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Search for "erythrocytes" in Full Text gives 19 result(s) in Beilstein Journal of Nanotechnology.
A nanocarrier containing carboxylic and histamine groups with dual action: acetylcholine hydrolysis and antidote atropine delivery
Beilstein J. Nanotechnol. 2025, 16, 11–24, doi:10.3762/bjnano.16.2
- CA-RA were 0.57 mM and 0.48 mM for WI38 and Chang liver, respectively. For these cell lines, p(Hist-CA) had an IC50 higher than 1.4 mg/mL (Table 2). The agglutination activity results are shown in Figure 3. Control plate wells with erythrocytes in saline exhibited a dense layer at the bottom
- , indicating no agglutination (K(−), Figure 3). The positive control (K(+), Figure 3) displayed agglutinated cells (mixture of erythrocytes of blood groups IV and II) evenly distributed in the well. The results revealed that CA-RA exposure to blood samples did not induce agglutination across a wide
- directly in the growth medium. Нemocompatibility Human erythrocytes were obtained at the medical office of the A.E. Arbuzov Institute of Organic and Physical Chemistry from two Caucasian volunteers (52 years old, blood group II and 24 years old, blood group IV), after receiving informed consent. The study
Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications
Beilstein J. Nanotechnol. 2024, 15, 1619–1626, doi:10.3762/bjnano.15.127
- involves increased material waste and costs [34][35][53]. Regardless of the membrane-masking technique, various cell types can enhance the efficiency of delivery systems, including immune cells (phagocytes, lymphocytes, and NK cells) [54], erythrocytes [55], platelets [56], cancer cells [57] and hybrid
- drug delivery in cancer therapy has been extensively studied in the pursuit of biocompatible components with high specificity. In this context, the integration of synthetic compounds such as nanoparticles with natural components, including membranes from various cell types (e.g., erythrocytes
Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects
Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118
- ., erythrocytes) to develop membrane-camouflaged PLHNPs. These hybrid nanocarriers are also called biomimetic hybrid nanocarriers because their surface chemistry mimics natural cell membranes [57]. The PLHNPs are coated with cell membranes via the extrusion technique. The coating of PLHNPs with red blood cells
Recent updates in applications of nanomedicine for the treatment of hepatic fibrosis
Beilstein J. Nanotechnol. 2024, 15, 1105–1116, doi:10.3762/bjnano.15.89
- the elevation of plasma enzyme activity of aspartate transaminase (ALT) and alanine transaminase (AST), the orally administered curcumin loaded PLA-PEG NPs successfully improved the in vivo structure of the liver and reduced microvesicular steatosis, congestion of erythrocytes, and the infiltration of
Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one
Beilstein J. Nanotechnol. 2023, 14, 1028–1040, doi:10.3762/bjnano.14.85
- ]. For decades, science has been trying to overcome these problems [6]. Although erythrocytes also pose as a CO2 transporter and native hemoglobin as a buffer system [7], research is being focused on their function as oxygen transporters. The search is on for a laboratory-produced oxygen carrier that is
- retention time of oxygen carriers in the circulatory system. Erythrocytes and the Hb they contain have a mean survival time of about 120 days within the human body [7]. HBOCs, in contrast, have been eliminated within minutes to a few hours in previous experiments [5][23]. Much of this process appears to
Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies
Beilstein J. Nanotechnol. 2023, 14, 804–818, doi:10.3762/bjnano.14.66
- -VEHICLE and NLC-BNZ, the latter exhibiting a higher HA, could be explained by adding the HA of the free drug to the effect of the vehicle on erythrocytes. More studies would be necessary to investigate the effect of the composition, size, or porosity of these nanoparticles after a long term exposure to
Recent progress in cancer cell membrane-based nanoparticles for biomedical applications
Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24
- membranes, provides a new approach to address NP deficiencies [9]. The encapsulation of NPs with cell membranes can endow the NPs with biomimetic functions and replicate the biological characteristics derived from the original cells, such as the immune evasion of erythrocytes [10] and platelets [11] and the
- membranes have been exploited for the development of novel membrane NP-based therapies, such as erythrocytes [10], platelets [11], cancer cells [14], stem cells [12], immune cells [13], central nervous system-derived cells [17], bacterial outer membrane vesicles [18], and extracellular vesicles [19]. Cancer
Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer
Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23
Key for crossing the BBB with nanoparticles: the rational design
Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72
- and high biocompatibility. SPIONs are metabolized in the lysosomes into a soluble non-superparamagnetic form or iron. Then, iron ions join the iron pool in the blood and can be incorporated by erythrocytes as part of hemoglobin [21][183]. However, the concern about serious anaphylactic reactions, the
Understanding nanoparticle flow with a new in vitro experimental and computational approach using hydrogel channels
Beilstein J. Nanotechnol. 2020, 11, 296–309, doi:10.3762/bjnano.11.22
- Newtonian. Particle–particle interactions between erythrocytes and NPs and ligand–receptor binding have not been considered in this model as we first wanted to understand the flow of NPs through soft, biomimetic channels. In addition, particles that came in contact with the wall were assumed to be deposited
