Recent advances in photothermal nanomaterials for ophthalmic applications

• Jiayuan Zhuang,
• Linhui Jia,
• Chenghao Li,
• Rui Yang,
• Jiapeng Wang,
• Wen-an Wang,
• Heng Zhou and
• Xiangxia Luo

Beilstein J. Nanotechnol. 2025, 16, 195–215, doi:10.3762/bjnano.16.16

• adjacent healthy cells [109]. After eliminating tumor cells, small gold nanorods can penetrate the blood–brain barrier and be effectively excreted from the body through renal excretion, thereby avoiding the production of VNBs near non-cancerous cells. 3.2 Posterior capsule opacity after cataract surgery

• PAI contrast agents [195][196]. Gold nanorods [197], gold nanostars [198], hollow gold nanocages [199], chains of gold nanoparticles [200], and ultraminiature chain-like gold nanoparticle clusters [201] have been used for the detection of ocular structures such as retinal blood vessels, choroidal

Nanoarchitectonics with cetrimonium bromide on metal nanoparticles for linker-free detection of toxic metal ions and catalytic degradation of 4-nitrophenol

• Akash Kumar and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2024, 15, 1312–1332, doi:10.3762/bjnano.15.106

• degrading 94.37% of 4-NP within 1 min. In contrast, silver nanospheres effectively detected Hg2+, Cu2+, and Fe3+ at concentrations as low as 1 ppm and degraded 90.78% of 4-NP within 30 min. Moreover, anisotropic gold nanorods (CTAB-AuNR1 and CTAB-AuNR2) showed promising sensing capabilities towards Cu2

• , respectively, to remove impurities. The supernatants were discarded and the pellets were dispersed in DD water and stored at room temperature. Tunable aspect ratio of gold nanorods capped with CTAB Gold nanorods of different lengths were synthesized using a two-step protocol as described in previous reports

• with slight modifications [30]. Briefly, in the first step, gold seeds were prepared by mixing CTAB, HAuCl4·3H2O and NaBH4. The seed solution acts as an initiator for synthesizing gold nanorods. In the second step, the growth solution was prepared, consisting of CTAB, AgNO3, HAuCl4·3H2O, HCl, and

Gold nanomakura: nanoarchitectonics and their photothermal response in association with carrageenan hydrogels

• Nabojit Das,
• Vikas,
• Akash Kumar,
• Sanjeev Soni and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2024, 15, 678–693, doi:10.3762/bjnano.15.56

• hydrogel beads attained up to ≈17.2, ≈17.2, and ≈15.7 °C, respectively. On the other hand, gold nanorods after incorporation into k-CG did not yield much photothermal response as compared to that of AuNMs. The results showed a promising platform to utilize nanomakura particles along with kappa-carrageenan

• ]. A very recent study reported photothermal effect of gold nanorods of shorter and longer lengths in gel and aqueous media [18]. In recent times, anisotropic nanoparticles due to their unique physicochemical properties have garnered attention among researchers and enabled them to manoeuvre into an

• aspiring venture of soft intelligent materials [19]. Soft intelligent materials are primarily hydrogel materials that are stimuli responsive. A recent study showed the use of hydrogels by incorporating gold nanorods for the development of thermo-responsive actuators [20]. The photothermal conversion of

Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• reduction in infarction size, TNF-α levels, cardiac fibrosis, and improvement in cardiac systolic function. Gold nanorods serving as surface-enhanced Raman scattering probes have demonstrated sensitivity for the early detection of ICAM-1, a significant signal for screening atherosclerosis, particularly in

Influence of conductive carbon and MnCo₂O₄ on morphological and electrical properties of hydrogels for electrochemical energy conversion

• Sylwia Pawłowska,
• Karolina Cysewska,
• Yasamin Ziai,
• Jakub Karczewski,
• Piotr Jasiński and
• Sebastian Molin

Beilstein J. Nanotechnol. 2024, 15, 57–70, doi:10.3762/bjnano.15.6

• surface for the sample Hgel-MCO-cCB 1:3 showed the presence of MCO and cCB particles in the hydrogel scaffold, confirming their entrapment in the polymer matrix (Figure 1b and Figure 1e). A similar composite structure with gold nanorods suspended in the PNIPAAm matrix was observed by Nakielski et al. [47

