Aprepitant-loaded solid lipid nanoparticles: a novel approach to enhance oral bioavailability

• Mazhar Hussain,
• Muhammad Farooq,
• Muhammad Asad Saeed,
• Muhammad Ijaz,
• Sherjeel Adnan,
• Zeeshan Masood,
• Muhammad Waqas,
• Wafa Ishaq and
• Nabeela Ameer

Beilstein J. Nanotechnol. 2025, 16, 652–663, doi:10.3762/bjnano.16.50

• patients in the delayed phase (days 2 to 5) in their first cycle of high-dose cisplatin [5]. Aprepitant (APT) is a selective antagonist of neurokinin-1 receptor that blocks the substance P emetic effect. NK-1 receptors occur in the gastrointestinal tract on vagal afferents and in the nucleus of the

• reducing the thickness of the diffusional layer in the gastrointestinal tract. The PDI is a parameter used to define particle size distribution. PDI values above 0.7 indicate a disperse particle size distribution. The APT-loaded SLNs APT-CD-NP4 and APT-PX-NP8 showed PDI values below 0.2, indicating uniform

• APT because of the surfactant in the formulations. APT-CD-NP4 showed a better outcome than APT-PX-NP8 because of the influence of β-CD. We propose that the medication has great penetrability in the gastrointestinal tract and would be quickly ingested to the same extent as to which it had been

A formulation containing Cymbopogon flexuosus essential oil: improvement of biochemical parameters and oxidative stress in diabetic rats

• Ailton Santos Sena-Júnior,
• Cleverton Nascimento Santana Andrade,
• Pedro Henrique Macedo Moura,
• Jocsã Hémany Cândido dos Santos,
• Cauãn Torres Trancoso,
• Eloia Emanuelly Dias Silva,
• Deise Maria Rego Rodrigues Silva,
• Ênio Pereira Telles,
• Luiz André Santos Silva,
• Isabella Lima Dantas Teles,
• Sara Fernanda Mota de Almeida,
• Daniel Alves de Souza,
• Jileno Ferreira Santos,
• Felipe José Aidar Martins,
• Ana Mara de Oliveira e Silva,
• Sandra Lauton-Santos,
• Guilherme Rodolfo Souza de Araujo,
• Cristiane Bani Correa,
• Rogéria De Souza Nunes,
• Lysandro Pinto Borges and
• Ana Amélia Moreira Lira

Beilstein J. Nanotechnol. 2025, 16, 617–636, doi:10.3762/bjnano.16.48

• -viscosity liquids. SMEDDSs are concentrated microemulsions that contain only the oil phase and the surfactant phase (without water). SMEDDSs can form MEs spontaneously through the addition of water and gentle agitation, such as movement of the gastrointestinal tract, and can be formulated into capsules [26

Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

• Ana Cubillo Alvarez,
• Dylan Maguire and
• Ruairí P. Brannigan

Beilstein J. Nanotechnol. 2025, 16, 435–463, doi:10.3762/bjnano.16.34

Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy

• Naths Grazia Sukubo,
• Paolo Bigini and
• Annalisa Morelli

Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10

• healthy mice and in a murine model of Huntington's disease [42]. Similarly, inhalation for lung targeting [43], subcutaneous injection for reaching lymph nodes [44], or oral administration for gastrointestinal tract disorders [45] are important alternative routes. 4.2 Macrophage depletion and modulation

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

• water solubility. Many phytochemicals are hydrophobic and show poor water solubility, which significantly restricts their absorption in the gastrointestinal tract (GIT) when administered orally. This low solubility leads to low bioavailability, resulting in sub-therapeutic levels of the phytochemical at

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

• Shakhzodjon Uzokboev,
• Khojimukhammad Akhmadbekov,
• Ra’no Nuritdinova,
• Salah M. Tawfik and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

• gastrointestinal tract to deliver the active pharmaceutical substance without any damage to its site of action. In addition to that, biopolymers can protect patients from the negative effects of chemicals, serving as a small container to safely store drugs inside. Moreover, biopolymers are not harmful to the human

• digestive enzymes in the gastrointestinal tract can break down some medications before they reach the bloodstream [45]. In addition to this, lack of selectivity can minimize their effectiveness. Also, drug absorption may be high in detoxifying organs such as liver and kidneys, causing toxicity in those

• drugs that need to be delivered to the gastrointestinal tract, as it ensures maximum absorption and therapeutic efficacy. Drug encapsulation without organic solvents is advantageous because organic solvents can be toxic and pose a risk to patient safety. The nanoparticles have a large surface area-to

