Development of a mucoadhesive drug delivery system and its interaction with gastric cells

• Ahmet Baki Sahin,
• Serdar Karakurt and
• Deniz Sezlev Bilecen

Beilstein J. Nanotechnol. 2025, 16, 371–384, doi:10.3762/bjnano.16.28

• one of the driving force behind mucoadhesion [57]. Therefore, the presence of the Eudragit polymer layer on the designed nanoparticles is beneficial for the enhancement of the electrostatic interactions between the nanoparticles and the gastric mucus, thus increasing their entrapment into the mucus

Vortex lattices of layered HTSCs at different vortex–vortex interaction potentials

• Valerii P. Lenkov,
• Anastasia N. Maksimova,
• Anna N. Moroz and
• Vladimir A. Kashurnikov

Beilstein J. Nanotechnol. 2025, 16, 362–370, doi:10.3762/bjnano.16.27

• distances greater than 10λ, repulsion is observed). In this work, the formation of vortex clusters and their motion under the action of the Lorentz force were investigated. Since their interaction potential is similar to intertype, our results are applicable to them. A description of the mechanism of the

Tailoring of physical properties of RF-sputtered ZnTe films: role of substrate temperature

• Kafi Devi,
• Usha Rani,
• Arun Kumar,
• Divya Gupta and
• Sanjeev Aggarwal

Beilstein J. Nanotechnol. 2025, 16, 333–348, doi:10.3762/bjnano.16.25

• the optical bandgap of the films can be tuned from 1.47 ± 0.02 eV to 3.11 ± 0.14 eV. The surface morphology of the films studied using atomic force microscopy reveals that there is uniform grain growth on the surface. Various morphological parameters such as roughness, particle size, particle density

• ) spectrophotometer under 320 nm excitation produced by a xenon arc lamp. For investigating the surface topography, atomic force microscopy (AFM) micrographs of ZnTe/Qz films were recorded (scan area 2 × 2 µm2) using a Bruker multimode-8 AFM in the ScanAsyst mode at the Ion Beam Centre, Kurukshetra University. The

Graphene oxide–chloroquine conjugate induces DNA damage in A549 lung cancer cells through autophagy modulation

• Braham Dutt Arya,
• Sandeep Mittal,
• Prachi Joshi,
• Alok Kumar Pandey,
• Jaime E. Ramirez-Vick,
• Govind Gupta and
• Surinder P. Singh

Beilstein J. Nanotechnol. 2025, 16, 316–332, doi:10.3762/bjnano.16.24

• -resolution transmission electron microscope (Technai G2 F30 STWIN, Japan), field emission scanning electron microscope (FEI, Quanta FEG 450, USA), and atomic force microscope (Nanoscope, Veeco V, USA) [28][29][30]. Cell culture A549 cells from the American Type Culture Collection (ATCC, Manassas, VA, USA

• ][51]. Further, the morphology and topography of GO nanosheets were analyzed employing atomic force microscopy. Supporting Information File 1, Figure S2 reveals the appearance of few layered interlocked GO nanosheets, and the topographical analysis reveals the thickness in the range of 0.6 to 1.06 nm

• GO and GO–Chl nanoconjugate via UV–vis, FTIR, Raman Spectroscopy, FESEM, and HRTEM. Figure S2 shows the atomic force microscopy-based topographical analysis of GO nanosheets. Figure S3 represents the XPS survey spectra of GO, GO–Chl, and Chl. Table S1 shows the summary of fitting parameters for the

Enhancing mechanical properties of chitosan/PVA electrospun nanofibers: a comprehensive review

• Nur Areisman Mohd Salleh,
• Amalina Muhammad Afifi,
• Fathiah Mohamed Zuki and
• Hanna Sofia SalehHudin

Beilstein J. Nanotechnol. 2025, 16, 286–307, doi:10.3762/bjnano.16.22

• , including irregular fluid jet movement, variations in surface tension, and sensitivity to external parameters such as temperature, humidity, and airflow. These factors can disrupt the uniformity of the fiber formation. When the fiber jets are drawn in the direction of the electric field force, the polymer

• . When an external force is applied to electrospun nanofibers, the load is distributed across a network of thousands of fibers. However, because of their random orientation, the force is not evenly distributed. In some cases, the load is concentrated on a single fiber, which can result in significant