Density functional theory study of Au-fcc/Ge and Au-hcp/Ge interfaces

• Olga Sikora,
• Małgorzata Sternik,
• Benedykt R. Jany,
• Franciszek Krok,
• Przemysław Piekarz and
• Andrzej M. Oleś

Beilstein J. Nanotechnol. 2023, 14, 1093–1105, doi:10.3762/bjnano.14.90

• . Recently, nanostructures including different polytypes of gold have been observed in various experiments and have gained interest regarding potential applications. For example, the interface regions of polytypic gold nanorods were found to be highly active in catalysis [15]. The hexagonal phases seen in

Nanoarchitectonics of photothermal materials to enhance the sensitivity of lateral flow assays

• Elangovan Sarathkumar,
• Rajasekharan S. Anjana and
• Ramapurath S. Jayasree

Beilstein J. Nanotechnol. 2023, 14, 988–1003, doi:10.3762/bjnano.14.82

• architecture of the gold nanoparticles, their plasmonic absorption can be tuned from the visible to the NIR region. Among the different structures of gold, gold nanorods are commonly used as photothermal agents because of the tuneable aspect ratio, anisotropic architecture, and high photoconversion efficiency

• (PCE). However, studies report that gold nanorods suffer from poor photostability, and loss of shape and NIR LSPR upon laser irradiation [39]. By using palladium nanostructures, photothermal stability could be achieved to some extent as they did not change their shape upon laser irradiation. Palladium

• -to-scattering ratios of gold nanorods and gold nanoshells are high compared to that of gold nanoparticles and can be further increased by changing the dimensions or the cross-sectional areas [56][57]. Light scattering of nanomaterials should be minimum for an efficient photon-to-heat conversion. The

Plasmonic nanotechnology for photothermal applications – an evaluation

• A. R. Indhu,
• L. Keerthana and
• Gnanaprakash Dharmalingam

Beilstein J. Nanotechnol. 2023, 14, 380–419, doi:10.3762/bjnano.14.33

Concentration-dependent photothermal conversion efficiency of gold nanoparticles under near-infrared laser and broadband irradiation

• Vikas,
• Raj Kumar and
• Sanjeev Soni

Beilstein J. Nanotechnol. 2023, 14, 205–217, doi:10.3762/bjnano.14.20

• evaluated. Results show that for a concentration of 20.0 µg/mL, 40 nm gold nanospheres, 25 × 47 nm gold nanorods (GNRs), and 10 × 41 nm GNRs show a 4–110% higher photothermal conversion efficiency under NIR broadband irradiation than under NIR laser irradiation. Broadband irradiation seems suitable to

• broadband light source and a near-infrared laser (for comparison). Gold nanospheres (GNSs) of 40 nm diameter and gold nanorods (GNRs) of sizes 25 × 47 nm, 10 × 38 nm, and 10 × 41 nm were examined. The photothermal conversion efficiency for these GNPs is reported for different nanoparticle concentrations and

• laser or broadband irradiation. Broadband irradiation results in a much higher efficiency for 25 × 47 nm GNRs, whose peak absorption wavelength highly differs from the irradiation wavelength. A photothermal conversion efficiency of 53% for 10 × 41 nm gold nanorods, as determined in our study, has also

Solvent-induced assembly of mono- and divalent silica nanoparticles

• Bin Liu,
• Etienne Duguet and
• Serge Ravaine

Beilstein J. Nanotechnol. 2023, 14, 52–60, doi:10.3762/bjnano.14.6

• by liquid bridging [23], and into a series of structures under an AC electric field [24]. The linear self-assembly of patchy gold nanorods tethered with hydrophobic polymer chains at both ends can be triggered by solvophobic attractions induced by a change in solvent quality [25]. By using post

• -assembly ligand photo-cross-linking [26] or by adding monofunctional nanospheres into a suspension of bifunctional gold nanorods [27], it has been shown that the average degree of polymerization of the resulting chains can be controlled. The reduction of solvent quality may also be employed to induce the