Cholesterol nanoarchaeosomes for alendronate targeted delivery as an anti-endothelial dysfunction agent

• Horacio Emanuel Jerez,
• Yamila Roxana Simioni,
• Kajal Ghosal,
• Maria Jose Morilla and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 517–534, doi:10.3762/bjnano.15.46

• -inflammatory effects of ALN only occur at micromolar concentrations [12]. Such high concentrations, however, may hardly be achieved in blood because of the low bioavailability and high affinity of ALN to the hydroxyapatite matrix. At high oral dosages, ALN causes severe irritation of the upper gastrointestinal

• tract, osteonecrosis of the jaws (BRONJ), and serious musculoskeletal pain and cardiovascular risks [13][59][60]. Its intravenous delivery poses the risk of nephrotoxicity, fever, flu symptoms, and electrolyte imbalance [61]. Together, these disadvantages complicate its exploitation as an anti

Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• ingredients of antioxidant supplements. However, these compounds have low bioavailability related to low stability, solubility, and absorbance in the gastrointestinal tract [124][125][126][127]. Recently, with extraordinary progress in nanotechnology development, nanodelivery systems have been considered as

• an effective solution because of their ability to overcome the physical and chemical barriers in the gastrointestinal tract. Such barriers are the intestinal mucosal barrier, acidic conditions in the stomach, and selectively permeable membranes of enterocytes. Moreover, natural compounds delivered by

Nanotechnological approaches in the treatment of schistosomiasis: an overview

• Lucas Carvalho,
• Michelle Sarcinelli and
• Beatriz Patrício

Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2

• ]. Praziquantel is a class II compound according to the biopharmaceutical classification system (BCS), so it has low solubility and high permeability in the gastrointestinal tract [6]. This drug is affected by the first-pass effect on the liver, which also impacts its bioavailability [6]. Unfortunately, this

• a bioavailability improvement. That is because bioavailability of orally administered drugs depends on their ability to be absorbed in the gastrointestinal tract. For class II drugs (e.g., PZQ) the absorption process is limited by drug dissolution rate in gastrointestinal media. Therefore

Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies

• Giuliana Muraca,
• María Esperanza Ruiz,
• Rocío C. Gambaro,
• Sebastián Scioli-Montoto,
• María Laura Sbaraglini,
• Gisel Padula,
• José Sebastián Cisneros,
• Cecilia Yamil Chain,
• Vera A. Álvarez,
• Cristián Huck-Iriart,
• Guillermo R. Castro,
• María Belén Piñero,
• Matias Ildebrando Marchetto,
• Catalina Alba Soto,
• Germán A. Islan and
• Alan Talevi

Beilstein J. Nanotechnol. 2023, 14, 804–818, doi:10.3762/bjnano.14.66

• might present or mild, nonspecific, or no symptoms. This phase is followed by a chronic stage where parasites can be primarily found inside specific tissues. Decades after infection, signs and symptoms of damage to target organs, mainly the heart, gastrointestinal tract, and brain appear in 20–30% of

Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

• gastrointestinal tract and distributed in the body, they interact with EGFR signaling pathways of many normal cells influencing their proliferation, differentiation, migration, and apoptosis. This leads to side effects, including rash, erythema, diarrhea, gastrointestinal perforations, ocular lesions, and

Orally administered docetaxel-loaded chitosan-decorated cationic PLGA nanoparticles for intestinal tumors: formulation, comprehensive in vitro characterization, and release kinetics

• Sedat Ünal,
• Osman Doğan and
• Yeşim Aktaş

Beilstein J. Nanotechnol. 2022, 13, 1393–1407, doi:10.3762/bjnano.13.115

• orally applicable nanodrug formulations that can act against diseases seen in the distant region of the gastrointestinal tract (GIT), such as intestinal tumor, brings with it a series of difficulties depending on the drug and/or GIT physiology. The aim of this study is to develop an oral nanoparticle

• . However, the occurrence of colon carcinomas in the most distant region of the gastrointestinal tract makes the development of oral formulations for colon carcinomas more difficult than that of other formulations [10]. Considering multiple factors such as the variable pH of the gastrointestinal tract

• , enzymatic destructive environment, and transit time through the gastrointestinal tract, the ability of an orally administered formulation to reach colon carcinomas stably and effectively necessitates a serious pharmaceutical formulation study and a comprehensive evaluation. It is possible to overcome the

Bioselectivity of silk protein-based materials and their bio-inspired applications

• Hendrik Bargel,
• Vanessa T. Trossmann,
• Christoph Sommer and
• Thomas Scheibel

