutic dose and altering the profile of dose-dependent effects. Additionally, both Fe3O4 NPs and their composites are presumed
PDF
Album
Full Research Paper
Published 11 Dec 2024

Green synthesis of silver nanoparticles derived from algae and their larvicidal properties to control Aedes aegypti

  • Matheus Alves Siqueira de Assunção,
  • Douglas Dourado,
  • Daiane Rodrigues dos Santos,
  • Gabriel Bezerra Faierstein,
  • Mara Elga Medeiros Braga,
  • Severino Alves Junior,
  • Rosângela Maria Rodrigues Barbosa,
  • Herminio José Cipriano de Sousa and
  • Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 1566–1575, doi:10.3762/bjnano.15.123

Graphical Abstract
  • characteristics such as greater absorption capacity, greater bioavailability, controlled release of active ingredients, improved solubility of hydrophobic substances in water, and good kinetic stability [12][13][14]. Metallic nanoparticles have been investigated as a promising approach for vector control. The
PDF
Album
Review
Published 04 Dec 2024

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

  • Iqra Rahat,
  • Pooja Yadav,
  • Aditi Singhal,
  • Mohammad Fareed,
  • Jaganathan Raja Purushothaman,
  • Mohammed Aslam,
  • Raju Balaji,
  • Sonali Patil-Shinde and
  • Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

Graphical Abstract
  • wide range of therapeutic properties, including antioxidant, anti-inflammatory, anticancer, and antimicrobial activities. However, their clinical application is often hindered by poor water solubility, low bioavailability, rapid metabolism, and instability under physiological conditions. Polymer lipid
  • diseases. Keywords: bioavailability; phytochemical; polymer lipid hybrid nanoparticles; solubility; stability; surface modification; Introduction Phytochemicals are naturally occurring compounds found in plants (from the Greek word “phyton” meaning plant) [1]. These bioactive compounds are responsible
  • compounds, and antimicrobials, offering a natural and multifaceted arsenal for combating a wide array of diseases [6][7][8]. Despite their promising bioactivities, the clinical application of phytochemicals is often limited by several inherent drawbacks such as poor water solubility, low bioavailability
PDF
Album
Review
Published 22 Nov 2024

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

  • Selin Akpinar Adscheid,
  • Akif E. Türeli,
  • Nazende Günday-Türeli and
  • Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

Graphical Abstract
  • ][26] and protect the drug from biological or chemical degradation or deactivation, which results in increased bioavailability in the brain [18][27]. This is particularly important since many other routes of administration pose multiple barriers and lead to relevant drug degradation, which are huge
  • administration also suffers from enzymatic degradation including peptidase and protease activity, making it challenging to deliver peptides and proteins [29][30]. Yet, the intranasal route still yields lower enzymatic degradation and higher bioavailability in the brain [31]. While the challenges of the
  • intranasal administration of biopharmaceuticals to target the brain. In addition, using DDSs to deliver biopharmaceuticals to the CNS can present additional advantages such as enhanced retention on the mucosal surface, drug stability, and bioavailability [35]. In this review, we focus on the recent
PDF
Album
Review
Published 12 Nov 2024

Recent updates in applications of nanomedicine for the treatment of hepatic fibrosis

  • Damai Ria Setyawati,
  • Fransiska Christydira Sekaringtyas,
  • Riyona Desvy Pratiwi,
  • A’liyatur Rosyidah,
  • Rohimmahtunnissa Azhar,
  • Nunik Gustini,
  • Gita Syahputra,
  • Idah Rosidah,
  • Etik Mardliyati,
  • Tarwadi and
  • Sjaikhurrizal El Muttaqien

Beilstein J. Nanotechnol. 2024, 15, 1105–1116, doi:10.3762/bjnano.15.89

Graphical Abstract
  • of nanoparticulates researched regarding liver fibrosis treatment. These nanocarriers allow for efficient containment of the antifibrotic compounds, particularly those with poor water solubility and low bioavailability. In addition, they protect the drug from unwanted metabolism and may facilitate
  • targeting strategy to the liver To endow passive targeting, specific nanocarriers with extended blood circulation profile are favorable to achieve an improvement in the bioavailability of the active pharmaceutical ingredients (APIs) and an increased accumulation at the target site. Nanoencapsulation of APIs
  • through modified nanocarriers could enhance their bioavailability by altering the pharmacokinetics as well as by protecting the unstable cargo against environmental factors [44]. Various potent antifibrosis substances from synthetic and herbal compounds suffer from limited solubility and lack of stability
PDF
Album
Review
Published 23 Aug 2024

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

  • Shakhzodjon Uzokboev,
  • Khojimukhammad Akhmadbekov,
  • Ra’no Nuritdinova,
  • Salah M. Tawfik and
  • Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