• act as chain stoppers, as their addition into suspensions of soft patchy nanoparticles [36], gold nanorods [27], or silver nanoplates [37] allowed for the control of chain length. We thus studied the capability of 1-PSN to act as chain stoppers when they are mixed with 2-PSN, whose solvent-induced

Facile preparation of Au- and BODIPY-grafted lipid nanoparticles for synergized photothermal therapy

• Yuran Wang,
• Xudong Li,
• Haijun Chen and
• Yu Gao

Beilstein J. Nanotechnol. 2022, 13, 1432–1444, doi:10.3762/bjnano.13.118

• near-infrared (NIR) absorption [2]. Various gold nanoscale platforms, including nanostars, nanorods, nanospheres, nanoshells, and nanocages, have been designed as PTAs for PTT. Gold nanorods (ca. 50 nm), nanoshells (ca. 130 nm), and nanoparticles with large sizes (>50 nm) are suitable for PTT because

The role of deep eutectic solvents and carrageenan in synthesizing biocompatible anisotropic metal nanoparticles

• Nabojit Das,
• Akash Kumar and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2021, 12, 924–938, doi:10.3762/bjnano.12.69

• maintaining high yield and monodispersity. Initially, gold nanorods were synthesized using electrochemical methods using polycarbonate membrane templates or porous alumina for shape control in the presence of surfactants (mostly CTAB) [34][35]. Because of their optical properties, gold nanorods became

• ), dodecyltrimethylammonium bromide (DTAB), hexadecyltrimethylammonium chloride (CTAC), and benzyldimethylhexadecylammonium chloride (BDAC) have been used as structure-directing agents for synthesizing gold nanorods [41][42][43]. Co-mixtures of these quaternary ammonium surfactants are also being used to synthesize

• cytotoxicity of quaternary ammonium surfactants in which cytotoxicity increased with the increase in carbon chain length of the surfactants [47]. Several reports have shown that the toxicity of CTAB-capped gold nanorods depends on nanoparticle size, shape, particle concentration, surface modification, and

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

Rapid controlled synthesis of gold–platinum nanorods with excellent photothermal properties under 808 nm excitation

• Jialin Wang,
• Qianqian Duan,
• Min Yang,
• Boye Zhang,
• Li Guo,
• Pengcui Li,
• Wendong Zhang and
• Shengbo Sang

Beilstein J. Nanotechnol. 2021, 12, 462–472, doi:10.3762/bjnano.12.37

• –Pt nanoparticles with adjustable LSPR wavelength range. In this work, the effects of Ag+ and K2PtCl4 on the deposition of Pt on the surface of gold nanorods (AuNRs) were investigated. A fast, precise, and controlled synthesis of dumbbell-like Pt-coated AuNRs (Au@Pt NRs) under mild conditions is

Doxorubicin-loaded gold nanorods: a multifunctional chemo-photothermal nanoplatform for cancer management

• Uzma Azeem Awan,
• Abida Raza,
• Shaukat Ali,
• Rida Fatima Saeed and
• Nosheen Akhtar

Beilstein J. Nanotechnol. 2021, 12, 295–303, doi:10.3762/bjnano.12.24

• study was to fabricate biocompatible multifunctional drug-loaded nanoscale moieties for co-therapy (chemo-photothermal therapy) with maximum efficacy and minimum side effects. Herein, we report in vitro anticancerous effects of doxorubicin (DOX) loaded on gold nanorods coated with the polyelectrolyte

• based on chemotherapy and photothermal strategies appears to be a promising platform in cancer management. Keywords: chemotherapy; doxorubicin; gold nanorods; NIR laser; photothermal therapy; Introduction Despite the enormous advances in medical research, cancer is still the second most common cause

• , nanorods, nanoshells, and nanocages) have great potential in photothermal cancer therapy due to plasmonic properties and the ease of biofunctionalization. Gold nanorods (GNRs) are more preferable than other gold nanomaterials because of their photothermal conversion efficiency. Better nanotherapeutics can

Photothermally active nanoparticles as a promising tool for eliminating bacteria and biofilms

• Mykola Borzenkov,
• Piersandro Pallavicini,
• Angelo Taglietti,
• Laura D’Alfonso,
• Maddalena Collini and
• Giuseppe Chirico