• ]. Electrospinning involves applying a high voltage to a polymer solution delivered through a nozzle or capillary [71]. The electrostatic charge builds up at the tip of the droplet, and when the repulsive force of the charges overcomes the droplet’s surface tension, a cone-like jet, known as the Taylor cone, forms

Recent advances in photothermal nanomaterials for ophthalmic applications

• Jiayuan Zhuang,
• Linhui Jia,
• Chenghao Li,
• Rui Yang,
• Jiapeng Wang,
• Wen-an Wang,
• Heng Zhou and
• Xiangxia Luo

Beilstein J. Nanotechnol. 2025, 16, 195–215, doi:10.3762/bjnano.16.16

• photothermal conversion of iron oxide minimizes the necessary laser energy. The mechanical force generated by laser-induced VNBs enables the selective destruction of single corneal cells. The PLA films aid in precisely positioning the photothermal therapy, restrain the dispersion of iron oxide nanoclusters

Probing the potential of rare earth elements in the development of new anticancer drugs: single molecule studies

• Josiane A. D. Batista,
• Rayane M. de Oliveira,
• Carlos H. M. Lima,
• Milton L. Lana Júnior,
• Virgílio C. dos Anjos,
• Maria J. V. Bell and
• Márcio S. Rocha

Beilstein J. Nanotechnol. 2025, 16, 187–194, doi:10.3762/bjnano.16.15

• , Minas Gerais, Brazil Departamento de Ciências Naturais, Universidade Federal do Acre, Rio Branco, Acre, Brazil 10.3762/bjnano.16.15 Abstract We use optical tweezers and atomic force microscopy to investigate the potential of rare earth elements to be used as anticancer agents in the development of new

• what occurs with classical DNA condensing agents such as polycations and depletants. Keywords: DNA; optical tweezers; rare earth elements; single molecule force spectroscopy; Introduction The development of new drugs to treat human diseases is a field of singular importance that usually involves

• -molecule force spectroscopy using optical tweezers (OT) on DNA complexes formed with the three rare earths at various concentrations. The mechanical properties of these complexes were then determined as a function of the element concentration. From these data, the physical chemistry of the interaction was

A review of metal-organic frameworks and polymers in mixed matrix membranes for CO₂ capture

• Charlotte Skjold Qvist Christensen,
• Nicholas Hansen,
• Mahboubeh Motadayen,
• Nina Lock,
• Martin Lahn Henriksen and
• Jonathan Quinson

Beilstein J. Nanotechnol. 2025, 16, 155–186, doi:10.3762/bjnano.16.14

Instance maps as an organising concept for complex experimental workflows as demonstrated for (nano)material safety research

• Benjamin Punz,
• Maja Brajnik,
• Joh Dokler,
• Jaleesia D. Amos,
• Litty Johnson,
• Katie Reilly,
• Anastasios G. Papadiamantis,
• Amaia Green Etxabe,
• Lee Walker,
• Diego S. T. Martinez,
• Steffi Friedrichs,
• Klaus M. Weltring,
• Nazende Günday-Türeli,
• Claus Svendsen,
• Christine Ogilvie Hendren,
• Mark R. Wiesner,
• Martin Himly,
• Iseult Lynch and
• Thomas E. Exner

Beilstein J. Nanotechnol. 2025, 16, 57–77, doi:10.3762/bjnano.16.7

Advanced atomic force microscopy techniques V

• Philipp Rahe,
• Ilko Bald,
• Nadine Hauptmann,
• Regina Hoffmann-Vogel,
• Harry Mönig and
• Michael Reichling

Beilstein J. Nanotechnol. 2025, 16, 54–56, doi:10.3762/bjnano.16.6

• 10.3762/bjnano.16.6 Keywords: AFM; atomic force microscopy; conductivity; drift correction; force spectroscopy; NC-AFM; non-contact atomic force microscopy; resistivity; tip–surface interaction; With the restrictions on travelling and social distancing lifted, we were delighted to continue two series of

• meetings on atomic force microscopy (AFM), the 23rd International Conference on Non-Contact Atomic Force Microscopy (NC-AFM) held in Nijmegen (Netherlands) and the 6th International Workshop on Advanced Atomic Force Microscopy Techniques held in Potsdam (Germany). The strong advance in the field and the