Beilstein J. Nanotechnol. 2022, 13, 902–921, doi:10.3762/bjnano.13.81

• , gastrointestinal tract, and respiratory tract, as well as in leukocyte cells such as monocytes, neutrophils, and others, thus forming a central part of mammalian innate immunity [87]. The multitude of immuno-functional roles of the broad-spectrum antimicrobial peptides includes (1) eliminating bacterial growth

Ciprofloxacin-loaded dissolving polymeric microneedles as a potential therapeutic for the treatment of S. aureus skin infections

• Sharif Abdelghany,
• Walhan Alshaer,
• Yazan Al Thaher,
• Maram Al Fawares,
• Amal G. Al-Bakri,
• Saja Zuriekat and
• Randa SH. Mansour

Beilstein J. Nanotechnol. 2022, 13, 517–527, doi:10.3762/bjnano.13.43

• low bioavailability of orally administered drugs due to poor absorption and enzymatic degradation in the gastrointestinal tract [3][4]. Among the different types of microneedles, dissolving microneedles have attracted research due to their advantages, which include low cost and simple preparation

Engineered titania nanomaterials in advanced clinical applications

• Padmavati Sahare,
• Paulina Govea Alvarez,
• Juan Manual Sanchez Yanez,
• Gabriel Luna-Bárcenas,
• Samik Chakraborty,
• Sujay Paul and
• Miriam Estevez

Beilstein J. Nanotechnol. 2022, 13, 201–218, doi:10.3762/bjnano.13.15

• /kg body weight did not lead to absorption from the gastrointestinal tract into the blood, urine, or other internal organs. Furthermore, human studies revealed that gastrointestinal absorption of TiO2 nps into blood and urine was minimal and that the nps are expected to be removed mostly by renal

• therapeutic molecules) in the gastrointestinal tract. These inherent limitations led to the development of nanomedicines as potent drug delivery vehicles approved for medicinal use and treatment of life-threatening diseases. Several types of nps, such as liposomal, polymer-based, terpenoid-based, and

An overview of microneedle applications, materials, and fabrication methods

• Zahra Faraji Rad,
• Philip D. Prewett and
• Graham J. Davies

Beilstein J. Nanotechnol. 2021, 12, 1034–1046, doi:10.3762/bjnano.12.77

• -administration of tests and treatments, particularly in transitional and developing countries. Although oral delivery of drugs may overcome some of these problems, many drugs cannot be absorbed orally because of degradation in the liver and gastrointestinal tract [11], so that intravenous, intramuscular, or

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

• -uptake” cells showed endocytic uptake, while the ‘high-uptake” cells showed uptake through cell membrane pores [72]. Schoellhammer et al. hypothesized that US could permeabilize the gastrointestinal tract through transient cavitation bubbles. For the first time, they locally demonstrated the

Nanogenerator-based self-powered sensors for data collection

• Yicheng Shao,
• Maoliang Shen,
• Yuankai Zhou,
• Xin Cui,
• Lijie Li and
• Yan Zhang

Beilstein J. Nanotechnol. 2021, 12, 680–693, doi:10.3762/bjnano.12.54

• gastrointestinal tract is weaker. Traditional TENGs are affected by the heart and respiration, and it is difficult to obtain accurate information on the physiological activity of the gastrointestinal tract. Cheng et al. proposed an asymmetrical and ultrasensitive TENG (ATNG), which can monitor tiny

• injected into the stomach of the rabbit. After 5 min, the gastrointestinal peristalsis becomes intense, and after 10 min, the peristaltic recovery becomes smooth (Figure 3f). It shows that the ATNG can monitor the weak activity of the gastrointestinal tract of a rabbit and can provide data on weak

Selective detection of complex gas mixtures using point contacts: concept, method and tools

• Alexander P. Pospelov,
• Victor I. Belan,
• Dmytro O. Harbuz,
• Volodymyr L. Vakula,
• Lyudmila V. Kamarchuk,
• Yuliya V. Volkova and
• Gennadii V. Kamarchuk

Beilstein J. Nanotechnol. 2020, 11, 1631–1643, doi:10.3762/bjnano.11.146

• at the National Academy of Medical Sciences of Ukraine", within the framework of the program that studies the fundamental mechanisms of disease development in the upper gastrointestinal tract. The development and testing of the method to detect the breath components involved patients in the age range

• -invasive diagnosis of erosive-ulcerative lesions of the gastrointestinal tract based on the detection in the breath of ill patients of waste products from the bacterium Helicobacter pylori, including cytotoxic strains of this microorganism. However, it should be noted that further improvement of analytical

Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations

• Jaison Jeevanandam,
• Ahmed Barhoum,
• Yen S. Chan,
• Alain Dufresne and
• Michael K. Danquah

Beilstein J. Nanotechnol. 2018, 9, 1050–1074, doi:10.3762/bjnano.9.98

Selective detection of Mg²⁺ ions via enhanced fluorescence emission using Au–DNA nanocomposites

• Tanushree Basu,
• Khyati Rana,
• Niranjan Das and
• Bonamali Pal

Beilstein J. Nanotechnol. 2017, 8, 762–771, doi:10.3762/bjnano.8.79

• . However, at higher concentrations in the body, it causes severe damage to the gastrointestinal tract (GIT), liver and heart. Some methods employing radioactive isotopes [10][11], fluorescent indicators [12][13][14] and electrophysiology [12][15] have been used for the detection of Mg2+ ions in biological

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

• Huijuan Zhang,
• Fuqiang Wu,
• Yazhen Li,
• Xiping Yang,
• Jiamei Huang,
• Tingting Lv,
• Yingying Zhang,
• Jianzhong Chen,
• Haijun Chen,
• Yu Gao,
• Guannan Liu and
• Lee Jia

Beilstein J. Nanotechnol. 2016, 7, 1861–1870, doi:10.3762/bjnano.7.178

• likely to dissolve in acidic solution [33]. The sustained-release manner of MCNs could prolong the time of drug absorption in the gastrointestinal tract, which might be beneficial to enhanced bioavailability of MIF [31][34]. The sustained-release phenomenon also proved that TPP is an appropriate

• area produced by the nanoparticles and the bioadhesive properties of Cs allow more of the drug to interact with the gastrointestinal tract [38][39]. These pharmacokinetic data clearly evidence the ability of CNs to enhance the absorption of MIF, which suggests that CNs could be a good formulation for

The distribution and degradation of radiolabeled superparamagnetic iron oxide nanoparticles and quantum dots in mice

• Denise Bargheer,
• Artur Giemsa,
• Barbara Freund,
• Markus Heine,
• Christian Waurisch,
• Gordon M. Stachowski,
• Stephen G. Hickey,
• Alexander Eychmüller,
• Jörg Heeren and
• Peter Nielsen

Beilstein J. Nanotechnol. 2015, 6, 111–123, doi:10.3762/bjnano.6.11

• sensitivity in insulin-dependent cells [27]. In this model, after interaction, Cr3+ would be excreted via the kidneys and replaced by freshly absorbed Cr [28]. As shown here by the 51Cr-WBR over 28 d, the excretion of 51Cr via the kidneys and gastrointestinal tract is rather slow when using 51Cr-SPIOs and

• very different from 51CrCl3 (Figure 4). Excretion of 51Cr from SPIOs was found mostly in feces and very little in urine (data not shown). After 4 weeks, a small loss of 51Cr from the liver seems to be distributed mainly to the spleen, gastrointestinal tract (GIT), and carcass, whereas from CrCl3, 51Cr

• elegantly used to study the absorption of intact nanoparticles from the gastrointestinal tract, an important topic in nanotoxicology. For this, 59Fe-labeled SPIOs were given by gavage to groups of mice and the 59Fe-WBR was followed in living mice for 14 d using a whole body counter (Figure 5A). Most of the

Functionalized polystyrene nanoparticles as a platform for studying bio–nano interactions

• Cornelia Loos,
• Tatiana Syrovets,
• Anna Musyanovych,
• Volker Mailänder,
• Katharina Landfester,
• G. Ulrich Nienhaus and
• Thomas Simmet

Beilstein J. Nanotechnol. 2014, 5, 2403–2412, doi:10.3762/bjnano.5.250

• et al. is 300 ppm (1,000 µg/m3) [9]. If the level of styrene in the air exceeds this value, there is a possibility of adverse health effects. Among others, the EPA has declared styrene as a suspected carcinogen and a suspected toxin to the gastrointestinal tract, kidney, and respiratory system [10

Coating with luminal gut-constituents alters adherence of nanoparticles to intestinal epithelial cells

• Heike Sinnecker,
• Katrin Ramaker and
• Andreas Frey

Beilstein J. Nanotechnol. 2014, 5, 2308–2315, doi:10.3762/bjnano.5.239

• NP uptake. Considering that NPs are covered by luminal gut-constituents en route through the gastrointestinal tract, we wanted to know if such modifications have an influence on the interaction between NPs and enterocytes. Results: We investigated the consequences of a treatment with various luminal