Beilstein J. Nanotechnol. 2020, 11, 1134–1146, doi:10.3762/bjnano.11.98

• the main causes of bacterial damage. The polygonally shaped vancomycin-bound gold nanoparticles efficiently killed (>99%) of the targeted bacteria that were submitted to irradiation with 808 nm light for 5 min [48]. In another study, gold nanorods covalently linked with primary antibodies efficiently

• eliminated the pathogenic P. aeruginosa upon NIR irradiation [49]. Gold nanorods were also applied to efficiently ablate (up to 97%) S. aureus upon NIR laser irradiation [50]. In these studies, the results suggested that the thermal damage of the bacterial membranes led to bacterial death. In 2013, the first

• the observed LSPR band, increasing both the NIR absorption and the photothermal conversion, which allowed for the elimination of Gram-positive bacteria. In another recent work, the photothermal-triggered effect of phospholipid-coated gold nanorods against P. aeruginosa planktonic and biofilm cultures

Key for crossing the BBB with nanoparticles: the rational design

• Sonia M. Lombardo,
• Marc Schneider,
• Akif E. Türeli and
• Nazende Günday Türeli

Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72

• targeting ligands, such as angiopep-2, TAT or EGF, allows their accumulation to be increased in these specific areas [70][78][107][176]. Although to a lower extent, gold nanorods (AuNRs) have also been used for brain delivery. AuNRs, like AuNPs, exhibit an optical feature called surface plasmon resonance

Luminescent gold nanoclusters for bioimaging applications

• Nonappa

Beilstein J. Nanotechnol. 2020, 11, 533–546, doi:10.3762/bjnano.11.42

• luminescence phenomenon in detail. The realization by Wilcoxon et al. that AuNPs with sizes of less than 5 nm show luminescence has provided the foundation for extensive investigation on various nanostructures [33]. Since the 1990s, several groups have reported AuNPs, including gold nanorods showing

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

• Varsha Sharma and
• Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

Using gold nanoparticles to detect single-nucleotide polymorphisms: toward liquid biopsy

• María Sanromán Iglesias and
• Marek Grzelczak

Beilstein J. Nanotechnol. 2020, 11, 263–284, doi:10.3762/bjnano.11.20

• nanorods as a signal transducers. Due to their intense longitudinal surface plasmon band, gold nanorods exhibit a higher sensitivity to changes of the colloidal stability as compared to spherical nanoparticles. Thus, by using gold nanorods one can lower the detection limit. The authors used unmodified gold

• nanorods for an HCR process as illustrated in Figure 6. The presence of a target DNA induced the hybridization of a hairpin DNA, producing a nicked double helix. Through electrostatic repulsion, this double helix prevented the aggregation of the gold nanorods at high salt concentrations. However, in the

• absence of a target DNA, the gold nanorods easily aggregated because of weak protection by hairpin DNA. Following this approach, the authors were able to detect target DNA in a range of 0–60 nM at a detection limit of 1.47 nM. The method is highly selective in distinguishing matching and single-base

Gold-coated plant virus as computed tomography imaging contrast agent

• Alaa A. A. Aljabali,
• Mazhar S. Al Zoubi,
• Khalid M. Al-Batanyeh,
• Ali Al-Radaideh,
• Mohammad A. Obeid,
• Abeer Al Sharabi,
• Walhan Alshaer,
• Bayan AbuFares,
• Tasnim Al-Zanati,
• Murtaza M. Tambuwala,
• Naveed Akbar and
• David J. Evans

Beilstein J. Nanotechnol. 2019, 10, 1983–1993, doi:10.3762/bjnano.10.195

• with a mean circulation half-life of 14.6 h. Von Maltzahan et al. developed PEGylated gold nanorods (13 × 47 nm) as CT contrast agents and for photothermal tumor therapy. The study resulted in tumor elimination and mice survival over 50 days [23]. Further, van Schooneveld et al. reported micelle-based

• AuNPs by generating 66 nm AuNPs coated with an 11 nm layer of silica and showed that for mice injected with these particles a contrast signal was observed [13]. Popovtzer et al. reported successful CT imaging of squamous cell carcinoma using gold nanorods coated with anti-antigen A9 [24]. The low