• high quality of the presentations motivated us to establish this thematic issue in the Beilstein Journal of Nanotechnology for compiling the latest results on developments and applications of atomic force microscopy techniques. Atomic force microscopy, a technique soon celebrating its 40th anniversary

Mechanistic insights into endosomal escape by sodium oleate-modified liposomes

• Ebrahim Sadaqa,
• Satrialdi,
• Fransiska Kurniawan and
• Diky Mudhakir

Beilstein J. Nanotechnol. 2024, 15, 1667–1685, doi:10.3762/bjnano.15.131

Attempts to preserve and visualize protein corona on the surface of biological nanoparticles in blood serum using photomodification

• Julia E. Poletaeva,
• Anastasiya V. Tupitsyna,
• Alina E. Grigor’eva,
• Ilya S. Dovydenko and
• Elena I. Ryabchikova

Beilstein J. Nanotechnol. 2024, 15, 1654–1666, doi:10.3762/bjnano.15.130

• . The former is tightly linked the surface of the NPs and is stable when isolating the NPs, which allows for determining its protein composition [4][5][6][7]. In contrast, the components of the soft corona are weakly bonded to the underlying hard one and are easily separated by the slightest force. The

Heterogeneous reactions in a HFCVD reactor: simulation using a 2D model

• Xochitl Aleyda Morán Martínez,
• José Alberto Luna López,
• Zaira Jocelyn Hernández Simón,
• Gabriel Omar Mendoza Conde,
• José Álvaro David Hernández de Luz and
• Godofredo García Salgado

Beilstein J. Nanotechnol. 2024, 15, 1627–1638, doi:10.3762/bjnano.15.128

• density (kg·m−3), p is the pressure (Pa), F is the volume force vector (N·m−3), Cp is the specific heat capacity at constant pressure (J·kg−1·K−1), T is the absolute temperature (K), q is the heat flux vector (W·m−2), qr is the heat flux vector by radiation (W·m−2), I is the identity matrix (unitless

Natural nanofibers embedded in the seed mucilage envelope: composite hydrogels with specific adhesive and frictional properties

• Agnieszka Kreitschitz and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2024, 15, 1603–1618, doi:10.3762/bjnano.15.126

• atomic force microscopy (AFM), transmission electron microscopy (TEM), SEM, or cryo-SEM [45][57][63][64][65][66]. Very often, the procedures for preparing mucilage envelope samples can destroy and/or influence the organisation of polysaccharides, making the analysis of spatial structure of the mucilage

• brasilianum [121] or the human-mediated dispersal of Plantago asiatica seeds [122]. The mucilage envelope reveals its adhesive properties in a hydrated state. However, just after the seed hydration and mucilage envelope formation, the adhesion force is very low. With the loss of water, adhesion increases and

• cemented to the substrate (glass, soil, or animals) [29]. The results of our studies on adhesive force measurements of dried-in-contact seed mucilage gave us rather unexpected results. The mucilage (of individual seed samples) demonstrated adhesive properties even better than the commercial UHU glue (UHU

Ultrablack color in velvet ant cuticle

• Vinicius Marques Lopez,
• Wencke Krings,
• Juliana Reis Machado,
• Stanislav Gorb and
• Rhainer Guillermo-Ferreira

Beilstein J. Nanotechnol. 2024, 15, 1554–1565, doi:10.3762/bjnano.15.122

• most predators fear their panful stings and venom, but also because of their hard exoskeleton [29][30]. The sculptured cuticle may have a similar structure and force-resisting mechanisms as other wasps [34]. In some wasp species, the sculpturing of the cuticle and the lamellae terraces may form an

The round-robin approach applied to nanoinformatics: consensus prediction of nanomaterials zeta potential

• Dimitra-Danai Varsou,
• Arkaprava Banerjee,
• Joyita Roy,
• Kunal Roy,
• Giannis Savvas,
• Haralambos Sarimveis,
• Ewelina Wyrzykowska,
• Mateusz Balicki,
• Tomasz Puzyn,
• Georgia Melagraki,
• Iseult Lynch and
• Antreas Afantitis