Facile biogenic fabrication of hydroxyapatite nanorods using cuttlefish bone and their bactericidal and biocompatibility study
Beilstein J. Nanotechnol. 2020, 11, 285–295, doi:10.3762/bjnano.11.21
- and Materials standard F756-00. Generally, the addition of hydroxyapatite microcrystals with blood will lead to hemolysis via aggregation of erythrocytes and membrane damage induced by crystals [49]. Moreover, Wiessner et al. (1988) showed that the crystallinity of the Hap plays a crucial role in
Non-agglomerated silicon–organic nanoparticles and their nanocomplexes with oligonucleotides: synthesis and properties
Beilstein J. Nanotechnol. 2018, 9, 2516–2525, doi:10.3762/bjnano.9.234
- -glutamine (Sigma-Aldrich, USA); RPMI-1640 medium; antibiotics (BioloT, Russia); fetal calf serum (Gibco, USA). Сhicken erythrocytes, MDCK cells, and influenza A virus strain A/chicken/Kurgan/05/2005 (H5N1) were from FBRI Vector, Russia. Trypsin (1 mg/mL) and penicillin-streptomycin (100 U/mL) were stored at
- the virus titer. The presence of the virus was visually determined under a microscope by the cytopathic action and in the hemagglutination reaction with a 1% suspension of chicken erythrocytes. The virus titer was expressed in terms of log TCID50/mL (Figure 6). The titer was evaluated by noting the
Evaluation of quantum dot conjugated antibodies for immunofluorescent labelling of cellular targets
Beilstein J. Nanotechnol. 2017, 8, 1238–1249, doi:10.3762/bjnano.8.125
- fibrillary acidic proteins (GFAPs) [12], mortalin [23], erythrocytes [24], GRP78 protein [25], caveolin-1 [26], golgi [20], and nuclear HER2 targets [6]. The majority of this labelling, however, was done with in-house synthesised Qdots rather than commercially available Qdots [27]. The use of commercially
High antiviral effect of TiO2·PL–DNA nanocomposites targeted to conservative regions of (−)RNA and (+)RNA of influenza A virus in cell culture
Beilstein J. Nanotechnol. 2016, 7, 1166–1173, doi:10.3762/bjnano.7.108
- : RPMI-1640 medium; antibiotics (BioloT, Russia); trypsin, L-glutamine; PBS buffer (Sigma, USA); and fetal calf serum (Gibco, USA). TiO2 nanoparticles were synthesized in the crystal form (anatase) as described in [17]. Сhicken erythrocytes, MDCK cells, and influenza A virus strains Aichi/2/68 (H3N2), A
- visually determined under a microscope by the cytopathic action and in the hemagglutination reaction with a 1% suspension of chicken erythrocytes. The virus titer was expressed in terms of TCID50/mL or log TCID50/mL (Table 2 and Figure 2, respectively). The titer was evaluated by noting the highest
Fabrication of hybrid graphene oxide/polyelectrolyte capsules by means of layer-by-layer assembly on erythrocyte cell templates
Beilstein J. Nanotechnol. 2015, 6, 2310–2318, doi:10.3762/bjnano.6.237
- FTIR spectroscopies. Keywords: capsules; erythrocytes; graphene; layer by layer; polyelectrolyte membranes; Introduction The past decades have witnessed explosive growth in research on low-dimensional carbon forms with graphene and carbon nanotubes in the forefront [1][2][3]. The unique electrical
- top of the erythrocytes, 3D closed films containing walls of PE/GO and an empty volume can be produced. Capsules based on GO can have applications in drug delivery, especially for topical applications, as the LbL capsules provide low degradability and high stability through the GO. The use of GO in
- and show the prominent (002) peak at 12.0 degrees 2θ, indicating an inter-planar GO sheet distance of 0.737 nm [29]. Prominent FTIR bands for GO were observed at 3415, 1723, 1623, 1394 and 1050 cm−1 as reported in [30]. A scheme of the layer-by-layer assembly applied on the erythrocytes for the
Protein corona – from molecular adsorption to physiological complexity
Beilstein J. Nanotechnol. 2015, 6, 857–873, doi:10.3762/bjnano.6.88
- experiments by using primary human cell models of the blood system. Pristine NPs immediately affected the vitality of endothelial cells, triggered thrombocyte activation and aggregation, and resulted in hemolysis of erythrocytes. However, such pristine NPs existed only for a very brief period of time in the
Hematopoietic and mesenchymal stem cells: polymeric nanoparticle uptake and lineage differentiation
Beilstein J. Nanotechnol. 2015, 6, 383–395, doi:10.3762/bjnano.6.38
- assume that this is due to an increase of free intracellular iron ions but obviously also depends on the cell type. For hHSCs and hMSCs, lineage differentiation into erythrocytes, granulocytes, and megakaryocytes or adipocytes, osteocytes and chondrocytes, was not influenced by the particles when
Overview about the localization of nanoparticles in tissue and cellular context by different imaging techniques
Beilstein J. Nanotechnol. 2015, 6, 263–280, doi:10.3762/bjnano.6.25
- pink cells with finely stippled cytoplasm whereas erythrocytes within sinusoids can be identified by their intensely pink color. Autoradiographic detection of radiolabeled dPG35S amine in organs and tissues. (a) Semiquantitative micro imager analysis detected different amounts of dPG35S amine in mouse
Distinction of nucleobases – a tip-enhanced Raman approach
Beilstein J. Nanotechnol. 2011, 2, 628–637, doi:10.3762/bjnano.2.66
- virus investigation [10] and studies of bacterial [11] and cellular systems [12][13], as well as of erythrocytes [14]. The first TERS experiments on DNA base nanocrystals [15][16][17] and a study of the hydrogen bonding between adenine and thymine on a gold substrate [18] showed that a distinction of
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