Porous silver-coated pNIPAM-co-AAc hydrogel nanocapsules

• William W. Bryan,
• Riddhiman Medhi,
• Maria D. Marquez,
• Supparesk Rittikulsittichai,
• Michael Tran and
• T. Randall Lee

Beilstein J. Nanotechnol. 2019, 10, 1973–1982, doi:10.3762/bjnano.10.194

• , Zhao et al. created pH- and temperature-sensitive bioprobes by incorporating pNIPAM hydrogel cores with europium organic complexes [67]. In separate studies, Lee and co-workers utilized both biocompatible gold nanoshells, iron oxide nanoparticles, and gold nanorods with thermo-responsive hydrogel

Self-assembly and wetting properties of gold nanorod–CTAB molecules on HOPG

• Imtiaz Ahmad,
• Floor Derkink,
• Tim Boulogne,
• Pantelis Bampoulis,
• Harold J. W. Zandvliet,
• Hidayat Ullah Khan,
• Rahim Jan and
• E. Stefan Kooij

Beilstein J. Nanotechnol. 2019, 10, 696–705, doi:10.3762/bjnano.10.69

• surface. The self-assembled layers of CTAB molecules on the HOPG terraces prior to nanorod deposition were shown to change the wettability of the surface, and as a result, gold nanorod deposition takes place on nonwetting HOPG terraces. Keywords: CTAB; gold nanorods; micelles; self-assembly; wettability

• gold nanorods align with the step edges whereas side-by-side close packed arrays oriented in all possible directions were observed at the terraces on HOPG [51]. In their work, however, the notable role of CTAB on a HOPG surface is not highlighted. It has been reported [43][45] that on nonpolar surfaces

• assembled nanorods can disturb the desired properties between the associated gold nanorods and the HOPG surface. Furthermore, the study and understanding of various assembled morphologies of surfactant molecules is relevant in many other areas [13][14][32]. Results and Discussion In drying experiments on

Surface plasmon resonance enhancement of photoluminescence intensity and bioimaging application of gold nanorod@CdSe/ZnS quantum dots

• Siyi Hu,
• Yu Ren,
• Yue Wang,
• Jinhua Li,
• Junle Qu,
• Liwei Liu,
• Hanbin Ma and
• Yuguo Tang

Beilstein J. Nanotechnol. 2019, 10, 22–31, doi:10.3762/bjnano.10.3

• nanoparticle comprised of CdSe/ZnS QDs and gold nanorods (GNRs) where the GNRs were applied to enhance the photoluminescence (PL) of the CdSe/ZnS QDs. In particular, we have obtained the scattering PL spectrum of a single CdSe/ZnS QD and GNR@CdSe/ZnS nanoparticle and comparison results show that the CdSe/ZnS

• as an optical process for MCF-7 breast cancer cells. Keywords: bioimaging; gold nanorods; photoluminescence enhancement; quantum dots; Introduction In the past decades, quantum dots (QDs) have proven to be increasingly useful for their unique features [1][2][3][4][5]. The light emission from QDs

• metal materials play a role in the enhancement of fluorescence in QDs, especially gold nanorods (GNRs) and Cu or Ca+ ion binding of QDs [16][17][18][19]. GNRs possess two plasmonic resonance bands – a longitudinal band and a transverse band. These bands correspond to the electron oscillations along the

The nanoscaled metal-organic framework ICR-2 as a carrier of porphyrins for photodynamic therapy

• Jan Hynek,
• Sebastian Jurík,
• Martina Koncošová,
• Jaroslav Zelenka,
• Ivana Křížová,
• Tomáš Ruml,
• Kaplan Kirakci,
• Ivo Jakubec,
• František Kovanda,
• Kamil Lang and
• Jan Demel

Beilstein J. Nanotechnol. 2018, 9, 2960–2967, doi:10.3762/bjnano.9.275

• light [23]. Alternatively, the antitumor activity of porphyrinic PCN-224 was increased by combining photodynamic and photothermal effects with chemotherapy; in this case the MOF was deposited onto gold nanorods and impregnated with a chemotherapeutic agent [24]. Strong phototoxic effects were reported