Graphical Abstract
  • and pharmacy are looking for such materials for DDSs because targeted drug delivery is becoming a vital way of carrying drugs. Traditional drug delivery methods including tablets, capsules, syrups, and ointments, have significant disadvantages such as low bioavailability and variability of drug levels
  • example, it is possible to deliver medications to cancer cells with little side effects and minimum damage to healthy cells. As a result, DDSs can improve patient compliance and adherence to medications [39]. Furthermore, smart drug delivery can also increase the bioavailability of drugs, which refers to
  • organs [46]. Another drawback is that current drug delivery technologies yield only limited bioavailability and change drug levels in plasma, making them incapable of long-term release. Without proper dispensing techniques, the entire treatment process may fail. In addition, the drug must be delivered at
PDF
Album
Review
Published 22 Aug 2024

Identification of structural features of surface modifiers in engineered nanostructured metal oxides regarding cell uptake through ML-based classification

  • Indrasis Dasgupta,
  • Totan Das,
  • Biplab Das and
  • Shovanlal Gayen

Beilstein J. Nanotechnol. 2024, 15, 909–924, doi:10.3762/bjnano.15.75

Graphical Abstract
  • procedures [19][20][21]. Understanding the structural features related to the surface modifiers of ENMOs that influence their uptake in human cell lines is crucial for designing nanomaterials with enhanced bioavailability. The surface modifiers are, in general, chemical groups or molecules that are attached
PDF
Album
Supp Info
Full Research Paper
Published 22 Jul 2024

When nanomedicines meet tropical diseases

  • Eder Lilia Romero,
  • Katrien Van Bocxlaer and
  • Fabio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 830–832, doi:10.3762/bjnano.15.69

Graphical Abstract
  • ]. Potentially beneficial properties of nanomedicines include enhanced drug solubility, improved bioavailability, targeted drug delivery, longer half-life, and reduced toxicity. This thematic issue covers pre-clinical research employing chemotherapeutic or prophylactic nanomedicines against NTDs in a concise
  • article collection. Among the articles, an interesting strategy to improve the bioavailability of benzonidazole towards Chagas disease has been presented by Muraca and colleagues, who reported a stable and safe nanostructured lipid formulation with potential effects against Trypanosoma cruzi [2]. In turn
PDF
Editorial
Published 08 Jul 2024

Radiofrequency enhances drug release from responsive nanoflowers for hepatocellular carcinoma therapy

  • Yanyan Wen,
  • Ningning Song,
  • Yueyou Peng,
  • Weiwei Wu,
  • Qixiong Lin,
  • Minjie Cui,
  • Rongrong Li,
  • Qiufeng Yu,
  • Sixue Wu,
  • Yongkang Liang,
  • Wei Tian and
  • Yanfeng Meng

Beilstein J. Nanotechnol. 2024, 15, 569–579, doi:10.3762/bjnano.15.49

Graphical Abstract
  • leading cause of cancer death worldwide. Most patients are diagnosed at an advanced stage, and systemic chemotherapy is the preferred treatment modality for advanced HCC. Curcumin (CUR) is a polyphenolic antineoplastic drug with low toxicity obtained from plants. However, its low bioavailability and poor
PDF
Album
Full Research Paper
Published 22 May 2024

On the additive artificial intelligence-based discovery of nanoparticle neurodegenerative disease drug delivery systems

  • Shan He,
  • Julen Segura Abarrategi,
  • Harbil Bediaga,
  • Sonia Arrasate and
  • Humberto González-Díaz

Beilstein J. Nanotechnol. 2024, 15, 535–555, doi:10.3762/bjnano.15.47

Graphical Abstract
  • diseases are characterized by slowly progressing neuronal cell death. Conventional drug treatment strategies often fail because of poor solubility, low bioavailability, and the inability of the drugs to effectively cross the blood–brain barrier. Therefore, the development of new neurodegenerative disease
  • inadequate solubility, limited bioavailability, and inability to effectively penetrate the blood–brain barrier (BBB) [6]. Therefore, there is an urgent need to focus on the advancement of novel neurodegenerative disease drugs (NDDs) [7][8]. The major obstacle encountered by NDDs is the selectivity of the BBB
  • compound towards the target site with a substantial reduction of toxicity for the adjacent tissues, and help the NDDs to pass physiological barriers, increasing bioavailability without resorting to high dosages [5][11]. Therefore, researchers are studying and developing new treatment approaches that use
PDF
Album
Supp Info
Full Research Paper
Published 15 May 2024

Cholesterol nanoarchaeosomes for alendronate targeted delivery as an anti-endothelial dysfunction agent

  • Horacio Emanuel Jerez,
  • Yamila Roxana Simioni,
  • Kajal Ghosal,
  • Maria Jose Morilla and
  • Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 517–534, doi:10.3762/bjnano.15.46