Beilstein J. Nanotechnol. 2024, 15, 1536–1553, doi:10.3762/bjnano.15.121

• the ZP values of particles (expressing their electrostatic repulsion) controls the stability of colloidal dispersions according to the Derjaguin–Landau–Verwey–Overbeek (DLVO) theory [39]. For the computational analysis, the TIP3P force field was employed for water, while the DREIDING force field was

Integrating high-performance computing, machine learning, data management workflows, and infrastructures for multiscale simulations and nanomaterials technologies

• Fabio Le Piane,
• Mario Vozza,
• Matteo Baldoni and
• Francesco Mercuri

Beilstein J. Nanotechnol. 2024, 15, 1498–1521, doi:10.3762/bjnano.15.119

• molecules based on force-field molecular dynamics (MD). While simple, this workflow exhibits the main features of more complex simulations. The consistent representation of this workflow within MAMBO can therefore be instructive of the approach pursued and gives possible hints of the ability to formalize

Effect of radiation-induced vacancy saturation on the first-order phase transformation in nanoparticles: insights from a model

• Aram Shirinyan and
• Yuriy Bilogorodskyy

Beilstein J. Nanotechnol. 2024, 15, 1453–1472, doi:10.3762/bjnano.15.117

• thermodynamic stimulus for phase change, (ii) the contribution of surface energy due to a high percentage of surface atoms, (iii) interfaces acting as sinks for radiation-induced point defects, (iv) the accumulation of defects (saturation of vacancies) in the material as a driving force of phase changes, and (v

• , which is represented by the bulk driving force for the phase transition and the surface energy term, can be expressed as follows: ΔGbulk represents the bulk Gibbs free energy change, which serves as the bulk thermodynamic stimulus for the phase transition from one phase to another. ΔGsurf denotes the

• example, at 1500 K, it is nearly 7.92·1028 m−3 for the β phase and 7.94·1028 m−3 for the α phase). Both the driving force of the transformation, Δgbulk = gβ − gα, and the density, n, are functions of the temperature [33][37][38][39][40][41][45]. The model parameters for irradiation include a defect

Strain-induced bandgap engineering in 2D ψ-graphene materials: a first-principles study

• Kamal Kumar,
• Nora H. de Leeuw,
• Jost Adam and
• Abhishek Kumar Mishra

Beilstein J. Nanotechnol. 2024, 15, 1440–1452, doi:10.3762/bjnano.15.116

• graphene to a piezoelectric substrate, by shrinking or elongating the substrate by applying a bias voltage, or by using the tip of an atomic force microscope (AFM) to push graphene over a hole created in the substrate [29]. A wealth of literature on strain engineering of graphene and other 2D materials

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• microfluidics and high-shear-force homogenization [110]. As DDS, nanoemulsions can be reservoirs for encapsulating hydrophobic substances [111]. Moreover, emulsions of emulsions or double emulsions can be prepared by dispersing the droplets of primary emulsion into another liquid phase. Double emulsions can be

A biomimetic approach towards a universal slippery liquid infused surface coating

• Ryan A. Faase,
• Madeleine H. Hummel,
• AnneMarie V. Hasbrook,
• Andrew P. Carpenter and
• Joe E. Baio

Beilstein J. Nanotechnol. 2024, 15, 1376–1389, doi:10.3762/bjnano.15.111

• force microscopy (AFM), sum frequency generation spectroscopy (SFG), and X-ray photoelectron spectroscopy (XPS). Measuring static water contact angles is a straightforward method to determine the relative wettability of a material and allows for a quick check if our surface modifications were successful

• measurements were conducted with the sessile drop method. Droplets of 5 µL were pipetted onto the surface, and an image was captured. Eight images from two duplicates of each sample type were acquired on a smartphone device and processed in ImageJ (NIH). Atomic force microscopy AFM was conducted on a Veeco di

Hymenoptera and biomimetic surfaces: insights and innovations

• Vinicius Marques Lopez,
• Carlo Polidori and
• Rhainer Guillermo Ferreira

Beilstein J. Nanotechnol. 2024, 15, 1333–1352, doi:10.3762/bjnano.15.107

• joint axis and the tilt in the mandibular axis, provide insights for designing more efficient gripping devices [66]. Recently, a commercially available endoscopic needle holder was developed based on the morphology of Formica rufa, resulting in a remarkable increase in force amplification by up to 296

• . Additionally, when threatened, these ants possess the remarkable ability to jump several centimeters propelled by the force of their mandibles [69]. Engineers and material scientists can draw inspiration from these natural designs to develop lightweight yet durable components that enhance energy absorption and

• essential functions, insect wings must effectively transmit force from the muscles at their base to the surrounding air, generate lift, and uphold structural integrity without deformation [102]. Hence, wings need to be lightweight, flexible, and resilient, rendering them captivating subjects for biomimetic

Interaction of graphene oxide with tannic acid: computational modeling and toxicity mitigation in C. elegans

• Romana Petry,
• James M. de Almeida,
• Francine Côa,
• Felipe Crasto de Lima,
• Diego Stéfani T. Martinez and
• Adalberto Fazzio

Beilstein J. Nanotechnol. 2024, 15, 1297–1311, doi:10.3762/bjnano.15.105

• complete characterization of the GO sample is available in [36]. Atomic force microscopy (AFM), Raman spectroscopy, and X-ray photoelectron spectroscopy (XPS) were used to assess size, morphology, number of layers, and surface chemistry of GO. The GO sample used in this study consists of single layers with

• Agency (EPA), herein named EPA medium, in absence and presence of TA. Atomic force microscopy AFM has been extensively used to characterize the distribution and morphology of biomolecules on the surface of nanomaterials, especially 2D materials [37]. Figure 1a and Figure 1b show AFM images of GO sheets

• mechanisms of toxicity mitigation, we employed a computational workflow that involved studying the interactions between GO and TA at different theoretical levels. Molecular dynamics (MD) simulations were performed using the ReaxFF reactive force field to examine the evolution of TA conformation on the

The role of a tantalum interlayer in enhancing the properties of Fe₃O₄ thin films

• Hai Dang Ngo,
• Vo Doan Thanh Truong,
• Van Qui Le,
• Hoai Phuong Pham and
• Thi Kim Hang Pham

Beilstein J. Nanotechnol. 2024, 15, 1253–1259, doi:10.3762/bjnano.15.101

• morphological, structural, and magnetic properties of the deposited samples were characterized with atomic force microscopy, X-ray diffractometry, and vibrating sample magnetometry. The polycrystalline Fe3O4 film grown on MgO/Ta/SiO2/Si(100) presented very interesting morphology and structure characteristics

• films on three different types of substrates, namely an amorphous SiO2/Si(100) substrate, a single crystal MgO(100) substrate, and a buffer layer consisting of MgO/Ta/SiO2/Si(100). The properties of Fe3O4 thin films were analyzed using atomic force microscopy (AFM), X-ray diffractometry (XRD), and

• annealed at a temperature of 723 K for a duration of 2 h under a base pressure of 2.3 × 10−8 Torr. The Fe3O4 films were analyzed regarding their surface morphology, magnetic properties, and structural properties using atomic force microscopy (EasyScan2, Nanosurf), vibration sample magnetometry (Quantum

AI-assisted models to predict chemotherapy drugs modified with C₆₀ fullerene derivatives

• Jonathan-Siu-Loong Robles-Hernández,
• Dora Iliana Medina,
• Katerin Aguirre-Hurtado,
• Marlene Bosquez,
• Roberto Salcedo and
• Alan Miralrio

Beilstein J. Nanotechnol. 2024, 15, 1170–1188, doi:10.3762/bjnano.15.95

• genetic algorithms and final optimization at the DFTB3 level, respectively. London dispersion forces were considered in the DFTB3 and global optimization procedures by Lennard-Jones potentials, as implemented in UFF and MMFF94 force fields, respectively. The solvent effect was included by the Born

• structure, as in the study of Muthiah and coworkers [45], was validated using PROCHECK [46] to check the quality of the protein structure. The PDB produced with the previous step was subsequently optimized by an energy minimization through Amber force fields using the USCF Chimera 1.14 toolkit [47]. The

• the carbonyl group is the more nucleophilic center, whereas there are two positive-density regions near the carbonyl group and in the C–C bond next to the amine-substituted carbon atom. Both pharmaceutical agents are susceptible to interaction with fullerenes to form a force dispersion complex as it