Graphical Abstract
  • Biopharmaceutical Classification System, ALN is a class-III molecule (high solubility and low permeability due to a polar hydrophilic nature) [13]. Its use as a vascular anti-inflammatory agent is limited by its low bioavailability, which after oral administration is minimal (about 0.7%) and highly variable [14][15
  • -inflammatory effects of ALN only occur at micromolar concentrations [12]. Such high concentrations, however, may hardly be achieved in blood because of the low bioavailability and high affinity of ALN to the hydroxyapatite matrix. At high oral dosages, ALN causes severe irritation of the upper gastrointestinal
PDF
Album
Supp Info
Full Research Paper
Published 13 May 2024

Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems

  • Hsuan-Ang Tsai,
  • Tsai-Miao Shih,
  • Theodore Tsai,
  • Jhe-Wei Hu,
  • Yi-An Lai,
  • Jui-Fu Hsiao and
  • Guochuan Emil Tsai

Beilstein J. Nanotechnol. 2024, 15, 465–474, doi:10.3762/bjnano.15.42

Graphical Abstract
  • improve the bioavailability. In this study, for the first time, DCS, a highly water-soluble compound, has formed nanocrystals and this was confirmed by scanning electronic microscopy and X-ray powder diffraction. Furthermore, DCS nanocrystals were applied to several formulations to test their stability
  • disease, and post-traumatic stress disorder [13][14][15][16]. In general, solid dosage forms for oral administration are preferable for therapies against CNS disorders. Nevertheless, challenges persist with oral solid dosage forms, including issues of bioavailability and clinical efficacy [17]. On the
  • hydrolyzed and decomposed into hydroxylamine and ᴅ-serine [17]. Thus, controlling the pH of the formulation is essential for obtaining a stable product. Therefore, an enteric formulation was warranted for DCS nanocrystals in order to achieve targeted delivery and improved bioavailability. In vitro
PDF
Album
Full Research Paper
Published 25 Apr 2024

Classification and application of metal-based nanoantioxidants in medicine and healthcare

  • Nguyen Nhat Nam,
  • Nguyen Khoi Song Tran,
  • Tan Tai Nguyen,
  • Nguyen Ngoc Trai,
  • Nguyen Phuong Thuy,
  • Hoang Dang Khoa Do,
  • Nhu Hoa Thi Tran and
  • Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

Graphical Abstract
  • oxidative stress, antioxidants from natural sources still have some notable limitations. These are low stability, low bioavailability, difficult long-term storage, and high cost of large-scale production [5][6]. Recently, nanomaterials have emerged as a promising strategy to overcome the limitations of
  • ingredients of antioxidant supplements. However, these compounds have low bioavailability related to low stability, solubility, and absorbance in the gastrointestinal tract [124][125][126][127]. Recently, with extraordinary progress in nanotechnology development, nanodelivery systems have been considered as
  • better anti-aging properties than natural curcumin. By encapsulating curcumin in nanocarriers or by conjugating it to metal oxide nanoparticles, the solubility and bioavailability of curcumin have been substantially improved, leading to a rise in its pharmacological efficiency [136][137][138][139
PDF
Album
Review
Published 12 Apr 2024

Nanomedicines against Chagas disease: a critical review

  • Maria Jose Morilla,
  • Kajal Ghosal and
  • Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

Graphical Abstract
  • ]. The dosage of BNZ has been reported to be inadequate [21]. In children, markedly lower plasma BNZ concentrations than those previously reported in adults treated with comparable BNZ milligram per kilogram doses (possibly due to a higher clearance/bioavailability), but still retaining a high
  • , according to the Biopharmaceutical Classification System (BCS) [31], which means that it is a poorly soluble but permeable molecule. The limitation in the absorption of class-II drugs is due to their rate of dissolution, except at very high doses. Their bioavailability is variable but can be increased by
  • pharmaceutical technology such as lyophilization, micrometerization, microemulsion, the inclusion of surfactants, solid dispersion, and the use of complexing agents such as cyclodextrins, Zer-Os tablet innovation, soft gels, and triglas [32]. Nanomedicines can also be used to increase the oral bioavailability of
PDF
Album
Review
Published 27 Mar 2024

Assessing phytotoxicity and tolerance levels of ZnO nanoparticles on Raphanus sativus: implications for widespread adoptions

  • Pathirannahalage Sahan Samuditha,
  • Nadeesh Madusanka Adassooriya and
  • Nazeera Salim

Beilstein J. Nanotechnol. 2024, 15, 115–125, doi:10.3762/bjnano.15.11

Graphical Abstract
  • the sample [34]. Phytotoxicity experiments on R. sativus grown in an inert solid medium The high bioavailability of Zn caused by the acidic pH (5.8–6.5) of coir might have caused the death of R. sativus grown with the application of 10,000 mg/L of ZnO NPs. This is confirmed by leaf chlorosis after 18
PDF
Album
Full Research Paper
Published 23 Jan 2024
Other Beilstein-Institut Open Science Activities